8DAU


Conserved Protein Domain Family
NPL4

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pfam05021: NPL4 (This model is not part of the current CDD release)
NPL4 family
The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.
Statistics
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PSSM-Id: 516577
Aligned: 23 rows
Threshold Bit Score: 472.524
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8DAU_G       262 RFGYMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMdveQVKNEMLQIDRQAQEMGLSRIGLIFTDLSDAGAGDGS 341 brewer's yeast
XP_002632107 151 RVGYLIGQYQPHPEVPLGIKATVAAIYEPPQHCREDGIEF---LEDKNEKIVDKLLEMLGLQRVGWIFTDCWTAARAEGT 227
EDO30963     172 RLGFLYGRYEEHKDVPLGIRAVVAAIYEPPQEGTPDSLEL---LPNTNLDTVNKLAADLGLRIVGWIFSDLVPDDVKKGT 248
1_pfamImport   1 RIGFLFGKYEIHPDVPLGIRARVAAIYEPPQESNRDSIRL---LDDPHDADVDELARQLGLQRVGWIFTDLLSENLASGT 77 
Q2HAC4       250 RLGILYGKYMEYDVVPLGIKAVVEAIYEPPQVDEVDGVSL---NPWENQEEINTIARYCGLEQVGVIWTDLVDAGMGDGT 326 Chaetomium glob...
A7EGK5       289 RFGYLYGRYEEYTEVPLGVKAVVEAIYEPPQVDELDGITL---NKWESEKDVDEMARLCGMERVGVIWTDLLDSGAGDGT 365 Sclerotinia scl...
P0C7N6       275 RLGFLYGRYEEYTEVPLGTKAVVETIYEPPQVNELDGISL---GDWDNEKEIDEIAAQCGLQRVGVIFTDLLDADKGDGS 351 Parastagonospor...
Q2URI8       287 RLGFLYGTYEEYTEVPLGVKAVVQAIYEPPQVDEIDGVTL---HEWHNEKEVDEVARLCGLEKVGVIFTDLLDAGQGDGS 363 Aspergillus ory...
Q1DY54       290 RLGFLYGTYEEYSEVPLGVKAVVQAIYEPPQVDEVDGITL---REWENERDVDEVAKLCGLEKVGVIFTDLLDSGLGDGT 366 Coccidioides im...
A6R538       292 RLGFLYGTYEEYTEVPLGIKAVVQAIYEPPQVGEVDGVTL---HEWGNEKDVDEVAKFCGLEKIGVIFTDLLDAGAGD-- 366 Histoplasma mis...
8DAU_G       342 VFCKRHKDSFFLSSLEVIMAARHQTRHPNVSKYSEQGFFSSKFVTCVISGNLEGEIDISSYQVSTEAEALVTADMISGST 421 brewer's yeast
XP_002632107 228 VHYTRHKDSFFLSAEECITAGMLQNAHPNVTDYSMDRRYGSKFVTVVASGDESMHVNFHGYQVSNQCAAMVEAEILCPTL 307
EDO30963     249 VKHLRDINTHFLTAEECIMAGDFQNQYVSPCRYASSGKFGSKFVTVVVSGNDENQIGFDGFQVSNQCMALVRDDCLVPTL 328
1_pfamImport  78 VKHVRNIKTHFLTAQECILAGHLQNKYPNRCKDSSNGYFGSKFVTVCVTGDEKKQVHMEGYAVSAQCMALVRDNCLIPTK 157
Q2HAC4       327 AVCKRHADSYFLASQEVVFAARMQAQHPKPSKWSDTGRFGSNFVTCIISGNEKGEISISAYQMSNDAVEMVRADIVEPSA 406 Chaetomium glob...
A7EGK5       366 VICKRHIDSYYLSSLEIAFAARLQAKHPKPTKWSDTGKFGSNFVTCVVTADETGGIAISAYQVSNTAVEMVRADIVEPSA 445 Sclerotinia scl...
P0C7N6       352 VICKRHIDSYYLSSLEIAFAARYQAKYPRPTKWSETGKFGSNFVTCVISGDDQGQIGISSYQASNDAVEMVRADIIEPSA 431 Parastagonospor...
Q2URI8       364 VICKRHIDSYFLSSLEITFAARLQAQYPKATKWSRTGRFGSNFVTCVLSGDEEGAISVSAYQASVAAVEMVRADIVEPSA 443 Aspergillus ory...
Q1DY54       367 VICRRHIDSYYLSSLEVAFAARLQARYPKPSKWSETGRFGSNFVTCILSGDENGAISISAYQASNSAVEMVRADIVEPSA 446 Coccidioides im...
A6R538       367 ---------------EIVFAAQLQARYPKATKWSETGRFGSNFVTCVLSGDEDGAISISAYQASNSAVEMVKADIIEPSA 431 Histoplasma mis...
