4KSA,4KSF


Conserved Protein Domain Family
MCD
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pfam05292: MCD (This model is not part of the current CDD release)
Malonyl-CoA decarboxylase C-terminal domain
This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidised. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).
Links
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Statistics
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PSSM-Id: 516745
Aligned: 34 rows
Threshold Bit Score: 350.749
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4KSA_A       171 GFLVLQRIDWTTPANILEKIIRYEQVHTIHDWDDLRARLaPPDRRCYGFFHPRLVDEPLIFVEVALTKDSPAAIAPLLDL 250 Rhodopseudomona...
Q2GG23       183 GLLDLHQITWDSPASLLEKLILYEAVHAISSWDDLRDRL-DSDRRCFSFFHYKMSREPLIFVEVALVDEIATSIQMLLDS 261 Ehrlichia chaff...
WP_010263522 184 GLLDLHQITWDSPASLLEKLIFYEAVHAISSWDDLHYRL-DSDRRCFAFFHYKMPGEPLIFVEVALVDTVADNVQALLDG 262 Anaplasma
WP_012585989 173 GFLELQRITWSSPAALLEKLVEYEAVHEIRSWKDLKNRL-DSDRRCYAFFHPRMPLEPLIFVQVALLEEIADDVQRLLDI 251 Thauera aminoar...
WP_015437467 172 GFLELSRVTWNSPAALLEKIVKYEAVHEIRSWRDLKNRL-GSDRRCYAFFHPRMPLEPLIFVEVALLDELADNVQKLLDE 250 Azoarcus sp. KH32C
Q5P6E6       172 GFLELTRLTWNSPAALLEKIVQYEAVHEIQSWRDLKNRL-GSDRRCYAFFHPRMPQEPLIFVEVALMEELADNVQKLLDE 250 Aromatoleum aro...
2_pfamImport   1 GFLNLERVTWKSPCEMLQKISEYEAVHPVRSWADLKRRV-GSYRRCFVYTHSSMPFEPIVVLHTALSTEIASSMKGIVQA 79 
Q20048       153 GNLKLERLTWSSPGDILQKVAEYEAVHPVRGLSDFRKRL-GPLRRCFYFSHEALPRNPLVMVHVALVDEIADSVQEITKR 231 Caenorhabditis ...
WP_013695522 164 GFLRLERITWETKAAVLEKIIKYEKVHKILDMNDLKRRL-QEDRRFFAYFHPVLADEPLIFVQVAFGDGLGKSIQDIMKP 242 Candidatus Pela...
XP_011456853 165 GFLHLQRITWQSPCDMVQKISQYEAVHPIRDMTDLKRRV-GSYRRCFVFTHGSMPGEPVVVLHTALTGSISSSIHSILKT 243

4KSA_A       251 EREP-----------------IAASDATTAVFYSISNTQQGLAGISFGNFLIKQVVEEIKRELPNVQTFVTLSPVPGFAK 313 Rhodopseudomona...
Q2GG23       262 HIPA-----------------KDPKNAKVAIFYSISNTQKGLSGISLGNFLIKRVVNKLSEEFQSIKIYATLSPIPGFVK 324 Ehrlichia chaff...
WP_010263522 263 SIPK-----------------KDPADAKVAVFYSISNTQVGLSGINLGNFLIKRVVERLSCEFRNIKTYVTLSPVPGFVQ 325 Anaplasma
WP_012585989 252 EAPL-----------------ADASRATTAIFYSISATQKGLRGVSFGNFLLKRVIDDLKRDFPRLKTFATLSPMPGLVR 314 Thauera aminoar...
WP_015437467 251 NAPA-----------------HDVARATTAIFYSISATQAGLRGVSFGNFLLKRVVDDLQRDFPQLTTFATLSPIPGLVR 313 Azoarcus sp. KH32C
Q5P6E6       251 NAPA-----------------ADTGRATTAIFYSISATQEGLRGVSFGNFLLKRVLDDLKRDFPKLDTFATLSPLPGLVR 313 Aromatoleum aro...
2_pfamImport  80 TQRMse--------------iEDPNLVTAAVFYSITSTQQGLQGIELGNYLIKRVVRELQAEFPRVTQFSSLSPIPNFKN 145
Q20048       232 GAPT-----------------GKEEDQTTAIYYSITSTQPGLSGIDLGNMLIKKVATKLQKDVPSVTTHSTLSPIPGFRP 294 Caenorhabditis ...
WP_013695522 243 ITGN-------------------FEKSNTATFYSISNCQEGLMRVTLGNFLIKRVVHEIQSENSNIKNFGTLSPLPGFAD 303 Candidatus Pela...
XP_011456853 244 PTFSgrrpetdsssdgdveekEELSKISAAIFYSITSTQKGLQGVDLGNYLIKTVVKELQNEFSGITQFSSLSPIPGFKT 323

