4M00,4M00


Conserved Protein Domain Family
He_PIG
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pfam05345: He_PIG 
Putative Ig domain
This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.
Links
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Statistics
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PSSM-Id: 398814
Aligned: 97 rows
Threshold Bit Score: 32.828
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4M00_A  454 APTVTP----------IGDQSSEVYSPISPIKIATQDNSGN------------AVT-------NTVTGLPSGLTFDSTN- 503 
Q83FH2  608 PFVAGNs--------tVYVSTDQTLDKTTGVLTG-IVGGTDvtvslpqgtnqnATT-------PGSNSLPKGLSLSVSGt 671  Tropheryma whipplei...
Q83FH2  505 THVVAGva------ysLSPASGNQDNPLSQPTSVSYYRLADgtn------qnaTT--------PGSNSLPKGLSLNPNT- 563  Tropheryma whipplei...
Q83FH2 1062 NPVYAApg------grVSIPQLDGKGGFKYTLVDARNQaet---------vkkSDG-------PVQFGLPTGLSLNPET- 1118 Tropheryma whipplei...
Q83FH2  836 GTIVLP----------PSVTGLTTAGTYSIGEPDTKSKKKKpeeg-----atsP---------DTHDKLPKGLHLSPET- 890  Tropheryma whipplei...
Q83FH2  951 NPVKVKtldgqdfsglPITPTATDTNTYTWSLYD---SGSTegtg-----iipA---------DST--LPRGLSLDKST- 1010 Tropheryma whipplei...
Q8A1R7  191 APQINN----------PLTYGARPGNPFLMPIMVsgk-------------rpmTYK-------AKG--LPKGLKLNRKT- 237  Bacteroides thetaio...
Q8A389   39 KPCINS----------PRAIGNYPASPFLFYIPTtgq-------------rpmEWS-------AEK--LPKGLKLDSKT- 85   Bacteroides thetaio...
Q83H45  233 PMHFNVd---------DQNFELQAYKPFKFPLSANgaa------------iawV---------ATG--LPKGIYLSPA-- 278  Tropheryma whipplei...
Q83H45  135 QIVLGD-----------VLAQIKQGDPVRIPAKIIggh------------slfNFRlagkprtTPGIAYPMGLSVDSKT- 190  Tropheryma whipplei...

4M00_A  504 ----------NTISGT-----PTNI--GTSTISI---VSTDASGnkt------ttTFKYEVT 539 
Q83FH2  672 gesstasarsVHLTGKp----DGSVapGRYLTRL---SVTSGGvtk-------tvVLVVVVT 719  Tropheryma whipplei str. Twist
Q83FH2  564 ----------GTISGTvastgDEIPasGTYSFRV---IAVSLGGekt------evTYTLRVE 606  Tropheryma whipplei str. Twist
Q83FH2 1119 ----------GYVSGTv----GKTVlpGTYVFGVk--VSADSLDtgrfpgssetiYYALTVT 1164 Tropheryma whipplei str. Twist
Q83FH2  891 ----------GTIYGVi----DKTVktGVYSFPL---TLTYGDDkn-------kkSVSAVVE 928  Tropheryma whipplei str. Twist
Q83FH2 1011 ----------GKITGTi----DSSVeyGTYTFRL---RATNATGgyg------vaDISLIYV 1049 Tropheryma whipplei str. Twist
Q8A1R7  238 ----------GLITGS-------TNtnGNFKVRL---QATNEKGtd-------ekEITLKIG 272  Bacteroides thetaiotaomicron
Q8A389   86 ----------GIITGS-------VAskGEYTVTL---KAKNALGts-------teKLVIRIG 120  Bacteroides thetaiotaomicron
Q83H45  279 ----------GLLYGV-----PA-VppGEYSARL---TVYGLEVrsg-----vlkIVSVTAN 316  Tropheryma whipplei str. Twist
Q83H45  191 ----------GVLFGTv----SYEVeyGVYNFLLwadEVVHGEIvsh------faYYTLLVS 232  Tropheryma whipplei str. Twist
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