1M1L,4KMA


Conserved Protein Domain Family
SUFU

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pfam05076: SUFU 
Suppressor of fused protein (SUFU)
SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.
Statistics
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PSSM-Id: 398651
Aligned: 122 rows
Threshold Bit Score: 56.178
Threshold Setting Gi: 122315912
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M1L_A                  42 LDYVSMYRNVG-SPsanipeHWHYISFGLSDLYGDNRVHeftGTDgp---sGFGFELTFRLK-R--ETGESapptwpaeL 114
P45941                  36 IDILSVSDQPQ-EG------ITSYSTLGLSDHSINYEVN---Gt-------PLRIEIVAAME-SasDIYAN--------V 89  Bacil...
WP_014823215            36 IDILSTVNRPF-DG------VSSYSTIGLSDHSIELTVE---Kt-------PLRIEIVGALA-TdyKQYPN--------I 89  Solib...
goetting:CLSA_c35200    36 IDILSCSDRPY-NG------ITSYSTIGLSSYSIGYKAD---Tv-------PLRVEIVGACA-SgvDCFRN--------I 89  Clost...
CCY67708                34 IDLMICENCPD-EG------ITSYGTIGLFNCNIGLTYE---Ek-------PLCMELLAACA-SsiEDFAN--------I 87  Clost...
Q8XQT6                  37 VDLLAAAGSPC-SG------VMSYGTIGLSDHPVRINDD---Gd-------EVCVELLGACA-DavKNFPN--------A 90  Ralst...
WP_013663489            45 LHILNCIDPMD-PK------SKIYCTIGLSDYPNEIEMN---Kgv----lkNIPIELMIAGN-EssDKWAN--------I 101 Sphin...
SLUandSVAtrep:TPE_1362  37 IDILSCDDPTD-SE------VKFYSTIGLSGYPNPINIK---Dgs----vaNIPVELLMAGY-KeyEQIPN--------I 93  Trepo...
faib:Ccan_23810         36 IDILSIDDPLN-TE------NSFYSTIGLSDFPNKIEMN---Dns----mlNIPVELLMCGY-KkyDKIGN--------I 92  Capno...
WP_011956448            60 FTVLVY---RAnPL------YTTLCTLGASYRTIP---F---SRAsfgderGVRYEYIMHAApSheQQVAQ--------L 116 Rosei...
1M1L_A                 115 MQGLARYVFQS-ENtFCSGDHVSWHS-PLD-NS-ESRIQHMLLTE----DPQMQPVQTPFG-V---------------VT 170
P45941                  90 LSTCAFNIINSnFT-CAPGVIF---KnVISmYDqETDMKHIMFVPpflwEEDLELLEF-SNkN---------------VT 149 Bacil...
WP_014823215            90 LASCAFCIINSkFS-VSHGSVF---RdIIKtYYpNTEMKHILFVSpf-lwEDLNTLEF-PNkK---------------VA 148 Solib...
goetting:CLSA_c35200    90 VASCAFNIMNTkFK-CYPGVIF---EnVVKfYMpDCFMKHILFISpflwDDRLKTLSF-EDkK---------------VA 149 Clost...
CCY67708                88 VTTTAFEIMDGk-S-VYPGYIF---DdVVSmYIgNSDMEHILLTYpflwGDVHNSV-F-DDiT---------------VA 145 Clost...
Q8XQT6                  91 LTTAAFYTIRNqWH-CVHGGVL---QnALDmYKlSVTMKHFLFTSpf-lwEEFNGVDF-GDkK---------------VH 149 Ralst...
WP_013663489           102 LSTAGFFVTKNkWN-CQPGTVF---KnMIDmYHkGTRLKHLLFVEpvmwQEKLEQMKL-SNkK---------------VH 161 Sphin...
SLUandSVAtrep:TPE_1362  94 LSTASFFIIKNkWN-CQPGTVF---EtIVSdYYr-CDMKHIMFTPpflwEDKLSRVEI-DNrK---------------IY 152 Trepo...
faib:Ccan_23810         93 LATVSFYISKNkWT-CQPGTVF---EnIVSdYYv-SQMQHIMFVRpflwEDKLSDLKF-GKkK---------------IH 151 Capno...
WP_011956448           117 LALIAEYPFIHtIE-IGPGYILPVGEpVVP----GSSMEYLYFTYp----------YLDDGrLyesdpwgqierpdllIQ 181 Rosei...
1M1L_A                 171 FLQIVGVCTEELHSAQQWNGQGILELLRtvpiA--GGPWLITDMRR 214
P45941                 150 WLMALPISEGELQVAEKHGSDYLQ-DLL----E--SKQIDIFDIKR 188 Bacillus subtilis subsp. subtilis str. 168
WP_014823215           149 WLLAVPISENEYLFAQEKGTDTLE-ELF----E--QEEIDIFDLER 187 Solibacillus silvestris
goetting:CLSA_c35200   150 WLLAIPISEEEFKYAKDKGSDALE-ELF----E--EKQIDIFNLNR 188 Clostridium saccharobutylicum DSM 13864
CCY67708               146 YLMAVPISDKEKEYCLKNGLDALE-SVF----E--EKQIDIFDIFR 184 Clostridium sp. CAG:678
Q8XQT6                 150 WLLAVPISDAEHAYLRDHGLDALE-RAF----E--DRQIDIFDINR 188 Ralstonia solanacearum
WP_013663489           162 FLLLIPISDAECKYREKHGFDALE-SIF----M--EKEIDITNLNR 200 Sphingobacterium sp. 21
SLUandSVAtrep:TPE_1362 153 PLLLVPISDKELEYKSKYGTDALE-TLF----E--NEAIDIFDIKR 191 Treponema pedis str. T A4
faib:Ccan_23810        152 CLLCIPISEKELRFKEENGLTSLEKMLF----Q--QKNIDIFDIER 191 Capnocytophaga canimorsus Cc5
WP_011956448           182 MLWVLPIYRSEAQFIRTNGMEAFEQRLQ----ErhSRIYDAYDMLR 223 Roseiflexus sp. RS-1
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