4XWH,7MFK


Conserved Protein Domain Family
NAGLU

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pfam05089: NAGLU (This model is not part of the current CDD release)
Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold.
Statistics
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PSSM-Id: 516619
Aligned: 106 rows
Threshold Bit Score: 340.657
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XWH_A       109 YQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWD 188 human
CCX48275     159 YLNYCTFSYSMPFWNEARWQQEVDWMALHGVNMPLMLVGSAAVWRTTLRDIGYPENKINSFVAGPAYQAWWLMNNLQGWG 238
WP_022278118 115 DFNYCTFSYSMAFWDWKRWEQEIDWMALHGINLPLAMVGTDVVWKNVLEELGYTREEINAFIAGPGFQAWWLMNNLEGWG 194 Phocaeicola cop...
3_pfamImport   3 DFNYCTFSYSMAFWDWKRWEKEIDWMALHGINMPLAIVGEECVWRNMLLKLGYTEKEVGEFIAGPAFLAWWEMNNLEGWG 82 
EGQ13735     135 DFNYCTFSYSMVFWNWDRWQQEIDWMALHGVNMPLAIVGEEVVWRNMLLRLGYTRDEVNRFIAGPAFLAWWAMNNLEGWG 214
CDB04643     119 YLNYCTLSYSMAFWDWKRWEQELDWMALHGINLCLDIVGTDVVWRNVLLQLGYTRAEIDKIIAGPAFQAWWLMNNMEGWG 198
CCY16788     110 DLNYCTFSYTMPFWDWARWEEELDWMAMHGINLPLALVGTDVVWRNVLLRLGYTTDEVNAFIAGPAWQAWWLMNNLEGWG 189
Q89ZL8       133 YLNYCTYSYSMAFWDWERWEKEIDWMAMHGINMPLSITGMEVVWYNLLKRIGYTTEEINEFISGPAFMAWWQMNNLEGWG 212 Bacteroides the...
WP_021987418 114 DLNYCTYSYSMAFWDWERWEKELDWMALHGINLPLALTGTETVWRNVLLQLGYSAEEIGKFIAGPGFLAWWHMNNLEGWG 193 Culturomica mas...
WP_022047963 114 DFNYCTYSYSMAFWDWERWERELDWMAMHGINMALALTGMEVVWHNVLQQLGYTAEEIGQFIAGPGFLAWWHMNNLEGWG 193 Odoribacter laneus
4XWH_A       189 GPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQvNVTKMgsWghfncsYSCSFLLAPEDPIFPII 268 human
CCX48275     239 GPQSSHMYDRDARLGRFVADAMRQMDMQPVLPGYSGMVPADADTQLGL-HTADPglWl----gYVRPAFLLPTDSAFAAI 313
WP_022278118 195 GPNPDSWYERQAELQKRILKRMREYGIEPVLPGYSGMVPHNAKDRLGL-NVADPgrWn----gYPRPAFLQPTDPQFERI 269 Phocaeicola cop...
3_pfamImport  83 GPLPTSWYARQEKLQKQILARMKQLGMHPVLPGYCGMVPHDAKEKLGL-NVADAglWn----gFQRPANLLPTDARFSEI 157
EGQ13735     215 GPLPDSWYRQQEALQKRILQRERELGMEPVLPGYCGMMPHDAKQKLGL-DVTPGgtWn----gYVRPANLSATDPRFDEI 289
CDB04643     199 GPNSDAWYDQREALQKKILKRMNELGINVCLPGYSGMVPHDARQRLGL-DVSDPgmWc----gYKRPAFLLPTDKRFTEI 273
CCY16788     190 GPNTDNWYRRQEELQRRIVGRMRELDIEPVLPGYSGMVPSNAKAKLGL-DVTDPgtWn----aYQRPAFLSPTDPRFADI 264
Q89ZL8       213 GPNPDSWYRQQEALQKKIIARMRELGIEPVFPGYAGMVPRNIGEKLGY-QIADPgkWc----gFPRPAFLSTEDEHFDSF 287 Bacteroides the...
WP_021987418 194 GPNPENWYKQQVQLQQRILNRMREFGIEPVFPGYAGMVPHDVKEKLGL-NVTDPgkWc----gFTRPAFLQPEDPAFQRV 268 Culturomica mas...
WP_022047963 194 GPNPESWYERQMQLQHRILNRMREYGIEPVFPGYAGMLPHNASEKLGI-EVKDPglWc----gYQRPAFLYPENPAFKRI 268 Odoribacter laneus
4XWH_A       269 GSLFLRELIKEFGTDXIYGADTFNEMQppSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFqhqpqfwgpAQIRAVLG 348 human
CCX48275     314 ARTYYSAQQSILGRASCYAMDPFHEDG--STDGVDLPAAGNALLSAAQLASPGARWVIQAWQN---------NPRAALID 382
WP_022278118 270 AALYYREMTRLYGKASYYSMDPFHEGG--NTSGVDLEAAGKAIWKAMKQANPRAAWVVQAWGA---------NPRPQMIR 338 Phocaeicola cop...
3_pfamImport 158 ATLYYNELTKLFGKADYYSMDPFHESN--DDPNIDYAKAGQAMMQAMKRVNPKAVWVIQGWTE---------NPREAMVD 226
EGQ13735     290 ADLYYREQTRLYGKSHYYSMDPFHETS--DDVYIDYAQAGRKLMAAMKRENPKANWVIQGWTE---------NPRPAMTD 358
CDB04643     274 ATLYYKEQQRLYGKARFYSMDPFHEGG--SVEGVDLRAAGEAIMREMKRVNPEAVWVVQAWQA---------CPHPEMIS 342
CCY16788     265 AGLYYDELTRLYGRTRYYAMDPFHEGG--NTAGVDLRAAGRAIHAAMKRCNPNAAWVVQAWQA---------NPRRELIA 333
Q89ZL8       288 AAMYYEELEKLYGKAKYYSMDPFHEGG--NTEGVDLAKAGTSIMSAMKKANPEAVWVMQAWQA---------NPREAMVS 356 Bacteroides the...
WP_021987418 269 AGLYYAEMEKLFGKARFYSMDPFHEGG--STEGVDLAAAGKSILEAMKRANSSAVWVIQAWQA---------NPRPQILD 337 Culturomica mas...
WP_022047963 269 AGLYYMEMEKRFGKAKFYGMDPFHEGG--NVQGIDLAAAAQSVLQAMKTANPEAVWVMQAWQA---------NPRHEMIT 337 Odoribacter laneus
4XWH_A       349 AVPRGRLLVLDLFAESQP-------VYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARL-FP---NST--- 414 human
CCX48275     383 SLPPDDVLVLDLFAESMPqcgdpssPWYRPEGFGSHPRVWCMLLNYGGNVGLHGKLHHLPAAYYSQTGdSL--------- 453
WP_022278118 339 NLPAGDMVVLDLFSESRPqwgdpasSWHRKEGFGQHDWLFCMLLNYGGNVGLHGKMAHLIEEFYKAKds---sfGKT--- 412 Phocaeicola cop...
3_pfamImport 227 DMKTGDLLVLDLFSECRPmfg-ipsIWKREQGYKQHQWLFCLLENFGANVGLHGRMDQLLDNFYMLQss---kfQAQssk 302
EGQ13735     359 GLPAGSLTVLDLFSECRPmfg-apsIWKRAEGYGQHDWLFCMLENFGGNVGLHGRMDQLIGNFRLATs-PQsplQQArrh 436
CDB04643     343 HLRNGDMLVLDLFSESRPqwgdpesTWYRKNGFDGHDWTFCMLLNYGGNVGLFGKLQHVVDEFYKARss---rfAPT--- 416
CCY16788     334 AVPRGDLVVLDLFAESRPqwgdtasTWCRPDGFDGHDWIYCMLLNYGGNVGLHGKMDHVLDEFRKARas---rfGAT--- 407
Q89ZL8       357 TLDSGDLLVLDLYSEKLPqwgdpesMWYREKGFGKHDWLYCMLLNFGGNVGLHGRMEQLVNGYYNACah---vnGKT--- 430 Bacteroides the...
WP_021987418 338 AIEAGDMLVLDLSSENRPmwgdkesPWYRENGYGKHDWLYCMLLNFGGNVGMYGRMDRVIDGFYAARel----rKGT--- 410 Culturomica mas...
WP_022047963 338 ALQPGNVLILDLSSENRPmwgdkesVWYREKGFEGQDWLYCMLLNFGGNVGMYGRMDRVINGFYAAVqh---pnGAS--- 411 Odoribacter laneus
4XWH_A       415 MVGTGMAPEGISQNEVVYSLMAELGWRK 442 human
CCX48275     454 MQGIGMTMEGIENNSILFELLSELPWRD 481
WP_022278118 413 LKGVGMTMEGIENNPVMYELLCELPWRE 440 Phocaeicola coprophilus
3_pfamImport 303 LKGIGFTMEGSENNPVMFELMSELPWRP 330
EGQ13735     437 LRGIGFTMEGSENNPIMFELMSELPWRT 464
CDB04643     417 MRGVGLTMEGIENNPVMYELVCELPWST 444
CCY16788     408 LRGVGMTMEGSENNPVMFELLCDLPWLA 435
Q89ZL8       431 LRGVGATPEGIENNPVMFELLYELPWRE 458 Bacteroides thetaiotaomicron
WP_021987418 411 LCGVGITMEGIENNPVMYELLLELPWRP 438 Culturomica massiliensis
WP_022047963 412 LRGVGKTMEGIENNPVMYELLLELPWRK 439 Odoribacter laneus
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