3UA3,4GQB


Conserved Protein Domain Family
PRMT5

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pfam05185: PRMT5 
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PRMT5 arginine-N-methyltransferase
The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
Statistics
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PSSM-Id: 398725
Aligned: 30 rows
Threshold Bit Score: 230.94
Threshold Setting Gi: 74953024
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3UA3_A       349 DSTHYLNvIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVv--------------IY 414 Caenorhabditis ...
Q5CY57       304 SSKQKYE-YNYIDVLQMPLQPLSNNLKSIEYEVFERDHIKYEKYFHAVKLFLSENNIKSEEIK---------------VL 367 Cryptosporidium...
XP_001616393 341 DRDTLFD-SAYWDYLQIPLQPLKDNLPSQTYEIFEKDRTKYEQYELAISKYLSVELQKGGDNNgkgrn------rdfiIF 413 malaria parasit...
XP_001609241 290 TEAEKFK-QGFYDVLQEPLQPVRDNLETATYENFERCTRKYAQYEAAISAWLKDYLNGKIGSQdenvrqdcgkskapvIY 368 Babesia bovis T2Bo
Q4UG56       334 TIRELYG-RGYEDLFQVPLQPLRDNLDSSTYNEFEKCSFKYNCYDQAIHSFISTKLISLNQLSklnsnisysspvnyiVY 412 Theileria annulata
Q75DB6       277 LLQAPGE--DGAPRVMQPLQPHAVDLSSEVYQIFEQDKTKYDLYAKAITAALRSIRSTMNKMWlhd---------dlnII 345 Eremothecium go...
Q6CT32       303 DVVHSA------PTIMPPLLPHHDNLSNAVYQVFEKDTVKYELYERAIMVAVSEILTENSSSWrgpt--------eliTL 368 Kluyveromyces l...
XP_001644616 311 ENDITIEdNYWIPRVMPPLLPNSENLSNLVYSNFERDTVKYELYQRAIELAVRDQIDYRRSYNl-------------vIL 377 Vanderwaltozyma...
Q6FX40       302 KMLKACE-KLAEPRILPQLKPHSEDLSNQTYALFEEDIVKYDLYEVAIKDAILENTKIWKNRGssf----------itIL 370 [Candida] glabrata
A0BU75       261 SEQAHLA-SEFFDELQIPLQPYKDNLNSGTYEVFEQDKIKYDLYEDACRKYLKNVKKAEi-----------------nIL 322 Paramecium tetr...
3UA3_A       415 LLGGGRGPIGTKILKSEREYNn-TfrqgqeslKVKLYIVEKNPNAIVTL--KYXNVRT---WkRR-VTIIESDXRSLPGI 487 Caenorhabditis ...
Q5CY57       368 IVGSGRGGLIKSAFNAFSYIGi-N--------SFKIMCVEKNRNAVLTLk-AKMNYKDnanW-EK-VDIINSDIRTVQLD 435 Cryptosporidium...
XP_001616393 414 VVGAGRGPLVDCTLQALEKNKi-S--------KFQIYAIEKNDSAILVLq-NRVTNPK---W--KqVHVIHSDMRYLQMG 478 malaria parasit...
XP_001609241 369 IVGAGRGPLVDCSLRALAYHNv-E--------EYSIFALEKNPAAVFALk-HKIATNAikgW-DK-VQIIFHDMRTLKPT 436 Babesia bovis T2Bo
Q4UG56       413 VLGAGRGPLVEVVMEVFKRNNipTn-------DFVVFALEKNPYTMLTLd-HKIQNNR---W-TN-VRLIYSDMRDLNRG 479 Theileria annulata
Q75DB6       346 VVGAGRGGLVDRAYTCLRQLGi-S--------RFKLVALEKNPQAVIHLq-KK-NIEK---WgNS-VDIVSANMREWSSK 410 Eremothecium go...
Q6CT32       369 VAGAGRGPLVDKTFQVLHKLGv-T--------NFRLLAIEKNPQALLYLq-KR-NFEH---WdNK-VEVIRTDIREWDEN 433 Kluyveromyces l...
XP_001644616 378 IAGAGRGALVDRTFEVANFLNilN--------NVKIIALEKNPQACLYLq-KR-KFDS---WgEK-VEIIRDDMKKWGDS 443 Vanderwaltozyma...
Q6FX40       371 VAGAGRGPLVDRVFKVLQELSilS--------ECRVIAIEKNSRAYLYLq-KR-NFDK---WqNR-VTLINEDIQNWQIN 436 [Candida] glabrata
A0BU75       323 MAGAGRGGILERVIFAAQGAK--C--------KTKIVALEKNPYAYMTLvfQKKRQKQ---W--KdVEIVLDDLKSWQTE 387 Paramecium tetr...
3UA3_A       488 Akdr----gfeQPDIIVSELLGSFGDNELSPECLDGVTG-----FLKPT-TISI 531 Caenorhabditis elegans
Q5CY57       436 E----------KYDLIISELIGSFGDNELSPECLIFAQR-----FLKPS-GIMI 473 Cryptosporidium parvum
XP_001616393 479 K----------KADLIVSELLGSFGDNELFPECLDGIQK-----YLQED-GVSI 516 malaria parasite P. vivax
XP_001609241 437 I----------PADLVLSELLGSFGDNELAPECLDGVQHafykaFPNHH-VTFM 479 Babesia bovis T2Bo
Q4UG56       480 MvqsnlnnaskTVHLVLSELLGSFGDNELSPECLYGFERsfnslFSQGVrLEFI 533 Theileria annulata
Q75DB6       411 V----------KFDLCISELLGSFGCNELAPECLEAFEK-----TNCTDrTIFI 449 Eremothecium gossypii
Q6CT32       434 I----------KVDLCISELLGSFGCNELSPECIAPIEA-----FHSKPnTRFI 472 Kluyveromyces lactis
XP_001644616 444 Si---------KVDICISELLGSFGCNELSPECLFNIQK-----NHSKPsTIFI 483 Vanderwaltozyma polyspora DSM 70294
Q6FX40       437 Maes----qrtKVDLCISELLGSFGCNELSPECLLSLQK-----YHSQKeTVYI 481 [Candida] glabrata
A0BU75       388 L----------KFDLIVSELLGSFGDNELSPECLMWAQR-----FLQPD-AVSI 425 Paramecium tetraurelia
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