Conserved Protein Domain Family
TIMELESS_C

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pfam05029: TIMELESS_C (This model is not part of the current CDD release)
Timeless PAB domain
The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. This entry corresponds to the PAB (PARP-1-binding domain).
Statistics
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PSSM-Id: 516584
Aligned: 34 rows
Threshold Bit Score: 43.4463
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014326198  1017 MVKALQQ-EGLS--GPLLWLQNSLNKTAi-------------dRN---DDCP-F-QPVPLCPFSEENEDAMENRNFLKLL 1075
CDY50493      1004 VSRKLKQ-LGLR--LPRGKKSEAGMKLQd------------------dHDDSsAdESDNETLLAFKKRKSMTRRKLEKHT 1062
XP_002559117   881 EGEDIPD--GPLfpANPRSKSSALDDLK----------------K---KRKK-KqATTEREPLDDETLEARRDARLSNAL 938 
RWS04784       934 LVTELIE-LGFR--QQLNWIKDLLLETCfvkilndkelnnysiPEpvvYYNNyIgQSIPIVPYNEKQEKALYNNKFLQLL 1010
12_pfamImport    1 SASILRPkRGFIi-EPVAYH--CISKNK----------------------------SIPIVPWNSDHSAMMQYHPFVLLL 49  
XP_002432421   864 LNCDVNY-DPIT--KPLEPIPHYYSHLN---------------------------QSIPIVSWNAEQADVLLLQPFQLLL 913 
XP_008482101   397 TIRNLMD-AGLQ--AIVEWVKESLEETLa-------------dID---DDET----DVPLVPIIPETQQGIEHEDVVNML 453 
RZF48533        84 ALNNAVF-DGFK--EPLEWLVSSMTEMLe-------------dLE---DNQE----DVPLLPLTETCTQAMENGSFTSMI 140 
9_pfamImport     1 AIKKVID-KDMK--TALLWLVESLDEAAn-------------dLD---VDES----DIPLLPLTDECMTAVNDIDFQEMM 57  
XP_027230629  1090 LIGQLKE-EGYG--AQVQWLQLQLLEACysklkmv--gpnlpkAEpvpCHFTlSnQSIPLVPWTSEQEEAFSSLKFRQLL 1164 Pacific whit...
XP_014326198  1076 SKL-GIRP---------PENEQ--ETFWRIPENISTSQLC 1103
CDY50493      1063 RPSnEISP---------EGSEDktERNETSPDVIATSKEE 1093
XP_002559117   939 SRQaKIKSdlfihasdeESDEEadKEFFRLEEERRIQQAK 978 
RWS04784      1011 HKL-GFHL---------PTDVG--RIYPRIPSFFTPDLLF 1038
12_pfamImport   50 HKL-GFHL---------PADSG--SVYPRVPEFWTADLMY 77  
XP_002432421   914 HKL-GFHL---------PADTG--KVFARIPSFWTVDVLF 941 
XP_008482101   454 RSL-GLKS---------PRENM--EIYWRIPGVWNTNALR 481 
RZF48533       141 EVL-GVKK---------P-DEQ--EIFWRLPGNWSEAKIK 167 
9_pfamImport    58 QVL-GIHK---------PSSIQ--ETYWRIPGRWQANDIR 85  
XP_027230629  1165 GEL-GFHL---------PSDTG--KIFPRIPHFWCPEVLF 1192 Pacific white shrimp
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