4EPP


Conserved Protein Domain Family
PARG_cat

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pfam05028: PARG_cat 
Poly (ADP-ribose) glycohydrolase (PARG)
Poly(ADP-ribose) glycohydrolase (PARG), is a ubiquitously expressed exo- and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death.
Statistics
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PSSM-Id: 398620
Aligned: 73 rows
Threshold Bit Score: 261.72
Threshold Setting Gi: 171682530
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4EPP_A                    98 LDKEEQTYFLEQFIPKICQLVLKIKKKqLKNQ--IP--KE-------SKIYEAAFSREEISYYVSCMFLCILKDqdR--- 163
EAS28217                  82 mgEAAEGQFFNRVWPVLVEIALEMPSL-FPESs-LPilSE--------QHDQVTLSRRQVACLVVHQFLCSLPSqpWpt- 150 Coc...
XP_001906208              89 tsfdTAEVFFAKVWSRIVDIALQMPVL-FQNGr-IPvlSR--------ENYSLPFSRRQIACLVVHQFLRTLSLppFrdd 158 Pod...
XP_004032358               9 qnQGQKDFYLQDLIPFIAQLALKIEQI-PQIIf----lQA-------YKKNQITLNRLQVAVIIANMFFCTLIPqeK--- 73  Ich...
Q22S90                   208 ylKEKQSDFFENLVPFIAKLALEITQL-DDVPi----lVQ-------NKEGKITLTKRQVATFLANMFFCTLSSqiS--- 272 Tet...
WGS:AAFB:cds.EHI_057660A  91 lppIESSHFFRDTIPIIASLAAIHPKL-FPTP--LIl-PT-------TPNSILRLNRLQVASLFALSFLGLFRLplKf-- 157 Ent...
A0E0D0                    62 LDQNLRVLFFQNALPKMAQYSLNLl-------------NSppkkellVTQGTIQFTRKEIYQFLSLSFFGLLKIqhD--- 125 Par...
Q23CY6                    66 LDNAEKQFFLNDLIKFIAEQALKMTRF-QNEDkkIKylGA-------NQQDKVSLTKEEVSILLANMFLLSTPRrmEnn- 136 Tet...
Q22MR4                    94 LDEADQKYFIEEFLPSLAIRALELETL-FLNSp-VKilKQ-------YDSTPSIFTKRQISSVLANMFFGTI-------- 156 Tet...
Q23CV5                    92 LSMKKQQLYQNELIPYMAKLALDISNA-FQQEp-IKllLQ-------GEKEEQKFTKYQIAVLLSNMFFCTLHKqpD--- 159 Tet...
4EPP_A                   164 -KiYKDFR-LIY-------LKDLVQ-----QINIRRQEKIKCFYEYL----KQAldfS-----------EKESK--EVV- 211
EAS28217                 151 dS-SPDFRiWYS-------TDI--------RHPKAVAAYISSVFTYF----GRL---AgsshgsdspslLSAEW--PIIf 205 Coc...
XP_001906208             159 dG-THDFGiWYS-------SQQ--------RHPVAVRGYLRALMLYFgd------------------vlCDEKTmdGWVv 204 Pod...
XP_004032358              74 ---KYNLPnTYN-------LNTLYKs---tYQNNRKIQKIKCIFNYFslikKTQ----------------EKTLenEKI- 123 Ich...
Q22S90                   273 ----KNIPyGNS-------FKSLYTgslnyNQSDRKIEKIICIYNYFlsvkEAIen-----------rpGEYEQ--QKV- 327 Tet...
WGS:AAFB:cds.EHI_057660A 158 qD-AKQFPrCLS------------------IVDKVSATKLRCYMAYF----STI---Gia-------iiNKDPIlqEQI- 203 Ent...
A0E0D0                   126 -----SFPtPCN----------LH------YILQEQPEKAKCYLHYFit------------------anNDLEH--ELV- 163 Par...
Q23CY6                   137 sL-EQSLPkCCSkicyefiFNI--------SSGKAMKSKLRCIHNYF----KRIyq-----------rrHDQKYlnLVV- 191 Tet...
