Conserved Protein Domain Family
Gpi1

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pfam05024: Gpi1 (This model is not part of the current CDD release)
N-acetylglucosaminyl transferase component (Gpi1)
Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.
Statistics
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PSSM-Id: 516580
Aligned: 88 rows
Threshold Bit Score: 155.799
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007403772 172 VHAI-------NANTTQINH--SQELNERAHgkylsdvtnqdnnqdhskakskhpwpkpdsffaclmlsttvglratKRY 242
2_pfamImport   1 WNQL------------KLSQwnNHFIKSRKQ------------------------------------------------- 19 
XP_002670473  93 NSRIiltdhsdDYSINNIYYiyYDRNTKYKYsldrdeektlsslehlnngnska-rreaieyslfntpinssilkkhLEN 171
Q582S8       338 AALL-------EFRLRMVIHwlLLLRGDTRVcclhpvlp------------------------------hiqhndpaLRR 380 Trypanosoma brucei
Q4E3J3       391 AALL-------EFRLRELIHwlALLQGRTHVcglhpvlp------------------------------hmihedptFQR 433 Trypanosoma cruzi
XP_002139278 270 LKGI-------AYKFNTQSQwiVLYNILIINydnfn-------------------------------------hnydAIK 305
A0DJF9       109 MKQV-------NFKYNLFNKwnDQAGELVSQhqplf------------------------------------isnlkYNY 145 Paramecium tetr...
XP_966174    419 WHNI-------FRSFMKNKQnpSEYYKYREIl------------------------------------------------ 443
CBJ34151      98 CAHL-------AARLRGALSlpLRLSRCWKErhqpae------------------------------------------- 127
9_pfamImport   1 CKNM-------EIRCCQLLYwpVILKDYGLRsqscve------------------------------------------- 30 
XP_007403772 243 gekslprclsagpnmsgictytyttvIELFNTLWL-----------------IANDIIFGRSSATFLME-NRNVLAA-WL 303
2_pfamImport  20 ---------------------------------FFediknkklskhmqntiaVIVDHLLGISLFIILYK------VDiFS 60 
XP_002670473 172 --------------------------ISRIGMSFN-----------------MILDLILGFLIIYHVWKlDESTLIDlKK 208
Q582S8       381 --------------------------FCVVDFLVR-----------------FAVDTICGMLLSLLLSH-GSGLLVT-KA 415 Trypanosoma brucei
Q4E3J3       434 --------------------------FCAVNFLIR-----------------LLVDGLLGTLGSLLLAV-GGTALIT-KS 468 Trypanosoma cruzi
XP_002139278 306 --------------------------VLLYSTITS-----------------IIIDHIFGVLLIYIINS-FSMQILQ-FI 340
A0DJF9       146 --------------------------HKLFSGILF-----------------VFLDILFGVLSLLILYY-NVTQLRD-FL 180 Paramecium tetr...
XP_966174    444 -------------------------lIRIIN---------------------LIIDIFLGFLIFLLLYF---NVINLhYI 474
CBJ34151     128 --------------------rrveglVGLSHWLFG-----------------VAADAALGVVACALLLR-HTEAAAR-AA 168
9_pfamImport  31 ---------------------yaekaAFHKHSMWAs----------------LVVDLLLGNFLGIILWS-RARAACV-WV 71 
XP_007403772 304 ETNLE-EYTVAFIKKALQWT-N-SYPVGLKLNDELCETFYTGSVLIVDLWHA-----YVLKPTFga---lPHILLLTGYA 372
2_pfamImport  61 YVFPLlFRLINFIEHSVKWF-I-TNPGGFKFNINFNYFLSSLSLFFLHFWRScl--iFIVLPSF-------YIFKIITFA 129
XP_002670473 209 RFISLyKYILINMFQHFEWLiKdSNPGGIKLNKQLNIILGQMALGGLRWWQTllsfgFYYLSDFftvdlfRVLIWSISSS 288
Q582S8       416 VSWCR-WLLYDLHMEYMDWF-E-GWPAGLKMNGDLSMTLSCIAKAVLEASWAsved----------lsnvGLFYKLLIFV 482 Trypanosoma brucei
Q4E3J3       469 GSFCR-YFLYDVHMGYMEWF-E-GWPAGLKMNEDLNMTLCFFAKWVLQTSWDfvvd----------fnwvELVYKLLVYI 535 Trypanosoma cruzi
XP_002139278 341 SKVYY-FLYNDAIYLQFNWL-A---SSELRLNKDLSSFLISLLFEAFQLWKSi---tNYIFSDI------ELIFFFLKLL 406
A0DJF9       181 HKYGS-SIHIEVLSKEVEWL-M-GFPAGLKTNKPLNYVLGQMIMYIIVLWNHi---tTFITPYE------NILLRAVMIF 248 Paramecium tetr...
