6W2T,6YAM


Conserved Protein Domain Family
eIF-3_zeta

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pfam05091: eIF-3_zeta (This model is not part of the current CDD release)
Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery. The gene coding for the protein has been implicated in cancer in mammals.
Statistics
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PSSM-Id: 516621
Aligned: 91 rows
Threshold Bit Score: 365.796
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W2T_9        22 FIRPMVQNNPD-GWGPC-ELPDQ--FK-------DIP---YQPFSKSDRLGKISDWTGTaYQDKKFQNkynsQ------F 81  rabbit
XP_001018258   8 adlenlksFTKqTWGPDrNyvf-tkFD-------NLP---FTPFSRLEKLGACCDLQNImATRTGLKQ----TqvirstA 72 
XP_004030408   8 qdlenlqiSQKqNWGPDpNykf-prFE-------NMA---FAPFSRLEKLGKCCDFANMmAVRTGQKQ------------ 64 
XP_002140877   3 ALQLTINFNSN-TWSPSmD---DlaGDnclekikYFP---FAPSIKVDKLGSVCDFSYT--------------------- 54 
Q5CPM5         3 KFNYILNFSPD-TWTPTiE---SkaGEnclggikNFP---FAPSMKIDRLGAVCDFSYT--------------------- 54  Cryptosporidium...
Q4MYQ4         3 NLNIVANFNSN-GWGPDeE--DDqtINtclhtinKFP---FDPKLKLDKQIHICDFTFS--------------------- 55  Theileria parva
Q8IJW4         3 SFNLVGVINNR-TWGPDsK--NEelVNycmpdikKYQ---FEPSMKFERIGKVCDFTMN--------------------- 55  Plasmodium falc...
Q7RGS7         3 TFKLFGVVNNR-TWGPDiK--NEelVNscmedikKYQ---FEPSMKFEKIGKICDFTTT--------------------- 55  Plasmodium yoel...
XP_002675413   9 saislLEQSKE-GWGPI--HPASssVEqskseilSLPtnlFHIIPSKISIGKIADWTSEqSAPTTSTTt----------- 74 
XP_001614386   3 AFKLIGVANNR-TWGPDsK--NEelVNqcmgelkKYQ---FEPSMKFEKIGKICDFTSS--------------------- 55  malaria parasit...
6W2T_9        82 GG----SGM-KAY-AYEH---------------DEDETTFHLVDTTRVQK-PP--------YQrgrfgqrnqrmrgRG-G 130 rabbit
XP_001018258  73 PAnaptNTVeSVQvTTTA---------------VDAENDFHTVTAKKDKN--Lyaq--kiiKQ-------------GL-R 119
XP_004030408  65 -------IQsSNMpQLQQ---------------QQNNQ--------------------------------------QQ-Q 83 
XP_002140877  55 --------------SYSRarea--------kvmQVENHDFHLVDSRPFPKtKIryi---qrrF-------------QKeT 96 
Q5CPM5        55 --------------SYSRgrda--------kssQADNQDFHLVDSRPFPKtKVryv---qrkF-------------QKeT 96  Cryptosporidium...
Q4MYQ4        56 --------------TYQRnaregnrlnrvnstsMDEELQFQTVDSRTIVKiKPtthykkktPI-------------KQ-T 107 Theileria parva
Q8IJW4        56 --------------SYQKntkdink-nsndvnaFEEELQFQTVDLRTGQKqKGsifnkkkiHN-------------KQnT 107 Plasmodium falc...
Q7RGS7        56 --------------SYQKnikdinknsgdgdnaFEEELQFQTVDLRTGQKpKGtlfnkkkiIN-------------KQ-T 107 Plasmodium yoel...
XP_002675413  75 ------HSVaAAIaNVTG---------------AND--DFNLVVSNTQSQ--------------------------RK-S 104
XP_001614386  56 --------------SYQKnvkdank-nsnegnaFEDELQFQTVDLRAGQKqKGpmygkkkiMN-------------KQ-T 106 malaria parasit...
