5VCR


Conserved Protein Domain Family
MGAT2

?
pfam05060: MGAT2 (This model is not part of the current CDD release)
N-acetylglucosaminyltransferase II (MGAT2)
UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.
Statistics
?
PSSM-Id: 516604
Aligned: 28 rows
Threshold Bit Score: 414.368
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5VCR_A        64 RSLVYQLNFDQTLRNV---DKAGTw----------APRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWST 130 human
XP_018648329 113 RQYISHINMVQYVKNE---DLYGQlptrdnfnstrSSPNHVIIIQVHNRSIELSLLIESLRRTKGIETALIIFSHDFYSD 189
XP_004343299 159 RAKVAQMNSNIVVQNNn-dARLPAl----------KPNFPVIVIQIHNRLLYFMHTIQSLAQVENIGSALIVLSHDFWDE 227
XP_015625629  89 RNALPPRNA----------DRFPRl----------PDGHLNIVLYVHNRPRYLRLVVDSLSRAHGIGEALLIVSHDGYFP 148
Q9FT88        80 RNHFSPRNT----------DLFPDl----------AKDRVVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFE 139 thale cress
XP_020303455  79 VRSIEFLNANYEILNT---DKYGHl----------QNVEIVLVVQVHDRIEYLKELISTLRAARYIETALLIFSHDYSSA 145
O17560        99 VESVSFLNENFDILNA---AKFGDl----------STVKTILVIQVHDRPVYLQYLIESMRNTKGIEDTLLVFSHDINVG 165 Caenorhabditis ...
OWR49661      67 KNVINDANRKQSTEDDemdWDFSF----------------IIVIQVYRGINNLNHLVDGLKQAKGIGTALLLFSHSFYSK 130
XP_004990454 172 RQRAAAMNRAQTIQNPaicKQHLLn---------nNDDLVVFVVMAHNRLNYFEALLQSMRAVRYIEDAVLVVSQDMFSS 242
XP_009858387  74 RNKAISMNFDQEMKNV---AKFGMh----------APDSVIFLLQVHSRPEFVQQLINSLRASTGIEHATVVISVDVDSP 140 vase tunicate
5VCR_A       131 EINQLIAG-VNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWK 209 human
XP_018648329 190 ELNSLIGS-IRFTRTVQIFYPHSMQIFPDTFPGTDPRDCDSRIKPAEARNIECLNARWPDTFQHYRESHFTQIKNHWLWK 268
XP_004343299 228 PIMDYIRSnLKFCRYVQIFMPHSMQLHPEAFPGQGTNDCPRDLSKSDARALGCVNAEFPDTYGHYREAPFAMIKHHWWWK 307
XP_015625629 149 EMDKIVQT-ITFCQVKQIFAPYSPHLFPEAFPGVSSGDCQ---GKDKAAEKHCQGD--PDQYGNHRSPRIVSLKHHWWWM 222
Q9FT88       140 EMNRIVES-IKFCQVKQIFSPYSPHIYRTSFPGVTLNDCK---NKGDEAKGHCEGN--PDQYGNHRSPKIVSLKHHWWWM 213 thale cress
XP_020303455 146 VINKLIRG-IDFCLVMQIFYPYSIQLFPDVFPGLDPLDCPEKATKKEAASLKCNNWKNPDKYGHFRVAKLTQIKHHWWWK 224
O17560       166 IINEMIRN-ITFARVYQIFYPYNLQLFPTVFPGQSPSDCPEKMKRDKAQETNCSNWSSPDKYGNYRVAQLTQIKHHWWWK 244 Caenorhabditis ...
OWR49661     131 DINRVVRN-ISFARVLQIYYPYSVQLHPFVFPGYDQKTC--------DEVMSCRKSD--------RKALVIQHKHHWWWS 193
XP_004990454 243 EQDALLDS-IDFMCVIRVFYPGSLQLNPDQFPGTDPNDCPRDISKEEALRIGCNNARNPDQYHHYREAQFTVIKHHWWWK 321
XP_009858387 141 EINEVLAR-IDFCRYMVIFFPFAKVLYPNSFPGEDPNDCPKKIPKAQALERKCNNAEYPDMFGNYREVDFVQIKHHWFWK 219 vase tunicate
5VCR_A       210 LHFVWERVKILRDY---AGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRs-fYGMADKVDVKTWK 285 human
XP_018648329 269 IEFVMNHFYPTKYY---EGYFILLEEDHFVVEDILHVSELISKNVWSPLKTDGIIALGSYDKDN---NYLSNVVELTYWL 342
XP_004343299 308 ANTVFDVLQVTREN---NGPMLFLEEDHVLAPDALVAVMAATAARPRLCPSCQLVGIATYNPLEatiDHKAATAHTAAWL 384
XP_015625629 223 MNTVWDGLDETRDF---DGHILFIEEDHYIFPNAYRNAQLLVDLKPSKCPQCYAINLAPSDVKA----------KGEGWE 289
Q9FT88       214 MNTVWDGLEETKGH---EGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKS----------RGEGLE 280 thale cress
XP_020303455 225 MNYVFDGI--LKQYaltKVWVILLEEDHYVSPDFLHVMRLIVGSKSNFCAECQVISLGLYLKQYnnfKSNLNRLGIHPWF 302
O17560       245 MNFVFDGI--VEKYsmkDPWVLLLEEDHMLAPDALHVLDIIVSNRPKYCENCEIISLGFYLKSTnkyGQDIAHLGVHPWY 322 Caenorhabditis ...
OWR49661     194 ASFVFDRVFATRNY---NGTILFLEENQYVTSDFIYIFRILDGLLRSSNLHCDIISLGNGKSKSssyRLINSSILLKPWD 270
XP_004990454 322 LNFVFDHMPVLKNH---NGLKVLLEEDHYLAPDTIHMLLKTWRVAQEQKHTSDIIVLGDYDAGHg--AFAGNVVHRQPWV 396
XP_009858387 220 LNMAFSGIRAFNNQ---KAPIILLEDDYFVVPDIIHCAKQAEELRKSKCPRCQTISLGNYEQTQd-yQAQGNQVEIKSWI 295 vase tunicate
5VCR_A       286 S----TEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVS-CLPK-FWKVLVPQ-IPR--IFHAGDC-GMH-- 353 human
XP_018648329 343 A----PKHNMGMAVSRVVWKNIEQCLNLFCFYDDYNWDWSLQYIGQN-CFPG-KLKALTLPlSTR--VFHSGECrGLH-- 412
XP_004343299 385 S----AQNNMGMVIDRAAWSSIKSCHRDFCTFDDYNWDWSLQYAAST-CVGS--LNILVLD-HPR--VVHIGTC-GAHay 453
XP_015625629 290 SlvaeKMGNIGYAFNRTVWRKIHAKAKQFCTFDEYNWDITMWATV----YPSfGSPVYSLR-GPRrsAAHFGKC-GLHq- 362
Q9FT88       281 SlvaeRMGNVGYSFNRSVWENIHQKAREFCFFDDYNWDITMWATV----FPSfGSPVYTLR-GPRtsAVHFGKC-GLHq- 353 thale cress
XP_020303455 303 S----SKHNMGMAIKADTWELIKNCTELFCKYDDYNWDWSLLRVSMK-CLPS-RLKVIAVK-APR--VIHVGDC-GIH-- 370
O17560       323 S----SKHNMGMALQKNTWQKIKGCSEMFCKWDDYNWDWSLMQISAK-CLPQ-RFRVIFTK-SPR--VIHIGDC-GVH-- 390 Caenorhabditis ...
OWR49661     271 T-----RETLGIAFNKDTWKTVKNLSEHFCRYNDNRWSKSLIHLSTK--TSLgKFYALSIE-GSR--VFRLNKC------ 334
XP_004990454 397 S----TKHNMGMALSRQLFDKIKQCARMFCEFDDYNWDWSLFAVSARgCIDQmAIHALVMA-GQR--IQHLGVC-GVH-- 466
XP_009858387 296 S----SKHNLGMVVSSDFYNKIANCAEQFCNYDDYNWDWSLQAVSPH-CEMG-NLFTLAFK-ATR--VFHLGSC-GVH-- 363 vase tunicate
5VCR_A       354 HKKT---CRPSTQSAQ-IESLLNNNKQYMF--------PETLTISEKFTv------VAISPPRKN-GGWGDIRDHELC 412 human
XP_018648329 413 HQKTs--CSTELLVTNiLQMFSGPLLTRLY--------PTSLHLSEKIH-------TENIKQRVN-GGWSDERDRSLC 472
XP_004343299 454 QHSPgkpCNPAQLMDQ-LNALWNYKKSSMLhfaadgtpSESISLSSKGA-------MAVPRPSPN-GGWGDHRDHALC 522
XP_015625629 363 GQGLsnvCVDNGDATVqLDAI-----------------DKVPNIKANWPvhiikrqEGYQAGFKGwGGWGDKRDQELC 423
Q9FT88       354 GRGDegdCIDNGVVNIeVKET-----------------DKVVNIKEGWGvrvykhqAGYKAGFEGwGGWGDDRDRHLC 414 thale cress
XP_020303455 371 THR----CAVHNTAAV-AAELFSSSANSLF--------PKKMILAENLK-------RTLKPPREN-GGWGDIRDHELC 427
O17560       391 THR----CEAHKALQS-TQELFRQHKDLLF--------PTSLSVTDTSR-------RSLKPSKEN-GGWGDIRDRQLC 447 Caenorhabditis el...
OWR49661     335 KDHKt--C-NETKNNEiLLNFVRKIRKKLF--------PFKMHIVKSN--------SVEEVGEGN-GGWTDVRDHELC 392
XP_004990454 467 SAGKd--CSGTDAIER-AKRFNAANAAQMF--------PQSLQVVTKTG-------QAPFVRAGY-GGWGDPRDVNLC 525
XP_009858387 364 SKGE---CNAKQSAESrTAQLQNQ---KLY--------PESLHIAVDSP-------TVVPAPRPN-GGWGDLRDQTLC 419 vase tunicate
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap