Conserved Protein Domain Family
AF-4

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pfam05110: AF-4 
AF-4 proto-oncoprotein
This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Statistics
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PSSM-Id: 398672
Aligned: 30 rows
Threshold Bit Score: 366.746
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007495991    8 FNEDRNLLRIREKERRNQEVHQEKKFFPVNTPLFGEPYKTSKGDELSSRIQNTLGNYEEVKELISTK-NQ-NLFGIPEEs 85   gray short-ta...
6_pfamImport    1 YNEERKLLRLRAWEQRNQGTSQAKD--QENMPLFGEPYKTNKGDELSNLIQRMLGSYEDVNH-------P-----NPAAm 66  
XP_002664429   20 YEQDRSALKKKEWERRTQEVQQDEDLFSTGFNLFGEPYKTNKGDALANRVQNTLGNYDEMKELLTSHsNQsHLVGIPKNs 99   zebrafish
KFO61033        2 YEQDRSALKRKEWERRNQEVQQDEDLFASGFNLFGEPYKTNKGDALANRVQNTLGNYDEMKDLLTNHsNQsHLVGIPKNs 81   American crow
XP_011936965   18 YEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKGDALANRVQNTLGNYDEMKDLLTNHsNQnHLVGIPKNs 97   sooty mangabey
XP_016282184   71 YDQDRNALKRKEWERRSQEVQQDEDLFASGFSLFGEPYKTNKGDALASRVQNTLGNYDEMKDLLTNHsNQsQLVGIPKNs 150  gray short-ta...
XP_015207298   20 YEQDRNALKKKEWERRTQEVQQDEDLFSSGFNLFGEPYKTNKGDALANRVQNTLGNYDEMKDLLTNHsNQsHLVGIPKNs 99   spotted gar
PKK32498       31 YEPDRNVLRRKEWERRNQEAQQEDGAFNTSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDLLTDRsNQsHLVGVPKPg 110  rock pigeon
XP_027959726   20 YEPDRNVLRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRsNQsHLVGVPKPg 99   Steller sea lion
XP_002934593   18 YEQDRSALKRKEWERRTQEVQQDEDLFASGFNLFGEPYKTNKGDALANRVQNTLGNYDEMKDLLTNHnNQsHLVGIPKNs 97   tropical claw...
XP_007495991   86 sl----sltSQGKSRC-SFYPEKtGSiTHPPFFSSV-HHQVTNSASGPS-IYI-P---THCPKATQARMEPAMSLHARSD 154  gray short-ta...
6_pfamImport   67 epfriptyaSFSQSDQgQTSLDGqAG---PPFHTQAsGSQSQKAPGGSGvP-------SQSSRTSGAASSPDHQGNSSPF 136 
XP_002664429  100 vp-----qtPVEKPDQpGFFPEAqRSrPALS-QPGS-HSTSMPPPPANTiPGSsVm-hGHQGKKSR-SSDWSQGGHRSSG 170  zebrafish
KFO61033       82 vp-----qtPIDKNEQ-NFFPEPr-NrMIPSHQISGnTSTSMPPPSSLSsNSTlLh-sHQSSRKSR--TDWSRSGHNSSG 151  American crow
XP_011936965   98 vp-----qnPINKNEP-SFFPEQkNR-IIPPHQDNThPSAPMPPPSVVIlNST-L---IHSNRKSK--PEWSRDSHNPST 164  sooty mangabey
XP_016282184  151 ip-----qtPTEKNEQ-SFFPDQrNR-MIAPHQ--G-SSQSVPLLSSVTsS-S-S---HQNIRK--PRADWPRAGHCSTI 213  gray short-ta...
XP_015207298  100 ip-----qtPVEKSEQsSFFSEGqRNrMAPSHQ--S-ATTSMPPPSSTSlSSStLlhgHQGNKKSR-STEWSRGTHSSAT 170  spotted gar
PKK32498      111 vp-----qtSLPKPDE-HHIADSrPM-PPPPISSTT-SS----TPAALP---------AQQSK-S-TTMGWQKAGHNAAS 167  rock pigeon
XP_027959726  100 vp-----qaPVNKIDE-HFVADSrAQ-TQPSSV----CSTASSTPATVP---------AQQSKRGT--MGWQKPGHPPSD 157  Steller sea lion
XP_002934593   98 vpq---tpaPVEKNEQ-SFFPDQ-RNrLAPCHQSSShPSSSMPPPSSLApNTTlT---HNHEGSRKSRVDWAHGGHTSSC 169  tropical claw...
XP_007495991  155 SISSnqhqGKYYn--GQDRHHRSQNKKDElLRPDGTSCVELSDSa-LEMDNSLLSSTlsssvaplasHHSNQP------- 224  gray short-ta...
6_pfamImport  137 SNASlnpsQLSYavpCHQRSEDRLRD-----------HARLAQE----------ARShsppakplslQCSGDL------- 188 
XP_002664429  171 VQTTqa--------aSRGKHSSHEQT--S-NRHDQDQ----EDS--SPNPNGPTTSS-----------HSSRK------- 215  zebrafish
KFO61033      152 AQPSqssgQQSR-----TKHSSSHDQSQG-RYEDLYNCQSEQHKsgGTEEANPMATS----------SHSRRH------- 208  American crow
XP_011936965  165 VLASqasgQP-------NKMQTLTQDQSQaKLEDFFVYPAEQPQigEVEESNPSA-----------------K------- 213  sooty mangabey
XP_016282184  214 TQASqs----tGl-pNRMKQSNPHD-QPQgRYEDLFNCQSDQHKngGMEDASMSTSS----------SNSRRL------- 270  gray short-ta...
XP_015207298  171 GQPSq----aGGqqcGRAKHNSSSHEPSQtRYEDLFSSQGDLHK----GDSSPASSS----------SHSRRH------- 225  spotted gar
PKK32498      168 DG------QQRAskhGHRSLESHKGD---------FKLANQKSS---LEKLKRYAsspts---ssssSNAAQQ------- 219  rock pigeon
XP_027959726  158 GQQRaskhGHRLldlNRSANPKNHNK-------------KPNQS-----VSSPSSSSss------ssSSSSSSssssssn 213  Steller sea lion
XP_002934593  170 TQSN----QLSNq-pSRLKHTSSHDLLQI-RYEDLYNCQNDQYKsgVIDELIPATSS----------SHSRRH------- 226  tropical claw...
XP_007495991  225 ---TGSRMlGSSK--GSS---------KGCAQA-KSPSHLALEPKEEETpqyslaPVTGLGMVN-SQPSSQSFPPPsLPS 288  gray short-ta...
6_pfamImport  189 ---GTTGAnTKEAcdH-HpritpsecpGFGDASaLVPRDSTKDSCLPQA------------SKG-HSLPSQTFPSL-LSK 250 
XP_002664429  216 ---QAQ---AGKG--PAT---------AELGLG-KSPAEQDSCSHGSSS------PLASTSLLP-SGLSTPTFPQG-LHC 269  zebrafish
KFO61033      209 ---THAKSa-PGE--HTY---------KENSHS-KSPTELEFVGHGPGSp----lPSTSLLTAN-NGLSTQNFPPG-LHC 266  American crow
XP_011936965  214 ---EDSNPkSSVE--DAF---------KEIFQS-NSPEKSEFAVQAPGSp----lVASSLLAPS-SGLSVQNFPPG-LYC 272  sooty mangabey
XP_016282184  271 ---SHSKA-SGGD--HFY---------KESIPC-PSPIDFEFLANGPISp----lSSTSLLSSA-SSLSVQNFPQG-LYC 328  gray short-ta...
XP_015207298  226 ---VHSSKsSTVD--QTY---------KESNHS-KSPAEQDFGSHGVSS------PLPSTSLIP-SGLSTPNFPPV-LHS 282  spotted gar
PKK32498      220 ---SSLRn-TLGD--NVN---------RVQQPA-KLNCSSEGGGQSQER----------PAKHS-GGHCVQNFPPS-LAS 271  rock pigeon
XP_027959726  214 saqQGSLRtLLGD--GVG---------RQQPRA-KQVCNVEVGLQTQER------PPAMAAKHSgSGHCVQNFPPS-LAS 274  Steller sea lion
XP_002934593  227 ---NHPKA-LSGE--HVF---------KENAHS-KSPVDSETLGHGSVSp----lPSTSLLAAN-NSLSSQNFPPG-IHS 284  tropical claw...
XP_007495991  289 KTtA-MQQKPTAYVRPMDGQDQAPSESPELKPL-P---DDYHGHSYEKiPDFKVT---AKAKL-SKLKMPpQSTEQ---- 355  gray short-ta...
6_pfamImport  251 QPsVvMTQKPTAYVRPMDGQDQVVTDSPELKPS-P--------EPYGPlPELI-----TKPLMeTDRETLpPYLEFiklk 316 
XP_002664429  270 KPsSaVQQKPTAYVRPMDGQDQVPNDSPELKPPvEl-vEGYNTVPFGGlLDTKSSttgTKGKI-PKLTLP-QSGEV---- 342  zebrafish
KFO61033      267 KNsM-VQQKPTAYVRPMDGQDQVPNDSPELKPPiEi-eSGYGNQSFGTlLEGKVNtpsSKNKV-PKLNIP-PVSEV---- 338  American crow
XP_011936965  273 KTsM-GQQKPTAYVRPMDGQDQAPDISPTLKPSiEf-eNSFGNLSFGTlLDGKPSaasSKTKL-PKFTIL-QTSEV---- 344  sooty mangabey
XP_016282184  329 KTsM-VQQKPTAYVRPMDGQEQLPDFSPALKPLlEi-eSGYSSQTFGTlLEGKPSattAKTKL-PKLTIP-QPSEI---- 400  gray short-ta...
XP_015207298  283 KPsI-IQQKPTAYVRPMDGQDQVPNDSPDLKTP-AeigDGYNNPSFGGmIDGKANatnAKSKL-PKLTLP-QPGEV---- 354  spotted gar
PKK32498      272 KP------------RPMDGQDQAPDESPKLKLP-A---E--TTKSYRGvPSNKPDsarTKSKI-AKFSIP-KQEED---- 327  rock pigeon
XP_027959726  275 KPsL-VQQKPTAYVRPMDGQDQAPDESPKLKSStE---TSVHCTSYRGvPTTKPEsarAKAKL-SKFSIPkQGEES---- 345  Steller sea lion
XP_002934593  285 KTsM-VQQKPTAYVRPMDGQDQVPNDSPELKPS-TeidDGYNNPLFGTlLEGKVNvpvTKSKL-PKLTIP-QGNEV---- 356  tropical claw...
XP_007495991  356 --------AFPNEVHCVEEILKEMTHSWPPPLTAIHTPNTAESSKFPFPTKEFQHLESVLQNHkQHGSSSKPCSNSQQ-G 426  gray short-ta...
6_pfamImport  317 lrertfteMRPNEAQCVEAILREMTCSWPPILTALNTPNSDEPSKSPSQPRGAEHVSSHPGQRnRLNFSSQTVVQNQQ-L 395 
XP_002664429  343 --------SLPNDSNCVEEILREMTHSWPPPLTAIHTPGKAEQTKFPIPSKDSQHVTSGYNAk-RCSVPSNKPATKSV-P 412  zebrafish
KFO61033      339 --------ALPNDSSCVEEILREMTHSWPPPLTAIHTPGKAEQTKFSIPSKDSQHLTSGYNVQ-KWSDPAGKVAT----- 404  American crow
XP_011936965  345 --------SLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQNTFSIPGQESQHLTPGFTLQ-KWNDPTTRAST----- 410  sooty mangabey
XP_016282184  401 --------NLSNDPNCVEEILR-----------------------------DLQLSTSAYSVQ-KWSDPEIKAATKPP-V 441  gray short-ta...
XP_015207298  355 --------SLSNESSCVEEILREMTHSWPPPLTAIHTPGKADQTKFPIPSKDSQHLTSGYNGQkRCNVPSNKPAT----- 421  spotted gar
PKK32498      328 --------GGTGDNSCIEEILREMTHSWPPPLSAIHTPGKAEQSKFPFPNKESQQGSTGHSNTrKSDVEPRSPEKSAT-H 398  rock pigeon
XP_027959726  346 --------RSGDTNSCVEEIIREMT--WLPPLSAIPAPGKVEPSKFPFPNKDSQLVSSGHSNPkKGDAEPESPDNGTS-N 414  Steller sea lion
XP_002934593  357 --------SLPNDPNCVEEILREMTHSWPPPLTAIHTPCKAEQTKFPIPSKESQHLTSGYNVQ-KRCDATNKTTAKSApQ 427  tropical claw...
XP_007495991  427 T--S------MLEDDLQISDSDDSGDE--------------QVSEKPPPSSAPASVPQSLADS--------VVSAHSSNT 476  gray short-ta...
6_pfamImport  396 GftS------AFRSDLSFLFSFSFHLA--------------VLPEKCDTSAADASQQVHRRSSc------sFKVPHSRGL 449 
XP_002664429  413 Qk-S------MLEDDLKISSDEEDND---------------QAAEKPKPRSTALNLPGSTAVRs-------SEAAGHSSG 463  zebrafish
KFO61033      405 ---K------MLEDDLKLSSDEDDNEQvntsnikhhsgtanVAAEKTKLRNIPVNLPVPAAHA--------TGLAHSS-G 466  American crow
XP_011936965  411 ---K------MLEDDLKLSSDEDDLEPvktlttqctatelyQAVEKAKPRNNPVNPPLATPQ---------PPPAVQTSG 472  sooty mangabey
XP_016282184  442 PqkS------MLEDDLKISSDEDEIE---------------QDIEKAKTMDIPSNPTVPPAPE---------PVVIPSSG 491  gray short-ta...
XP_015207298  422 ---KsvpqksMLEDDLKLSSDEEDSE---------------QTPEKAKPRSTPPNLPGSTART--------A-EPGHSSG 474  spotted gar
PKK32498      399 T--S------MLEDDLKLSSDEEENDQ--------------QAAQRSALRVLSDSLVVPPSNTr-------ASGLSSKGS 449  rock pigeon
XP_027959726  415 T--S------MLEDDLKLSSDEEENEQ--------------QAAQRTVLHALSDSAVVQQANCrasvpsskGSGSSSSGS 472  Steller sea lion
XP_002934593  428 K--S------MLEDDLKLSSDEEDSE---------------QANEKTKPRNIPVNGLPLQAVH--------GANLVNSSG 476  tropical claw...
XP_007495991  477 ESESTSDSDSS--SDSESESSSSGSEENEPLEPVPAEPDPPIAN-KWQLDNWLT 527  gray short-tailed opossum
6_pfamImport  450 ESTSSSDSESSsrSDSDSES-----AAEEPPKCPRSGPAA--KHvDWQLGNWIR 496 
XP_002664429  464 ASGSSSESESSseSDSDSESSSSDSECNRASRAATPEPEPS----KWQLDKWIK 513  zebrafish
KFO61033      467 GSGSSSESESSseSDSDSESSSSDSECNEESRSATPEPEPPSTN-KWQLDKWLN 519  American crow
XP_011936965  473 GSGSSSESESSseSDSDTESSTTDSESNEAPRVATPEPEPPSTN-KWQLDKWLN 525  sooty mangabey
XP_016282184  492 GSES-SSSDSSseSDSDSESSSSDSEGNEESRSNTPEPEPPSTN-KWQLDKWLN 543  gray short-tailed opossum
XP_015207298  475 ASGSSSESESSseSDSDSESSSSDSECNEGSRSATPEPEPPSTN-KWQLDKWLN 527  spotted gar
PKK32498      450 SSSSSSESETSseSDSESESSSSESDGSKPSHYSSPEPEPPSSN-KWQLDKWLN 502  rock pigeon
XP_027959726  473 GSSSSSDSESSsgSDSETESSSSESEGSKPPHYSSPEAEPASSN-KWQLDKWLN 525  Steller sea lion
XP_002934593  477 GSGSSSESESSseSDSDSESSSSDSECNEQARSATPEPEPPSTN-KWQLDKWLN 529  tropical clawed frog
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