6MTC


Conserved Protein Domain Family
IFRD

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pfam05004: IFRD (This model is not part of the current CDD release)
Interferon-related developmental regulator (IFRD)
Interferon-related developmental regulator (IFRD1) is the human homologue of the rat early response protein PC4 and its murine homologue TIS7. The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.
Statistics
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PSSM-Id: 516566
Aligned: 67 rows
Threshold Bit Score: 117.717
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MTC_v         60 GGD-----TVD-EQGPQEDLEEKLKEYVDGLT-----DKSAKTRQGALESLRLAL-AS-RLLPDFLlERRFTLADALEKC 126 rabbit
XP_031887249   81 DSG-----DEGiGGASDASWATLLQDRIVELQdr--kRTNTKGRETTLMSYLHLV-KH-HYGGRQIsGSINEIVSALMKN 151
12_pfamImport  10 DSGa--------EDASESSWTTNLHDHIVDLQdr--kRTNTKIREATLMSYLHII-KH-HYAARQVsPHLNAIVSALVRS 77 
XP_014174278  108 GEG------ERgTAASQNTPEDTLHACITLLQdr--kRTSYEARINALETYLQLV-QD-HYLGSCVaDALPTVLEQLLKS 177
XP_003346355   86 GED-------VnEDDTNNTWPDRLQDRITELLdr--kRSSAQGREATMKAYEHIL-KH-HYAQKYIeRNISDISAALIRS 154
Q2GY70         78 VDG-------DeDVGSTTTWVERLQDRVTELQdr--kRSSVQGREATLGGYNHLL-KH-HFAQGQLqRSVAEIMPVLLRD 146 Chaetomium glo...
EMR66248       73 DDG-------EdNNGVTTAWTDRLQDRITELLdr--kRSSAKGRESTLNAYAHLI-RH-HYAAEQVeGHFGELVPALLRS 141
XP_002489916   87 LKEpsdldQVKrNKEITNQDLYSTDNLISSLTstsrtQVSQESRELLLAQLFNLYtTSsRYQHTYDeFQLEQLIRVFINA 166
O42973         28 DQLsvgsmEDSgILKGSKTWLEELESTIDDLIev--kKIGAKEREEHLEKIYVIC-TR-HYAKR-IsENVASLEELLLKI 102 Schizosaccharo...
XP_013024407   26 DQLsvgssEDLnMVENPRTWNQQFESIVDELLev--rKVGSKEREGHLRKLYNLC-TR-YYVKR-VaEKIGPLEEILLKL 100
6MTC_v        127 LKKGKGE--EQALAAAVLGLLCVQlgpgPKGEE---LFHSLQPLLLS-VLSDSTa-SPAARLHCASALG--LGCYVAAAD 197 rabbit
XP_031887249  152 IRSGGSTv-ERIYSLKSLQATLLT----SPSEV---LFDDIYPQLEK-TCEDDE--DSDVKAAAIWAMA--IATLYAGGS 218
12_pfamImport  78 VRSGNSSv-ERLFAIKSLQATLLT----CPSED---LFEDLHSQLEQ-VCENDE--DNNIKTAAIWAMA--VAALYGGAS 144
XP_014174278  178 IRRSNTDpeEQMLALQALIVTTLT----CPKEDsarILESTFSPVRA-VCKAADv-HEKSKVIAVEALT--MVVVFGGGT 249
XP_003346355  155 IRSGSSDq-ERLFALKALTATILT----CPSET---IFDHVWSVLKV-ATEDGE--EDKIKVEAINAIS--IAVTLGGGS 221
Q2GY70        147 VKNGSSDe-ERLRALKAFTLTVLT----CSSDT---VFEQALPILKA-ACHDSE--EEDNKIEAIHALS--IAVTYGGGS 213 Chaetomium glo...
EMR66248      142 VRGGANHe-ETVAALKALTLTILS----AQSET---VYDQVWNSLKG-ACENSD--EESVKVEAIDAMS--IAVMCGGGS 208
XP_002489916  167 KTEN-----EKLFALKCGAYMga----iDTEESsqiIVDEFLPLLKRdIIVDDDsvSVTLKANYIMAFSslLLVVMDGSG 237
O42973        103 FNGPRSDk-ELILTIRIMCTFCLAs--vFQVEE---LWTKTEGRFNA-LANDAE--SSGIKCESILCFS--LLTALLDSE 171 Schizosaccharo...
