Conserved Protein Domain Family
AF-4

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pfam05110: AF-4 (This model is not part of the current CDD release)
AF-4 proto-oncoprotein N-terminal region
This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Statistics
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PSSM-Id: 516630
Aligned: 24 rows
Threshold Bit Score: 380.241
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014068153   20 YEQDRNALKKREWERRTQEVQQDEDLFSSGFNLFGEPYKteapslstlggtnnlnkTNKGDALANRVQNTLGNYDEMKEL 99  
PKK32498       31 YEPDRNVLRRKEWERRNQEAQQEDGAFNTSYSLFSEPYK-----------------TNKGDELSNRIQNTLGNYDEMKDL 93  
XP_011945625    2 NREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKv----------------TSKEDKLSSRIQSMLGNYDEMKDF 65  
XP_023818477    9 NREDRNVLRMKERERRNQEIQQGGEAFPANSPLFPEPYKv----------------VSKEDKLSSRIQSMLGNYDEMKEP 72  
XP_015204977    9 NREDRNALRLKERERRNQEIHQGGEAFPANSPLFPEPYKv----------------SSKEDKLSSRIQSMLGNYDEMKEL 72  
3_pfamImport    1 YNEERKLLRLRAWEQRNQGTSQAKD--QENMPLFGEPYK-----------------TNKGDELSNLIQRMLGSYEDVNH- 60  
XP_011936965   18 YEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYK-----------------TNKGDALANRVQNTLGNYDEMKDL 80  
KFO61033        2 YEQDRSALKRKEWERRNQEVQQDEDLFASGFNLFGEPYK-----------------TNKGDALANRVQNTLGNYDEMKDL 64  
XP_002934593   18 YEQDRSALKRKEWERRTQEVQQDEDLFASGFNLFGEPYK-----------------TNKGDALANRVQNTLGNYDEMKDL 80  
XP_016282184   71 YDQDRNALKRKEWERRSQEVQQDEDLFASGFSLFGEPYK-----------------TNKGDALASRVQNTLGNYDEMKDL 133 
XP_014068153  100 LTSHSNQsHLVGIPKNFVPq---Tp-gPMEKQDQ-PSFLTKGGQrGSNRVGTGN-HTtsmpPPPSSSsltsssllhgHQS 173 
PKK32498       94 LTDRSNQsHLVGVPKPGVPq---T---SLPKPDE-HHIADSRPM-PPPPISSTT-SS----TPAALP----------AQQ 150 
XP_011945625   66 IGDRSIP-KLVAIPKPTVPp---S---ADEKSNP-NFFEQRH-G----GSHQSS-KWtpvgPAPSTS-----------QS 120 
XP_023818477   73 IGD-TLP-KLGGKPSNSSS----S---SEEKLAA-PLFGGDQRG------SESS-KWtpvgPAPGGS-----------TS 124 
XP_015204977   73 IGDKSLQ-KYMGLPQPAVP----St--PEEKPNQ-TFFAEQQRG---SGSSHSS-KWtpvgPAASTSs---------SQS 131 
3_pfamImport   61 ------P-----NPAAMEPfripTy-aSFSQSDQgQTSLDGQAG---PPFHTQAsGSqsqkAPGGSGv--------pSQS 117 
XP_011936965   81 LTNHSNQnHLVGIPKNSVPq---N---PINKNEP-SFFPEQKNR-IIPPHQDNThPSapmpPPSVVIlns-----tlIHS 147 
KFO61033       65 LTNHSNQsHLVGIPKNSVP----Qt--PIDKNEQ-NFFPEPR-NrMIPSHQISGnTStsmpPPSSLSsnst--llhsHQS 134 
XP_002934593   81 LTNHNNQsHLVGIPKNSVP----QtpaPVEKNEQ-SFFPDQRNR-LAPCHQSSShPSssmpPPSSLApnt----tltHNH 150 
XP_016282184  134 LTNHSNQsQLVGIPKNSIP----Qt--PTEKNEQ-SFFPDQRNR-MIAPHQ--G-SSqsvpLLSSVTss------ssHQN 196 
XP_014068153  174 SKkSw-SSDWSRGA-HCST-QGVggqgvgGQGvHGvgglgvqgvggpSCSRGKHSFTHEQqqqpqrheelLISQGEVVD- 249 
PKK32498      151 SK-St-TMGWQKAG-HNAA-SDG------QQR-AS------------KHGHRSLESHKGD----------FKLANQKSS- 196 
XP_011945625  121 QKrSs-GLQSGHSS-QRTSaGSSsgtnssGQR-HD---------------RESYNSSGSSsrkkg-qhgsEHSKSRSSS- 180 
XP_023818477  125 QKrSg--LQGGHGS-QRSS-GGSssssqrGER-EK------------KSSKHSGGSEHSK----------------SHT- 170 
XP_015204977  132 QKrSg--LQSSHGSgQRTT-GSGggggssSQR-HE---------------RDYSSSSNSGgnsq---kksKHGSDHS--- 186 
3_pfamImport  118 SRtSgaASSPDHQG-NSSP-FSNaslnpsQLS-YA------------VPCHQRSEDRLRD------------HARLAQE- 169 
XP_011936965  148 NRkSk--PEWSRDS-HNPS-TVLasqasgQP--------------------NKMQTLTQDqsqak-ledfFVYPAEQPQi 202 
KFO61033      135 SRkSr--TDWSRSG-HNSS-GAQpsqssgQQS-R-----------------TKHSSSHDQsqgr--yedlYNCQSEQHKs 190 
XP_002934593  151 EGsRksRVDWAHGG-HTSS-CTQsnqlsnQPS-RL-----------------KHTSSHDLlqir--yedlYNCQNDQYKs 208 
XP_016282184  197 IRkPr--ADWPRAG-HCST-ITQa-----sQS-TG------------LPNRMKQSNPHDQpqgr--yedlFNCQSDQHKn 252 
XP_014068153  250 --HRGDSSSSp-sSSSTSTLSRRHGGGQQQAAkAPSAA--EHGsy------kDSNTHV-KSPLEQEPGSHGASSpv--as 315 
PKK32498      197 --LEKLKRYA---SSPTSSSSSSNAAQQSSLR-NTLGD--NVN---------RVQQPA-KLNCSSEGGGQSQER------ 252 
XP_011945625  181 -------PGk---PQAVSSLSSSHSRSHG-------ND--HHS---------KEHQRS-KSPRDPDANWDSPSR------ 225 
XP_023818477  171 -----SSPAKs-------sLSSSGSQSRGSLSa---EQ--HHC---------KERYRS-KSPLDREANWDSPSRv----h 219 
XP_015204977  187 -------KSHt-sSPAKGSLSSSHSRSH-------GGD--HHG---------KERHRS-KSPRDRDANWDSPSRv----h 235 
3_pfamImport  170 ---------ArshSPPAKPLSLQCSGDLGTTGaNTKEAcdH-HpritpsecpGFGDASaLVPRDSTKDSCLPQA------ 233 
XP_011936965  203 geVEESNPSA-----------------KEDSNpKSSVE--DAF---------KEIFQS-NSPEKSEFAVQAPGSplvass 253 
KFO61033      191 ggTEEANPMAt----------sSHSRRHTHAKsA-PGE--HTY---------KENSHS-KSPTELEFVGHGPGSplpsts 247 
XP_002934593  209 gvIDELIPATs----------sSHSRRHNHPKa-LSGE--HVF---------KENAHS-KSPVDSETLGHGSVSplpsts 265 
XP_016282184  253 ggMEDASMSTs----------sSNSRRLSHSKa-SGGD--HFY---------KESIPC-PSPIDFEFLANGPISplssts 309 
XP_014068153  316 TSLLPSGLSTPTFPQGLHVKPsavqqqkptayvRPMDGQDQMPLDSPELKPPlEvvdVgySNPAF-GS---TITS---SK 388 
PKK32498      253 PAKHSGGHCVQNFPPSLASKP------------RPMDGQDQAPDESPKLKLP-A---E--TTKSY-RGvpsNKPDsarTK 313 
XP_011945625  226 VPFSSGQHSNQSFPPSLMSKSnsmlqk-ptayvRPMDGQ-----ESMEPKLS-S---EhySSQSHgNSmteLKPS---SK 292 
XP_023818477  220 TSFPSGQHSSQSFPSSLMPKTssmqqk-ptayvRPMDGQ-----ETAEPKSSqA---EsySGQPHsGPmgeMKSN---GK 287 
XP_015204977  236 AFSSNGQHPGQAFPPSLMSKPssmqqk-ptayvRPMDGQ-----ESLEPKTP-S---EnySSQSHsSSmgeMKPS---SK 302 
3_pfamImport  234 --SKGHSLPSQTFPSLLSKQPsvvmtqkptayvRPMDGQDQVVTDSPELKPS-P--------EPY-GPlpeLI-----TK 296 
XP_011936965  254 LLAPSSGLSVQNFPPGLYCKTsmgqqk-ptayvRPMDGQDQAPDISPTLKPSiEf-eNsfGNLSF-GTlldGKPSaasSK 330 
KFO61033      248 LLTANNGLSTQNFPPGLHCKNsmvqqk-ptayvRPMDGQDQVPNDSPELKPPiEi-eSgyGNQSF-GTlleGKVNtpsSK 324 
XP_002934593  266 LLAANNSLSSQNFPPGIHSKTsmvqqk-ptayvRPMDGQDQVPNDSPELKPS-TeidDgyNNPLF-GTlleGKVNvpvTK 342 
XP_016282184  310 LLSSASSLSVQNFPQGLYCKTsmvqqk-ptayvRPMDGQEQLPDFSPALKPL-LeieSgySSQTF-GTlleGKPSattAK 386 
XP_014068153  389 SKL-PKLTLT-QTGEV------------GLSSDSSCVEEILREMTHSWPPPLTAIHTPGKAEQTRFPIPSKESQHIPSGC 454 
PKK32498      314 SKI-AKFSIP-KQEED------------GGTGDNSCIEEILREMTHSWPPPLSAIHTPGKAEQSKFPFPNKESQQGSTGH 379 
XP_011945625  293 AHL-TKLKIPsQPLDA------------SASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGT 359 
XP_023818477  288 ASL-TKLKIPsQPVEG--------------SGDANSVAEILKEMTQSWPPPLTAIHTPCKTEPSKFPFPTKEAHPFPSGH 352 
XP_015204977  303 ASL-SKLKIPsQPLDA------------SMSGDANCVDEILKEMTQSWPPPLTAIHTPCKTEPSKFPFPAKDNQHSNFNK 369 
3_pfamImport  297 PLMeTDRETLpPYLEFiklklrertfteMRPNEAQCVEAILREMTCSWPPILTALNTPNSDEPSKSPSQPRGAEHVSSHP 376 
XP_011936965  331 TKL-PKFTIL-QTSEV------------SLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQNTFSIPGQESQHLTPGF 396 
KFO61033      325 NKV-PKLNIP-PVSEV------------ALPNDSSCVEEILREMTHSWPPPLTAIHTPGKAEQTKFSIPSKDSQHLTSGY 390 
XP_002934593  343 SKL-PKLTIP-QGNEV------------SLPNDPNCVEEILREMTHSWPPPLTAIHTPCKAEQTKFPIPSKESQHLTSGY 408 
XP_016282184  387 TKL-PKLTIP-QPSEI------------NLSNDPNCVEEILR-----------------------------DLQLSTSAY 423 
XP_014068153  455 AGQKRCNVPVNKPATKSVPQk--SMLEDDLKISSDEEDTEQ--------------QGAEKPKPRSTPLSIPVATSRT--S 516 
PKK32498      380 SNTRKSDVEPRSPEKSATHT---SMLEDDLKLSSDEEENDQ--------------QAAQRSALRVLSDSLVVPPSNTr-A 441 
XP_011945625  360 GEQKRYN-PS-KTSNGHQSK---SMLKDDLKLSSSEDSDGE--------------QDCDKTMPRSTPGSNSEPSHHN--S 418 
XP_023818477  353 KRG----SSSKSSSSHQTKDg--SMLKEDLMISSSEDSDGE--------------QE-------AKNASRNTSASNN--S 403 
XP_015204977  370 RYS-SEKTSSSSHQPKTCDGdqaNMLEDDLKLSSSEDSDGE--------------QEPAKPGSRITPSTSEPSQDT---N 431 
3_pfamImport  377 GQRNRLNFSSQTVVQNQQLGf-tSAFRSDLSFLFSFSFHLA--------------VLPEKCDTSAADASQQVHRRSScsF 441 
XP_011936965  397 TLQ-KWNDPTTRAST--------KMLEDDLKLSSDEDDLEPvktlttqctatelyQAVEKAKPRNNPVNPPLATPQ---P 464 
KFO61033      391 NVQ-KWSDPAGKVAT--------KMLEDDLKLSSDEDDNEQvntsnikhhsgtanVAAEKTKLRNIPVNLPVPAAHA--T 459 
XP_002934593  409 NVQKRCDATNKTTAKSAPQK---SMLEDDLKLSSDEEDSE---------------QANEKTKPRNIPVNGLPLQAVH--G 468 
XP_016282184  424 SVQKWSDPEIKAATKPPVPQk--SMLEDDLKISSDEDEIE---------------QDIEKAKTMDIPSNPTVPPAP---E 483 
XP_014068153  517 DPGH-SSGASASSSESESSSESDSDSESSSSDSECNRASRTATPEPEPPSTN-KWQLDKWLN 576 
PKK32498      442 SGLSsKGSSSSSSSESETSSESDSESESSSSESDGSKPSHYSSPEPEPPSSN-KWQLDKWLN 502 
XP_011945625  419 EGADnSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTN-KWQLDNWLN 479 
XP_023818477  404 EAAEqSRDDSSSHSGSESSSGSDSESESSTSDSEANEPPQPASPDPQG--SN-KWQLENWIK 462 
XP_015204977  432 EGADhSRDDSSSHSGSESSSGSDSESESSSSDSEANEPPRVASPEPEPPTAN-KWQLDNWLQ 492 
3_pfamImport  442 KVPHsRGLESTSSSDSESSSRSDSDSES-----AAEEPPKCPRSGPAA--KHvDWQLGNWIR 496 
XP_011936965  465 PPAVqTSGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTN-KWQLDKWLN 525 
KFO61033      460 GLAHsS-GGSGSSSESESSSESDSDSESSSSDSECNEESRSATPEPEPPSTN-KWQLDKWLN 519 
XP_002934593  469 ANLVnSSGGSGSSSESESSSESDSDSESSSSDSECNEQARSATPEPEPPSTN-KWQLDKWLN 529 
XP_016282184  484 PVVIpSSGGSES-SSSDSSSESDSDSESSSSDSEGNEESRSNTPEPEPPSTN-KWQLDKWLN 543 
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