7MQ8


Conserved Protein Domain Family
RTC_insert
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pfam05189: RTC_insert (This model is not part of the current CDD release)
RNA 3'-terminal phosphate cyclase (RTC), insert domain
RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Links
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Statistics
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PSSM-Id: 516684
Aligned: 222 rows
Threshold Bit Score: 41.3792
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7MQ8_SH            183 TDPGKIKRIRGMAYSVR-VSPQMANRIVDSARSILNKF-IPDIYIYTD--HMKGVN------SGKSPGFGLSLVAETTSG 252 human
XP_002492486       181 LEINKISSIRGIAYCTR-VSPSIVNRIVSSVRDVLRNTiGCEVNITTD--VWRGET------SGKSPGFGLTLFSESKkG 251
EPR78031           160 KDEKTIFKIRGLAISNR-LNSLTTTKMVEIVQTNLKQI---CKNLKISkdICGGSD------AGPSPGYQIVLFAEGNN- 228
EED43460           103 ikmEPIDKIRGMVISSH-LGSDFVCRMTRVIKEECKKY---LSDVKVLniVDNKNT------SGPSPGFECSVFAETRH- 171
Q8SRP7             167 ESPEKILKVRGLVLSSR-VSSVPAKEMTDRIKEMLGDI----LNTKVFsnMSNRVD------SGPSPGFQCAVFAESKS- 234 Encephali...
licsiro:TALC_00249 181 DHLGELKGIRGLCFVQH-LSDRIGQDMMDACRRVFEP----EYPIEIEyqKCEGTS----------RGAGMVLVAEYEN- 244
WP_400234486       181 DDLGQLKGLHGICFVQH-LSDRIGSDMIEACKHVFEP----QYDIDIQfqRTEGTS----------RGAGMVLVAEYEN- 244 Methanome...
WP_014811998       182 KDRGTIATVQGIALASHlEEQMVAERMAQRTLENLQRS---KIR--AEikKLHDSS------AAQR-GAALVVWAETStG 249 Desulfomo...
Q2LWJ0             183 TAQGNLLEIRGIALSSLlKERQVSERMAEECRKTLQAE---GHDARIDllYDTAGNpvyeksAVQA-GAALALWAKTDtE 258 Syntrophu...
EDO36080           335 TTPGRLVKITGWTSVAGaKPIRIAQVMSKLTRSALKDR-FPGVDIYVEslRERDSR------VDGT-GQAVMILGETSsG 406

7MQ8_SH            253 --TFLSAELASNpQgqgaaVLPEDLGRNCARLLLEEIY 288 human
XP_002492486       252 knWRYCIEDIGLaR-----ETPEDIGEATSYKFLELLE 284
EPR78031           229 --MIYYSEEINReN-----KKLEEITMNTIHKLLQSID 259
EED43460           172 --GIFYYMSPGSsD-----ISPEDLAGTCVRQLLNAIN 202
Q8SRP7             235 --GIYYSIGSGE-G-----LTPRETATAACKDLLRSVK 264 Encephalitozoon cuniculi
licsiro:TALC_00249 245 --GLLSSNVLSSkG-----HSAHQSGLDAASDLLQEMR 275
WP_400234486       245 --GILSSNVLSSkG-----HSPQQSGLDAASDLLQEMS 275 Methanomethylophilus alvi
WP_014811998       250 --AILGADRAGKqG-----RSSESIADFVTRSFLEDLK 280 Desulfomonile tiedjei
Q2LWJ0             259 --CLLGADRAGApR-----RSSETIGRQVARMMTETLQ 289 Syntrophus aciditrophicus SB
EDO36080           407 --MMLSGTALWRrG-----MSNEEVVQKAVNMFTQNSS 437
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