6TH5


Conserved Protein Domain Family
Phytochelatin
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pfam05023: Phytochelatin (This model is not part of the current CDD release)
Phytochelatin synthase
Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols. The crystal structure of a member of this family shows it to possess a papain fold. The enzyme catalyzes the deglycination of a GSH donor molecule. The enzyme contains a catalytic triad of cysteine, histidine and aspartate residues.
Links
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Statistics
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PSSM-Id: 516579
Aligned: 59 rows
Threshold Bit Score: 184.292
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6TH5_A             1 QTLTLSPNLIGFNSNEGEKLLLTSRSR---EDFFPLSMQFVTQVNQAYCGVASIIMVLNSL--GINa------PETAQYS 69  Nostoc sp. ...
Q21NE9            77 DDWSLPENMVDLRSEEGQTRLLECsy---cEDYPTLATAYLTQATQTFCGLASTTMVLNA-----DaesrkwrPVTQPYQ 148 Saccharopha...
Q7V6X1            36 SNPALAEKLVPITTSEGMVLLQRSKSV---SDYGSLMEAFLTQSNLAYCGVASAVMVLNSL--AIPa------PPVDGFR 104 Prochloroco...
XP_001750428      32 REMPLPPELIASNSSAGVQLLLSAQAQgyaEPFWQLSMTYTTQQNQAYCSVASSAMSLNAL--GVPa------PVDAVYS 103
XP_002504454      29 tlLPVPTDDIPLNSTEGERLLRDCTHY----PGVDVLMHLATQRNQAFCSAATAATLLNAMarTVTa------PVDVEFA 98 
WP_015157589      24 QTLPLSPQLIPFSSSDGEQLLVESQAK---QDYFLLSNQFVTQINQAYCGVASSVMVLNAL--GLPa------PESAQHK 92  Chamaesipho...
WP_013323642      31 QTLPLAPNLINFNSTEGEKLLLQSKAR---QDYFPLSIHFLTQENPAWCGVASIVMVLNAL--GISa------PEDPVHK 99  Gloeothece ...
WP_009545706      26 TSLPLAENLINFNSSQGETLLVESKAR---QDYIPLSLQFETQENLAFCGVASIVMVLNAL--SIPa------PKATEWV 94  Crocosphaer...
jgi:Syn6312_3727  38 qTLTLEAGLTSLTSRTGESLLETSQAK---ADVLPLMSHFVTQINPAYCGVASSVMVLNAL--GVTt------ANTPAW- 105
Q63T30            24 QPLPLPAGLIDLGSLAGEQMLAESGAR---SAYASLGSHFVTQKTQSYCGVASLVMVLNAL--RVPa------PAAAQYP 92  Burkholderi...

6TH5_A            70 PYRVFTQDNFfsnektKA-V------------IAPEVVARQGMTLDELGRLIASYG-VKVKVNHAs--dTN--------- 124 Nostoc sp. ...
Q21NE9           149 PFNFYTQCNLl-----NDeVre---------hIDVAKVLNEGMELNEIFFVVKNQP-SVVEAYCQhatsaqnkgelpasd 213 Saccharopha...
Q7V6X1           105 NYHFWTQDNIf-----NSdSsq--------vvISPAKIRRQGMTLQELQNLLSHHG-VSSKRLHGd--iLS--------- 159 Prochloroco...
XP_001750428     104 PYNYFTQSDVf-----TPcAvn--------qnITEAYVATHGLTLAQAHALLACFPaVDAQLHHAgqagAD--------- 161
XP_002504454      99 PYPYFTQRSIl-----QDaCvrrvpthedgtlMSVKFLATHGATLHEWATYLSCF--AEVEHVHAe--vST--------- 160
WP_015157589      93 PFRVFTQDNFf-----DReEak--------kvISPDIVSKRGMTLAQLGGLLASHG-AKVTVYHGs--dVD--------- 147 Chamaesipho...
WP_013323642     100 PYHAFTQTNLf-----DNpKts--------qiITAEQVSRQGMTLQQLGQLLESYS-LKVKVYYGs--eVS--------- 154 Gloeothece ...
WP_009545706      95 MYHRFTQDNVf-----DNpKte--------siITKETVSRQGMTLQELAGLLKSYP-VEVEVYHGn--eVS--------- 149 Crocosphaer...
jgi:Syn6312_3727 106 QRGYLNQDTIf-----Tp-Qtn--------avIDRHLIAHQGLTLSQLAEFLQTYP-VTVERYYGs--dLG--------- 159
Q63T30            93 PFHYFTQDNVl-----Gd-Ate--------riRPRALIERHGMTLDQLGALANALG-ASGDVRHAs--dVS--------- 146 Burkholderi...

