Conserved Protein Domain Family
Sperm_Ag_HE2
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pfam05324: Sperm_Ag_HE2 (This model is not part of the current CDD release)
Sperm antigen HE2
This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.
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Statistics
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PSSM-Id: 516756
Aligned: 7 rows
Threshold Bit Score: 82.2451
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_054354764   5 LLLSvaSLLLVALLLPGSSQARHVNHSATDA---LGElRERAPGQGTNRFQLLRHPVKRDLLpPRTPPYQGDV 74 
1_pfamImport   1 LAPS--TLLFVVLLFPGLSRVTHANRQDPKG---PRK-QEESLGRGTNRSHPLHHQVKRYLV-PRKPPFPDTD 66 
Q3UW43         5 LLPFfaSLLFAALLFPGLSNASSINHLVTEP---PSFpKDEFPARGVNGSQLLHHRVKR--LpPRTPPYHEPE 72  house mouse
XP_002929982   4 SLSLfiSLLLVALMPPGQSRAGNVNHQGTEGlrePREsREESPGQGKNGSPLFHHQEKRQLL-PRTPPYPEPE 75 
Q30KR3         4 PLSPlvSFLLVALMFPGPSRARNINHQGTEG---PREpWEESPGQGKNESHLLHHREKRRLL-PRTPPYLEPE 72  dog
XP_003803643   5 FLPPftSLLLVVLLFSGLSGTQYVDHSSTEG---PRElGEQSPGHSS------HQQVKRYVLpPRTPPYQEPE 68 
XP_054188233   5 LLPSvtSLLLVALLFPGSSQARHVNHSATEA---LGElRERAPGQGTNGFQLLRHAVKRDLLpPRTPPYQEPA 74  human
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