Conserved Protein Domain Family
TRM13

?
pfam05206: TRM13 
Methyltransferase TRM13
This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4. TRM13 shows no sequence similarity to other known methyltransferases.
Statistics
?
PSSM-Id: 398743
Aligned: 20 rows
Threshold Bit Score: 270.321
Threshold Setting Gi: 121974349
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EDK42053       1 MQQSSLIGNLKRLDMl---SQEFFYMEFGCGKGELSRYINQ--CILEDvkgekhqkkmeeknsikngEGSHYGYGLIDRG 75  Lodderomyces el...
Q9UTH1       119 IQQASLLGHMEKLHYf--dNQGSIYYEFGAGRAELSRYVQH--CSQQE-----------------------NVYILIDRD 171 Schizosaccharom...
Q54BD5       252 QQESSIINLLENSNLy---NSDNVYLEFGAGSGKLSNHIFM--SHEKK-----------------------SGHILIDRM 303 Dictyostelium d...
Q236Z5       312 STDETVEEIKEENKDl------------------MDQEQNQkdDIQEDqp---------------syKPYHACHVLLELE 358 Tetrahymena the...
XP_001416220 171 LQRVAIAEAVQKVRDvfdlSTNSALVELCSGRAYLSAEIMK--TW------------------------PFSKLLLVDRR 224 Ostreococcus lu...
NP_192097    186 inveccesdLEEKDD----NTAPAVVEFGAGRGYLTQMLAD--CY------------------------GIKKVYLVERK 235 thale cress
Q8SX24       183 TQTTSLLGILEHDHQl---MDHTSYIEFGAGKGQLAYFLAT--VLQEQ-------------------KLSHSQVVLIDRM 238 fruit fly
Q16QR4       180 IQSASLLGILRRENFf---QNDVAFVEFGAGKGQVAFWLAT--VLQQS-------------------DLKNVKVFLVDKA 235 yellow fever mo...
Q7QEF3       170 VQSSALLGLAEQCDFl---RPDTTFVEFGAGKGQVAYWLAR--IVETA-------------------PLARSAVLLVDRA 225 Anopheles gambi...
Q8BYH3       165 KQQASILGNIEKLKLl---GPRRCFVEFGAGKGKLSHWVDI--ALKDA---------------------ENVHFILVERV 218 house mouse
EDK42053      76 KNRL--KADSKIITDSESsessqilPQIKRSKIDIKDLNVSKFLEd---vDYKNV-------VTVSKHLCGAATDLTLKL 143 Lodderomyces el...
Q9UTH1       172 SNRT--KHDSRILKDSIKnnw--pePKIIRCKIDIKDLKLDFFASef-rnSGKPV-------FAYSKHLCGAATDLTLNC 239 Schizosaccharom...
Q54BD5       304 KFRSlkKVDRLIKNEKGC-------HHFSRLLIDIRHLNLSNLSIl----eEKPF-------VITSKHLCGCATDFTLDS 365 Dictyostelium d...
Q236Z5       359 SRRN--KMDRLHRDNP----------FYLRYRTNILDFNVNALHQil-leQKYPYinqdlrvVGVSKHMCGGATDLSINT 425 Tetrahymena the...
XP_001416220 225 SHRF--KADRFLRHQS----------ELRRLLIDIKDLDLYKVSLl----nKSEV-------TIVGKHLCGEATDFALKC 281 Ostreococcus lu...
NP_192097    236 SYKL--KADRSLRQKES--------LVLERMRIDIEDLNLNAVESl----hGVPY-------VAVGKHLCGPATDLSLRC 294 thale cress
Q8SX24       239 SLRH--KKDNKLANRE----------VVQRIRADIADLKLSALPEl---kKTQRT-------VAFSKHLCGAATDLTLRC 296 fruit fly
Q16QR4       236 SHRH--KKDNKIEDRE----------IIQRVRADIGDLVLQKLDVl---rDSRKI-------VGVGKHLCGGATDLALRC 293 yellow fever mo...
Q7QEF3       226 SHRH--KKDNKIETRE----------IVQRVRADIADLELHRVELieagaGRSGV-------VGIGKHLCGAATDLALRC 286 Anopheles gambi...
Q8BYH3       219 TTRF--KVDGKHRKKDS---------VFERLQIDIQHLCLNRVPVlr--eGRLPV-------VGIGKHLCGVATDVALRC 278 house mouse
EDK42053     144 LLNSDLFS-------------------------------------KDKFAGVLIAMCCRHVCSHDQLLPqsKKYlf-dHG 185 Lodderomyces el...
Q9UTH1       240 LKSSPPN-------------------------------------------ALVIALCCHHHCRWRTLSTfaREQls-hWG 275 Schizosaccharom...
Q54BD5       366 IFNLLNNSne---------------------------------kvNNNFKGIGIATCCHHICNFNTYSN--QSYlkdqLN 410 Dictyostelium d...
