Conserved Protein Domain Family
IFRD

?
pfam05004: IFRD 
Interferon-related developmental regulator (IFRD)
Interferon-related developmental regulator (IFRD1) is the human homolog of the rat early response protein PC4 and its murine homolog TIS7. The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.
Statistics
?
PSSM-Id: 398602
Aligned: 73 rows
Threshold Bit Score: 111.596
Threshold Setting Gi: 754413877
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q0CBI1        51 DEDAGylsdET-AMS---IGSLDD-----LtDnPDADNHNWTQELIDVVQDILdr--kRSSVLSREESYAAFCRLA-KC- 117 Aspergillus ter...
CAY67635      66 epsrtsrsenpqSTSpnsSKKLKEpsdldQvKrNKEITNQDLYSTDNLISSLTstsrtQVSQESRELLLAQLFNLYtTSs 145 Komagataella ph...
O42973        12 SDDDS-----FdTISilsGSMDQLsvgsmEdSgILKGSKTWLEELESTIDDLIev--kKIGAKEREEHLEKIYVIC-TR- 82  Schizosaccharom...
XP_013024407  10 leDET-----MdTISilsSSVDQLsvgssEdLnMVENPRTWNQQFESIVDELLev--rKVGSKEREGHLRKLYNLC-TR- 80  Schizosaccharom...
XP_007273854  60 DEASDdeydDNmTMStlsNGTDSG-----DeGiGGASDASWATLLQDRIVELQdr--kRTNTKGRETTLMSYLHLV-KH- 130 Colletotrichum ...
ENH82002      60 EEGSDaeleDNmTMStlsNGSDSGa--------EDASESSWTTNLHDHIVDLQdr--kRTNTKIREATLMSYLHII-KH- 127 Colletotrichum ...
EFX04796      87 DDDLDdgtdSEiELDdnsDTTGEGe------RgTAASQNTPEDTLHACITLLQdr--kRTSYEARINALETYLQLV-QD- 156 Grosmannia clav...
XP_003346355  65 DEASDheydDAmTLSsanSVSGED-------VnEDDTNNTWPDRLQDRITELLdr--kRSSAQGREATMKAYEHIL-KH- 133 Sordaria macros...
Q2GY70        60 EFASDsendDImTMS---ANSVDG-------DeDVGSTTTWVERLQDRVTELQdr--kRSSVQGREATLGGYNHLL-KH- 125 Chaetomium glob...
EMR66248      54 DAASDseydDSiASSvlnS--DDG-------EdNNGVTTAWTDRLQDRITELLdr--kRSSAKGRESTLNAYAHLI-RH- 120 Eutypa lata UCREL1
Q0CBI1       118 HYIEENIRRSMSDLMAAFCRSIRQETSVr-ETTLALRALELLAIT--AFDDT---IYENVEPVLTR-AIRDST--SHPVK 188 Aspergillus ter...
CAY67635     146 RYQHTYDEFQLEQLIRVFINAKTEN-----EKLFALKCGAYMga--iDTEESsqiIVDEFLPLLKRdIIVDDDsvSVTLK 218 Komagataella ph...
O42973        83 HYAKR-ISENVASLEELLLKIFNGPRSDk-ELILTIRIMCTFCLAsvFQVEE---LWTKTEGRFNA-LANDAE--SSGIK 154 Schizosaccharom...
XP_013024407  81 YYVKR-VAEKIGPLEEILLKLFHSSRSDa-EVIITMRLLCALCLAsvFSVEG---LWTATEGRFNA-LVNDAQ--STAVK 152 Schizosaccharom...
XP_007273854 131 HYGGRQISGSINEIVSALMKNIRSGGSTv-ERIYSLKSLQATLLT--SPSEV---LFDDIYPQLEK-TCEDDE--DSDVK 201 Colletotrichum ...
ENH82002     128 HYAARQVSPHLNAIVSALVRSVRSGNSSv-ERLFAIKSLQATLLT--CPSED---LFEDLHSQLEQ-VCENDE--DNNIK 198 Colletotrichum ...
EFX04796     157 HYLGSCVADALPTVLEQLLKSIRRSNTDpeEQMLALQALIVTTLT--CPKEDsarILESTFSPVRA-VCKAADv-HEKSK 232 Grosmannia clav...
XP_003346355 134 HYAQKYIERNISDISAALIRSIRSGSSDq-ERLFALKALTATILT--CPSET---IFDHVWSVLKV-ATEDGE--EDKIK 204 Sordaria macros...
Q2GY70       126 HFAQGQLQRSVAEIMPVLLRDVKNGSSDe-ERLRALKAFTLTVLT--CSSDT---VFEQALPILKA-ACHDSE--EEDNK 196 Chaetomium glob...
EMR66248     121 HYAAEQVEGHFGELVPALLRSVRGGANHe-ETVAALKALTLTILS--AQSET---VYDQVWNSLKG-ACENSD--EESVK 191 Eutypa lata UCREL1
Q0CBI1       189 AAAIHALG--ACTIFGGAGEDAIMDQMTFFLDIAASDGQSIDAADDAGCVTAALQEWGVLAVEI---------------- 250 Aspergillus ter...
CAY67635     219 ANYIMAFSslLLVVMDGSGCYGIEENSEMFLEVIEGQLNSKNPSTS--IVVNSLQSVGIILTLIysgrggps-------- 288 Komagataella ph...
