7KHA,7XZ3


Conserved Protein Domain Family
Cas_Cas7
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pfam05107: Cas_Cas7 (This model is not part of the current CDD release)
CRISPR-associated protein Cas7
CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defence complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.
Links
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Statistics
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PSSM-Id: 516627
Aligned: 106 rows
Threshold Bit Score: 158.111
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7KHA_B            6 NRYEFVLLFDVENGNPNGDPDAGNMPRIDPETGHGLVTDVCLKRKIRNHVALTKEGae---rFNIYIQEKAI-------- 74  Nitratidesul...
WP_012636456      9 NNSEILFLYDAKRSNPNGDMDNENKPRMDWDTGTNLVSDVRLKRYIRDYLQKVKGK-------NLFV---SEeaekae-- 76  Halothermoth...
WP_012876352      4 LDSDILYLYDAKLTNPNGDPDDENRPRMDSVTGRNLVSDVRLKRYLRDYWLD-DGQ-------DIWVR--KNedgtttda 73  Thermobaculu...
jgi:Metfor_2153  30 NNHEILFVYDAKMCNPNGDPDNENKPRMDPDREINLVSDLRLKRYIRDYFEQYLGE-------PIFV---CNidgrsvts 99 
WP_015738985      9 KNGEILYLYDAKMCNPNGDPDDENRPRMDVDRERNLVSDVRLKRYIRDYLYEYFQEkg--gdQTIYVTKAEGvvnate-- 84  Ammonifex de...
WP_013842964     11 GRREFLFLYDIKMGNPNGDP-DENRPRV-LPDGTYYVTDVRMKRFVRDFLKMRG--------FDILV---DTiegrttnl 77  Desulforamul...
Q2NFS4            7 NYYQGIFVTETILGNPNGDFID-NSPRN--IDGNVFTTDKCIKYNIRNYIHSNYENikenenMVFFYPRLQE-------- 75  Methanosphae...
5_pfamImport      1 NRVFGCVVIKSVNSNYNAD-FS-HQPRT-LPDGSVYATDKALKYTVRNYIDKNYPEd-----KVFYFKSLNGdmq----- 67 
tigr:NT01CX0204   4 KRVYGILGIASIMANWNAD-FT-GYPKT-ISTGEIFGSDKAFKYPIKKMWDQQGE-------KVLYIKSMKL-------- 65 
Q894R8            5 KRVYGVLGIVSRMSNWNAD-FT-GYPKT-TSSGDVFGSDKAFKYPMKKMWENGGE-------KVLYIKSIKF-------- 66  Clostridium ...

7KHA_B           75 -------LNETHERAYTacdlkpepkklpkkvEDAKr--------VTDWMCTNF-------------------------- 113 Nitratidesul...
WP_012636456     77 -nrvhqiLGRKPSSNKP---------------VTDEel---------tkIAEEC-------------------------- 105 Halothermoth...
WP_012876352     74 ksrmsvlLEEYNRTSGQ---------------KLSTkear-nsgeFRSWLLDRL-------------------------- 111 Thermobaculu...
jgi:Metfor_2153 100 tgrleelAREKNMDKAD---------------LLNDdk----------fLMDNL-------------------------- 128
WP_015738985     85 --rlkrlLGLGEKEQPtk--------------------------eHLPTLLQKL-------------------------- 110 Ammonifex de...
WP_013842964     78 tgrvvhyLNTTGNKKVeg-------------------------kaLVDILLNAF-------------------------- 106 Desulforamul...
Q2NFS4           76 ----------------------------------NAkpyeskfltRDQVFSKYFnkkfed-------------------- 101 Methanosphae...
5_pfamImport     68 ------------------------------------------prdLDQNYARFFgdypkadkkeavk-------arkvil 98 
tigr:NT01CX0204  66 ----------------E---------------KDKNgitdltprsLKERYEFLFekdkpnndkqtkgksksskkdgkevl 114
Q894R8           67 ----------------Q---------------ENKKkereliprtLKERYEYIFdvedlkknkds-----------eevl 104 Clostridium ...

7KHA_B          114 ------YDIRTFGAVMTteVN-------------C--------GQVR-GPVQMAFARSVEPV-VPQEVSITRMAVTTKa- 163 Nitratidesul...
WP_012636456    106 ------CDVIYFGAVLG--TSggn--------------------thLtGPVQFNWGYSLNKVeLQESKTITSSFSs---- 153 Halothermoth...
WP_012876352    112 ------MDVRLFGATMP--MEnss--------------------itFtGPVQFSWGYSLHRVeINNSATISSHFAGRDt- 162 Thermobaculu...
jgi:Metfor_2153 129 ------MDVRFFGATMT--IKgssekeekagsksTksg-----skkFtGPVQFNWGYSLNKVnIMESSGITSHFSs---- 191
WP_015738985    111 ------VDVRLFGATMP--VKgdrrge--------------geainLtGPVQFNWGYSLNRVqLVESNTLSSQFASEAd- 167 Ammonifex de...
WP_013842964    107 ------IDARLFGSSFAfkk------------ekDdnwdpkpePKTMtGAVQLNMGEILHKAeSVDIHGTTTFGSDELk- 167 Desulforamul...
Q2NFS4          102 -vlenaVDVKMFGGTFSlk----------------------kdPKQIyGPIQISYGLDINDA-QIKKLQIGAPFANKEk- 156 Methanosphae...
5_pfamImport     99 gnllscLDVRLFGGTFAsk----------------------taNLSIhGVVQPTHGVNRYVEgIIYSEQIASPFRNSNdn 156
tigr:NT01CX0204 115 tnlfsaIDVKNFGATFAee----------------------gnNISItGAVQIGQGFNKYEDsYAEVQQILSPFRDASkd 172
Q894R8          105 knlftaVDVKNFGATFAee----------------------gnNISItGAVQIGQGFNKYKEtYAEEQQILSPFRDPNqk 162 Clostridium ...

7KHA_B          164 -------E-A----EKQqgdnRTMGRKHIVPYGLYVAHGFISAPLA--------E----------K-TGFSDEDLTLFWD 212 Nitratidesul...
WP_012636456    154 ------gE-G-------------VGKDYRVKYSFIAFSGGINGLAA--------K----------D-TKLTENDVKLLDE 194 Halothermoth...
WP_012876352    163 ------eG-K----GDY----GTFGKDWRVLYSLIGFHGIVSRNRA--------R----------H-TGLRESDLEALDR 208 Thermobaculu...
jgi:Metfor_2153 192 ------eA-G----NKQ----GAMGKDYRVDYSLIAFHGIISAKRA--------E----------H-TSLTDKDIELFDQ 237
WP_015738985    168 --------------aRQ----GTFGKDYRLYYSFIAFHGIISARRA--------AvmyklakenpA-GALSCRDLELLDQ 220 Ammonifex de...
WP_013842964    168 ---------------TQ----GTFTVYYGLRYALIGFSGIANEHSA-------------------RiSRMSDEDYDLFLK 209 Desulforamul...
Q2NFS4          157 --------------dKQ----KTIGTESIVDDAIITYDIIINPNNY--------P------------ELLSENNLKLFKE 198 Methanosphae...
5_pfamImport    157 s-----------tdsMQ----TTLGTQFKLQEGHYVHHFSVNPGNLdeltefvdN------------GRLTGEDIAKLKE 209
tigr:NT01CX0204 173 nnktsknKdeekeeaKA----STLGTKIVSNEAHYFYPFAINPTSYdefvelgvT------------DGYTEEDYKRFKD 236
Q894R8          163 eksk------dgeeaKS----STLGTKIVSNEAHYFYPLTVNPSAYsqfeeigvT------------NGYTEEDYEKFKE 220 Clostridium ...

7KHA_B          213 ALVNMFEHDRS-AARGLMSSRKLIVFKHQNRLGNAPAHKLFDL---VKVSR-A-------------EGSSgPARSFA-DY 273 Nitratidesul...
WP_012636456    195 AIIKSIPLNRT-RSKIGQTPRLYLRVEM----NDNETA-LNDLreyISLDYnVr------------EE---DVRDIN-NI 252 Halothermoth...
WP_012876352    209 AMLEAIPTEATsRSKIGQIPRFYLRLEY----SEGYPYRVGDLredVVLEPvQg------------KTLD-TLRDVR-DY 270 Thermobaculu...
jgi:Metfor_2153 238 AIVNSIPLMAT-RTKIGQYPRLYLRIEY----NSPEFF-LGDLrkyISISHd-------------pKI---PIRYVS-DY 294
WP_015738985    221 AMLKAIPLLAT-RSKIGQYPRLYLRFEF----TDADTF-MGDMredLRLEPdT------------------DLRSIQ-DV 275 Ammonifex de...
WP_013842964    210 ALWHGVRANANtRTKVGQIPHLLISIEY----KADEEFQFGRLheyVRLIAaTg------------KEEK-VWASPE-DY 271 Desulforamul...
Q2NFS4          199 ALWYGTNSRKT-TSK-KTDAKVLILIKFKNEKDTIKSFNIGELketLSIKNkNerlnhgkivfdttNLIK-KLETYEeYI 275 Methanosphae...
5_pfamImport    210 ALRCGVTYYDS-SSKAGTENEALLWVEL----KEESKLVLPSFvdlIEVNAeR--------------------------- 257
tigr:NT01CX0204 237 ASLIAATSFNT-NSKVGCENEFALFIET------DKELYLPNLsefVEFKKkD-------------------------NK 284
Q894R8          221 TSMIAATSFNT-NSKIGCENEFALFVET------KEDLYLPDLsqyVDFEKvE-------------------------DK 268 Clostridium ...

7KHA_B          274 -AVTV 277 Nitratidesulfovibrio vulgaris str. Hildenborough
WP_012636456    253 -ELVI 256 Halothermothrix orenii
WP_012876352    271 -VINL 274 Thermobaculum terrenum
jgi:Metfor_2153 295 -TLDV 298
WP_015738985    276 -KLEI 279 Ammonifex degensii
WP_013842964    272 -KVDL 275 Desulforamulus ruminis
Q2NFS4          276 dSIDI 280 Methanosphaera stadtmanae DSM 3091
5_pfamImport    258 -EIDF 261
tigr:NT01CX0204 285 gVIKL 289
Q894R8          269 nIIIL 273 Clostridium tetani
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