Q236Z5       426 LLNCQN---------------------------------------PQKFEGMMIATCCHHRCSPDTYTN--NEFlmneLG 464 Tetrahymena the...
XP_001416220 282 ALSYLKDSt-------------------------------------VTFRGLAIAPCCHHACKWSSFVN--TPFle-tLG 321 Ostreococcus lu...
NP_192097    295 CLSRQDGE-------------------------------------SPVLRGLAIATCCHHLSQWKSYIN--KEYil-sLG 334 thale cress
Q8SX24       297 ILGDGNASs----------------------------------------DYVLIALCCHHRCSWRSYVG--RKFlq-eAG 333 fruit fly
Q16QR4       294 LIRANKHRpe---------------------------------gdTLQSDGFVFALCCHHRCDWKTYAG--KKFll-eKG 337 yellow fever mo...
Q7QEF3       287 LVRSGTSGt--------------------------------------AVRGCLFALCCHHRCDWRTFAG--KRFll-eSG 325 Anopheles gambi...
Q8BYH3       279 LVETYAASfeekdeeplakrikndktekesntlakegsekdvpetWTPVAGIVIALCCHHRCDWRHYVG--KEYfk-aLG 355 house mouse
EDK42053     186 FESKqSFNVLKKIVSWAVDAKDdkptgtkfne-----gdesnkcneSNGrtetnarnenNKVNAIDENNPSGLTSKQRQE 260 Lodderomyces el...
Q9UTH1       276 ISNPqEFQILRQMTGWAVNSLRe-----------------------------------hMHASGGADSHISGLSHEERVK 320 Schizosaccharom...
Q54BD5       411 ITPL-EFQLICSISSWATIDENkcnndddd---------neveeddELIkkdkkekkefENQLKIEFNKQDVFSIKRKEE 480 Dictyostelium d...
Q236Z5       465 YTSE-DLQILFYCSSWYVSGQIkeeimkkieqseqkqvseqlnqiqNENsqdnkqeeskKVIEQSQPNNKEWLSSEKKSL 543 Tetrahymena the...
XP_001416220 322 FSET-DFGYLIRMTSWATTLSTgct-------------------shGFSsdfaihtedmDACRT--------LSSNDKLR 373 Ostreococcus lu...
NP_192097    335 ISKD-EFHIMTSFTSWAVDDDHgsklpgv-----------ddidllDSNakeeeegevrDASLISVEEVVKKMKPMERAV 402 thale cress
Q8SX24       334 IGPR-EFVILTKMVSWAVCGTGlsrer---------------------------rkameSADFQLTETNTQRLTRQEREQ 385 fruit fly
Q16QR4       338 ISRE-DFDLVVKMVSWAVCGTGtsrer-------------------------------rnaegDEGDGIKYGMTRSQREE 385 yellow fever mo...
Q7QEF3       326 ITRA-EFESIVRMVSWAVCGTGrsrer----------------------------------qqeddKPDRCGMTRPEREA 370 Anopheles gambi...
Q8BYH3       356 LGAV-EFYYFQRMSSWATCGMRtslegsdv---------tperkdaQRDeneehddggdRLTDGNTDSLPGILTVEEKKK 425 house mouse
EDK42053     261 YGLKARRIIDESRAFAMRSIlgeDYNVELFWYIDDNITLENVCLSIV 307 Lodderomyces elongisporus NRRL YB-4239
Q9UTH1       321 IGLKCKHIINYMRKLECEKM---GYESSLVYYVGEETTLENVALIAY 364 Schizosaccharomyces pombe 972h-
Q54BD5       481 LGYKAKRLIDYGRYLFIKEK---LNLPNTKFWIYTNQSKENLFLVSN 524 Dictyostelium discoideum
Q236Z5       544 IGKMVKRTVDIGRILNLVKK---GKKGRIVKYCDFILSPENFVIIAK 587 Tetrahymena thermophila SB210
XP_001416220 374 VGRYVKLILNTARVLWCKER---GFDVSLEEYTNVWVTPENQLILVR 417 Ostreococcus lucimarinus CCE9901
NP_192097    403 LGFKCKQIIDAGRMKWVKKH---GLNSKLVKYIPASISPENTLLIAg 446 thale cress
Q8SX24       386 IGQQCKRVLDYGRLEHLRSH---GYQAELKFYVPRDVTLENVVLLAR 429 fruit fly
Q16QR4       386 VGRRCKRMLDWGRIQYLKEN---GFEAGLKLYAKAETTLENVCLIGH 429 yellow fever mosquito
Q7QEF3       371 IGRRCKRLLDIARLRYMERH---GYEASLKYYVTSDVTLENVCLVCV 414 Anopheles gambiae str. PEST
Q8BYH3       426 IGHLCKLLIDQGRLQYLQQK---GFSPALQYYTDPLVSLENVLLTAV 469 house mouse
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap