3PQV


Conserved Protein Domain Family
RTC_insert

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pfam05189: RTC_insert 
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RNA 3'-terminal phosphate cyclase (RTC), insert domain
RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Statistics
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PSSM-Id: 398729
Aligned: 242 rows
Threshold Bit Score: 38.6868
Threshold Setting Gi: 663072134
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PQV_A       183 LDKTMISSIRGVSYSTRVSPSLVNRMIDGAKKVLKSASCEVNITAD--VWRGENSGKSP---------------GWGLTL 245 Kluyveromyces l...
WP_015491780 181 DHLGELKGIRGLCFVQHLSDRIGQDMMDACRRVFEP---EYPIEIEyqKCEGTS----R---------------GAGMVL 238 Thermoplasmatal...
EPR78031     160 KDEKTIFKIRGLAISNRLNSLTTTKMVEIVQTNLKQI--CKNLKISkdICGGSDAGPSP---------------GYQIVL 222 Spraguea lophii...
EED43460     103 ikmEPIDKIRGMVISSHLGSDFVCRMTRVIKEECKKY--LSDVKVLniVDNKNTSGPSP---------------GFECSV 165 Enterocytozoon ...
Q8SRP7       167 ESPEKILKVRGLVLSSRVSSVPAKEMTDRIKEMLGDI---LNTKVFsnMSNRVDSGPSP---------------GFQCAV 228 Encephalitozoon...
EPQ63010     204 NSPGRVRRIRGVAYCTGVSASGNARMIHSARKVLNPLLFDINIAAQ--------YDQAPqpkknqt--tkrqgiGFGLSL 273 Blumeria gramin...
EHA53708     211 RTPGRIRRIGGVAYSTGVSASNNKRMIHAARGVLNALTGEIKIG------------EAPpgkdda---knkigiGFGLSL 275 Pyricularia ory...
EFX00833     209 RGAGRIRRIAGVAYTVGVTASNNKRMIHAARAVLNTLTGEIRIA------------EAPpaqdda---rnkpgiGFGLCL 273 Grosmannia clav...
EPE05576     214 RTAGRIKRIGGVVYSTGVTASNNKRMIHAARGVLNVLTSEIKIA------------EAPpskednp--dgkpgiGFGICL 279 Ophiostoma pice...
ERS98606     209 RGAGRIKRIGGVAYSVGVSASNNKRMIHAARGVLNALTGEIKIA------------EAPpskddghgggdkpgiGFGLCL 276 Sporothrix sche...
3PQV_A       246 VAENKq-GWRIFSEAI--GDAGDVPEDIGASVAYHLLEEIS 283 Kluyveromyces lactis
WP_015491780 239 VAEYEn--GLLSSNVL--SSKGHSAHQSGLDAASDLLQEMR 275 Thermoplasmatales archaeon BRNA1
EPR78031     223 FAEGNn--MIYYSEEI--NRENKKLEEITMNTIHKLLQSID 259 Spraguea lophii 42_110
EED43460     166 FAETRh--GIFYYMSP--GSSDISPEDLAGTCVRQLLNAIN 202 Enterocytozoon bieneusi H348
Q8SRP7       229 FAESKs--GIYYSIGS--GE-GLTPRETATAACKDLLRSVK 264 Encephalitozoon cuniculi
EPQ63010     274 IAETVnsSVIYSADVSapSEGGITPEDIGKKCALQLLEVIS 314 Blumeria graminis f. sp. tritici 96224
EHA53708     276 VAESSvpGVVYSADVVspARGGALPEDLGAQCAHQLLEAIA 316 Pyricularia oryzae 70-15
EFX00833     274 VAESNvpGVVYSADVVapARGGVLAEDIGTQCAHQLLANIA 314 Grosmannia clavigera kw1407
EPE05576     280 VAESNtaGVVYSADVVspPHGGVLAEDVGTQCAYRLLEAIA 320 Ophiostoma piceae UAMH 11346
ERS98606     277 VAESTvnGVVYSADVVspAQGGVLAEDLGTQCAHRLLEAIA 317 Sporothrix schenckii ATCC 58251
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