6OHU


Conserved Protein Domain Family
EBP

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pfam05241: EBP 
Emopamil binding protein
Emopamil binding protein (EBP) is as a gene that encodes a non-glycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains, including the sterol acceptor site and the catalytic centre, which show Delta8-Delta7 sterol isomerase activity. Human sterol isomerase, a homolog of mouse EBP, is suggested not only to play a role in cholesterol biosynthesis, but also to affect lipoprotein internalisation. In humans, mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.
Statistics
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PSSM-Id: 398767
Aligned: 704 rows
Threshold Bit Score: 34.442
Threshold Setting Gi: 300143431
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6OHU_A                  104 FLSQLWKEYaKGDSR-YILgdn--ftVCMETITACLWGPLSLWVVIAFLr-Qh-----PLRFILQLVVSVGQIYGDVLYF 174
PRJNA321464:A7982_06059  53 ALVDLVHSY--GDTFdPLQnarpvwwKATIWIDALGFGPFYAAALWAWVkgKdwirlpAIIWASVMMTNVTIIMSEEI-W 129 Mini...
RKR85961                 51 PAIDLVHWW--GNTYdPLLmarppfwRMTIWIDVVFFGPFYLFALYAFIrgRnwikvpALVWSGTMLANVLIILMDERYG 128 Micr...
PNY82634                 51 PLVELIHWY--GRAAdPLLmarppfwRATIWMDNLLFGPFYVAAIVAFVrqAewirvpSLVYAGMLLANVNCILFEELQG 128 Dein...
KNC55189                 94 AFIKLIHAY--SRAFdPVLlarpawwQATLWPDVLFYGPYYMVGLYAFAkgCawirdvTMVYAASIMTIVFIIMMEEAYG 171 Thec...
SCC04634                 51 FMVDLTHWY--GYNFdPALiarpawwRAAIWVDVLYFGPFYMVAIYAHIkrKnwiripTIMWACVLLTDMYFIIFEELKG 128 Chit...
OBB01199                 65 YMIDFLHWY-FAN-YdPLLyerpvwyTTIVVIDQIVYGPFYIAALYAFWkgKewirnwSIIWASVMLATVTVILGEEIA- 141 Myco...
EOD07899                232 PCVRAVRWW--SAAAdPLMharpvwfRAAIWVEVLVQAPFYAVAIYAFVrqRswvrvpAIVYATVLLTIMPIVLAE-QYF 308 Emil...
WP_089715669             52 VLVDLVHWY--GHNFdPVLmarpawwRATIWIDAIFFGPFYAVAIYAYAkgKnwirfaSIVWASVMLTNVFIILFEEING 129 Chit...
WP_112431394             63 PVVDLIHWW--GQHFdPLLmarpvffKVTIWLDDLLYGPFYLVAIYAYAkgRewirlpSIIYAVAMIEGVVIILSEEAFG 140 Ther...
6OHU_A                  175 LTEHRdgfqhgeLGHPLYFWFYFVFMNALWLVLPGVLVLDA 215
PRJNA321464:A7982_06059 130 GP----------HASPR--LAIVTLLNAPWFLFPVGVIARM 158 Minicystis rosea
RKR85961                129 VT-----------PTPN--FPIVLAANTAWLVTPFLVIWRL 156 Micromonospora pisi
PNY82634                129 LH-----------RTPQ--PALVLALNAPWVLVPLYLIWRM 156 Deinococcus koreensis
KNC55189                172 EHP-------------TPHFGFVLCLNSPWFVVPACLLLRM 199 Thecamonas trahens ATCC 50062
SCC04634                129 VNATP----------EV---GRMLLANASWIIFPILALIRM 156 Chitinophaga costaii
OBB01199                142 GP----------FASDH--LALVFATNAGWLIIPVWVLIRM 170 Mycobacteriaceae bacterium 1482268.1
EOD07899                309 GP----------HASRR--PLLVTAVYGAYVLMPVLLLVRV 337 Emiliania huxleyi CCMP1516
WP_089715669            130 EH-----------ATPQ--LSRVLLSNAAWVIFPVIVMYRM 157 Chitinophaga costaii
WP_112431394            141 AY-----------RSPH--LGLVIAANASWIIFPLVILFRM 168 Thermogemmatispora tikiterensis
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