Conserved Protein Domain Family
Luciferase_N
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pfam05295: Luciferase_N 
Luciferase/LBP N-terminal domain
This family consists of a presumed N-terminal domain that is conserved between dinoflagellate luciferase and luciferin binding proteins. Luciferase is involved in catalysing the light emitting reaction in bioluminescence and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme and therefore switching off the bioluminescence function. The expression of these two proteins is controlled by a circadian clock at the translational level, with synthesis and degradation occurring on a daily basis. However This domain is not the catalytic part of the protein. It has been suggested that this region may mediate an interaction between LBP and Luciferase or their association with the vacuolar membrane.
Links
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Statistics
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PSSM-Id: 253138
Aligned: 13 rows
Threshold Bit Score: 124.534
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q39911    1 MASrgQLVQFLANEGKVDQKVIAYMTNQMKLASVSDFANYFTSTEFEKGVQDDILAQVAPFNADlSKPDAKIQTARLRAA 80   Lingulodinium polyedra
O77206    1 MAA--QLEQFLVNEGQVDQRAVTYMLKGLQLESLSDFASFWTSKDYENGVRDDIISKVAPFNSDlSLPAAKLQVARLRAA 78   Lingulodinium polyedra
Q39909    1 MASrgQLVQFLANEGKVDQKVIAYMTNQMKLTSVSDFANYFTSSEFEKGVQDDIVAQVSPFNADvSKPDAKIQTARLRAA 80   Lingulodinium polyedra
Q39910    1 MASrgQLVQFLANEGKVDQKVIAYMTNQMKLTSVSDFANYFTSSEFEKGVQDDIVAQVSPFNADvSKPDAKIQTARLRAA 80   Lingulodinium polyedra
Q39913    1 MASrgQLVQFLANEGKVDQKVIAYMTNQMKLTSVSDFANYFTSSEFEKGVQDDIVAQVSPFNADvSKPDAKIQTARLRAA 80   Lingulodinium polyedra
Q8W209    1 MSR--EFAAFLTNDAKLDPTVVTYMTRDLKLDSISDFANYWTTGDYEKGVQDDIVRKVPAFQDT-SKAASKVQVARLRAA 77   Pyrocystis lunula
Q8W210    1 MST--QFLTFLTNDAKLDPNIVTYMTRDLKLESIADFAHLWTTGEYEKGVQDDIVRKVPAFQDT-SKAPSKVQIARLRAA 77   Pyrocystis lunula
Q5UAZ5    1 MSA--QFTGFLTNDAKLDPRVVEYMTKTLQLESISDFANFWTSDEYENGVRDDILLNVAAFQNT-SQAATKIQVARLRAA 77   Pyrocystis fusiformis
Q5UAZ4    1 MSA--QLTGFLTKDAKLDPRIVEYITKTLLMENISDFSNSWTSTEYETGVRDDIVLNVAAFQNT-SQAASKVQIARLRAA 77   Pyrocystis noctiluca
Q7XYY5    1 MA---ELQAFL-QEAKVDPKVIGHITKALPHKSVADFAKGWTSANFEQGMQNDIVAKTGL-----SGMEAKLQVSRLRAA 71   Pyrocystis lunula
Q5UAZ3    1 MA---ELACFLTKDAKVDASVAAYVTKQLQLESVADFANYWTACEYERGVQDDVISQIELFK---SGPAGKLQVARLRAA 74   Protoceratium retic...
Q5UAZ7    1 MA---ELIRFLTDDANIDASVAAYVTKQLQLESVADFANYWTRDEYERGVQDDVISQIELFR---SKPAGKLQVARLRAA 74   Alexandrium affine
Q5UAZ6    1 MA---ELVRFLTDEANIDASVAAYVTKQLQLESVADFANYWTRDEYERGMQDDIISQLELFR---SKPAGKLQVARLRAA 74   Alexandrium tamarense

Q39911   81 WKAAQ 85   Lingulodinium polyedra
O77206   79 WRKAQ 83   Lingulodinium polyedra
Q39909   81 WKAAQ 85   Lingulodinium polyedra
Q39910   81 WKAAQ 85   Lingulodinium polyedra
Q39913   81 WKAAQ 85   Lingulodinium polyedra
Q8W209   78 WLSAQ 82   Pyrocystis lunula
Q8W210   78 WLSAQ 82   Pyrocystis lunula
Q5UAZ5   78 WRLVQ 82   Pyrocystis fusiformis
Q5UAZ4   78 WRLAQ 82   Pyrocystis noctiluca
Q7XYY5   72 WKAAS 76   Pyrocystis lunula
Q5UAZ3   75 WQGAQ 79   Protoceratium reticulatum
Q5UAZ7   75 WQRAQ 79   Alexandrium affine
Q5UAZ6   75 WQGAQ 79   Alexandrium tamarense
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