Conserved Protein Domain Family
Peptidase_M26_N
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pfam05342: Peptidase_M26_N (This model is not part of the current CDD release)
M26 IgA1-specific Metallo-endopeptidase N-terminal region
These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated with pfam00746, they may be attached to the cell wall.
Links
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Statistics
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PSSM-Id: 516765
Aligned: 14 rows
Threshold Bit Score: 301.548
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011999920  689 GLDYYTPYDIETTLSYDL--GNGSESKELARETVQLDLKKVELKSITNVALMKVENGQTKLM-PTLAEKPANLDQYYLHF 765  Streptococcus...
WP_369351160  459 GLDYDTPYEIETSYTYDIg-AGSVTKTLPDRVPFELEIKKIEMRNIVSTKLFEMVDNTPAER-SSLTSQPTDMSKFYIQI 536  Streptococcus...
Q8DQN5        581 KLKYYQGYTLSTTMVYDR--GEGEETEKLEDKQIQLDLKKVEIKNIKETSLMNVDAEGNETDkSLLSEKPTDVSQLYLRV 658  Streptococcus...
WP_005608185  612 GLDYYKDYTLSTSMTFDR--GNGTETQLLEDQTVRLELKKIEIKDVREVRLIRYENQEEHNE-TRLSSVPTDTSHYYLKI 688  Granulicatell...
WP_011837491  613 GLDYYTPYKVETTLSYDL--GNGPESQELAQETVQLDLKKVELKSITNVALMKVENGQTKLM-PTLAEKPANLDQYYLHF 689  Streptococcus...
WP_023392522 2673 GLNYEVPYRLVTELTYADklGVSKTDPQLSEELVELKLKKFELKQIKEEGLYQVEGQELKRV-SALASVPQDLSGYLVKV 2751 Abiotrophia d...
WP_315025976  957 GLDYHVPYRLHTVMDYENq-QGAQSKDQLEDQAIELDLKKIELKQIKGVQLFHRQADGSHQLmASLSQIPSDLSNYYVKV 1035 Abiotrophia d...
WP_104967957  752 DLDWHVKYTLKTQYSYDLedGQGVQIEHLADREFELDYKRLEIKHVVSAGLFQKQPDGSYLQlDNVSQVAADLNDYYVRV 831  Streptococcus...
WP_115268188  552 NLDFYTDYTLKTKVFYTLd-SVEHNAIQESLREFDLVYKKIEVKDIDAVTVYRRKNGEYTSA-YILDETPTNPDDLFVKV 629  Streptococcus...
WP_011836924  551 QVEPPQEYTENIEPATPEa-ENPTEKAQEPKEQKQEPEKNIELRNVSDVELYSLTDGKYKQH-VSLDANPTNQENYFVKV 628  Streptococcus...

WP_011999920  766 TSDQFKDTVLPVTSIEEVVVDNQPVFKIKAQLPDLLQRs--ATGLQNSFDFYLEKAKKREGNVYYDFQDLLDGIKENPSG 843  Streptococcus...
WP_369351160  537 DTTDKRDAYIPVHAIEEAVVDGEAAYKVTVKMDELVQD---RQGYKEDYTFYVRKSKVSANNTYYNFGDLVTAIKANPLG 613  Streptococcus...
Q8DQN5        659 TTHDNKVTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRr-aDDTLSEEYVHYFEKQLPKVNNVYYNFNELVKDMQANPMG 737  Streptococcus...
WP_005608185  689 TSENQKTTLLAVKTIEEILSNGKEVYKVTAMAENLVDRq-kNQTFDDVYTYFIEKPRTHVGNVYYDFEDLVNAIRENPTG 767  Granulicatell...
WP_011837491  690 TSDQFKDTVLPVTSIEEVVVDNQPVFKIQAQLPDLLQRs--ATGLQNSFDFYLEKAKKREGNVYYDFQDLLDGIKEDPSG 767  Streptococcus...
WP_023392522 2752 SSDRYKDVVLKVAAIEATTYNGEDYYQVTATAPELVQNnggTTDYHQTHQFLVRKAAPAVNNVYHSFGELLTAMKANLSG 2831 Abiotrophia d...
WP_315025976 1036 QSDRFKDVYLPVASIETVSHDGQSYYQVTTQAPELVQNqggSSDYHQGYQFLVGQERPADGNVHYSFKSLLEAIRQNPAG 1115 Abiotrophia d...
WP_104967957  832 VSDQQRDIYLPVTDMVEDTYDGKPVFKVTTSIPELIQYdqaIADNTANYSFYIRKFVPSSDGKYRTFSDLITAIKNNMSG 911  Streptococcus...
WP_115268188  630 TSDRFKDIYLPISSVKETTKDGQQVYELTSTFDQLVEDn--GTSFNQLKVFYIPKVTK-ENGVYTDFTSLLDAMKANPTG 706  Streptococcus...
WP_011836924  629 KSSKFKDVFLPISSIVDSTKDGQPVYKITASAEKLKQDv--DNKYVDNFTFYLAKKAEREVTNFTSFSNLVQAINNDLGG 706  Streptococcus...

