pfam05361: PP1_inhibitor (This model is not part of the current CDD release)
PKC-activated protein phosphatase-1 inhibitor
Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction.
Jiyao W et al.(2023). "The conserved domain database in 2023.",