Q22MR4                   157 -D-YSKYRtLIQ----------WYDg---pYRIETKIEKIKCLYNYF----KRI---Ls----------ASEEHlnLFI- 203 Tet...
Q23CV5                   160 ---LDNFPlCFD-------FSKLYMkgtdaSLNNLKKEKLKFLFNYFeq------------------vyNDKINldLCV- 210 Tet...
4EPP_A                   212 -----IFQRIn---CGQLe------------dYENWvdKLKA-IKLK----NVQLTD---DKLIEDF-P-GTLQVDFANC 261
EAS28217                 206 rlrtlGVHKSalphTLPMgc---------------------mlRPMTvtyePIISTK---PSLLGI--PdGACIVS-ANK 258 Coc...
XP_001906208             205 eyslhSLPEn----------------------YDEI--SAQD-RPLSelkvVVVETYdtlPGSLGVGdGdGQAVVISANR 259 Pod...
XP_004032358             124 -----EYIRlynqny-----------inarslIENQ--QKLK---------KIYIQKn--NKNIED--IkNSIQIDFANK 172 Ich...
Q22S90                   328 -----TYHRivfdqni----------hsnsdvSIFW--KQNT-TKLI----KVTNEK---DANIED--FkDAIHLDFANA 380 Tet...
WGS:AAFB:cds.EHI_057660A 204 -----TYQRvy-------------------geSPQW--SNIS-IPVSa---NVTIV----DGLIEKE-NrNVLKAVFSSK 248 Ent...
A0E0D0                   164 -----TLERIdfnvNYHIhqffpnnqgiqildIKLW--SNCD-KNLQ----KIDFV----DTFLEE--QqNALIVDFANK 225 Par...
Q23CY6                   192 -----EFQR-----------------------IQYQ--NNSLrLDQDillgEIQFEE---DKKIEDFkDqNYIHVDFANK 238 Tet...
Q22MR4                   204 -----IIQR-----------------------LQYV--NQNNyKVPPtlnsNIKIFT---DKRIEDFlQsQHIHIDFANQ 250 Tet...
Q23CV5                   211 -----SFERvnysy-------------gqqasINDL--KKSNiTKKS----LVEVYS---DKSIES--GrNLIQVTFANK 261 Tet...
4EPP_A                   262 DIGGGILGNGLVQEEIRFCVCPEMLVSLLvFDQSMEANEVIIMKGIKQYSDYQGYS-NSFRFV-KMG-N--SKIQKQKRN 336
EAS28217                 259 NVGFGQSAT---QEEMHVGSTPESCPIVL-LTPTLQDTQILVVQGAEAMTVVEGYGrEARLLEtSYK-DslHGVHPHTW- 332 Coc...
XP_001906208             260 VVGFGQSAT---QEEVHVGISPEACPIVL-FTPPLGDEQVLKVRGAQAMVNVVGKGrDII--VgSML-Dp-PQGGDATW- 330 Pod...
XP_004032358             173 YIGGGVLDTGLVQEEIRFVISPELLILRL-FSFKIEDQEAILVSGIDTYSIYRGYS-NTFECLgENK-N----------- 238 Ich...
Q22S90                   381 YIGGGVLDHGLVQEEIRFMISPELIISRL-FCPKMEDREAIMIIGSEIYTKYSGYG-DSFHCEgRV--DqsNIKLDSQNR 456 Tet...
WGS:AAFB:cds.EHI_057660A 249 AVGGNVLEDGCSQEEIMFIKCPECMVALL-IAPVLNANESFRIYNVLQYSEVTGYA-TEISFKgNVAsL----------Q 316 Ent...
A0E0D0                   226 YVGGGVLHTGCVQEEILFTIMPENIIAVI-FSKVLSNTEVIIIKNTIRYCDYLGYG-LSFHF----------LQRKPSN- 292 Par...
Q23CY6                   239 YIGGGSLYDGDVQEEILFNTCPEMLVSTI-FCQKMEEKEAILIIGAERFNSYIGYG-YDFQVTgEYF-DksSINKEKNY- 314 Tet...
Q22MR4                   251 CIGGGVLDTGRVQEEIMFVTNPELLICCQ-ICECIEDKEGILITGAERYSSYTGYS-QTFAFEdNFI-DprGVDTQRNC- 326 Tet...
Q23CV5                   262 LIGGGVLNRGALQEEIRYLISPECLVGIL-LFSELQDNEAIVIQGAQQVSDYEGYG-CNLTFKgPYYdDqlEVQEENNM- 338 Tet...
4EPP_A                   337 NPQTI-LAIDALCfn-------sSDN--QFSEVNVSRELNKSYMGFKQEDQLKT------------ISTGKWGCGAFLGV 394
EAS28217                 333 QRRVM-LFMDALEfdm----ydsSEGvpDLLPGHTDRELLKAYNAFSSQQGGHTys---------rIVTGLWGCGAFGGN 398 Coc...
XP_001906208             331 KFRTM-LFMDALEldlv---ndgRLA--DLDPGNMEREIAKAYTAFSSSLDGTIs----------eIKTGPWGCGAFRGD 394 Pod...
XP_004032358             239 RKNDIlVAIDALNfsq----sydSGI--QYRINVLLREINKAFVGFQAPQVPLDv----------pISTGRWGCGAFQGD 302 Ich...
Q22S90                   457 KLTAV-LAIDAIHygq----sydQNI--QYRMNSIIRELLKAYIGFHGGQELIQseqslgngkkfqISTGRWGCGIFMGD 529 Tet...
WGS:AAFB:cds.EHI_057660A 317 LKHDF-VIFDALIcv-------dKKL--QYTQYGIDRELNKVFSAIKKTDDDCDvm--------qpFATGKWGCGSMLGD 378 Ent...
A0E0D0                   293 LNQNI-LVLDALYyg------nyPTL--QFQSKFILRDINKAFIGFSLSQSAKEedf------llpISTGKWGCGAFRGN 357 Par...
Q23CY6                   315 INTYV-ACIDAIAflpqd------tyyqQYEQKNIYRELFKSLAGFQGPLKEEKqnky----dktpVVTGNWGCGIFNGD 383 Tet...
Q22MR4                   327 KQTAV-IAIDALFfhe-----hiLAL--QYQPKMIFRELIKALTGFQITDYTPKgh---------qIVTGNWGCGSFHGD 389 Tet...
Q23CV5                   339 LNVVI-VGMDAIDfskveienekYEHnyQFEQNNVMRDIAKAYTAFRCDNVLKYnnr------rqgIITGNWGCGDFKGD 411 Tet...
4EPP_A                   395 FDLKFAIQWIASSR------SNKKMIICTFQDEQ 422
EAS28217                 399 REIKTILQWCAASL------AGVRLEFICSGDAq 426 Coccidioides immitis RS
XP_001906208             395 PEVKMLLLWLASSM------VGVNLTVVC--DYE 420 Podospora anserina S mat+
XP_004032358             303 SQLKLVIQWIACSL------VGREMYFFPYMDCL 330 Ichthyophthirius multifiliis
Q22S90                   530 PQLKFLIQWVAASL------AQREMIFCSFKDKE 557 Tetrahymena thermophila SB210
WGS:AAFB:cds.EHI_057660A 379 SRLKFIIQLLASSL------TGREMRYHPLNDIQ 406 Entamoeba histolytica HM-1:IMSS
A0E0D0                   358 CELKTLIQLIAFSAsrkridQKRRMIFSTFEDEQ 391 Paramecium tetraurelia
Q23CY6                   384 PQLKLLIQWISCSL------LQKKMIYCSFKDRR 411 Tetrahymena thermophila SB210
Q22MR4                   390 VQLKFIIQWIACSM------QERDMIYCTFGNEH 417 Tetrahymena thermophila SB210
Q23CV5                   412 KELKFLIQWIAASW------CKRELYYCTHNDQL 439 Tetrahymena thermophila SB210
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