WP_011999920  844 TFILGRSISAKLIDkpansKSYLPGeFKGQLIGg-qNGERhaILDLAHPLFDTITGg-TVKDIDFKRVNMVypDSqagDT 921  Streptococcus...
WP_369351160  614 HFTLGSDLFAPEAK-----DAYVKE-FSGILTG---GNFA--IYNLTAPLIAKASG--KISDLDLKNVKINs-DQ---SF 676  Streptococcus...
Q8DQN5        738 EFKLGADLNAVNVKpa--gKAYVMAkFRGTLSSvenHQYT--IHNLERPLFNEAEGa-TLKNFNLGNVNINmpWA---DK 809  Streptococcus...
WP_005608185  768 EFRLGQSMSARNVAsq--gKSYIKAeFTGKLLSe--DGKRfaIKDLEHPLFNVIKNa-TIKNVNFENVDI---DQknqDD 839  Granulicatell...
WP_011837491  768 TFILGRSISAKLIDkpansKSYLPGeFKGQLIGg-qNGERhaILDLAHPLFDTITGg-TVKDIDFKRVNMVypDSqagDT 845  Streptococcus...
WP_023392522 2832 TFILGSNVSAADVVlakgqEAYLMDtFRGKLLGrgaDGQShaIFDLKAPLFKETNQa-TISNLDLKRVDIR--DR---DN 2905 Abiotrophia d...
WP_315025976 1116 DYILGANLSASEVSlaanaTAYFVGtFTGTLSGqtaDGTQhaIYNLVAPLFDQLNKa-TIKHLDLKQVAIE--SG---NS 1189 Abiotrophia d...
WP_104967957  912 TFEIDADLNADEIVldanaTSYIPGtFTGRLLG---NNNA--ILNLKAPLFEFLQGsfEIKDLDLKKVNI---QKpnmEQ 983  Streptococcus...
WP_115268188  707 TFKLGANLYADEVQvg-dvKAYITDtFQGTLLGe-sNGNKyaIHNLKAPLFAKIEHa-TISGIDLKNVQI---SSalhRD 780  Streptococcus...
WP_011836924  707 TYYLGASLNANEVElenaaSSYIKGrFTGKLFGs-kDGKNyaIYNLKKPLFDTLSAa-TVENLALKDVNIS--GK---TD 779  Streptococcus...

WP_011999920  922 IATIAARLKNKGV--IENVNVQG 942  Streptococcus gordonii
WP_369351160  677 VGALAGELTTGAR--LENVAVTG 697  Streptococcus hillyeri
Q8DQN5        810 VAPIGNMFKK-ST--LENIKVVG 829  Streptococcus pneumoniae R6
WP_005608185  840 IATVAQTMNGSSV--IEDVKVTG 860  Granulicatella adiacens
WP_011837491  846 IATIAARLKNKGV--IENVNVQG 866  Streptococcus sanguinis
WP_023392522 2906 VGSLAVVANQ-TT--ITDVTASG 2925 Abiotrophia defectiva
WP_315025976 1190 IAALAKRATN-ST--ISDVAVSG 1209 Abiotrophia defectiva
WP_104967957  984 FGALAKIANGDNVgkISNVAVEG 1006 Streptococcus pluranimalium
WP_115268188  781 LGSLANETAY-ST--ISDVAVQG 800  Streptococcus hyointestinalis
WP_011836924  780 VGALANEANNATR--INNVHVDG 800  Streptococcus sanguinis
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