2O8F,3THZ


Conserved Protein Domain Family
MutS_II

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pfam05188: MutS_II 
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MutS domain II
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam01624, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. This domain corresponds to domain II in Thermus aquaticus MutS and has similarity resembles RNAse-H-like domains (see pfam00075).
Statistics
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PSSM-Id: 398728
Aligned: 47 rows
Threshold Bit Score: 57.36
Threshold Setting Gi: 30580411
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2O8F_A  143 ASIGVvgVKMsa------vDGQRqVGVGYVDSIQRKLGLCEFPDndqFSNLEALLIQIGPKECVLPGGETAGDMgklr-- 214  human
O74773  143 SVLLAvtTRVk-------qDQRI-IGVAFIDPILKKLGVSEFVDsdaYTNFEALIVQVGAKECIISQSGHESTNgnsavs 214  Schizosaccharomyces...
P40965  104 CVLCC--IYEvp------rDISTrIGLCIINCNTGQMYLSDFMDsqiYIRVVHKLQIYQPTEILIPSSSLAPTVsklatm 175  Saccharomyces cerev...
O94065   39 EVVMS--VYSpk------aDSMD-VGVSVLKLKTLELTLMSFCDsstFVRTVNQIQVYEPTSIILPEAQSHSQIeklkyi 109  Candida albicans
O15457  155 SVIVAvvEGRg--------LARGeIGMASIDLKNPQIILSQFADnttYAKVITKLKILSPLEIIMSNTACAVGNstkl-- 224  human
P26359  233 QFILC--VADnvdk-skakSGRVqVGLIAIQLSSGTTVYDHFQDdflRSELQTRLSHFQPCELIYSNKLSSEsvalln-- 307  Schizosaccharomyces...
3THZ_B  150 SYLLC--ISEnkenvrdkkKGNIfIGIVGVQPATGEVVFDSFQDsasRSELETRMSSLQPVELLLPSALSEQTEalihra 227  human
Q9VUM0  391 NYMLA--IVEkd-----egTCSR-YGVCFIDTSIGDFHLGEFEDdknCSRLLTLVSHHMPVLFLNEKSALSQRTqq---- 458  fruit fly
Q9SMV7  388 VHLLAikEIKme-----lqKCSTvYGFAFVDCAALRFWVGSISDdasCAALGALLMQVSPKEVLYDSKGLSREAqkalrk 462  thale cress
O74502  501 TYCMAikESLqs-----dnEEPS-FGICFIDTSTGGFHMCEFTDdihRTKLDTLLTQVRPKELILEKSKISQKSiraik- 573  Schizosaccharomyces...
2O8F_A  215 --------qiiQRGGILITERKKAD-FSTKDI--YQDLN--RLLKGKKGEQMNSavl--peMENQVAVSSLSAV-----I 274  human
O74773  215 in--taeinrlRNIIEGCGALVTTI-RSSEFS--ARDVE--LELSKVLDSPVTHalv--peLGLQLAMASCNAL-----L 280  Schizosaccharomyces...
P40965  176 ikfnvaetvkiEEGSRKCFNSQDGL-AAITKY--LMDDTk-KDLKIEEIIDKTF------------ALCAASAA-----I 234  Saccharomyces cerev...
O94065  110 ih--snisdkvRERFMKAKVFNAFDgMNSLKL--YTDIN--ESTLGQVISNR------------KLSLAAANAC-----I 166  Candida albicans
O15457  225 --------ftlITENFKNVNFTTIQ-RKYFNE--TKGLEyiEQLCIAEFSTVlm-----evQSKYYCLAAVAAL-----L 283  human
P26359  308 -----hyvsteKTCGRVVRVQHAVQ-QDVKLA--LENLQ--DFFSSKCIMS-GSkii-elhMEKVKSLHSLSIIcldmaI 375  Schizosaccharomyces...
3THZ_B  228 ------tsvsvQDDRIRVERMDNIY-FEYSHA--FQAVT--EFYAKDTVDIKGSqiisgivNLEKPVICSLAAI-----I 291  human
Q9VUM0  459 ----------iVRTVLGGILKEPVP-GNGKHAcsAEKTL--KLLAERYYAGPGSd------DNWPLVLR----------- 508  fruit fly
Q9SMV7  463 y---tltgstaVQLAPVPQVMGDTD-AAGVRN--IIESN--GYFKGSS-ESWNCavd--glNECDVALSALGEL-----I 526  thale cress
O74502  574 ------ycvssSSIWNFIKPYTEFW-DNERVE--REIIA--GDYFKNGLEG-APkilksylSEKPLAISAFGAL-----F 636  Schizosaccharomyces...
2O8F_A  275 KFLELLSDDs------NFGQFE 290  human
O74773  281 RYLGPALLNpdmeddrENTSRK 302  Schizosaccharomyces pombe 972h-
P40965  235 SYMEEIISKss----rNLNAFR 252  Saccharomyces cerevisiae S288C
O94065  167 DYCVSTKMFr------VTNKIR 182  Candida albicans
O15457  284 KYVEFIQNS--------VYAPK 297  human
P26359  376 SYLMEFSLEdl----fVASNFY 393  Schizosaccharomyces pombe 972h-
3THZ_B  292 KYLKEFNLEk------MLSKPE 307  human
Q9VUM0  509 -----TMQSdm----dHLGLTP 521  fruit fly
Q9SMV7  527 NHLSRLKLEd------VLKHGD 542  thale cress
O74502  637 WYLRQLKLDkd---mcSMGNFD 655  Schizosaccharomyces pombe 972h-
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