XP_966174    475 SEKAQiFYGTSTLTSILGTL-L-QNPLGFKLNNNFTSFIGSILVSILDKWDLftnti---------pvnnSTVLNFVGYT 543
CBJ34151     169 HQALH-LLHVDVLSEELEWL-N-YFPAGFKLNVPLTHTLGSLTLVGMEAYASivgql---------aqweGAAMKAIAIC 236
9_pfamImport  72 SSFSE-NATNYLLRTGCVWL-M-GNPAGFKLNTELAGVLGTISLIAIQIWSTl---wWLLGFFL------IHLIKVVAVF 139
XP_007403772 373 SFC-GHTFTLAVASDFFALSTFHLWLVYRLFTFVFSWHLQTLQFLFNIFRGRKFNILRDRTEPAT-YQLDQLILGTILFT 450
2_pfamImport 130 SLItGITGILSFFNDTLVLIFLPIELLSVFFSGLEQTHLSLIVSLFRLFMGTKYNPLRKRVDTLV-YEQDNFLLGTILFA 208
XP_002670473 289 CLM-GASTMLALVCDLLLVVSINILLFYRIISRLYNQLIHLIFSLWRLFRGKKANPLKKRLDNCEdYSNDQLILGIILFT 367
Q582S8       483 APL-GASCAFAFVADLCLIASLHLYLVFHSVSLPYRFARFMLRNLFLQFQGKKHNPLRHRTDTYD-FPVEQTLVATVIFT 560 Trypanosoma brucei
Q4E3J3       536 APF-GASCAFALISDVSILVSLHVLLLFHAISVPYRVMRSVTGSLFLQLRGKKYNPLRRRTDTYD-FEVDQMLMGTLLFT 613 Trypanosoma cruzi
XP_002139278 407 SAVgGFSIAISFVWDIFNIYIFILHYIYVLFSKLHCINIQAISTFYHLFRGKKWNILRNRVDSTI-NNIEQLLFGTILFT 485
A0DJF9       249 GLF-GLNFELSLAIDIISLCTIHVYYIYKMLMVIYRQLWVMIICFYRITQNKFINKFRNKLEDHP-FLWDQKIISMFLGF 326 Paramecium tetr...
XP_966174    544 SLL-GFSFFLSFVIDYLRFVTAHVTIIYLFLKKICTLFHKNMYSLYLLFNGKKWNILKLRVDTNY-YSNEEVLLGTILFT 621
CBJ34151     237 AAGgGLTTALAVAHDILRLLALHTATAHTAFAALHNLHSSLLGSLWQLFRGRKRNVLRCRVDTCM-YDACQLLLGTLVFT 315
9_pfamImport 140 GSLfGLTAAAALIIDTISLATTHVSALQWLLTLLYSWQIQAVDALWRLFRGRKWNPLRQRLDSYA-YSVEQHVVGSLLFT 218
XP_007403772 451 LATFLFPTVLAFYLLLSVPRLLIVAIHAIIDTGLSLLNHFPLFTVMLRLKDP--ARLPG 507
2_pfamImport 209 LLVFLLPTSIIYYLYFTFVLMIVQLFKKILSVLIVLIVEFPIDDIIASYNQPffNTQPH 267
XP_002670473 368 ICIFLYPTVAVYYLSFSFLFFSIVSIRKIITSIMVLIHNFPINQLL---------NLNG 417
Q582S8       561 IIVFLLPTLAVYHVYFALICIAVWLLQGALLVAAHLTLYLPLYPLFYWALYR--RQWPG 617 Trypanosoma brucei
Q4E3J3       614 VTVFLFPTLAVYYFYFALARGFIWLVQEGLVSATHITLYLPVYPVIYWALNR--WKWPG 670 Trypanosoma cruzi
XP_002139278 486 ISIFLYPTVAIFYVNFLFIWVPVFLINILFYMIIYIASHFPYFLTTMYFIYP--DHFNS 542
A0DJF9       327 FLLMMIPTVSLYYFWFLLIVIFIYLVKLTLISFQRIFSKFPLFLLCSYLY-L--HNIPQ 382 Paramecium tetraurelia
XP_966174    622 ILIFLYPTIFVLVLVFGLIYLIINRIIYLLCVMEKIILYTPFYIFFIQPNCN--KYISK 678
CBJ34151     316 VLSFLTPTISVYYTFFCIVQAVAVGGQV---------------------RPP--SPPPH 351
9_pfamImport 219 PLLLLLPTTSLFYIFFTIMKTTISFVCIAIQFGISIIHATPYIKIFFWFMRR--KRFPS 275
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