2G0D,3E6U,3T33


Conserved Protein Domain Family
LANC_like

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pfam05147: LANC_like 
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Lanthionine synthetase C-like protein
Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.
Statistics
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PSSM-Id: 398697
Aligned: 46 rows
Threshold Bit Score: 158.699
Threshold Setting Gi: 81621954
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2G0D_A  27 DFGELTLSTGLPGIILMLAELKNKDNS-KIYq---KKI-DNYIEYIVSKLSTy-------gLLTGSLYS---GAAGIALS 91   Lactococcus lactis s...
O87238 635 GVLGYDLYSGRTGPALALAAAGRVLKD-KDSi---ELS-ADIFNKSSQILQEktydfrnlfASGIGGFS---GITGLFWA 706  Lactococcus lactis
Q8VVR0 622 GVLGYDLYSGRTGPFLALLLSGKQLKN-QKVi---DVA-YEFFDKVTKIFEEktydlrnllMSGIGAFS---GMSGIIWS 693  Staphylococcus aureus
Q5TLL6 605 HENPDSYYSGSVGILRCLLLLEK-----SGYk---DLPiNKLISDIEIDIDAiiny--gtvDTSIGAYN---GIAQYLRY 671  Streptococcus mutans
Q841L9 546 TSDPLNVQHGAAGLLSVLNRALGAEPG-PQLreavSTAaDWIVGRVGREPRA---------LPGLHF-----GRSGTAWA 610  Streptomyces griseoc...
Q8VVQ8 600 SMTNFSLHDTG-GVIFLLEHIKDFRQNp-------SLVkLDFLNSAKLGLQElqey--ffnDKTSNYFSiisGKSSIDFI 669  Staphylococcus aureus
Q9L3F1 565 AMLDWSLYSGIIGLGYMYISEYDKEPD--------VLA-KDMLQRIFCTLAKsydl-gvfkEYDISYFCgltGI--YAFL 632  [Ruminococcus] gnavus
Q75V17 572 ESLSDDLYKGLSGIGIALLKYYEINKNlKDMsrlkKIL-SSIYSSILSNINTns-----skEKDLSFFNgeiGKIAFLYN 645  Staphylococcus warneri
P37609 575 ESLENDIYKGISGIGLALLEYYEFYPN-INTkkilKLI-YKNISKDFINTNNe--------PQNYGFYVgliGEYSFLRK 644  Lactococcus lactis s...
O54330 561 EIMDDTIYKGIAGIKLAFLLSSRNFGM-SSD--------KVILDRINKSLSFsd-----ytLNRESFYEgtfGSQLPSYK 626  Streptococcus mutans
2G0D_A  92 ILHLREDDEKYKNLLDSLNRYIEYFVREKIEGFNlenitppdYDVIEGLSGILSYLLLINDEQ-----YDDLKILIINFL 166  Lactococcus lactis s...
O87238 707 LNAAGNILNNDD-WIKTSNQSMLLLNENMLKVDKn------fFDLISGNSGAIGMMYLTNPNFy---lSRSKINDILLTT 776  Lactococcus lactis
Q8VVR0 694 LYTAGKITENSK-WKNTALKVFDLIDEEIKKEEKgd-----fFDMISGSSGAIIMRYKIQEDYs---lSENFIKEKVKEA 764  Staphylococcus aureus
Q5TLL6 672 YAYIYKNNNFSVLSLKRIHYLLDLIENGFKNDEK--------LDILDGTAGVILTLIEIFQLDlsdclNNRVIKLVEKCR 743  Streptococcus mutans
Q841L9 611 LLDSAEVLGNDALAGAAADLARRVSLRWPN------------PDICHGSAGAGMTQLRFWEATg----DEDFLRRADKAA 674  Streptomyces griseoc...
