Conserved Protein Domain Family
GATA-N

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pfam05349: GATA-N 
GATA-type transcription activator, N-terminal
GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.
Statistics
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PSSM-Id: 398818
Aligned: 32 rows
Threshold Bit Score: 91.3602
Threshold Setting Gi: 395507321
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q61169       147 MYQTLAALSSQGPA--AY-DGAPGGFVHSaaaaaaaaaAASSPVYVPTTR-VGSMLSGLPYLQGAG-------------- 208 house mouse
XP_003777251   1 MYQSLAMAANHGPPpgAYeAGGPGAFMHGa-------gAASSPVYVPTPR-VPSSVLGLSYLQGGGagsasggasgg--- 69  Sumatran orangutan
XP_003757974   1 MYQSLAMA-NHGPPpgAYeTGGPGAFMHGa-------gATSSPVYVPTPR-VPSSMLGLSYLQGGGsgaagsgpggssss 71  Tasmanian devil
XP_008120695   1 MYQSLAMAANHGPP--SY--EGASGFMHSa--------AAASPVYIPTTR-VTSMISSLPYLQGSA-------------- 53  green anole
XP_005044495   1 MYQSLAMAANPGPP--AY--EGAGGFMHSa--------AAASPVYVPTTR-VTSMLPSLPYLQSSA-------------- 53  Collared flycat...
XP_006642996   1 MYQGIAMTTNHGAP--SY----ESRFMHSa--------AATSPVFVPTTR-ATPMIPALPYLQPHA-------------- 51  spotted gar
XP_015458327   1 MYQGLTISATHHAAh-SY----EASFLPSvg------sTARSPVYVPSPR-VPAVLPALPYLQAHG-------------- 54  Mexican tetra
NP_001266556   1 MYQGI-MTSNHGPS--SY----EAGFLHNa-------sTGTSPVYVPTTRvVTPMIPALPYLQTPG-------------- 52  Nile tilapia
NP_001016949   1 MYQSIAMAANHGPP--AY--EGAGGYMHSa-------tAATSPVYVPTTR-VSSMIPSLPYLQTSG-------------- 54  tropical clawed...
XP_019126150   1 MYQGI-MTTNHGPP--SY----EAGFLHNa-------sAGTSPVYVPTTRvVTPMIPALPYLQTPG-------------- 52  large yellow cr...
Q61169       209 ------------SGPSNHAGgagahpgWS-Q---ASA-DSP-PYGGggaagggaagpggagsatahA---SARFPY---S 264 house mouse
XP_003777251  70 -ssggaasgagpGTQQGSPG-------WS-Q---AGA-DGA-AYTP--------------------Pp-vSPRFSFpgtT 114 Sumatran orangutan
XP_003757974  72 ssagaapsgsgpAAQQGSPA-------WS-Q---PGP-EGS-TYTP--------------------Ps-vSPRFSFxxxX 117 Tasmanian devil
XP_008120695  54 ------------SSQQGSPVssh--siWTpQ---PGA-ESV-AYNPgs----------------shPs-vSPRFSF---A 94  green anole
XP_005044495  54 ------------SSQQGSPVssh--siWT-Q---PAA-ESA-AYNPgs----------------shPp-vSPRFSF---S 93  Collared flycat...
XP_006642996  52 ------------ASQQNSPVcsh--sgWA-Q---STE-EPVpSYTTgg----------------shQstmSPRFTF---S 93  spotted gar
XP_015458327  55 -------------APHHGASsssahsaWA-QdpgSSSsSPPsSYSAggsg------------ntahAppvSPRFVF---S 105 Mexican tetra
NP_001266556  53 ------------ASQQSSPAssh--saWA-Q---PGA-DSVpSYNh--------------------Sp-vSPRFTF---S 89  Nile tilapia
NP_001016949  55 ------------SSQQGSPVsgh--nmWA-Q---AGA-EPS-AYNPgt----------------shPp-vSPRFTF---S 94  tropical clawed...
XP_019126150  53 ------------ASQQSSPVssh--saWA-Q---PGA-DSVpSYNh--------------------Sp-vSPRFAF---S 89  large yellow cr...
Q61169       265 PSPPMAN--GAARDp-GGYvaaggtgagsvsgggGSLAAM--GGREhQYSslsaARPLNGTYhhhhhhhPtYS-----P- 333 house mouse
XP_003777251 115 GSLAAAAaaAAAREa-AAYss------------gGGAAGAglAGRE-QYG----RAGFAGSYs-----sP-YP-----A- 164 Sumatran orangutan
XP_003757974 118 XXXXXAAaaAAAREa-AAYgt------------sGAGGTAglGGRE-QYG----RPSFGGSYs-----sP-YPaaaaaA- 172 Tasmanian devil
XP_008120695  95 TSSPIAA--TTSREv-AAY---------------SSSLSItaNSRE-QY-----ARNFGGSYs-----sH-YP-----At 139 green anole
XP_005044495  94 TSTPIPA--TSSREaaAAY---------------SSSLNLsaNGRE-QY-----GRGFGSSYs-----sP-YP-----A- 138 Collared flycat...
XP_006642996  94 TSPPISAavAAVRDn-ATY---------------PSPLNIsaNGRE-QYG----TRGLGGSYh-----sP-YP-----A- 140 spotted gar
XP_015458327 106 ANSPLCSg-------------------------mTGTLDTpaGGAR--------GLGMGPSYhp----sP-YP-----A- 141 Mexican tetra
NP_001266556  90 TSPPLSSgvATAREtaVSY---------------TSPLNIsaNGRD-HYS----ARGLSGSYh-----sP-YS-----A- 137 Nile tilapia
NP_001016949  95 SSPPISA--ASNRE--VPY---------------SSPLAIsaNGRE-QY-----GRALGATYs-----sP-YP-----A- 137 tropical clawed...
XP_019126150  90 TSPPLSsgvatvrEtaASY---------------TSPLNIsaNGRE-HYG----ARSLSGSYh-----sP-YP-----A- 137 large yellow cr...
Q61169       334 YMAa-PLTPAW-------PAGPFETPVLHSLQGRaGAPLPvpRGPST 372 house mouse
XP_003777251 165 YMA--DVGASWaaa-aaaSAGPFDSPVLHSLPGR-ANPAA--RHPNL 205 Sumatran orangutan
XP_003757974 173 YMTaaDMGASWaaaaaaaSAGPFDGPVLHSLPGR-ANPAT--RHPNL 216 Tasmanian devil
XP_008120695 140 YMSp-ELGSTW-------TASHFENPMLHNLPNR-GSPGAa-RHGNl 176 green anole
XP_005044495 139 YMSp-EMATSW-------TSSPFDSPMLHNLQSR-GTPAAa-RHANI 175 Collared flycatcher
XP_006642996 141 YVSp-SMGGGW-------TTSPFDSSVLHSLQPG-GAPGTa-RHPSI 177 spotted gar
XP_015458327 142 YVSp-GMGGTW-------AASHFDSSVLHGLQSGdQNPVA--RHPDL 178 Mexican tetra
NP_001266556 138 YMSp-NVGGTW-------PASPFDSPVLHGLQAG-APPGTa-RHPNI 174 Nile tilapia
NP_001016949 138 YMSp-DMGATW-------TASPFDSSMLHNLQNR-AGPAAs-RHPNI 174 tropical clawed frog
XP_019126150 138 YMSp-NVGGTW-------PASPFDSPVLHGLQT--GAPPGttrhpnm 174 large yellow croaker
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