XP_013024407  101 FHSSRSDa-EVIITMRLLCALCLAs--vFSVEG---LWTATEGRFNA-LVNDAQ--STAVKCEAMLSLS--LLTVLLDSE 169
6MTC_v        198 VQDLVSCLACLEGVFSRSCGTGSSTshVAPAsLHGVCCaalQAWALLLTICpsahi------------------------ 253 rabbit
XP_031887249  219 EEAASEFLEYIVTIVESDGESISAA--DSGE-VVTAAL---ESWVFVASQIddit------------------------- 267
12_pfamImport 145 ESSATELLDYLVTIVESDGVSIGAE--DSAD-VVTAAL---ESWAFVASQIddia------------------------- 193
XP_014174278  250 KASANELLKFLLDIVSSDGQTAEAM--DSAG-VVTAAL---RMWAFVASYMmpdnhdsdnededssgdegptndiydnsl 323
XP_003346355  222 SSAAEEVLDFLLEIIESDGQNVGAP--DNGS-VVAAAL---RAWAFVASYVddls------------------------- 270
Q2GY70        214 TEAAEEVLDFLLEIIESDGHSVTAA--DSAP-VVTAAL---QAWAFVASHLddlt------------------------- 262 Chaetomium glo...
EMR66248      209 VEAAEDLMDFLVEIVESDGHSVDAP--DNGP-VVAAAL---TAWGFVASHLddlq------------------------- 257
XP_002489916  238 CYGIEENSEMFLEVIEGQLNSKNPS--TS---IVVNSL---QSVGIILTLIysgrggpss------------------sl 291
O42973        172 -ADVIEFGDFLISILESDGAVVNSE--DDEG-VVGCAC---QALGLLLTCVttes------------------------- 219 Schizosaccharo...
XP_013024407  170 -PDIIDFGYQLASIIESDGAVVNAE--DNED-VVGIAC---QSLGLLLTGItsys------------------------- 217
6MTC_v        254 shildRQLPRLPQLLSSESVNLRIAAGETIALLFELARDLeEDF---------------------VYEDMEALCSTLRTL 312 rabbit
XP_031887249  268 -envyAAIDAFVEQLDSTDVDVQTSAGFNIAFIFEAA----RDLeeetg------------epmnLQYDPKRLISRMREA 330
12_pfamImport 194 -dsihTALEAFVEQLDSTDVNVHTSAGFNVAFIFEMA----REYeeetg------------etmnLQYDPKRLINRMREA 256
XP_014174278  324 vaegqTALEAFIDQLQSTATEVQIAASEAIGLLFEMS----RRYeavte------------dqfgLREDPIKLAEQLRYI 387
XP_003346355  271 -vqsdQAMEAFMEQLDSTDSDVQTGAGVNIALLFEAA----RDYeeetg------------eksdLQYNQHRIMTRMAEI 333
Q2GY70        263 -dqseTAIEAFMEQLDSSDPDVQTGAGVNIALLFEAA----RDYeeetg------------qsfdMQYNQHRIMTRMAEI 325 Chaetomium glo...
EMR66248      258 -aqseQALEAFTEQLESTDAAVQIAAGINIALIFEAA----REYeeaegegdeengngassgawnLQYDQHRLVQRMTAL 332
XP_002489916  292 ndylieIAPRVVAVIDHPDFQIQLAATKLIGLIYELFDYDeGNEdeeeyde--------seafqpSPYHDEEILYSLREL 363
O42973        220 -eflaSAAEALSEQLDAASIDVQLAAGQALAALFERVNEIrPDKdeendesdv----sqtskfddIIPDRNQLLITLRDL 294 Schizosaccharo...
XP_013024407  218 -efvsSAAEALAEQLEAASIDVQMGAGQALAALYERITDThSEEengkg-----------sidndIFPDRIHLLSILRDL 285
6MTC_v        313 A-------TDSNKYRAKADRRRQRSTFRAVLHYVE 340 rabbit
XP_031887249  331 S-------KLSVKQTSRKDRRHLRKQFASIVTSLE 358
12_pfamImport 257 S-------KASVKQTSRKDRRHMNKQFASIATSLE 284
XP_014174278  388 SrgilpdgRSNTKSASRLDRRNLRETFISVATSLE 422
XP_003346355  334 V-------RDSSKAVSKSDRKQLKTNFQSIITSLE 361
Q2GY70        326 V-------RDSSKTISKKGRRNLRSNFSSIVTSLE 353 Chaetomium globosum CBS 148.51
EMR66248      333 A-------RESSKAVSKKDRKQLHASFNSVLTSLE 360
XP_002489916  364 Y-------NKGNKKTSKRDKSDTKSVFKDVIQSIE 391
O42973        295 A-------SESSKSIGKKQRKVLHQVFRNVLQTIE 322 Schizosaccharomyces pombe 972h-
XP_013024407  286 S-------TESSKSIAKKHRKVLHQTFRNVLQTIE 313
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