Q8VVQ8 670 FDYKNEKSDNLEKAGFDCCFTKKG------------------NDVFNGTPGLGLVLSSFPLTS------SDILFKILSTM 725  Staphylococcus aureus
Q9L3F1 633 KQIKDRNIIEPDIIEKYIKNIQEAIRNNIVKTSS--------YDTLAGIHSAVIYYFGCYEQDi---fSREILSSIEEYF 701  [Ruminococcus] gnavus
Q75V17 646 YQIEFK--ENCDSSKNYMKHILGIILSSEFe----------mNDIIAGLPGIISYLYNQEIFS------KELVIMGDRLL 707  Staphylococcus warneri
P37609 645 YEKVFHKTSSCNILKNILKDFTPEKCQTILPS----------DDVIAGEAGIIIYISNLNNYLe----YRDEIDILLKSL 710  Lactococcus lactis s...
O54330 627 -EISKEDLQNPKQW----------------------------DALLGASS----TIIGIYQNFkinptFKEIIEQYADYL 673  Streptococcus mutans
2G0D_A 167 SNLTkennglislyiksenqmsqseseMYPLg---CLNMGLAHGLAGvGCILAYAHIKGY-SNEASLSALQKIIFIYEKF 242  Lactococcus lactis s...
O87238 777 DCLI-----------------------TEMEk---DETSGLAHGVSQ-ILWFLSIMMQRQ-PSSEIKIRATIVDNIIKKK 828  Lactococcus lactis
Q8VVR0 765 YNII------------------------NNKk---NLSSGLAHGISQ-IMYFFAIIYKKQ-KLVYIRRIIEDIHKIIKSN 815  Staphylococcus aureus
Q5TLL6 744 LHLIdsiiydkg--------eayfpiaQEKN----RYFTGFAHGSSG-ITLAIYRASKL--LNIDDYTLIRSLLKTERRL 808  Streptococcus mutans
Q841L9 675 ESVAaaavrrdg-------lllwpvprDWPShlagLVHYGFAHGVAG-TGAFLLAAGRAT-GDERYLELAGEAARTLVSA 745  Streptomyces griseoc...
Q8VVQ8 726 VYDG--------------------------Kn---HSKKGIAHGELG-ILWSKYRINKFLkRKDTCKKLFEEVKNITYSL 775  Staphylococcus aureus
Q9L3F1 702 LNSFki--------------------dDMKRn---FNYASFAHGYSG-VMTSIMCMLQHK-YDIKLEKILCELWKEEKEL 756  [Ruminococcus] gnavus
Q75V17 708 KDLD--------------------------Nn---PTMAYYAHGKSG-VMVSLLYLYDLT-KDKKYLVKFHQEWKKENTL 756  Staphylococcus warneri
P37609 711 SNKI-------------------------KLk---ESIASYAHGNSG-IATAFVHGYKVT-KNEKYLKIFHELWNLENSS 760  Lactococcus lactis s...
O54330 674 VISLqknsing---------yswfdeeHQd-----LVNVSFAHGNSG-CMTALLISYALL-GKSEYLDTFQKLGKVNKKF 737  Streptococcus mutans
2G0D_A 243 ElerkkqflwkdglvadelkkekvireasfirdAWCYGGPGISLLYLYGGLal---------dNDYFVDKAEKILEsamq 313  Lactococcus lactis s...
O87238 829 Ytnsygeiecy------------yptdghskstSWCNGTSGILVAYIEGYKani-------vdKSSVYHIINQINVeq-- 887  Lactococcus lactis
Q8VVR0 816 Ftnvqnlieiy------------rsedknnissSWCNGLSGLLVSYYEGYKagi-------fsKDEVIDIIKQIEIi--- 873  Staphylococcus aureus
Q5TLL6 809 Fdktnqmwfk--------------dnnrnsyswGWCHGIPGILLSRLELIKhg--------yqDDYIIEEAYELYEiai- 865  Streptococcus mutans
Q841L9 746 Arhddgaaywt------------agpsggarrtNWCSGSSGIGTFLLRLSQh----------dKDARVREGAELAAvavr 803  Streptomyces griseoc...
Q8VVQ8 776 T--------------------------------GWCCGNAGLLMVLAEMCTel--------nvEKQFLKSIAKKAIils- 814  Staphylococcus aureus
Q9L3F1 757 Yvekfiwkdm--------------rahhivhshYWCHGSVGIMMARLIWKKfgfdkkfaedieEENLEEILSKYKEelln 822  [Ruminococcus] gnavus
Q75V17 757 Kleigwkdvr---------------qneetysvSWCNGVTGQLISRLVALEihdkvkifdavnKKLMQKEIEELLYllke 821  Staphylococcus warneri
P37609 761 Klrrgwtdsr---------------kvdssyssQWCHGASGQAIARMEWITvnktarflsnseLIKVKKELGELIDilkk 825  Lactococcus lactis s...
O54330 738 Midcgwedtr---------------ntdrlssaNWCHGSTGALTSRLLWFKlnkkfnilnehdIQRVYLEIDHSVNdiid 802  Streptococcus mutans
2G0D_A 314 rklGIDSYMICHGYSGLIEICSLFKRLLNTKKFdsymEEFNVNSEQILEEYGD-------------ESGTGFLEGISGCI 380  Lactococcus lactis s...
O87238 888 -lqHDNIPIMCHGSLGVYESLKYASKYFEIETKy---LLDVMRNGGCSSQEVLkyygk---gngryPLSPGLMAGQSGAL 960  Lactococcus lactis
Q8VVR0 874 --pLSVVPILCHGSLGVYDSLKYVSKDFEKETRy---LLMKLEKTTCSPAYIVnyfke---grgryTLSPGLMTGKTGAL 945  Staphylococcus aureus
Q5TLL6 866 kksLGVNLTFCHGDLGNIVICKYAEVMLDIEN-----SKVDKYIQEIFPYLTNatry-----hirgTETIGVMHGLVGVA 935  Streptococcus mutans
Q841L9 804 rsrWQAGTSHCHGLAGDGEFLLDMAEACEQPRYarwaEELALAIHARHTVREGrvlapdetgtavtTDYGTGLGGVL--- 880  Streptomyces griseoc...
Q8VVQ8 815 -nnEPIDLSVCHGASGVLQSLLFTYRATNDEWYl---SLANTFWQKVLDLSKKngfyt---geknrDYILGYFLGWSGFA 887  Staphylococcus aureus
Q9L3F1 823 kkfQSKNYSLCHGNFALIDFLISYRKIVGTD------ERIDAYIEEIIESGQEngyscv--gapgaINSIGFMVGEAGIQ 894  [Ruminococcus] gnavus
Q75V17 822 eglEQNNFCLCHGVMGNLLVLNYYQKKFENTNIhl-aNKIDSHFYSVANFGLNkgwic---glgnnFYSFSIMTGISGIL 897  Staphylococcus warneri
P37609 826 egmYTDNFCLCHGILGNLLILNTYQENFDNKNInl-kNEILNNYYSVCNYGLNkgwic---glgteFYSYGLMTGISGIL 901  Lactococcus lactis s...
O54330 803 kglSINNFSLCHGIMGNLIALNEYSLAFSNQKIq---QLVQSTLISLCSVGMKkdwlc---gvndlFYNNGLMTGLAGIL 876  Streptococcus mutans
2G0D_A 381 --LVLSKFEYSInftyWRQALL 400  Lactococcus lactis subsp. lactis
O87238 961 --LHCCKLEDNDis-vSPISLM 979  Lactococcus lactis
Q8VVR0 946 --LHLCKLLDGEid-vSPLTFE 964  Staphylococcus aureus
Q5TLL6 936 --TFLDSTICDNyl-rFLDILK 954  Streptococcus mutans
Q841L9 881 --AFLLRLRHGGprlwLPKTFT 900  Streptomyces griseochromogenes
Q8VVQ8 888 dsCLLLAQFNNKk---KPWIPL 906  Staphylococcus aureus
Q9L3F1 895 --YTENRSENSKl---HSVLML 911  [Ruminococcus] gnavus
Q75V17 898 --YAFLKYKTKDt---ELGILL 914  Staphylococcus warneri
P37609 902 --YGLIRQVKQKn---NFGVLM 918  Lactococcus lactis subsp. lactis
O54330 877 --YGIIKIYYDDn---YDQHVL 893  Streptococcus mutans
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