4KSA_A       314 WLKRE-----------R---DNPDstLLDASARTALEAL------------------DTPNWFDDADT----ADRL--KP 355 Rhodopseudomona...
Q2GG23       325 WIMNTlpshvellnelKiavSIDE--IISYVNARQYADL---------------------------------SQDI--KN 367 Ehrlichia chaff...
WP_010263522 326 WLKSl----------tR---DEVV--ILQKLGithtl---------------gevqsLVGKVSKYGSF----ALPI--QE 369 Anaplasma
WP_012585989 315 WAQ-------------R---DPEA--FAEAFTATDWKRLatlgiegvdstglaavlaGDPAWVEDEAL----AESL--RE 370 Thauera aminoar...
WP_015437467 314 WAT-------------K---NPNE--VLAVFAEADWERLaaagiegpesarlkavlaGSTDWTQDAAL----SAAL--RS 369 Azoarcus sp. KH32C
Q5P6E6       314 WAS-------------K---HPDE--VAAAFTEADWKRLaaigiegaeserlkpvlaGSHEWVADRSL----ARAL--RD 369 Aromatoleum aro...
2_pfamImport 146 WLMEKikl-----iekG---ETDV--GLSLEIWSPILKHvenwke-------ikrhlHNNTWHHDRNL----ASLF--EP 202
Q20048       295 WLIRNlk-------gnS---EYPS--IMNEKVVNWISDIseremneveatetllkviSNEKTKKEQ------LNAI--QH 354 Caenorhabditis ...
WP_013695522 304 WFKSLs---------dN---KLAN--ILKNYDIAKVA------------------------FLKSDTVklgdQRIVeeKE 345 Candidatus Pela...
XP_011456853 324 WLIIEinkalnlkdigE---HSEE--LLLLSEIEELKNFlgiseesv--lktvkdliQTHAWIQNEQI----CDVI--KK 390

4KSA_A       356 IVLQLAAAYFLQAKGPnGRPLDPVARFHLGNGARLDRLNFLGDRSPNGXRQSHGLXVNYLY 416 Rhodopseudomonas palustris CGA009
Q2GG23       368 LFLKLCAYYLVKAKNT-DRALDPVAHFHLSNGAIIKQLNWMADISEKGLNNSMGIMVNYHY 427 Ehrlichia chaffeensis str. Arkansas
WP_010263522 370 MFLKLCAHYLINEKKG-NRVLDQVAHFHLSNGASVKRLNWMADKSEKGLACSMGIMVNYYY 429 Anaplasma
WP_012585989 371 PLLRLGARYLSEARRG-DRPVDTVARFHLGNGARIERLNWLADRSDKGLRQSWGLMVNYLY 430 Thauera aminoaromatica
WP_015437467 370 PLLRATAAYLLHAKRD-MQPLDSVARFHLGNGARVERLNWLADASDKGLAQSWGVMVNYLY 429 Azoarcus sp. KH32C
Q5P6E6       370 PLLRTAAAYLLGGRRD-RKAIDPVARFHLGNGARIERLNWLADTSDKGLDQSWGIMVNYLY 429 Aromatoleum aromaticum EbN1
2_pfamImport 203 ALMSACAYYLFKEKRR-GAALDNVANFHLRNGAVMWRLNWMADTSPRGMTNSCGLMVNYRY 262
Q20048       355 ILMYACAHYLCNAKRN-GMALNSVANFHIRNGAELYRLNWNGDTSHRGINNSFGIMVNYRY 414 Caenorhabditis elegans
WP_013695522 346 AIKKIVVHYLLNEKNK-NQPLNPVSRFHLGNGASIEDVIINGNVSDYGYQESFGIMVNYIY 405 Candidatus Pelagibacter sp. IMCC9063
XP_011456853 391 PLMRLCARYLHREKRR-GFALNPVANFHLGNGAVLWRLNWKADMSIRGINQSCGMMVNYRY 450
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