Conserved Protein Domain Family
SH3BP5

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pfam05276: SH3BP5 (This model is not part of the current CDD release)
SH3 domain-binding protein 5 (SH3BP5)
This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk). Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule.
Statistics
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PSSM-Id: 516740
Aligned: 18 rows
Threshold Bit Score: 242.581
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002509328 237 EEVDPRVAGALDEMNEAMMSVNDAETALAAAKRRRRAHKAEGSQKIEETRKKLS-SSVRAAVPFFHAQAVAHMYQVRSIE 315
XP_015789482  18 SNLDPRIGLKLEELNKWTGRINTLEKSFEEANSKFRITLNESTDRLKLLSTKLG-KSIDDSRPYYEAKDRLTEVQAKCQK 96 
Q9V785         7 GELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLG-NCIEKARPYYEALDKAREAQIECQK 85  fruit fly
XP_008198596   7 NELDPRIQIELEKLNTTTDEINRLEIEYDEANTTFRMLLNESTRRLKILSKKLG-SCIERARPYYEALEIAKKAQQECQK 85 
XP_029343182  21 DSLDPRIQLELEKLNSSTDNINKLEIELDEANTTFRMLMAEASRRLKVRARKLG-SCIDKARPFYDALNMSKHSQQQCQI 99 
Q21194        33 TRHLNMIHEELEKLNISTDVINKMEVQLDLARADFRETQVQWSEKLKELSKQYS-SQIAKARPFYELKIKERSLREESQK 111 Caenorhabditis ...
1_pfamImport   1 ---MMSIRRQLENLNDATDDINSYEMKLEHVKKQFCETQLIFNREISGIPNKLA-KHISKARPFFDLKSREPNLRRFAQQ 76 
XP_001746898 283 EEVDPRVEIALQDMNDASDAINRLEKELEETKAAFKTAMDQVQIDLRDLANKLGrRNIDKARPYHQALFRARKAHYESRQ 362
XP_004365456 284 EIADPRIKGALEALNFATEEINRLERELEASKRTLRVLDRDGAKQLLALAQKLG-KAVDRSRAYYNLKHEASEAHRLAIE 362
XP_003977713  19 EEVDPRIQGELEKLNQSTDDINRCETELEEARQKFRSVLVEATVKLDELVKKIG-KAVDESKPYWEARRLARQAQLEAQK 97  torafugu
XP_002509328 316 CLRAYEKAHDMHAAAKESAAQLEAEMAssaspgkkitgNEGGTFDTDLMIALSDAMSKVVETEIMKKRAEGAHGRMTKLA 395
XP_015789482  97 AAINFEKACQAYLEAKERINLAEKKFN-----------SAAHEFDTTWQEMLNQANIKLMEAETMKKESERLHHNSMKDF 165
Q9V785        86 AAVKFQRANEIHAAAKETVALAEQRFMs---------nSHEWQFDNAWQEMLNHATQKVMDAETQKADCHAEHQRLTKLF 156 fruit fly
XP_008198596  86 AAVQFQRANEIHAAAKETVALAEQRFLs---------nQHEWQFDNAWQEMLNHATIKVMEAENQKAESGREHQRRATIF 156
XP_029343182 100 AAVKYQRANEIHQAAKETVALAEARFLs---------kQHEWKFDSAWQEMLNNAIQKVTEAENQKTESGREHQRKAALY 170
Q21194       112 AAERFERATSILGIAKQQVSLTQESLS------------RQTSVLPECLEVLNHHIQRVREVEEERTAAESLHASKAHAM 179 Caenorhabditis ...
1_pfamImport  77 AAALFERQKTVVEMAREQLTILHSSLNn----------NDEMDAEKKYIDVIEQQLELVNEAEAECAEAERAHAARVRDL 146
XP_001746898 363 AAVYFEKASGAYQQAKQKVKATEQQLE------------KGATFDANLQASLNKATQDLMTAFNRKEHADTIHQTKTQTF 430
XP_004365456 363 AAKTFEKACSAHDAAKERLAKAERHVL-----------TDNKKIDPVWHDMMATAATQVIESENAKRDASTTHQALLSAA 431
XP_003977713  98 ATQDFQKATEVLRAAKETISLAEQRLLe----------EDNRQFDSAWQEMLNHATQRVMEAEHGKTRSEVLHKETAAKY 167 torafugu
XP_002509328 396 TTAVNESMALRKKIAKSVEKAQPYFAVKSSVEAKARALEEEVVDVEKRVKEMKRRYHAAMDELAKISDEVHARRLREKEE 475
XP_015789482 166 HSAEMVVVDLKKKLKGSLHRSKRYFEEKKRFQKQLGSIKEEIESIISQINCSKARYAATLRELEAISEEIHEKRNCSLLK 245
Q9V785       157 NAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQKNRIQELQQQVAGAKSTYSTALRNLERISEDIHRQRGDFPT- 235 fruit fly
XP_008198596 157 KTAEDCVKQLESRLQKSIIKSRPYFDEKSLCQQQLNTQKDRIETIKRDIVKTKSSYAQTLKQLEQISNEIHMKRGSVTED 236
XP_029343182 171 QAAEQKVQMLEQKFKRSIIKSRPYFEEKYLCEGQLAAQKDTIIQIRYAVQRAKQEYSACLHRLEQISEEIHVQRQNNKLM 250
Q21194       180 LHLAEKIRAMEKDNRYAIKKSRLYFEKRLEFTKILEAQKATILCLEAEVRQKKNDYTTSLRNLERISERIHEERSTGSLE 259 Caenorhabditis ...
1_pfamImport 147 LQLETTLRRLLQENGPSIKKARPYYDRKEVLTKTMNSQIELMSILENEVQDRKDSYSTSMRALEQISEQIHQERSSQNSL 226
XP_001746898 431 LKADRELMELAKARKKIIIKTKPYYESKVQHDKILMGLRQQLLQQERDIKAAKEKYSNSLNTLSSISEEIHERREAEKAA 510
XP_004365456 432 AHVSTKLEAAARDIKPRIAKAKPYYDLQNELREQRTKLVDKQTFLAEEIALAKRHVQYSLSNLNDISMEIHEQRRARKAE 511
XP_003977713 168 TAAIGSMKQLEKKLKRTINKSKPYFEMKAKYYLQLENLKKNVDEHQAKLSQAKGDYKTALRNLEIISDEIHERRRNSTVG 247 torafugu
XP_002509328 476 RE 477
XP_015789482 246 HL 247
Q9V785       236 -P 236 fruit fly
XP_008198596 237 IL 238
XP_029343182 251 EC 252
Q21194       260 SA 261 Caenorhabditis elegans
1_pfamImport     --    
XP_001746898 511 kt 512
XP_004365456 512 as 513
XP_003977713 248 PR 249 torafugu
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