8ADJ,4A0D,4EPQ


Conserved Protein Domain Family
PARG_cat_C
?
pfam05028: PARG_cat_C (This model is not part of the current CDD release)
Poly (ADP-ribose) glycohydrolase (PARG), Macro domain fold
Poly(ADP-ribose) glycohydrolase (PARG), is a ubiquitously expressed exo- and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death. It catalyzes hydrolyzis of the O-glycosidic linkages of ADP-ribose polymers, which reverses the effects of poly(ADP-ribose). This entry represents the Macro domain fold localised in the C-terminal end of PARG catalytic domain from animals and plants.
Links
?
Statistics
?
PSSM-Id: 516583
Aligned: 71 rows
Threshold Bit Score: 197.763
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
8ADJ_A       310 DWSQSA-A--PLGd--vPLHVDA---EGTIEDE-GIGLLQVDFANKYLGGGVLGHGCVQEEIRFVICPELLVGKL-FTEC 379 fruit fly
Q22S90       347 FWKQNT-T--KLI----KVTNEK---DANIED--FKDAIHLDFANAYIGGGVLDHGLVQEEIRFMISPELIISRL-FCPK 413 Tetrahymena the...
A0DVP8       193 LWSNCE-K--SLQ----TIEFV----DQKIEE--QQNSILVDFANKYVGGGVLSYGCVQEEILFTIMPENIIAVL-FCKV 258 Paramecium tetr...
A0E0D0       193 LWSNCD-K--NLQ----KIDFV----DTFLEE--QQNALIVDFANKYVGGGVLHTGCVQEEILFTIMPENIIAVI-FSKV 258 Paramecium tetr...
XP_002679610 296 QIQQST-V--EISn--nQVIVLP---EGSIED--CENAIHSDFANKYIGGGVLRGGAVQEEIRFALSPECIISRL-IVEK 364
XP_002672129 222 SFEYSD-L--PLC----DVHVNS---QGSIAD--SHDAVQIDFANKFIGGASISFGCVQEEIEFSLCPEMNIARL-FCHV 288
Q23CV5       227 DLKKSNiT--KKS----LVEVYS---DKSIES--GRNLIQVTFANKLIGGGVLNRGALQEEIRYLISPECLVGIL-LFSE 294 Tetrahymena the...
XP_001906208 217 EISAQD-R--PLSelkvVVVETYdtlPGSLGVGdGDGQAVVISANRVVGFGQSAT---QEEVHVGISPEACPIVL-FTPP 289
4EPQ_A       226 NWVDKL-KaiKLK----NVQLTD---DKLIEDF-P-GTLQVDFANCDIGGGILGNGLVQEEIRFCVCPEMLVSLLvFDQS 295 Tetrahymena the...
XP_652095    214 QWSNIS-I--PVSa---NVTIV----DGLIEKE-NRNVLKAVFSSKAVGGNVLEDGCSQEEIMFIKCPECMVALL-IAPV 281 Entamoeba histo...

