5VCM


Conserved Protein Domain Family
MGAT2

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pfam05060: MGAT2 
N-acetylglucosaminyltransferase II (MGAT2)
UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.
Statistics
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PSSM-Id: 398644
Aligned: 33 rows
Threshold Bit Score: 402.42
Threshold Setting Gi: 1209701413
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5VCM_A        64 RSLVYQLNFdqtl---rnvDKAGTw-APRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAG- 138
Q9FT88        80 RNHFSPRNT----------DLFPDl-AKDRVVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFEEMNRIVES- 147 thale cress
Q69QZ8        89 RNALPPRNA----------DRFPRl-PDGHLNIVLYVHNRPRYLRLVVDSLSRAHGIGEALLIVSHDGYFPEMDKIVQT- 156 Japanese rice
ABF70149     133 RNKLPPRNM----------DRFPNl-AKDHTKIVLYVHNRPQYLRLVVSSLAAVEGISETMLIVSHDGYFAEMDRIVQD- 200 dwarf banana
KJE97612     159 RAKVAQMNSnivvq-nnndARLPAl-KPNFPVIVIQIHNRLLYFMHTIQSLAQVENIGSALIVLSHDFWDEPIMDYIRSn 236 Capsaspora owcz...
XP_004990454 172 RQRAAAMNRaqtiqnpaicKQHLLnnNDDLVVFVVMAHNRLNYFEALLQSMRAVRYIEDAVLVVSQDMFSSEQDALLDS- 250 Salpingoeca ros...
EFO25555      79 vrsIEFLNAnyei---lntDKYGHl-QNVEIVLVVQVHDRIEYLKELISTLRAARYIETALLIFSHDYSSAVINKLIRG- 153 eye worm
O17560        99 VESVSFLNEnfdi---lnaAKFGDl-STVKTILVIQVHDRPVYLQYLIESMRNTKGIEDTLLVFSHDINVGIINEMIRN- 173 Caenorhabditis ...
OWR49661      67 KNVINDANRkqsteddemdWDFSF-------IIVIQVYRGINNLNHLVDGLKQAKGIGTALLLFSHSFYSKDINRVVRN- 138 Danaus plexippu...
EDV20761       7 KNYVLLKNNlqtvlnshllQSTSN--HKFDLVVVVQSHKRYKYLQALMQSLHKARGINKILLIVSHDYLLTEMRTVVES- 83  Trichoplax adha...
5VCM_A       139 VNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPrdlPKNAALKLGCINAeyPDSFGHYREAKFSQTKHHWWWKLHFVWERVK 218
Q9FT88       148 IKFCQVKQIFSPYSPHIYRTSFPGVTLNDCK---NKGDEAKGHCEGN--PDQYGNHRSPKIVSLKHHWWWMMNTVWDGLE 222 thale cress
Q69QZ8       157 ITFCQVKQIFAPYSPHLFPEAFPGVSSGDCQ---GKDKAAEKHCQGD--PDQYGNHRSPRIVSLKHHWWWMMNTVWDGLD 231 Japanese rice
ABF70149     201 IRFCQAKQIFAPYSPHLFPDGFPGVSPGDCH---DKDDPIVTKCNGT--ADQYGNHRSPRTVSLKHHWWWMMNTVWDGME 275 dwarf banana
KJE97612     237 LKFCRYVQIFMPHSMQLHPEAFPGQGTNDCPrdlSKSDARALGCVNAefPDTYGHYREAPFAMIKHHWWWKANTVFDVLQ 316 Capsaspora owcz...
XP_004990454 251 IDFMCVIRVFYPGSLQLNPDQFPGTDPNDCPrdiSKEEALRIGCNNArnPDQYHHYREAQFTVIKHHWWWKLNFVFDHMP 330 Salpingoeca ros...
EFO25555     154 IDFCLVMQIFYPYSIQLFPDVFPGLDPLDCPekaTKKEAASLKCNNWknPDKYGHFRVAKLTQIKHHWWWKMNYVFDGI- 232 eye worm
O17560       174 ITFARVYQIFYPYNLQLFPTVFPGQSPSDCPekmKRDKAQETNCSNWssPDKYGNYRVAQLTQIKHHWWWKMNFVFDGI- 252 Caenorhabditis ...
OWR49661     139 ISFARVLQIYYPYSVQLHPFVFPGYDQKTC--------DEVMSCRKSd--------RKALVIQHKHHWWWSASFVFDRVF 202 Danaus plexippu...
EDV20761      84 VQFCPVIQIFFPYSAQLHPDVFPGTDPRDCKrdtPKELALVKKCLNAnyPDQFGHYREADYTMTKHHWWWKINFVFDQLN 163 Trichoplax adha...
5VCM_A       219 ILRDY---AGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRsfygm-adkvDVKTWKS----TEHN 290
Q9FT88       223 ETKGH---EGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKS----------RGEGLESlvaeRMGN 289 thale cress
Q69QZ8       232 ETRDF---DGHILFIEEDHYIFPNAYRNAQLLVDLKPSKCPQCYAINLAPSDVKA----------KGEGWESlvaeKMGN 298 Japanese rice
ABF70149     276 ETKGF---SGHILFIEEDHYIYPNAYRNLQLLIGLKPMKCPECYAANLSPMDVNS----------IGEGWDMlvaeKMGN 342 dwarf banana
KJE97612     317 VTREN---NGPMLFLEEDHVLAPDALVAVMAATAARPRLCPSCQLVGIATYNPLEatidhkaataHTAAWLS----AQNN 389 Capsaspora owcz...
XP_004990454 331 VLKNH---NGLKVLLEEDHYLAPDTIHMLLKTWRVAQEQKHTSDIIVLGDYDAGHgafa--gnvvHRQPWVS----TKHN 401 Salpingoeca ros...
EFO25555     233 -LKQYaltKVWVILLEEDHYVSPDFLHVMRLIVGSKSNFCAECQVISLGLYLKQYnnfksnlnrlGIHPWFS----SKHN 307 eye worm
O17560       253 -VEKYsmkDPWVLLLEEDHMLAPDALHVLDIIVSNRPKYCENCEIISLGFYLKSTnkygqdiahlGVHPWYS----SKHN 327 Caenorhabditis ...
OWR49661     203 ATRNY---NGTILFLEENQYVTSDFIYIFRILDGLLRSSNLHCDIISLGNGKSKSssyrlinssiLLKPWDT-----RET 274 Danaus plexippu...
EDV20761     164 ILKDY---KGLVLLLEEDHYVAPDFLTIMKLLEQKRNSEYPNCDFLGLGSYNRHGsyshfkhkvaDYVAWAS----NKNN 236 Trichoplax adha...
5VCM_A       291 MGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTvs-cLPK-FWKVLVPQIPR--IFHAGDC-GMH--HKKT---CRP 360
Q9FT88       290 VGYSFNRSVWENIHQKAREFCFFDDYNWDITMWATV----FPSfGSPVYTLRGPRtsAVHFGKC-GLHq-GRGDegdCID 363 thale cress
Q69QZ8       299 IGYAFNRTVWRKIHAKAKQFCTFDEYNWDITMWATV----YPSfGSPVYSLRGPRrsAAHFGKC-GLHq-GQGLsnvCVD 372 Japanese rice
ABF70149     343 VGYSFNRTVWRKIHTKAKEFCSFDEYNWDITMWATV----YPSfGTPVYTLRGPRrsAAHFGKC-GLHq-GRGKsssCID 416 dwarf banana
KJE97612     390 MGMVIDRAAWSSIKSCHRDFCTFDDYNWDWSLQYAAst-cVGS--LNILVLDHPR--VVHIGTC-GAHayQHSPgkpCNP 463 Capsaspora owcz...
XP_004990454 402 MGMALSRQLFDKIKQCARMFCEFDDYNWDWSLFAVSargcIDQmAIHALVMAGQR--IQHLGVC-GVH--SAGKd--CSG 474 Salpingoeca ros...
EFO25555     308 MGMAIKADTWELIKNCTELFCKYDDYNWDWSLLRVSmk-cLPS-RLKVIAVKAPR--VIHVGDC-GIH--THR----CAV 376 eye worm
O17560       328 MGMALQKNTWQKIKGCSEMFCKWDDYNWDWSLMQISak-cLPQ-RFRVIFTKSPR--VIHIGDC-GVH--THR----CEA 396 Caenorhabditis ...
OWR49661     275 LGIAFNKDTWKTVKNLSEHFCRYNDNRWSKSLIHLSt--kTSLgKFYALSIEGSR--VFRLNKC------KDHKt--C-N 341 Danaus plexippu...
EDV20761     237 MGMAMNRATFDKIKRCNNQFCRFDDYNWDWTIQSLSsk-cLNR-PLTILTMQAPH--VFHAGECsGLH--HKRF---CKM 307 Trichoplax adha...
5VCM_A       361 STQSAQ-IESLlnnnk--------qymfPETLTISEKFTv------VAISPPRKN-GGWGDIRDHELC 412
Q9FT88       364 NGVVNIeVKET-----------------DKVVNIKEGWGvrvykhqAGYKAGFEGwGGWGDDRDRHLC 414 thale cress
Q69QZ8       373 NGDATVqLDAI-----------------DKVPNIKANWPvhiikrqEGYQAGFKGwGGWGDKRDQELC 423 Japanese rice
ABF70149     417 NGEARFqLDEI-----------------DKILNIKPDWKvhvvkkqSGYQAGFKGwGGWGDERDRELC 467 dwarf banana
KJE97612     464 AQLMDQ-LNALwnykkssmlhfaadgtpSESISLSSKGA-------MAVPRPSPN-GGWGDHRDHALC 522 Capsaspora owczarzaki ATCC ...
XP_004990454 475 TDAIER-AKRFnaana--------aqmfPQSLQVVTKTG-------QAPFVRAGY-GGWGDPRDVNLC 525 Salpingoeca rosetta
EFO25555     377 HNTAAV-AAELfsssa--------nslfPKKMILAENLK-------RTLKPPREN-GGWGDIRDHELC 427 eye worm
O17560       397 HKALQS-TQELfrqhk--------dllfPTSLSVTDTSR-------RSLKPSKEN-GGWGDIRDRQLC 447 Caenorhabditis elegans
OWR49661     342 ETKNNEiLLNFvrkir--------kklfPFKMHIVKSN--------SVEEVGEGN-GGWTDVRDHELC 392 Danaus plexippus plexippus
EDV20761     308 EDTITA-IERSlsanm--------dylfPQTIGVTSQNReir--rfAGVSRPNGY-GGWGDIRDHKLC 363 Trichoplax adhaerens
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