6W2T_9       131 QRGGMSQMQALgKLKIHER-----DR---RGQNk-RWT-RRn---QAPIK-MRDASVTVRPDWVTIEEMDFPRLSKLT-- 194 rabbit
XP_001018258 120 DQKINKQREQEqKEQEKNSki--qNVk--KPKIisANN-KKq---VIIKT-KFKEYTNIKVDWEVLHESQKLNIEQHPi- 189
XP_004030408  84 QQVPLPEIPQEeEQYSNSYvk--qPSr--QRQKinPNK-TKi---VVIRT-KFKDSSNIQANWVLLTESQKINIEQHPi- 153
XP_002140877  97 TQAYQQKQQQQeKAELLGRqgkrgGKlrqGGQNy-QY--SRsrfvSRMRT-LTEWSIEPLSSWTSIAEIPLTSLPKQS-- 170
Q5CPM5        97 AQAYHQKQQQQeKAEMLLRqgkrsAKmrqAGTQqyQY--SRhrfvSRMRT-LTEWSIEPLSSWISVAEIPLSSLPKQF-- 171 Cryptosporidium...
Q4MYQ4       108 TQAFNQKVMEEeQLQFSKQkqypdLR-----RQkyIAKnRSlrlpTRYHP-LNEWSIEPTPAWNVVAEIPFNILLKQE-- 179 Theileria parva
Q8IJW4       108 TQAFTQKQQEEdNLYSSRIktaeqKK------QklLQQaKTarinARHRI-FTEWSIEPTPLWTVECEIMFNELPKKI-- 178 Plasmodium falc...
Q7RGS7       108 TQAFTQKQQEEdNLYSSRIktaeqKK------QkmLQQaKTarlnARHRI-FTEWSNEPTPSWTVDCEIMFNELPKKL-- 178 Plasmodium yoel...
XP_002675413 105 YTNYNQNKRRPtTQSQPPKaaynqEQnkqNKQKkkKATlSYy---QKTKTqNYKPSIKVKKSWVLIDKFLFGTLKKATte 181
XP_001614386 107 TQAFAQKQEEEnNLYSSRIktaeqKK------QklLQQaKTarmnARHRI-FTEWSIEPTPVWTVECEVMFNELPKKL-- 177 malaria parasit...
6W2T_9       195 -----LpGVK--EGEDVLCCGAVEYYDKSYDRVNVKNEKPLQR--IDRIFHTV--TTTDDPVIRKLSK--T--------- 252 rabbit
XP_001018258 190 -----N-NVT---ITPIKITGKLKQYEKAFDRID---PRGIKKldASKNLSVVnsSTLKDDILIELLQq-Dvde------ 250
XP_004030408 154 -----K-EVK---FTELECTGTLKKYNRSYDKID---PRYIKKveCNQTVILPsaSSLKDPVLIRLLEe-Dlen------ 214
XP_002140877 171 -----L-DISrlNVEDIAWYGTLRCYNKSIDRISPKLPVPLRDfgGAE-FLQP--TTSDDDVLREALLipEk-------- 233
Q5CPM5       172 -----L-DVSksTIEDIGWFGTLKSYNKSMDRISPKLPMVLKDfgNME-FLQP--TTSDDEILRDALLqpEr-------- 234 Cryptosporidium...
Q4MYQ4       180 -----M-DSSqvTVEDLFWRGKLGIYDRKMDQITPKNEVYLLHlsNSYDYYWT--STHDDDCIADVLLetYktspskple 251 Theileria parva
Q8IJW4       179 -----I-KIDnlKVEDLFFKGKSLFYDKKIENINVKNPPLLFHhtKEGINLIP--KTKEDHNLINILNneNknkiisne- 249 Plasmodium falc...
Q7RGS7       179 -----I-KIDhlKIEDIFFRGKVLYYDKRFENINVKNPPFLAHlnKDANVLVC--KASDDQTLMEILDneEkkake---- 246 Plasmodium yoel...
XP_002675413 182 plesgK-GYKtpEPIDRHICGSLGYYDKKFDRASAKQPLTLEKpqKLNGYILQppASSEDPLLNNKTAp----------- 249
XP_001614386 178 -----I-KMEnfQMQDIYFRGRLLYYDKKFENINVKSPPGLVNqsKDSINLVC--KTMDDQSLMEILLdeDkkskaaaav 249 malaria parasit...
6W2T_9       253 -----------------------------------------------EGNVYATDAILATIMCCTRSNYSWDIVIEKIGN 285 rabbit
XP_001018258 251 --------------------------------------------ksdKPTVYTTDALLLALMTCKKNEFPWDILVQKDGN 286
XP_004030408 215 --------------------------------------------kiqKPTVYTTDALLLALMTLKKGEFPWDIYVQKDGN 250
XP_002140877 234 -----------------------------------------------SVDVAITDQILACLVAATQSKYSWHILVTHIDG 266
Q5CPM5       235 -----------------------------------------------NIDVAITDQILACLVAAAQSKYSWHILVTNVDG 267 Cryptosporidium...
Q4MYQ4       252 seyqngvegedefdsgdkkqagnmplqgdsasydqamkverdllrydKIVLAATDQILSVLMTAGRSKHSWHLNVTKIEN 331 Theileria parva
Q8IJW4       250 ----------------------------------------edpnninNIIVISTDQILSCLMSCVQSKYSWHLLIKKKGN 289 Plasmodium falc...
Q7RGS7       247 -------------------------------------------nnstGLIIVSTDQILSCLMSCVHSKYSWHLIIKKKGN 283 Plasmodium yoel...
XP_002675413 250 -----------------------------------------------EANVFATDDAIATLMAASKSELPWDMAVRVSEG 282
XP_001614386 250 ---------------------------------------aedgvnssNIIVVSTDQILSCLMSAAQSKYSWHLLITKEGN 290 malaria parasit...
6W2T_9       286 KLFFDK----R--DNTEF----DLL-TVNETSVEPPQDD---GNSLNSPRNLALEATFINHNFSQQVLKSN--EPR-YKF 348 rabbit
XP_001018258 287 AIVFDTyeeeRmn-------ymDFQ-SVNENSNILPe----eEKDLN---KLCVEATTITKKFQAQTCKEDngEIWdISE 351
XP_004030408 251 QIILDKyeadKyeGNNKLfdymEYQ-TVNENGNILPe----eERELN---KLCIEATTVTRQFQYQTTQGEt-ELWeISE 321
XP_002140877 267 KLIFDK----Q--DGSII----DLV-TVNETSAEPPLpd--nINKNNRPHLLGMEALKANQNFTQNILLEGdgGII-QKY 332
Q5CPM5       268 KLIFDK----Q--DGSII----DLI-TVNETSAEPPLpd--nVNKNNRPHLLGLEALKSNQNYTQNIQIFGdeGII-KQF 333 Cryptosporidium...
Q4MYQ4       332 QIIIDK----A--NGSII----DML-TVNETAPDPPQpd--cEIKINRPSSLRYEAVKVNQNLRQQVLLQDeyS---ETF 395 Theileria parva
Q8IJW4       290 QIIIDK----D--DDSII----DLL-TVNENSIDAPTqd--nENKINSLQALGIEAVKINQRFRKQVILKNdiA---EEF 353 Plasmodium falc...
Q7RGS7       284 RIIIDK----D--DDSII----DLL-TVNENSLDAPTqd--sENKINSLQALGLEAVKINERFKNHVQLNNqiA---EQY 347 Plasmodium yoel...
XP_002675413 283 KIYLDM----RklEGRNI----NLWhSVSETSSNPPSVDeknVQSINSAFSLSKEATLVNAYLQKQAFKEDe----vKKL 350
XP_001614386 291 KIIIDK----D--EDSIV----DLL-TVNENSIDAPTqd--nENKINSLQALGFEAIKINQRFRKQVLLKNeqA---EQF 354 malaria parasit...
6W2T_9       349 DEPN-PFIseEeEG-E-VASVAYRYRKWDLNNG------------ITLIARCEHDAVMQGPNN----------ETqfLTI 403 rabbit
XP_001018258 352 GEPN------QiDE----QNIAFKYVNVNIDDk------------VNLKVRVQIDGYDIVNKVdpeta-epyqEKvpILV 408
XP_004030408 322 GKEN------QvEN-MeNENVAFKYINCNIDDk------------IDIKVRVQIDAFDYVKEYdpenndvvseQKvpILI 382
XP_002140877 333 DPS--PFT--EsCA-NfTESKSYRYRIFSLPPRtgaasteiaqrvVRVAIRTEVDAKLQNTTD----------ENglIFA 397
Q5CPM5       334 EPI--PFS--EeNQdTnIESKCYRYRIFSLPPRagasssenaqktVRVAIRTEIDAQIPNAESe---------NSgfIFA 400 Cryptosporidium...
Q4MYQ4       396 LDP--PFV--EeSDn--PATIAYRYRKFTLPGTpnatn--feklpILVITRCEVHAKLQGTDTy-------------TYV 454 Theileria parva
Q8IJW4       354 EPG--NFN--IkNIk--INDILYRYRKFQIPPLvqsn----nkktYTLITRGEIHSQIKGLNKs------------yVYV 411 Plasmodium falc...