8ADJ_A       380 LRPFEALVMLGAERYSNYTGYA-GSFEWS--GNFE-D--STPRDSSGR--------RQTAIVAIDALHf-------AQSH 438 fruit fly
Q22S90       414 MEDREAIMIIGSEIYTKYSGYG-DSFHCE--GRV--DqsNIKLDSQNR--------KLTAVLAIDAIHyg----qsYDQN 476 Tetrahymena the...
A0DVP8       259 LDFHQVVIVKNTIRYSDYEGYA-NSFRF------------VQRQPKN---------MNQNILVLDAINy------kNNPD 310 Paramecium tetr...
A0E0D0       259 LSNTEVIIIKNTIRYCDYLGYG-LSFHF------------LQRKPSN---------LNQNILVLDALYy------gNYPT 310 Paramecium tetr...
XP_002679610 365 LSNNESLLICGTEQFSSHQGYA-KSLLYK--GDFI-Dgn-------yEkesehlfcFKSQIVAFDSKYyy-----tNEKL 428
XP_002672129 289 MGDRESILITGAEQYSKHKGYA-FSLDYA--GNFI-D---LNKDSNGN--------SLKQTSAIDALIfn-----kLNFL 348
Q23CV5       295 LQDNEAIVIQGAQQVSDYEGYG-CNLTFK--GPYYdDqlEVQEENNM---------LNVVIVGMDAIDfskveienEKYE 362 Tetrahymena the...
XP_001906208 290 LGDEQVLKVRGAQAMVNVVGKGrDII--V--GSML-Dp-PQGGDATW---------KFRTMLFMDALEldl---vnDGRL 351
4EPQ_A       296 MEANEVIIMKGIKQYSDYQGYS-NSFRFVkmGNSK-I--QKQK---RT--------NPQTILAIDALCf-------NSSD 353 Tetrahymena the...
XP_652095    282 LNANESFRIYNVLQYSEVTGYA-TEISFK--GNVAsL----------Q--------LKHDFVIFDALIc-------VDKK 333 Entamoeba histo...

8ADJ_A       439 H--QYREDLMERELNKAYIGFVHWMVTPP----------PGVATGNWGCGAFGGDSYLKALLQLMVCAQ------LGRPL 500 fruit fly
Q22S90       477 I--QYRMNSIIRELLKAYIGFHGGQELIQseqslgngkkFQISTGRWGCGIFMGDPQLKFLIQWVAASL------AQREM 548 Tetrahymena the...
A0DVP8       311 K--QFQQNEIMREINKAFIGFSLSQSAKEee------flYPISTGKWGCGVFKGNTQLKTIIQLLAFSAstksenQKRRM 382 Paramecium tetr...
A0E0D0       311 L--QFQSKFILRDINKAFIGFSLSQSAKEed------flLPISTGKWGCGAFRGNCELKTLIQLIAFSAsrkridQKRRM 382 Paramecium tetr...
XP_002679610 429 K--QWKIDCIDREIIKAYSAFCSIRKNYGln------fySNISTGNWGGGAFNSDHELKFIIQLIVTCH------CEKPM 494
XP_002672129 349 S--QWEKETIDREIIKSLSGFSSSKTMDK------------ISTGNWGCGAFLGDVELKAIIQVISASL------AQKSL 408
Q23CV5       363 HnyQFEQNNVMRDIAKAYTAFRCDNVLKYnn------rrQGIITGNWGCGDFKGDKELKFLIQWIAASW------CKREL 430 Tetrahymena the...
XP_001906208 352 A--DLDPGNMEREIAKAYTAFSSSLDGTI----------SEIKTGPWGCGAFRGDPEVKMLLLWLASSM------VGVNL 413
4EPQ_A       354 N--QFSEVNVSRELNKSYMGFKQEDQLKT------------ISTGKWGCGAFLGVFDLKFAIQWIASSR------SNKKM 413 Tetrahymena the...
XP_652095    334 L--QYTQYGIDRELNKVFSAIKKTDDDCDv--------mQPFATGKWGCGSMLGDSRLKFIIQLLASSL------TGREM 397 Entamoeba histo...

8ADJ_A       501 AYYTFGNVEFRD 512 fruit fly
Q22S90       549 IFCSFKDKELDD 560 Tetrahymena thermophila SB210
A0DVP8       383 IFSTFKDKQLQF 394 Paramecium tetraurelia
A0E0D0       383 IFSTFEDEQLQF 394 Paramecium tetraurelia
XP_002679610 495 YYYTFKNTELAR 506
XP_002672129 409 VYYSFQRKEVEV 420
Q23CV5       431 YYCTHNDQLLKA 442 Tetrahymena thermophila SB210
XP_001906208 414 TVVC--DYELQT 423
4EPQ_A       414 IICTFQDEQttk 425 Tetrahymena thermophila
XP_652095    398 RYHPLNDIQHQN 409 Entamoeba histolytica HM-1:IMSS
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap