Conserved Protein Domain Family
TACC_C
?
pfam05010: TACC_C (This model is not part of the current CDD release)
Transforming acidic coiled-coil-containing protein (TACC), C-terminal
This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1). TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis. Maskin is also found to bind CPEB and elF-4E. Interestingly, the functional homologue (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organisation of bipolar spindles.
Links
?
Statistics
?
PSSM-Id: 516569
Aligned: 21 rows
Threshold Bit Score: 152.913
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_006677647   489 FSQRNLDEQRQRlqknFENEFEVaqle----------iqdLTLSSQNLERENQKMKDTLKQWEQAVKLMITEKdKDKQQK 558 
EFN83265       794 EKQKKHEVDLEK----QKATfqek-------------inkLQAQVAQEVKMKTQMSVVVEEYEKSISRLLTEReRDRTNF 856 
Q95TU9        1089 HNYNDMDELEKK----IKNEVTRsediekklkegelreeaLIKRITEKDKTNAKLNGVIEAYEKAIAELISEKeQQAQLH 1164 fruit fly
7_pfamImport     1 YDNLD---AINP----FQGSNMI----------------------------------LLSPAKPVVDHPPENIqEEPNVE 39  
XP_007247623   804 YSQKDMDAAMER----ARKQAEEke-------------eeLKAQIAKMTMDNEHMVLIVSEFETIIAQITAEHkQKEELV 866 
XP_005157032   737 YSQKDMDAALQK----ADRQSEErq-------------qeLKSQIEKLQLENQQMLFIMSEFETTITQITDEHkQKEALA 799 
5_pfamImport     1 VSQKNLDMMIKA----MQMENLE-----------------LKSKYEELHLKYLEMRKIMGGFLGTVPQETEEAqKQK--- 56  
XP_012915487   578 YSQKDLDAVVET----TREENVL-----------------LRSQCETLRARNLEMGKIMDGFEGIVYQAMEEAqKQKELA 636 
13_pfamImport    1 YSQKNLDSAVEA----TQKENEV-----------------LRGKCAALQERLLEMGKIMDSFEG-LYQVMEESqKQKELA 58  
3_pfamImport     1 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLLEMGKIMDSFEGTVYQVMEESqKQKELT 59  

XP_006677647   559 QAEIDRLKEQLDLAYAERNESKKELDQMSLKYKQLRVDISDLKELDERQREQISELEQTVATGNQRFDSLRAHAETKLDE 638 
EFN83265       857 EQEKAKLQEELQAANHHLTNTEAAFNDVHQKYERLKGVVSVYKNNEAVLKESIQENVDTIKTLETRYDQLKDHAMAQLEK 936 
Q95TU9        1165 ERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEI 1244 fruit fly
7_pfamImport    40 DLRQDDTLPFIPSVDNSLADVNISSTDSSVVIVTMNETVEG-QDNEEILKTRAQDYQERIKKEEQRYQILKAHAEGKIGQ 118 
XP_007247623   867 QAELSKVFQEKQQLAKDLNDMERSFSDVVKRLDRRKEVIDGFKKNEETLKQCAQSYLARLQKEEQRYQMLKTHAEEKIEQ 946 
XP_005157032   800 KMEMERVLEEKDQLAKDLNELERSFSSVVKRLDRCKEVIEGFKKNEETLKQYAKNCMDRLQKEEKRYQALKAHAEEKLEQ 879 
5_pfamImport    57 --EIAKGLKGKGQLITDMNSINTSFSGLFKGYEKQKEVIKGYSKNIESLNYECK---------------WKAHTDEKFNV 119 
XP_012915487   637 KAEIQKILKEKEQLTADLSSMEKSFSDLFKRFEKQKEVIEGYRKNEELLKKCVEGYIARIEKEGQRYQALKAHAEEKLQL 716 
13_pfamImport   59 KAEMQK-LKEKVQLMADLHSMEKSFSDLFKRFEKQKE-------NKESLKKCVE---ERVE-EAQKYQALKAQAEEKLQQ 126 
3_pfamImport    60 KAEMQKVLKEKAQLTADLHSMEKSFSDLFKRFEKQKEVIEGYRTNEESLKKCVEDYIERVEKEAQKYQALKAQAEEKLRQ 139 

XP_006677647   639 ANVEIARVRASYEKEAAAMRAKLSRVEIQMQTLDCNLKTKVQENQELTKICDDLV 693 
EFN83265       937 ANLELDGIRKQNEAETVKLHAMIRKAELKSNSLAELVEQKTKENKELAKILDEVI 991 
Q95TU9        1245 ANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELI 1299 fruit fly
7_pfamImport   119 ANEEIAEVRSKYKAEFSALQAQLRREQLKVQSVEKRLDQKEKEAQELTKLCDDLI 173 
XP_007247623   947 ANKEIADVRSKLGTEISALQVQLRREQLKVQSLEKNLEQKVKEVEDVTKLCDELI 1001
XP_005157032   880 ANKAIAEVRTKQGAEVAALQVQLKREQLKVQSLEKDLEQKAKEVKDVTELCDELL 934 
5_pfamImport   120 ADEEIAQVH-------RKVQVILTKGQMRNHSLE-IIRQKTKDYNKLIITCYDLI 166 
XP_012915487   717 ASEEIAQVRSKAQAESLAFQASLRKEQMRIHSLEKTVEQKTKENEELTRICDDLI 771 
13_pfamImport  127 ASEEIAQ---KAQTDPLVLQVVLRKKQMCVHSLKKVVEQKTKENDELTRICDDLI 178 
3_pfamImport   140 ASEEIAQVRSKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 194
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap