Conserved Protein Domain Family

pfam05051: COX17 
Cytochrome C oxidase copper chaperone (COX17)
Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast. The structure of Cox17 shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.
PSSM-Id: 398641
Aligned: 93 rows
Threshold Bit Score: 56.421
Threshold Setting Gi: 74832732
Created: 20-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
EIM23305      19 EGLKP----CCVCPETKKLRDECFLFN--GsNAdssngstdACKDVLEAHKACMRSFGFPV 73  Wallemia mellicola CBS 633.66
ESK90331      32 QGLKP----CCACPQTKSVRDDCFMKY--GsEAd------eKCQELVQNHLACMRGLGFKI 80  Moniliophthora roreri MCA 2997
XP_003033853  13 QGLKP----CCACPQTKRARDDCFLAN--GaEAd------eKCKELVASHVACMRGLGFNI 61  Schizophyllum commune H4-8
EPT06255      36 QGLKP----CCACPQTKSARDDCFLKHd-SlEVd------eKCKEVVQAHIACMRGYGFKV 85  Fomitopsis pinicola FP-58527 SS1
CCA71489      30 NNLKP----CCACPETKSARDDCFLKTd-AaVAd------eKCKELVQKHIACMRGYGFNV 79  Serendipita indica DSM 11827
EGN96388      38 KGLKP----CCACPETKSARDACFLQSktGgDEg-------ECAELVRRHVECMRSLGFQI 87  Serpula lacrymans var. lacrymans S7.3
XP_002911952  66 EGLKP----CCACPLTKRARDDCFLKFd-AaEAp------eKCKEQVEKHLACMRSLGFKI 115 Coprinopsis cinerea okayama7#130
XP_007326953  32 EGLKP----CCACPQTKSLRDDCFLKY--GdAAp------eQCKEALQNHLACMRSLGFKI 80  Agaricus bisporus var. burnettii J...
ELU38938      26 qglKPcaeiCCACPQTKSERDDCFLRY--DpSEap-----sKCADVLQKHIACMRSYGFDV 79  Rhizoctonia solani AG-1 IA
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