5UDN,2VPS,4OLK


Conserved Protein Domain Family
CHAP

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pfam05257: CHAP (This model is not part of the current CDD release)
CHAP domain
This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Gsp, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolyzis of Gsp (glutathionylspermidine) into glutathione and spermidine.
Statistics
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PSSM-Id: 516731
Aligned: 459 rows
Threshold Bit Score: 28.1814
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UDN_B           20 YDA-DLA----WgwqCADVT-------------NGTt---------tNFFgVt----lW-----G--NAIDLld--sA-- 57  Streptococcu...
ASGPB:SGRA_0145 498 TVK-TAN----W---CAAFV-------------SHCl---------kKSGq----------------pALSYydggrA-- 529
YP_003358563    183 GAS-EDEv--sW---CAAFV-------------GWV-----------ML-------------------QAGYtstrsAla 213
WP_013550475     93 DDK-DWP----W---CASFV-------------CWVyskskehtgkiTA------------------KATDW-------- 125 Cellulophaga...
WP_270097883    319 RDD-ETP----W---CASFV-------------NWVm---------nKAG-QggtgsaM---------AMSW-------- 350 Saprospira g...
CBA30494        616 NDG-STS----W---CSSFV-------------NWCm---------iQAG-Ys-----Ycatn--salANSWs------a 651
WP_003797429     44 QDD-EMP----W---CGTFVahcareakralpqHWY-------------------------------RAKDW-------- 76  Kingella
WP_009119466     45 WREdETP----W---CGTFV-------------AHCl---------rRA---------------GrpIPQHWyr--aR-- 76  Neisseria sh...
jgi:Tcur_3072   146 VYK-SAP----W---CAMFV-------------TWV-------------G-Eq-----VgtdelG---ADAYtv-thA-- 179
WP_012889993    117 gSP-RAYanapW---CAMFV-------------SWV-------------Geqag-----------irpTMGWdaytvSha 155 Streptospora...
5UDN_B           58 KAqgleviYD----APGINPkAGDLFVM-F--TYGH-PYG--HTGII--IADs--D--Gy---tIQTIEQN 109 Streptococcus pyogene...
ASGPB:SGRA_0145 530 KK------YLdygrKIDKPA-YGAIVVF-SrsGG-----G--HVGFV--A--------GqtdshILTLGGN 575
YP_003358563    214 RS------YLtwgsALSAPQ-YGAIVVF-RrgNNPT--FG--HVAFV--QKF---D--An---yVWCIGGN 262
WP_013550475    126 KN------WGkedsKEN--PmYGALAVI-DwdENDNgA-G--HVGFV--VNV---D--Gd---nVYLLGGN 174 Cellulophaga algicola
WP_270097883    351 AK------YG----KKVDKPaYGAIAVL-SygGGK----G--HVGFVvgKKG------Gn----VLLLGGN 394 Saprospira grandis
CBA30494        652 IN------WQggeqVDKPF--YGAIVVM-N--------YS--HVAFV--YGIn-kR--Gy----LLLLGGN 694
WP_003797429     77 --------LNtgtrLDKPA--YGCVVVFdRagG------G--HVGFV--VGK---DkqGn----LMVLGGN 120 Kingella
WP_009119466     77 AYad---gYG----TRLKKPaYGCLAVF-VrqG------Gg-HVGFV--VGIt-kD--Gy----LLVLGGN 123 Neisseria shayeganii
jgi:Tcur_3072   180 KS------FKdkgrWGTKPk-PGAVVFF-DwaGGKSiG-GidHVGLV--AEVl-dN--Gk----IKTVEGN 232
WP_012889993    156 KW------FKdnkhWGTTAK-PGAVVYF-DwnGgk-siSGidHVGFV---KKdngD--Gt----ISTIEGN 208 Streptosporangium roseum
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