Q7RGS7       348 DNT--SFN--SkQC-NnNSNILYRYRKINLPPLihgs----sktnCTIITRGEIHSKIKGSNNa------------yVYI 406 Plasmodium yoel...
XP_002675413 351 GNEAvPFS-------TgVFNLAYKYREFKLSDs------------INLLVRCEINGLSKETSG-----------DeeMSL 400
XP_001614386 355 DNA--SFT--AkNCk--NFDVLYRYRKILVPPIvngs----skkkCTLITRGEIHSKLKGTANs------------yVYI 412 malaria parasit...
6W2T_9       404 KALNEWDSKLANG--V--EWRRKLDTQRGAVLANELRNNACKLAKWTVQALLAGSDQLKFGYVSRASVRDSSKHVILETQ 479 rabbit
XP_001018258 409 RALNEFDSAA--------QWKTKLLNQKGSVTSTEYINNITLFMKWLIQMKLSGAERLKLAYTSRASPKDTQNHNILCVD 480
XP_004030408 383 RTINEYDHSN--------QWKNKLLTQKGTVTGGEYINNCCNYIKWLIQMEMTGAKMLKLGFTSRVSSKDNTTHDILCVD 454
XP_002140877 398 RALSEYDMKTIK------TWNTQLETQKGALLATEIRNNACQLTKWATQALLSSCDTLKLGYIVRRSANDRENHVIMSVQ 471
Q5CPM5       401 RALNEYDPKTVK------TWNTQLETQKGALLATEIRNNACQLTKWATQALLSSCDILKLGYIVRRTPNDRESHQIISVQ 474 Cryptosporidium...
Q4MYQ4       455 CALNECPNKNNK------SWRSQIETQKGALLANEIRNNTTKLQRFVACANMAGCGVFKLAYVTRRSPNDAENHSIIGIH 528 Theileria parva
Q8IJW4       412 CALNEYDIKSHK------NWRSQIENQKGALLANEIRNNTSKLQKFISQALLSGCDDVKLGFISRKNANDPDNHHILSIQ 485 Plasmodium falc...
Q7RGS7       407 CSLNEYDIKSHK------NWRSQIENQKGALLANEIRNNTYKLHKFICQALLSGCDDIKLGFISRKNANDYENHNILSIQ 480 Plasmodium yoel...
XP_002675413 401 KVLNEYFPAEQNQyhNvaDWKTSMESQKTSIIMAEFKNNSAKMAKWTAQALLSSSKQFKLGFVSRQSPKATKTHLILGTE 480
XP_001614386 413 CALNEYDIKSHK------NWRSQIENQKGALLANEIRNNTSKLQKFICQALISGCEDIKLGFISRKNANDAENHHILSIQ 486 malaria parasit...
6W2T_9       480 QYKPNEFATQINLNMDNAWGILRCIIDICMNQKD--GK----YLIMKDPNKPMIRLYD 531 rabbit
XP_001018258 481 SFDLQTLTNIIQFKFKDQWQVVKYFIDQILNEKD--GK----YMFVKTAFKQSVKTYl 532
XP_004030408 455 SFTFEDLFKNIQFRSLDQWQVVKYFIDFICKQPD--GN----YMFVKGAFKQSIRTYE 506
XP_002140877 472 SYKTRELSAQMGLKEENAWGITRALIDLLAEQPE--GQ----YVILRTPVKHVLRIYK 523
Q5CPM5       475 SYKTKELSAQMGLKEENAWGIVRALVDLLSEQPE--GQ----YVILRTPVKHVLRVYR 526 Cryptosporidium parvum
Q4MYQ4       529 THTTQNLALQMGFSLDNAWGSIKAIVHLVMRRPD--GQ----YVLLKDPMKPIIRLYS 580 Theileria parva
Q8IJW4       486 SHKTKDLSTQIGLKYDNMWGIFRFVIDNLADKPN--GN----YVILKDPLKPLLRLYC 537 Plasmodium falciparum 3D7
Q7RGS7       481 SHKTKDLSTQIGLKYENIWGILKFIVDNISDRSD--GK----YVILKDPLKSLLRLYC 532 Plasmodium yoelii yoelii
XP_002675413 481 KYRPEDFADQLQLHLYNMWGVVKLIIEYVQRYLQenNKqdceFVLLKHPNRDRLDLYE 538
XP_001614386 487 SHKTKDLSTQIGLKYENIWGILRYIVDIISEKPD--GK----YVILKDPLKALLRLYC 538 malaria parasite P. vivax
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