2LMD,1XPX


Conserved Protein Domain Family
HPD
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pfam05044: HPD 
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Homeo-prospero domain
Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.
Links
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Statistics
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PSSM-Id: 428277
Aligned: 13 rows
Threshold Bit Score: 308.58
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2LMD_A         16 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEE--LSIT 93   human
Q91018        578 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEE--LSIT 655  chicken
1_pfamImport    1 GLTPGHLKKAKLMFFFTRYPSSNILKTYFPDVQFNRCITSQLIKWFSNFREFYYIQMEKFARQAISEGVTNAEK--LIVP 78  
XP_016846775  488 ALTPGHLKKAKLMFFFSRYPTSSLLRAYFLDVQFTRCITSQLIKWFSNFREFYYIQMEKCARQALLEGVADSSR--LLVT 565  green anole
XP_005797823  520 GLTPSHLKKAKLMFFYTRYPSSNVLKTFFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIAEGVHDVKD--ITVS 597  southern plat...
CAP39453      467 MLTPMHLRKAKLMFFYTRYPSSNLLKSYFPDIRFNKNNTAQLVKWFSNFREFYYIQMEKFARQALSEGISDRSE--IFVS 544  Caenorhabditi...
EFX75472      830 TLTPMHLRKAKLMFFWCRYPSSSVLKTFFPDVNFNKNNTAQLVKWFSNFREFYYIQMEKYSRQLLSEGVVNADD--IHVS 907  common water ...
EKC41624       24 TLTPMHLRKAKLMFFYVRYPSSAILKVYFPDVKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAIAEGCKSIDD--LVVT 101  Pacific oyster
XP_002427668 1075 TLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIMFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVSEGIKNAED--IHVS 1152 human body louse
Q4H2W8        502 GLTSQHLKKSKLMFFYTRYPCVTTLKSYFSDVQFSRATTSQLIKWFSNFREFYYMQMERFARQALVDGITEAEQ--ILVG 579  vase tunicate
Q4H2W9        330 GLTPQHLKKAKLMFFYTRYPSANMLKAYFADVKFSRATTSQLIKWFSNFREFYYIQMEKFARQALTEGITDVNQ--ILVT 407  vase tunicate
XP_007248093  544 GLSPCHLKKAKLMFFYTRYPSSNTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQAAREGLPTSRDrvLRLS 623  Mexican tetra
1XPX_A          7 TLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDD--LLIA 84   fruit fly

2LMD_A         94 RDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 169  human
Q91018        656 RDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 731  chicken
1_pfamImport   79 RDSEIFRSLNTHYNKGNDFEVPDRFLEIASLTLQEFFEAVTAGRDSDPSWKKPIYKVISKLDGP-PDSQVPALYPR 153 
XP_016846775  566 RGSELFRILNVHYNKGNDFEVPDAFLDVASLTLQEFFNAVREGKDLDPSWKKPIYKIISKLDSEIPDAFKSSNCPK 641  green anole
XP_005797823  598 RDSELFRALNMHYNKANDFHVPDRFLEVAEITLHEFYNAISATKDSDSSWKKAIYKVICKLDSEIPEEFKTSSY-L 672  southern platyfish
CAP39453      545 KDSELFKVLNTHYNRNNHIKAPDRLVLVVQETLREFYDAIKLGKDAEPSWKKTIYKIINRLDDQIPDFFKEPNFLE 620  Caenorhabditis br...
EFX75472      908 PDSELFRALNLHYNRNNHIEVPAPFVFVVSETLREFFKAIQAGKDSEPSWKKAIYKIIARLDEQVPEYFRTPNFLE 983  common water flea
EKC41624      102 TESELYRVLNLHYNRNNQIEVPDNFRIVVQATLREFYKSIVACKDSEPSWKKAIYKVIARMDDSLPEYFKSPNWMD 177  Pacific oyster
XP_002427668 1153 ADSEIYRVLNLHYNRNNHIEVPSNFRFVVEQTLREFFKAIQTGKDTEQSWKKSIYKIISRMDDPVPDYFKSPNFLE 1228 human body louse
Q4H2W8        580 RNSEVFHILNIHYNKSNDFEAPQHFLDVVTKTIRNFFTNIKYGKDNEAGWKKVIYKVICKLDQDIPEIFKSPNVLN 655  vase tunicate
Q4H2W9        408 RDSEILRVLNLHYNKSNDFRVPDQFIDVTQTSLQEFYLSIKAGKDRDPAWKKVIYKVICKLDHDVPDIFKSANVLD 483  vase tunicate
XP_007248093  624 RNSELFRILNMHYNKSNDYQVPDRFVEVSELALREFFAAIQGGRDTDPCWKKSIYKIICKLDSPVPDSFRLPGCPM 699  Mexican tetra
1XPX_A         85 GDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLE 160  fruit fly
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