6OHU


Conserved Protein Domain Family
EBP
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pfam05241: EBP (This model is not part of the current CDD release)
EXPERA (EXPanded EBP superfamily)
The EXPERA (EXPanded EBP superfamily) domain is conserved among the following protein families: TM6SF1 (Transmembrane 6 Superfamily Member 1), TM6SF2 (Transmembrane 6 Superfamily Member 2), MAC30 (Meningioma-associated protein 30 also known as TMEM97, or Transmembrane protein 97), and EBP (Emopamil binding protein). EBP is an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. Mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.
Links
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Statistics
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PSSM-Id: 516724
Aligned: 647 rows
Threshold Bit Score: 29.8065
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6OHU_A       104 FLSQLWKEYaKGDSR-YILgdn-------ftVCMETITACLWGPLSLWVVIAFLr-Qh------PLRFILQLVVSVGQIY 168 human
XP_007252702 243 VFTSYVNEY-EPYLKdPAGf----------pKVMMLVLLFHALPLLGAFVYGLItpgctwmldwTMYVAGAIVQTQWCHV 311
WP_100344031  59 FFANSNYWY--AHDAdPLFmnpp-----awmRIVTGLSAFVYMPFYIVLVYALAtgRnwi-qlpSVIYGTMISTITGIIV 130 Compostimonas s...
WP_245741532  84 WLAQSNYWY--GHDAdPLFidpp-----vwmRFVTGLSAFVYGPFYLLLAFCLLtgRnwi-qlpAVIYASAISMITGVVV 155 Herbiconiux gin...
WP_091615265  49 FFVQSNYWY--AHDAdVLFmhpp-----dwmRIVTGLSAFVYMPFYVLLVYCLLtgRnwi-qlfAVIYATMIVTLTGVVV 120 Amycolatopsis s...
KQV07754      44 FFVNSNWWY-VHDTDpLFMtpp------vwmRIVTGLSAFVYMPFYVVLVLSLVrgWnwi-qlpSVIYATMIASITGIIV 115
WP_012832223  62 FLVNANWWY--AHDTdPLFmhpp-----vwmRIVTGLSAFVYPVFYVLLVISLVrgWnwi-qlpSVIYATMIASITGVIV 133 Gordonia bronch...
WP_055918463  64 ILAQWNYTY--SSQYdPLYmhep-----lwlRFITGTSAFVYLPFYILLIVCLVkgFnwi-qlfCVIYATMIISLTAIPI 135 Leifsonia sp. L...
WP_114628078  49 FIARANYAY--AYGTdPLFlftadhpvpvwmRFVTGLSAFVYPVFYILFIVSAIkgWnri-qvpAVMYATSISVITGVVV 125 unclassified Oc...
WP_106391872  43 PFGRAWLLY---TRWdPLFldtp-----mwlRIMCGIDGFVFGPFYLVLIWALWreRgwi-rvpALLYVSAIVYSTLVYF 113 Enhygromyxa salina

6OHU_A       169 GDVLYFLTEHRDgfqhGELGHPLYFWFYFVFMNALWLVLPGVLVLDA 215 human
XP_007252702 312 GASLHPRT---A----EALHTPESTLLPVLLLNLLYALGPLLLALRC 351
WP_100344031 131 FGVEFFGE--------PEFQTQN--PAKFLAFNLAYVLVPILLLIRM 167 Compostimonas suwonensis
WP_245741532 156 FGVEFFGE--------PEFQTQN--PLKFLAFNLPYVIIPILLLIRM 192 Herbiconiux ginsengi
WP_091615265 121 FGVEFFGDPAMR----------TGNPGKFLAFNLPYVLVPLLLLIRM 157 Amycolatopsis saalfeldensis
KQV07754     116 FGVEFFGE---A----QWVTP-N--PVKFLAFNLPYVLIPILLLIRM 152
WP_012832223 134 FGVEFFGE---P----EWVTPNP---AKFLAFNLPYVLIPILLLIRM 170 Gordonia bronchialis
WP_055918463 136 FGVEFFGP---V-------GERTPNPVVFLLYNGPYVLVPLLLLIRM 172 Leifsonia sp. Leaf336
WP_114628078 126 FGVEFFGE--------PEW-RCQN-IPKFLSLNLPYVLIPLFLLVRM 162 unclassified Oceanispirochaeta
WP_106391872 114 GYEFAVEG-----------E--RADLAMVVLINVPYTIVPLILAWRM 147 Enhygromyxa salina
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