Conserved Protein Domain Family
Sprouty
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pfam05210: Sprouty (This model is not part of the current CDD release)
Sprouty protein (Spry)
This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.
Links
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Statistics
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PSSM-Id: 516701
Aligned: 34 rows
Threshold Bit Score: 69.7115
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX90196     283 RCRCLSC----RTPRPLP-SKwlcgdKCLCS-----AESCVDYVSCLCCVKGLFYHCGsasdeddedddvhrrryhhhhq 352
EFX84664     356 RVRCKHCqdtyRPEENYR-GA--------CDhapdcVRSTIDAVSCVSCAECLMYHCYada------------------- 407
EEC18541     291 RRQCRHCleefSEDANAR-GS--------CEyapdgVLSCINAASCISCAHCMLYHCMada------------------- 342
8_pfamImport   1 KERCRHCqepfCSEQNVR-GS--------CEyapdcVKASINAVACISCAQCMLYHCMsdp------------------- 52 
NP_001164144 272 QIRCRHChelyFEDKNPK-GSc---eYAPDC-----IKSSINTITCIGCAQCICYHCAada------------------- 323
XP_002432432 126 RQRCRYCqelfVEEENKK-GA--------CEyapdcIRSAIDEVSCVRCARCMLYHCMada------------------- 177
EDW32088     308 RLRCRYChelySEEFNRR-GA--------CEyapdtFRAGYECISGMGCARCMIYHCMsda------------------- 359
6_pfamImport   1 RKRCRHChnfyAEDLNPK-GS--------CEyapdlFKTGIEAISGLCCARCMMYHCMsds------------------- 52 
EDS25817     144 RLRCRYCqefyNDEWNHK-GS--------CDyapdcFKTAIENVSGMLCARCMLYHCMkds------------------- 195
XP_038967511 263 AARCVHCralfRRRADGRgGR--------CAeapdpGRLLVRRLSCLWCAESLLYHCLsda------------------- 315 Norway rat

EFX90196     353 ptttsnasggGSCadAPCS-------------CVPsHHRMARWGCLASLTLVMPCLLCYWPLQGGVKVVEMCYQkctrhg 419
EFX84664     408 -------egdFAP--QPCVcgsgsvrrhngsgCCSiESSPKRWFGLALLSLVVPCLWCYLPLRACYRCGVRCGC------ 472
EEC18541     343 -------egdFSQ--RPCScsgt------prdCR------RRWAGLALLSLLVPCLWCYLPLRACHRAAVACGL------ 395
8_pfamImport  53 -------egdFVQ--HPCEcgpv------ddsCS------RRWIGLALLSLVVPCLWCYPPLRACHWCCVSCGL------ 105
NP_001164144 324 -------egdFAQ--HPCEc------------TNE-ENCSKRWVCLTVLSILVPCLWLYPPLKICHWCGIRCGM------ 375
XP_002432432 178 -------egdFAQ--HPCEcts-------degCS------RRWLGLAILSILVPCLWLYPPLRACHWCGVRCGL------ 229
EDW32088     360 -------egeTAQ--HPCEcnat------eagCT------KRWLGLAVLSLFVPCLWCYPPLRACHWMGIQCGL------ 412
6_pfamImport  53 -------egdTPA--HPCQcsf-------esgCA------KRWFGLTLLSLFVPCLLCYPPLKACHWVGVSCGL------ 104
EDS25817     196 -------egdTAS--HPCScta-------esgCT------KRWIGLALLSLLVPCLWCYPPLRACHWIGVSCRL------ 247
XP_038967511 316 -------egdFS---DPCAcepg-----hprpA-------ARWAALAALSLAVPCLCCYAPLRACHWVAARCGC------ 367 Norway rat

EFX90196     420 crCD 423
EFX84664     473 --CG 474
EEC18541     396 --CG 397
8_pfamImport 106 --CG 107
NP_001164144 376 --CG 377
XP_002432432 230 --CG 231
EDW32088     413 --CG 414
6_pfamImport 105 --CG 106
EDS25817     248 --CG 249
XP_038967511 368 --AG 369 Norway rat
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