Conserved Protein Domain Family
Pox_P21
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pfam05313: Pox_P21 
Poxvirus P21 membrane protein
The P21 membrane protein of vaccinia virus, encoded by the A17L (or A18L) gene, has been reported to localise on the inner of the two membranes of the intracellular mature virus (IMV). It has also been shown that P21 acts as a membrane anchor for the externally located fusion protein P14 (A27L gene).
Links
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Statistics
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PSSM-Id: 283071
Aligned: 8 rows
Threshold Bit Score: 226.588
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9Q8J3   1 MSYLSYYNMFTDFSAGAGVSEPELFTKEEEESFFPRlgs---daSGGKDTSHLPhlslptsLKG-LIPNILMRNDIKSLI 76  Myxoma virus
Q6TUR0   1 MSYLSYYNMFDDFAAGAGVSERDLFTKEEEESFLPK--------DDGNFKVSLPn------FKG-SFPDILVRNDIKSLI 65  Yaba monkey tumor virus
Q8V3J0   1 MSYLSYYNMFSDFNAGAGVTDTELFTKEEEEAFLPKhd-----nITGEYNFGFP-------FKGsSFPNILMRNDIRALI 68  Swinepox virus
Q08FN4   1 MSYLSYYNMFSDFNAGAGVSDMELFTKEEEESFLPRp------nESGEYTLSFPn------LKG-SFPDILMRNDIQSLI 67  Deerpox virus W-848-83
Q98289   1 MSYLNYYNIFDDFQAGAGVMDEELFTPEEEKSFLPHagva---------------------pgnaFFSSILRNADVRTLL 59  Molluscum contagiosum...
Q6TVM6   2 ESYFSYYN--DEFTAG-GVQDAELFSPEEQNAFLPKd-------PGTADSPLVPatprpvpGGNiAPYSVLQYEDIRILT 71  Orf virus
P68593   1 MSYLRYYNMLDDFSAGAGVLDKDLFTEEQQQSFMPKdggmmqndYGGMN----------------DYLGIFKNNDVRTLL 64  Vaccinia virus WR
Q9J551   3 NNYLNYYNVFEEFDAGAGIKEKELFTEEQQLSFLPKkglgnggfDGVER----------------LYSNIINNNDIKSLL 66  Fowlpox virus strain ...

Q9Q8J3  77 GLILFVLAITTPPYISVIMLGIASILIPFPSLVIAYCLLLQIVNTTSy---GTIGMTIVCVFMSF-FTMAMQ--T-VSRT 149 Myxoma virus
Q6TUR0  66 GLILFVLAITTTPVIAVIMIAVAAALIPFPSLVIAYCLSMQIINPTN----KTTVMSIICVAMAI-VTIVVN--S-LSRT 137 Yaba monkey tumor virus
Q8V3J0  69 GLILFVLAITTTPVIAVIMIAVASALLPFPSLVIAYCLSVQIINPGNn---NATTMSIICVALAI-IAIFIN--S-ISKT 141 Swinepox virus
Q08FN4  68 GLILFVLAITTTPVIAIIMIAVASALLPFPSLVIAYCLSMQILNFGNnggnRTIAMSIICVGLAI-LTMVMN--S-VSKT 143 Deerpox virus W-848-83
Q98289  60 GLVLFVIALGAPPSVGVFMVCAAALLMPLPCLVIAYCLAMQITHPNAg---ANVGMAVLCVLASVaVMLLVRsvA-ASAA 135 Molluscum contagiosum...
Q6TVM6  72 GIVIFVLALTSTPVLALVMIGIASLILPLPCLVIGYCAAMQIMHPYAa---NNTGMAIVCTIMSI-VTIIVThvT-GSVG 146 Orf virus
P68593  65 GLILFVLALYSPPLISILMIFISSFLLPLTSLVITYCLVTQMYRGGNg---NTVGMSIVCIVAAV-IIMAINvfT-NSQI 139 Vaccinia virus WR
Q9J551  67 ALIMLVFAINTNSLVALIFIILSAIFVPVPALIIAYCIALHLKNGSDa---THVGISILLMLASA-VTIYLTstSkISKG 142 Fowlpox virus strain ...

Q9Q8J3 150 VYTISYIILAILFCVYVFNIT-RARs-QSSEPT-----KCA--VKEGIRRCAE 193 Myxoma virus
Q6TUR0 138 AYTISYIILAVLFCIYAFNLT-KFK--LGSSIS-----KCSreFQGGDKYGGE 182 Yaba monkey tumor virus
Q8V3J0 142 AYIITYIILAVLFCIYAFNLT-RSSk-NNMNVT-----RCPrdIRGGDKHSIE 187 Swinepox virus
Q08FN4 144 AYTISYIILAVLFCIYAFNLT-KFSkiNTSTIN-----KCTreFRGGNKYGIE 190 Deerpox virus W-848-83
Q98289 136 LSLTAAGVLLALFCAYALRLS------RPSAVT-----GCK---RAGAGF-LP 173 Molluscum contagiosum virus subtype 1
Q6TVM6 147 ATTFMYIVLGLLFAIYAFRLTgRGIvrTRSAAP-----ACP--VYAGAKsedl 192 Orf virus
P68593 140 FNIISYIILFILFFAYVMNIE-RQDyrRSINVTipeqyTCNkpYTAGNKVDVD 191 Vaccinia virus WR
Q9J551 143 FKRAIDVVLLVILGFYIVKIYg-----IDRQISipsrrYCR--QMSGPSS-LE 187 Fowlpox virus strain NVSL
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