2LMD,1XPX


Conserved Protein Domain Family
HPD
?
pfam05044: HPD (This model is not part of the current CDD release)
Homeo-prospero domain
Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.
Links
?
Statistics
?
PSSM-Id: 516595
Aligned: 12 rows
Threshold Bit Score: 299.729
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2LMD_A         16 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEE--LSIT 93   human
Q91018        578 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEE--LSIT 655  chicken
2_pfamImport    1 ALTPGHLKKAKLMFFFSRYPTSSLLRAYFLDVQFTRCITSQLIKWFSNFREFYYIQMEKCARQALLEGVADSSR--LLVT 78  
XP_005797823  520 GLTPSHLKKAKLMFFYTRYPSSNVLKTFFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIAEGVHDVKD--ITVS 597 
XP_045097709  467 MLTPMHLRKAKLMFFYTRYPSSNLLKSYFPDIRFNKNNTAQLVKWFSNFREFYYIQMEKFARQALSEGISDRSE--IFVS 544 
EFX75472      830 TLTPMHLRKAKLMFFWCRYPSSSVLKTFFPDVNFNKNNTAQLVKWFSNFREFYYIQMEKYSRQLLSEGVVNADD--IHVS 907 
XP_002427668 1075 TLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIMFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVSEGIKNAED--IHVS 1152
Q4H2W8        502 GLTSQHLKKSKLMFFYTRYPCVTTLKSYFSDVQFSRATTSQLIKWFSNFREFYYMQMERFARQALVDGITEAEQ--ILVG 579  vase tunicate
Q4H2W9        330 GLTPQHLKKAKLMFFYTRYPSANMLKAYFADVKFSRATTSQLIKWFSNFREFYYIQMEKFARQALTEGITDVNQ--ILVT 407  vase tunicate
XP_007248093  544 GLSPCHLKKAKLMFFYTRYPSSNTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQAAREGLPTSRDrvLRLS 623 
1XPX_A          7 TLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDD--LLIA 84   fruit fly
XP_007655870  479 GLTPGHLKKAKLMFFFTRYPSSNILKTYFPDVQFNRCITSQLIKWFSNFREFYYIQMEKFARQAISEGVTNAEK--LIVP 556  platypus

2LMD_A         94 RDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 169  human
Q91018        656 RDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 731  chicken
2_pfamImport   79 RGSELFRILNVHYNKGNDFEVPDAFLDVASLTLQEFFNAVREGKDLDPSWKKPIYKIISKLDSEIPDAFKSSNCPK 154 
XP_005797823  598 RDSELFRALNMHYNKANDFHVPDRFLEVAEITLHEFYNAISATKDSDSSWKKAIYKVICKLDSEIPEEFKTSSY-L 672 
XP_045097709  545 KDSELFKVLNTHYNRNNHIKAPDRLVLVVQETLREFYDAIKLGKDAEPSWKKTIYKIINRLDDQIPDFFKEPNFLE 620 
EFX75472      908 PDSELFRALNLHYNRNNHIEVPAPFVFVVSETLREFFKAIQAGKDSEPSWKKAIYKIIARLDEQVPEYFRTPNFLE 983 
XP_002427668 1153 ADSEIYRVLNLHYNRNNHIEVPSNFRFVVEQTLREFFKAIQTGKDTEQSWKKSIYKIISRMDDPVPDYFKSPNFLE 1228
Q4H2W8        580 RNSEVFHILNIHYNKSNDFEAPQHFLDVVTKTIRNFFTNIKYGKDNEAGWKKVIYKVICKLDQDIPEIFKSPNVLN 655  vase tunicate
Q4H2W9        408 RDSEILRVLNLHYNKSNDFRVPDQFIDVTQTSLQEFYLSIKAGKDRDPAWKKVIYKVICKLDHDVPDIFKSANVLD 483  vase tunicate
XP_007248093  624 RNSELFRILNMHYNKSNDYQVPDRFVEVSELALREFFAAIQGGRDTDPCWKKSIYKIICKLDSPVPDSFRLPGCPM 699 
1XPX_A         85 GDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLE 160  fruit fly
XP_007655870  557 RDSEIFRSLNTHYNKGNDFEVPDRFLEIASLTLQEFFEAVTAGRDSDPSWKKPIYKVISKLDGdipeilsspsfla 632  platypus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap