7SUK,2ZPA,3K70


Conserved Protein Domain Family
Helicase_RecD
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pfam05127: Helicase_RecD (This model is not part of the current CDD release)
Helicase
This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolyzis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases.
Links
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Statistics
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PSSM-Id: 516637
Aligned: 97 rows
Threshold Bit Score: 70.6629
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7SUK_LY       280 LTAGRGRGKSAALGISIAAAVSHG---Y------SNIFVTSPSPENLKTLFEFIFKGFDalgyqehidydiiqstnpDFN 350  brewer's yeast
tigr:DNO_1061 132 ILGARGTGKSTLLAEKIIWLVQQN---I------APILVVAPFLANINRILTLPQSV----------------------- 179 
7_pfamImport    2 VTADRGRGKSGAVGIGLIGFVETF---KkskggfAKVIVTSADPIGVQTLFSLAMKAANvlgi----------kakrVEK 68  
WP_011822119  287 ITSDRGRGKSGAVGIASIGLAARL---Rkel-grVRIVVTAPNLSNVQSFFTLALKAAEklel----------kthiVRR 352  Hyperthermus ...
Q9Y993        276 ITADRGRGKSSALGIGLVALAHEL---Gkvk-hrVRIIVTAPSPSNVQSLMELAIKTAEtlgl----------epkpVRR 341  Aeropyrum pernix
WP_011839411  266 ITADRGRGKSCAVGIGSVGLIHVL---Rkvk-pkPRILVTAPSPSNVQSLMMLARKVLDalgy----------kyevIKR 331  Staphylotherm...
Q74MW6        250 LTADRGRGKSVAVGLGIAGITYVF---Ykk---pFYIGITAPNRGNIESLWEFLKKALEkle---------------lkY 308  Nanoarchaeum ...
WP_012185694  244 IIADRGRGKSAAVGLAVSLIGHRL---Rrrr-gvARIVVTAESPDNAETLMEFAKRGFEelgy----------dvevSRT 309  Caldivirga ma...
WP_011763175  245 IIADRGRGKSAALGLGLAGIGHKL---Rkak-srVQIVVSAMEYTNLETLLEFAIKGLEalgy----------kpgvERE 310  Pyrobaculum i...
3K70_D        169 isggpgtgktttVAKLLAALIQMAdgeR------CRIRLAAPTGKAAARLTESLGKALRqlp-------------ltDEQ 229  Escherichia c...

7SUK_LY       351 KAI---V-------------RVDikrdhRQTIQYIVPQD-HQVLgQAELVVIDEAAAIPLPIVKNL---L-GPYLVFM-- 407  brewer's yeast
tigr:DNO_1061 180 ----------------------------QRFLRFLPPDEaCRLLpTAQHLIIDEAAACAPAQLLQL---ChHYSNFTL-- 226 
7_pfamImport   69 KGYvyeL-------------HGE-----GWSIEYWPPADaAVKSa--DLVVVDEAAGIPVPLLHKI---WkNHKRSLF-- 123 
WP_011822119  353 GDNileI-------------HGK-----GFSIEYWEPIHvPRLKa--DIVIVDEAAGMHIPLLHKI---WrSHRKLVF-- 407  Hyperthermus ...
Q9Y993        342 GGRiieV-------------QGR-----KFSLEYWEPATvVRLQg--DIVAVDEASGIHVPLLHKI---WrAHRRLVF-- 396  Aeropyrum pernix
WP_011839411  332 EGNvieL-------------RGE-----KFSIEYWEPINiPRIRg--DIVIVDEAAGIHVPMLHKI---WmSHNRLVF-- 386  Staphylotherm...
Q74MW6        309 EEKknkI-------------KAG-----KVIIEYKQPQDlVKRKy--DLVAVDEAAGVYVTYLYKI---MnKYDRLVF-- 363  Nanoarchaeum ...
WP_012185694  310 GSNivgL-------------STR-----GIYVDYYKPYPlMSLQrPIDLVVVDEAAMMPLPILYGI---HnRFTRVIY-- 366  Caldivirga ma...
WP_011763175  311 GGEiraI-------------KAK-----GIFIDVVTPYMlLKREnA-DIVAVDEAAAVPLPVLYAV---HkKFDRLVF-- 366  Pyrobaculum i...
3K70_D        230 KKR---IpedastlhrllgaQPG-----SQRLRHHAGNPlHL-----DVLVVDEASMIDLPMMSRLidaLpDHARVIFlg 296  Escherichia c...

7SUK_LY       408 ---------ASTING----YEGTGRSLSLKLIQQLRNqnntsgrestqtavvsrdnkekdshlhsQSR-QLREISLDEPI 473  brewer's yeast
tigr:DNO_1061 227 ---------ATTTEG----YEGSANTFHYHTLNALKL----------------------------P---PAAITYLHHHY 262 
7_pfamImport  124 ---------ATTIHG----YEGAGRGFNVRFLPALKN----------------------------DKKtELKMIHMTEPI 162 
WP_011822119  408 ---------ATTIHG----YEGAGRGFSVRFLPALKN----------------------------DPNtELIEVEMHEPI 446  Hyperthermus ...
Q9Y993        397 ---------SATIHG----YEGAGRGFNVRFLSAVKK----------------------------SGDtIIREFKMEEPI 435  Aeropyrum pernix
WP_011839411  387 ---------STTIHG----YEGAGRGFSVRFLTKIRN----------------------------DKNtQLIEYEMTEPI 425  Staphylotherm...
Q74MW6        364 ---------STTIHG----YEGAGRTFNVRFLKALKE----------------------------NPNlMVIEHKMKEPI 402  Nanoarchaeum ...
WP_012185694  367 ---------STTIHG----YEGAGRGFSVRFLKYLRG----------------------------RRGiRVLEYEMTEPI 405  Caldivirga ma...
WP_011763175  367 ---------ATTIHG----YEGAGRGFSIRFLKYLKE----------------------------SKDtDVYLYEMEEPI 405  Pyrobaculum i...
3K70_D        297 drdqlasveAGAVLGdicaYANAG------FTAE-----------------------------------RARQLSRLTGT 335  Escherichia c...

7SUK_LY       474 RYAPGDPIEKW-LNKLLCLD 492  brewer's yeast
tigr:DNO_1061 263 RYHENDALDCV-LRRCFLRD 281 
7_pfamImport  163 RYAPGDPVERW-LYDSLLLD 181 
WP_011822119  447 RYAEDDPIERW-LFDALLLD 465  Hyperthermus butylicus
Q9Y993        436 RYAPGDPIERW-LYNTLLLN 454  Aeropyrum pernix
WP_011839411  426 RYSINDPIEEW-QFKTLLLD 444  Staphylothermus marinus
Q74MW6        403 RYAIDDPVERF-MYDVLLLD 421  Nanoarchaeum equitans
WP_012185694  406 RYARDDPIERW-LFKTFLLD 424  Caldivirga maquilingensis
WP_011763175  406 RYGRGDPVEQW-LFDAFLLN 424  Pyrobaculum islandicum
3K70_D        336 HVPAGTGTEAAsLRDSLCLl 355  Escherichia coli K-12
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