4NC8


Conserved Protein Domain Family
HARE-HTH

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pfam05066: HARE-HTH 
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HB1, ASXL, restriction endonuclease HTH domain
A winged helix-turn-helix domain present in the plant HB1, vertebrate ASXL, the H. pylori restriction endonuclease HpyAIII(HgrA), the RNA polymerase delta subunit(RpoE) of Gram positive bacteria and several restriction endonucleases. The domain is distinguished by the presence of a conserved one-turn helix between helix-3 and the preceding conserved turn. Its diverse architectures in eukaryotic species with extensive gene body methylation is suggestive of a chromatin function. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as hmC. Bacterial versions include fusions to diverse restriction endonucleases, and a DNA glycosylase where it may play a similar role in detecting modified DNA. Certain bacterial version of the HARE-HTH domain show fusions to the helix-hairpin-helix domain of the RNA polymerase alpha subunit and the HTH domains found in regions 3 and 4 of the sigma factors. These versions are predicted to function as a novel inhibitor of the binding of RNA polymerase to transcription start sites, similar to the Bacillus delta protein.
Statistics
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PSSM-Id: 398647
Aligned: 39 rows
Threshold Bit Score: 44.6042
Threshold Setting Gi: 961512647
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NC8_B            13 MALVEIAHELFEEHK--KPVPFQELLNEIASLLGVK----KEELGDRIA-QFYTDLN------IDGRFLALsdqTWGLRS 79  Bacillus su...
jgi:RoseRS_0411    1 MTYLDAAYTILKAAG--QPLHYEAITQEALKQGLIKp--qGATPAATMGsRLYTDTLe-----EGSRFVRAgrgTFGLAE 71  Roseiflexus...
Q67TG9            11 MSVTDLAFTILKKHG--KPMHFKELITEVMQVKAIS----QENPGRLIA-QMHTEIN------LDSRFIHQgggEWGLRE 77  Symbiobacte...
Q03YU3            14 faLVEIATAILTEHK--EAMPFSSLVQEIQEFLEVD----AETFKSRLS-QFYTDLN------TDGSFISLgnnEWALRA 80  Leuconostoc...
Q836G6            17 lSMIEVAHAILEQHA--DVMDFSDLVNQIQNYLGKS----DSEIRDQLA-QFYTDLN------IDGSFISLgdnRWGLRS 83  Enterococcu...
Q310J1           101 FSFTDCAQKVLETFGgkKPMHYKEITEKALQKGWLVt--gGKTPEATMYaQVITEIKrqqkcgERPRFVQHgrgNVGLSQ 178 Desulfovibr...
P75090             6 ldLISQAKEIAETQFkaEPFSFDAIWKEVVKHFKIS----KQDEPNLIS-RFYQDFL------EDPNFVYLgerNWKLRD 74  Mycoplasma ...
Q21D19            24 QTYLRVAETVLAKAL--SPLKAREIVERGIEQGLFGdhvmGRTPEKSMQaRLSIDILtr--agFSRFFRTAr-gRFALRA 98  Rhodopseudo...
Q1D4U3             1 MTFYEAALRILESEG--RPLHFLEITEKSIQQSLLSh--vGKTPEVTMLsRLAAMARrt---rDRKVLVTAk-dTFALVD 72  Myxococcus ...
jgi:Anae109_2176   1 MTFTEAAIEVLRREG--KPLHFKKLTEIAIRESLLDh--vGKIPEETMAdQLAAHCRlp--haDRRLIPVLp-gTFALVE 73  Anaeromyxob...
4NC8_B            80 W 80  Bacillus subtilis subsp. subtilis str. 168
jgi:RoseRS_0411   72 W 72  Roseiflexus sp. RS-1
Q67TG9            78 W 78  Symbiobacterium thermophilum
Q03YU3            81 W 81  Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Q836G6            84 W 84  Enterococcus faecalis
Q310J1           179 W 179 Desulfovibrio alaskensis G20
P75090            75 F 75  Mycoplasma pneumoniae M129
Q21D19            99 S 99  Rhodopseudomonas palustris BisB18
Q1D4U3            73 W 73  Myxococcus xanthus DK 1622
jgi:Anae109_2176  74 W 74  Anaeromyxobacter sp. Fw109-5
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