6TH5_A           125 ----------IEDFRKQVAENLKQ-----DGNFVIVNYLRKEIGQERGGHISPLAAYNEQTDRFLIMDVSRYKYPPVWVK 189 Nostoc sp. ...
Q21NE9           214 aphncgvdqdyntFMKTITNALNTp-----rHYVIANFAGAPSPERG-GHFSPIAAYHKASDSFLIMDVARYKYPPFWIS 287 Saccharopha...
Q7V6X1           160 ----------LQAFRSLIKANLDDs-----sDRLIVNYDRKVIGQKGGGHFSPLAAYDAVTDKVLILDVARYRYPSVWVK 224 Prochloroco...
XP_001750428     162 ----------LAAFSRDLNATSQGt-----hALIIINFLRTGMHQEGGGHFSPLAAYDPVSDRILVLDVARYKYPSFWAT 226
XP_002504454     161 ----------AAAFRDVVKAVFPTtrgakAEKFVGINFLRTGVGEDGGGHMSPIAAYDETADRVLIADVSRYKYPPVWAR 230
WP_015157589     148 ----------LAQFRSLLVQNLAKr-----dNFAIVNYLRKTIGQERGGHISPIAAYNQRTDRFLILDVSRYKYPPVWVK 212 Chamaesipho...
WP_013323642     155 ----------LEQFRQLVMKNLEQp-----nNYVIVNYLRSTLHQERGGHISPIAAYNKETDRFLILDVARYKYPPVWVS 219 Gloeothece ...
WP_009545706     150 ----------LPEFRQRIINNLKQe-----nNFVLVNYLRSTIGQERGGHISPIAAYNEQSDRFLILDVSRYKYPPVWVK 214 Crocosphaer...
jgi:Syn6312_3727 160 ----------LAEFRQILGISLGKa-----nQYILVNYLRSSIGQETGGHISPLAAYHAEQDQVLILDVARYKYPPIWVS 224
Q63T30           147 ----------VDVFRADAIAHLGRp-----gRYVLVNYLRSRLGQQTGGHISPLGAYDAAADRFLILDVSRYKYPPVWVT 211 Burkholderi...

6TH5_A           190 TTDLWKAMNTVDSVS-Q 205 Nostoc sp. PCC 7120 = FACHB-418
Q21NE9           288 SKELWQAMQKIDSGS-G 303 Saccharophagus degradans 2-40
Q7V6X1           225 THDLWRAMRTLDGIS-G 240 Prochlorococcus marinus str. MIT 9313
XP_001750428     227 RQDVFNAMNTIDSSS-Q 242
XP_002504454     231 LTSVYGAMNTTDDAS-G 246
WP_015157589     213 AVDLWQAIRTTDTDS-G 228 Chamaesiphon minutus
WP_013323642     220 ASELWQAIRTLDQAS-N 235 Gloeothece verrucosa
WP_009545706     215 AEDLWKATNTIDSVS-K 230 Crocosphaera subtropica
jgi:Syn6312_3727 225 VQALWQAMGTIDPVS-G 240
Q63T30           212 TADLYAAMNTPDADSgG 228 Burkholderia pseudomallei
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