Conserved Protein Domain Family
STOP
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pfam05217: STOP 
STOP protein
Neurons contain abundant subsets of highly stable microtubules that resist de-polymerizing conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. STOP is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity. Additionally knowledge of STOPs function and properties may help in the treatment of neuroleptics in illnesses such as schizophrenia, currently thought to result from synaptic defects.
Links
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Statistics
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PSSM-Id: 310081
Aligned: 23 rows
Threshold Bit Score: 42.3544
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q22ZA8       268 NCACFQCTCGLC--KCEHSNLKLTYK----PgfkTNYRKDY 302 Tetrahymena thermophila SB210
A0DL07        46 DCICGRCICGQC--KCPKMLLSNDFKkg----qeSLYQRDF 80  Paramecium tetraurelia
XP_001007658 328 DCICGRCICGKC--KCPYRNVPVDFRrg----mqTLYQADF 362
A0BXC2        21 TCFCSVCLCSKC--YCKQKPQQTYYIne----pkSIYNVDF 55  Paramecium tetraurelia
A0BXR7        22 TCLCGVCLCGNC--LCKAQPIKQTYLnk----lkSVYETDF 56  Paramecium tetraurelia
XP_001017361 395 KCACGQCECGRChvKCLVNQKKPQVYnmkwE---SSYNRSY 432
A0BVX1        31 TCVCSDCLCGQC--KCQVMQQHYDYPkl----llSNYKREY 65  Paramecium tetraurelia
A0DR47       243 KCICVQCPCGRC--KCKFQYKPFATNlc----wnSNYRSSY 277 Paramecium tetraurelia
A0C0X6       191 KCICVQCPCGKC--KCKFEYQPIKPNis----wkSHYNQEF 225 Paramecium tetraurelia
Q24BQ1       544 KCLCSLCSCGSCitKCKQLSQYLDTNlkqsWt--STYRQAF 582 Tetrahymena thermophila SB210
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