O42973       155 CESILCFS--LLTALLDSE-ADVIEFGDFLISILESDGAVVNSEDDEGVVGCACQALGLLLTCV---------------- 215 Schizosaccharom...
XP_013024407 153 CEAMLSLS--LLTVLLDSE-PDIIDFGYQLASIIESDGAVVNAEDNEDVVGIACQSLGLLLTGI---------------- 213 Schizosaccharom...
XP_007273854 202 AAAIWAMA--IATLYAGGSEEAASEFLEYIVTIVESDGESISAADSGEVVTAALESWVFVASQI---------------- 263 Colletotrichum ...
ENH82002     199 TAAIWAMA--VAALYGGASESSATELLDYLVTIVESDGVSIGAEDSADVVTAALESWAFVASQI---------------- 260 Colletotrichum ...
EFX04796     233 VIAVEALT--MVVVFGGGTKASANELLKFLLDIVSSDGQTAEAMDSAGVVTAALRMWAFVASYMmpdnhdsdnededssg 310 Grosmannia clav...
XP_003346355 205 VEAINAIS--IAVTLGGGSSSAAEEVLDFLLEIIESDGQNVGAPDNGSVVAAALRAWAFVASYV---------------- 266 Sordaria macros...
Q2GY70       197 IEAIHALS--IAVTYGGGSTEAAEEVLDFLLEIIESDGHSVTAADSAPVVTAALQAWAFVASHL---------------- 258 Chaetomium glob...
EMR66248     192 VEAIDAMS--IAVMCGGGSVEAAEDLMDFLVEIVESDGHSVDAPDNGPVVAAALTAWGFVASHL---------------- 253 Eutypa lata UCREL1
Q0CBI1       251 ----------EdlegesEdaVQIFMDQLDSGEAAVQIAAGENIALLYEKSYTP-QEDDeASsdedqhqgsgagadsddel 319 Aspergillus ter...
CAY67635     289 --sslndyliEi--------APRVVAVIDHPDFQIQLAATKLIGLIYELFDYDeGNEDeEEydesea------------- 345 Komagataella ph...
O42973       216 ----------TteseflAsaAEALSEQLDAASIDVQLAAGQALAALFERVNEIrPDKDeENdesdvsqt----------- 274 Schizosaccharom...
XP_013024407 214 ----------TsysefvSsaAEALAEQLEAASIDVQMGAGQALAALYERITDThSEEEnGKgsidn-------------- 269 Schizosaccharom...
XP_007273854 264 ----------DditenvYaaIDAFVEQLDSTDVDVQTSAGFNIAFIFEAA----RDLEeETgepm--------------- 314 Colletotrichum ...
ENH82002     261 ----------DdiadsiHtaLEAFVEQLDSTDVNVHTSAGFNVAFIFEMA----REYEeETgetm--------------- 311 Colletotrichum ...
EFX04796     311 degptndiydNslvaegQtaLEAFIDQLQSTATEVQIAASEAIGLLFEMS----RRYEaVTedqf--------------- 371 Grosmannia clav...
XP_003346355 267 ----------DdlsvqsDqaMEAFMEQLDSTDSDVQTGAGVNIALLFEAA----RDYEeETgeks--------------- 317 Sordaria macros...
Q2GY70       259 ----------DdltdqsEtaIEAFMEQLDSSDPDVQTGAGVNIALLFEAA----RDYEeETgqsf--------------- 309 Chaetomium glob...
EMR66248     254 ----------DdlqaqsEqaLEAFTEQLESTDAAVQIAAGINIALIFEAA----REYEeAEgegdeengng--------- 310 Eutypa lata UCREL1
Q0CBI1       320 dgrpadgprlikrynayhNTHELERQLQALA-------TVHGKRISKRDKKNLHSNFASILTTVE 377 Aspergillus terreus NIH2624
CAY67635     346 ------------fqpspyHDEEILYSLRELY-------NKGNKKTSKRDKSDTKSVFKDVIQSIE 391 Komagataella phaffii GS115
O42973       275 ----------skfddiipDRNQLLITLRDLA-------SESSKSIGKKQRKVLHQVFRNVLQTIE 322 Schizosaccharomyces pombe 972h-
XP_013024407 270 --------------difpDRIHLLSILRDLS-------TESSKSIAKKHRKVLHQTFRNVLQTIE 313 Schizosaccharomyces cryophilus...
XP_007273854 315 --------------nlqyDPKRLISRMREAS-------KLSVKQTSRKDRRHLRKQFASIVTSLE 358 Colletotrichum gloeosporioides...
ENH82002     312 --------------nlqyDPKRLINRMREAS-------KASVKQTSRKDRRHMNKQFASIATSLe 355 Colletotrichum orbiculare MAFF...
EFX04796     372 --------------glreDPIKLAEQLRYISrgilpdgRSNTKSASRLDRRNLRETFISVATSLE 422 Grosmannia clavigera kw1407
XP_003346355 318 --------------dlqyNQHRIMTRMAEIV-------RDSSKAVSKSDRKQLKTNFQSIITSLE 361 Sordaria macrospora k-hell
Q2GY70       310 --------------dmqyNQHRIMTRMAEIV-------RDSSKTISKKGRRNLRSNFSSIVTSLE 353 Chaetomium globosum CBS 148.51
EMR66248     311 --------assgawnlqyDQHRLVQRMTALA-------RESSKAVSKKDRKQLHASFNSVLTSLE 360 Eutypa lata UCREL1
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap