Conserved Protein Domain Family
HigB-like_toxin

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pfam05015: HigB-like_toxin 
RelE-like toxin of type II toxin-antitoxin system HigB
This family carries several different examples of type II bacterial toxins of toxin-antitoxin systems including many HigB-like ones. The fold is referred to as the RelE/YoeB/Txe/Yeeu fold suggesting all examples of these are present in this family. Several plasmids with proteic killer gene-systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of these systems results in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.
Statistics
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PSSM-Id: 398609
Aligned: 5 rows
Threshold Bit Score: 119.535
Threshold Setting Gi: 81547447
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9KMG5          3 LEFKDKWLEQFYEDDKRhRLIPSSIENALFRKLEILDAAQAESDLRIpPGNRFEHLEG-NLKGWCSIRVNKQYRLIFQW- 80  Vibrio cholera...
Q9PFE9         15 KSFRHKGIQQFFLEGST-AGIQTKHAAKLRIQLTALESAKHPKDMNA-PGWKLHSLKGaDLKGHWSIWVNGNYRLTFAFe 92  Xylella fastid...
tigr:DNO_1039  30 KSFAHKGLKRFFEDDDT-RGIQPHHAEKLRVLLYAMDIAETIQELDI-EGAELHRLKG-KLKTHWSLKVNGNWRVIFEFk 106 Dichelobacter ...
Q9PCR9          3 VKFEDPSLERL----EAnQKYTAGLVKVFHRRIQFIRASPDERAFYAmKSLHYEKLKD-DPDNLYSMHLNDQWHLIMYLk 77  Xylella fastid...
P44138          7 EHFRDDYLYRFYQYGDThSKIPSNLYKVLARKLDMISASENINDLRSpPANHLELLEP-KENKIYSIRVNKQYCLIFKY- 84  Haemophilus in...
Q9KMG5         81 -VDGVALNt-----YLDPH 93  Vibrio cholerae O1 biovar El Tor str. N16961
Q9PFE9         93 gEDAILVD------YQDYH 105 Xylella fastidiosa
tigr:DNO_1039 107 dGNAYIVD------YVDYH 119 Dichelobacter nodosus VCS1703A
Q9PCR9         78 aKEDDTRNlvvivsIVDYH 96  Xylella fastidiosa
P44138         85 -ENNEVNNl-----YLDPH 97  Haemophilus influenzae Rd KW20
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