Conserved Protein Domain Family
COMPASS-Shg1
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pfam05205: COMPASS-Shg1 
COMPASS (Complex proteins associated with Set1p) component shg1
The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.
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Statistics
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PSSM-Id: 487622
Aligned: 78 rows
Threshold Bit Score: 51.8172
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDK43794      26 TTIYKKNGNFDKQRKELLENFKESETCKNLLLKLQIMIESKVKHDP-LILIKnKGKMAALIQGEIVNQrsgsHSLSnnnt 104
EFX84815      21 VNQIKSQGTFDQWRRECLADVDTKPAYQNLTFRVDSAVAAFLGKQRwRPDMA-KNQVRENLRKHILEL----GLID---- 91 
XP_015793131   9 VNDLKARGVFDEFRKECLSAVDTRPAFENLRQKIDGKVKNYLESLTwDASLN-RNQLREKLRRSLTES----DNVI---- 79 
EEC16872      22 VSHLKSRGLFDQLRRDCLGDVDTKPAYLNLKQRIEGYITKFLAMQTwTPDMN-KNHVRDIMRREINES----GMLS---- 92 
3_pfamImport   2 VNHLKSQGLFDQFRRDCLADVDTKDAFEMNLYCFENFLGNQKETHKwELKKN-KNKYCS-IKQQVARS----GMLE---- 71 
Q68FB1        36 VEQLKSRGQFDGFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEwNADMN-KNQLRNGLRQSVIQS----GMLE---- 106 tropical clawed...
Q8IYS8        43 VGQLKSRGLFDSFRRDCKADVDTKPAYQNLSQKADNFVSTHLDKQEwNPPAN-DNQLHDGLRQSVVQS----GRSE---- 113 human
Q08CT1        26 VEHLKNKGHFDEFRRDCLADVDTKPGYQNLQQRVGTYVSTHLSTQEwNPTIN-KNQVRNALRQSVIQS----GMLE---- 96  zebrafish
Q4RRX6        27 VEHLKNRGLFDEFRRDCLADVDTKPAYQNLRQKVDNFVTSHLSTQDwNPSIN-KNQMRNGLRQSVVQS----GMLE---- 97  spotted green p...
XP_002114532  18 V---KSEGVFDQFRRDCNGDITQMDKYRQLEHFVQEYVNDWLLNERwTESSN-KNKHRNDLRQQVDRS----NKVK---- 85 

EDK43794     105 tdkgtgvslsekesytqdsngpsNTILGIVDRDIQekiiesEEFQFAIKEE 155
EFX84815      92 -----------------------KGVDRIVQQVVQ------PKVLPVFHPA 113
XP_015793131  80 -----------------------ATIQHLVDQVIA------QKATTYMLSR 101
EEC16872      93 -----------------------AGMDHLVDQIVN------PKIYHVFTPE 114
3_pfamImport  72 -----------------------SGVDRIISQVVD------PKINHTFRPQ 93 
Q68FB1       107 -----------------------AGVDRIISQVVD------PKLNHIFRPQ 128 tropical clawed frog
Q8IYS8       114 -----------------------AGVDRISSQVVD------PKLNHIFRPQ 135 human
Q08CT1        97 -----------------------SGVDRIISQVVE------PKLQHIFRPI 118 zebrafish
Q4RRX6        98 -----------------------SGVDRIITQVVD------PKMNHTFRPQ 119 spotted green pufferfish
XP_002114532  86 -----------------------ATLDSIISLNLR-------SRIENFRSR 106
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