8DAU_G       422 F-PSMAYIND--------TTDE-RYVPEIFYMKSNEYGITVKENAKPAFPVDYLLVTLTHGFPntdTETNSKF------- 484 brewer's yeast
XP_002632107 308 YtPELAYVREt------pLSEA-HYITDVQYTEKNEYGAEVLKNGRP-LPVEYLLVDVPAGMP---KEPHYTFhigtmtn 376
EDO30963     329 DdPGLGYIRE--------SSSE-QYVPDVFYKDTDSYGNEVTLLARP-MPIEYLLVQVSAAFP---VQPVYTFsp---pp 392
1_pfamImport 158 DaPELGYIRE---------SSDkQYVPDVYYKEKDVYGNEVQRLGRP-LPVEYLLVDVPASTP---LVPLYTFle---rk 221
Q2HAC4       407 D-PTQMLVRDeeed-dgsPSRT-RYIPEVFYRRINEYGANVQENAKPAFPVEYLFVTLTHGFP---EAPKPVF------- 473 Chaetomium glob...
A7EGK5       446 D-PAVMIVRSegd--ddsDTSA-RYIPEVFYRKINEYGRSVQENAKPSFPVEYLLVTLTHGFP---SDPKPAF------- 511 Sclerotinia scl...
P0C7N6       432 E-PSVMLVQSedd--neaLNRA-RYIPEVFYRRINEHGANVQENAKPDFPVEYLFVTLTHGFP---TQPNPLF------- 497 Parastagonospor...
Q2URI8       444 E-PSVMLVQSeed---dsENKS-RYIPEVFYRKINEYGVSAQQNAKPAFPVEYLLVTLTHGFP---TESSPLF------- 508 Aspergillus ory...
Q1DY54       447 D-PSVMLVQRenelenadTGNA-RYIPEVFYRKVNEYGANVQENAKPAFPVEYLFVTLTHGFP---TEPSALF------- 514 Coccidioides im...
A6R538       432 D-PGVMLVQQenhs-dddASKA-RYIPEVFYRKVNEYGANVQENAKPSFPVEYLLVTLTHGFP---TDPDVMF------- 498 Histoplasma mis...
8DAU_G       485 VSSTGFPWSNRQAMGQSQDYQELKKYLFnvaSSG-----DFNLLHEKISNFHLLLYINSL-QILS--PDEWKLLIEsAVK 556 brewer's yeast
XP_002632107 377 SKNVKFNVENRQAIGQLQGGANLTQYSG---EFS------TNQFLELATNFHFLLYLLTN-EMVQipEDWVKRLCD-AVK 445
EDO30963     393 SNGAVFPIENRENIGELQDFDAVRRHLS---QYP------PGDFLSAMSNFHLLVFLATN-DMLPl-KTHMEELCA-AIK 460
1_pfamImport 222 DAKQYFPVENRMIDGHIQDFAALANYLA---KSR------SLPFLDAVSDFHLLFYLYRMeDMLPm-KSQLGPLLE-AVR 290
Q2HAC4       474 -NNITFPIENREYVGEAQEVSAVAKALR---VN-------QKDDSINVSDFHLLCYIHAM-GVLA--KEEEALLCR-VAT 538 Chaetomium glob...
A7EGK5       512 MAKNSFTIENRLVIGQEQDIKDVGKQLG---LDKngqltQSSDGVLAVSDFHLLCYIYSM-GILS--KEEMALLCR-VAT 584 Sclerotinia scl...
P0C7N6       498 -TGGKFPIENREIMGEMPDVSALGKSLN---AKAnglalNTTSGLNAISNFHMLCFIHNL-GILS--KDEESLLFK-VAS 569 Parastagonospor...
Q2URI8       509 -VEGNFPIENREVIGESQELRHVAKKLV---SHG-----DPDKAIRAVSDFHLLCFLHSL-STFS--KDEEALLGR-VAT 575 Aspergillus ory...
Q1DY54       515 -ADTTFPIENREVIGESQDIRNVAKKLL---SRS-----DPDEAIRAVSNFHLLCFMHGL-GILS--KEEEALLCT-VAR 581 Coccidioides im...
A6R538       499 -NNSTFPIENREVIGESQDLRMLADKLV---SHG-----DPNKTICGVSDFHLLCFLNSL-GILN--KDEEFLLCT-VAR 565 Histoplasma mis...
8DAU_G       557 NEWEESLLKL-VSSAGWQTLVMILQ 580 brewer's yeast
XP_002632107 446 DQDRGKAMDWaQECEDWHQLMAVAH 470
EDO30963     461 NKDAEACDGW-RKGEQWGTVEQIIA 484
1_pfamImport 291 DKDKAKANEW-KTREVWKTLEELIE 314
Q2HAC4       539 QNDLAESFQL-RSTTGWQTLHMILQ 562 Chaetomium globosum CBS 148.51
A7EGK5       585 QHDLADGYQL-IATPGWANFLAILQ 608 Sclerotinia sclerotiorum 1980 UF-70
P0C7N6       570 THDTSEGSAL-QHTGGWATLLTILK 593 Parastagonospora nodorum SN15
Q2URI8       576 KHDPADGVQL-ISTPGWATLVTILQ 599 Aspergillus oryzae RIB40
Q1DY54       582 THDPADGVQL-INTPGWATLVTILQ 605 Coccidioides immitis RS
A6R538       566 SHDTADGMQL-INTSGWATLVTILQ 589 Histoplasma mississippiense (nom. inval.)
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