Conserved Protein Domain Family
MIC19_MIC25
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pfam05300: MIC19_MIC25 (This model is not part of the current CDD release)
MICOS complex subunit MIC19/MIC25
MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
Links
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Statistics
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PSSM-Id: 516748
Aligned: 26 rows
Threshold Bit Score: 101.624
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q63ZW2        30 SEDVLQRMRNTNADprppannkenqgh-----------------------------------------------qtrtps 62  zebrafish
Q5FVV3        30 SDEVVNRMKDSDLPskdqstsaasgtasapaafp---------------------------------skagpsashpast 76  tropical clawed...
Q9BRQ6        31 SENVVNRMKEPSspppaptsstfglqdgnlr--------------------------------------aphkestlprs 72  human
XP_008258535  31 SENVVNRMKDSSQPaagqqqapppsalgspggsa----------------------------------ntpqkeskplrs 76 
Q91VN4        31 SESVVNRMKDCSQPsageqlvpgfgpsssapvptvplpaisvptvpapttpvptapsssvrglpggtckgpltdvkvpsa 110 house mouse
EHB03687      31 SENVVQRMKDPSPLaegqqpapppaapdcgst-------------------------------------apqkepklpts 73 
3_pfamImport   1 SENVVNRMKDPNPPppapppstggsskgpe------------------------------------------kdskpprs 38 
Q32L35        31 SENVVNRMKEPGQPsrvgllappaaalgpsgg--------------------------------------rekdskpprp 72  domestic cattle
4_pfamImport   1 SEDVVNRMKQPCQTkkdqrappippspilqpaeg----------------------------------kskvptgisppt 46 
XP_016156984  32 TEDVVNRMRGCSVRkrdihpsprasdg-----------------------------------------------tapssl 64 

Q63ZW2        63 tsdaqapKTQ---AKTTFPDSKEELKKRYEQQQAIIQEELARIARKEREAARQDISRAVQRERAQTRQESERAKQL---- 135 zebrafish
Q5FVV3        77 stggahkPTA---AGVGQQYAEEDLYRRYEREQAIIQEELARLAKRERESAHEKLSASILLEKNSTNQERRKAEHL---- 149 tropical clawed...
Q9BRQ6        73 gssggqqPSG----------MKEG-VKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRL---- 137 human
XP_008258535  77 easggqqSSG----------MKED-LKRFKQEQATVQHELFQEAKREREADVKHSKVSLPQGTGSAEPEKQKSAQL---- 141
Q91VN4       111 esggglqSSA----------VKED-LKKFQQEQLAVQDEMVRVAKKEKEAAEKHLKASLPKKKASLTHEQQQSARL---- 175 house mouse
EHB03687      74 kigggrqPSG----------VKED-LKRFRQEQATVQDELFRVVRREREAAAKHVTAVPPAVEGSTDQEKQQSARL---- 138
3_pfamImport  39 eygggrqPSG----------VEEDFLKRYKQEQAKVQDELFQVVTREREAATKHRSASMQRGEGSVDQDKRKSTQL---- 104
Q32L35        73 dcgsgrgPPR----------VQVDPLERCDWEQAVLQDELVRVATTEREAAASPRSVTLRRGEGGVDQEKQRLAQR---- 138 domestic cattle
4_pfamImport  47 pdslgrkPSE----------AEEELYKRYEQEQAMVQEELLRLAKREREAATESLNVTLQRERSNTNEEKQKTSQI---- 112
XP_016156984  65 aagvkpkPTGiqpPKAGDSAAEHELYRRYVEEQALVQEELLWLAKKEREAACE------AKQRNSIIEERQKTAQVslss 138

Q63ZW2       136 ---------------GKQLDKKEAELKALEAFYQEQITQLEKKNEERFRMSAEQFHAAATRSEANI 186 zebrafish
Q5FVV3       150 ---------------AKELEQKEAELQRLNTFYREQLSSIEKKNLEIYRLTAEQYHTAATNAELRV 200 tropical clawed frog
Q9BRQ6       138 ---------------ARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTI 188 human
XP_008258535 142 ---------------ARELESREAELRRRDTLCKEQLGHMERKNAEMYKLSSQQFHEAASKAEGTI 192
Q91VN4       176 ---------------ARELEDREAELSRRDTFYKEQQGRIQEKNAELYKLSSQQFHEAASKAESTI 226 house mouse
EHB03687     139 ---------------ARELESREAELRHHDTFYQEQLGCIERKNVEMYKLSSQQFHEAASKAENTI 189
3_pfamImport 105 ---------------ARELESREAELSRRDTFYKEQLGRLERKNAEMYKLSSQQFHEAASKMEGTI 155
Q32L35       139 ---------------ARELESQEEELRCRDAFYKEQLGRLERQNLEAYRLSSQQFHEAATKIEGAI 189 domestic cattle
4_pfamImport 113 ---------------SKELQWKDEELKRRDTFYKDQLAHIEKKNSEIYKMTLSQFSDAVTNAEDRI 163
XP_016156984 139 plpdsekmpvdldawAMQLQVREAELKLQEDFYKEQLARIEKKNAEIYKMTTEQYQEAATKAEERI 204
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