6LPH,1M1L


Conserved Protein Domain Family
SUFU

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pfam05076: SUFU (This model is not part of the current CDD release)
Suppressor of fused protein (SUFU)
SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.
Statistics
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PSSM-Id: 516613
Aligned: 95 rows
Threshold Bit Score: 60.0467
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6LPH_A        52 LDYISM------YNYPGdvdrnvPPHWHYISFGLSDLHGDERvhlrEEGVTr----sGMGFELTFRLAKTE----IElkq 117 fruit fly
Q0AP68        39 FQIVEVaypdpvADR------------AFATLGLSNLRVCasn-----------pnqMIGTELIIGLSq----------- 84  Maricaulis mari...
Q8CMI1        50 HGVFKSp-------pNGn-----RSTWAYITSGMSNPWET----------NepeehsGLGVEFIIETE------------ 95  Shewanella onei...
WP_005371593  27 LQVVCF------EDSPF------KSVDTFFTVGLSHHELRISde------------kKVRQELVFPLSGSDtstaEN--- 79  Methylomicrobium
WP_012406451  28 LRVVRF------PNQPF------QGASTFATLGLSESKVSLP----NGN--------HCGQELLFAAWDRYq---AP--- 77  Paraburkholderia
Q5F702        26 LNIAAI------PSSPN------RDLKTYITLGLSKHDLn----------------yKSRFEILFVCSlk---ydEN--- 71  Neisseria gonor...
WP_013808126  36 IEVLRFgp---aPS----------GLVYYATCGCSQQPMGDP----ADLMAdp--vrGPRAEVVMRLRGG-----AD--- 88  Hoyosella subflava
WP_011730287  38 IDVLRYgp---dPR-TEg-----ADVYHYVTLGCSRHPMFDP----TELVSdp--ihGPRAEVMLSLRgp----tPT--- 95  Mycolicibacteri...
WP_019510456  38 IDILRFgp---dGA----------GVNHYVSLGCSRYPMADP----TDLVAdg--vrGPRAEVMVSLRpp----sPV--- 91  Mycobacteriaceae
WP_012395775  33 IEVLRFrs---aAS----------GLVHYVSLGCSRHPMNDP----TQLVAdp--hrGPRAEVVLSLR-NPe--pTS--- 87  Mycobacterium m...
6LPH_A       118 qienpEKPQRPPTWPANLLQAIGRYCFQ----T-GNG----LCFGDN-IPWRK-SLDGS----T-TSKLQNLLVAQ---- 177 fruit fly
Q0AP68        85 --------kHAGSWVLQMLERLAKSVIGgedpVgPGWgsnpVGPGWVsM------------------------IFDplpt 132 Maricaulis mari...
Q8CMI1        96 ---------KEETWAVEVLQMLMAYNLL-------------LAAGQM--GDFPlLGDgdrvplalSDAIRTMMFTQpv-- 149 Shewanella onei...
WP_005371593  80 -----MV-S--------LLLFICELILK----DhNA-----LLRGQV-Ir----LPVDA----AkKLGFDAVYCTIpv-- 125 Methylomicrobium
WP_012406451  78 -----HVGS--------FLLTFGAQVRN----RqRA-----LLRGDV-I---G-PSAPL----IpGVAANAIYASNpv-- 124 Paraburkholderia
Q5F702        72 -----QIFP--------FLRWLAETIIE----NkKI-----LLRGQV-Vy----LPRSI----VnSTKMDALYVSApf-- 118 Neisseria gonor...
WP_013808126  89 -----QVLR--------PLAVIAASPGV----EgLI-----LAEDSL-I---D--------------------LGEpl-- 120 Hoyosella subflava
WP_011730287  96 -----GLAR--------SLAVVAAAPAV----EgLI-----LDADAL-I---D--------------------LENpv-- 127 Mycolicibacteri...
WP_019510456  92 -----GLAK--------SIAILAAAPAV----EgLV-----LEPDAL-I---D--------------------LSGpl-- 123 Mycobacteriaceae
WP_012395775  88 -----GLAR--------SIAILAATPAV----DgVV-----LVADAL-I---D--------------------LGTplwa 121 Mycobacterium m...
6LPH_A       178 --------DPQLGCIDTPTG-T------------VDFCQIVGVFDDELEQASRWNGRGVLNFLRQdmqtGGDWLVTNMDR 236 fruit fly
Q0AP68       133 apwfdrfyLSELKTISPSTGdEitr------indVSILSVVPISESEHEFIAQSGSIEFDRALA-----NLRAHPWDLDR 201 Maricaulis mari...
Q8CMI1       150 ------sfPHCF---SLKSGr-------------VDLLQVVGITPAELQVAKQTSSDKIRTQLIS----KLGSLVTSKER 203 Shewanella onei...
WP_005371593 126 ------fmGDAFATFSGSEp-------------pTVVVWSIPIYTSEANYVNANGWNKFED-LLE----EKDPDLFSLER 181 Methylomicrobium
WP_012406451 125 ------iyPEELARY---DDdGs----------pTVFVWLVPLMEAEGRFAKTQGWNQFE-DALE----KANPDLLDLDR 180 Paraburkholderia
Q5F702       119 ------yfDDDFQVCYGEHy-------------nIVFPLLVPLYKQEAELVEKKGWNAFEQFLLD----NEVGNLSDMNR 175 Neisseria gonor...
WP_013808126 121 ------wpGSAFTAVVL-GRsEvqpltlsepmspIEFFDAVPITPTEAAWLRLRGVSALR-EAWA----EASIDTTDPAR 188 Hoyosella subflava
WP_011730287 128 ------feTAPFTAYLL-GLsDigevtlpdplspVKLLTATPITATEAAWVRLKGADAMR-EAWQ----TDGVDVLDPAR 195 Mycolicibacteri...
WP_019510456 124 ------feAAPFTAFLL-SAgPvadielgeplsaVTVLQATPITPTEAAWVRLKGAEAMR-EAWR----TDGVDVFDPHR 191 Mycobacteriaceae
WP_012395775 122 ----rpseRVAFTAVLL-GRsDipdlpqqqprdpVQFLCATPITATEAAWVRLKGAEAMR-QAWR----NDGVDVLDPHR 191 Mycobacterium m...
6LPH_A       237 Q 237 fruit fly
Q0AP68       202 A 202 Maricaulis maris MCS10
Q8CMI1       204 E 204 Shewanella oneidensis
WP_005371593 182 E 182 Methylomicrobium
WP_012406451 181 S 181 Paraburkholderia
Q5F702       176 K 176 Neisseria gonorrhoeae FA 1090
WP_013808126 189 S 189 Hoyosella subflava
WP_011730287 196 R 196 Mycolicibacterium smegmatis
WP_019510456 192 R 192 Mycobacteriaceae
WP_012395775 192 K 192 Mycobacterium marinum
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