Conserved Protein Domain Family
LicD

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pfam04991: LicD 
LicD family
The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent. These proteins are part of the nucleotidyltransferase superfamily.
Statistics
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PSSM-Id: 398589
Aligned: 38 rows
Threshold Bit Score: 130.177
Threshold Setting Gi: 149936474
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P36044        490 TKANGIISWLSHGTLYGYLYNGMAFPWDNDFDLQMPIKHLQLLSQ-YFNQslIL-----EDPRQgn--------gRYFLD 555  Saccharomyces...
WP_119963389   25 CEKHGLRYYLCGGTLLGAVRHQDFIPWDDDIDILMPRPDYERLQE-VIKE--QPfl--pEHKFLstslgnldepyTKLAD 99   Clostridium s...
CDC06053       23 CDEEQIRYYLSSGTLLGAVRHQGFIPWDDDIDIMIPRPDYERFLR-VASEk-LPp---yLALCHytkdcnypfrqAKVVD 97   Clostridium l...
EDO62957       22 CEKHSLEYFAIDGTLLGAVRHGGFIPWDDDVDIGLPRDSFERFVE-LAPKe-LPssmsiNYFKYhedddkelsygVRVYC 99   [Clostridium]...
wustl:BV2880   26 CKRHDLTYYVYGGTLLGAIRHQGFIPWDDDVDIAMSRKDFEKLKQ-YQNE--FPqy--mFLDTIqqkgh--qwtaAHVVD 98   Bacteroides v...
Q87Q28         24 CERHDLEYSLAGGTLLGAIRHKGYIPWDDDIDIMMPREDYEYLLQnFAKE--YPd---fTFFNLdtkhnpypflfSKLSL 98   Vibrio paraha...
WP_011966606   44 CEKEGLTLMLSGGSCLGAVRHKGFIPWDDDLDVMMRRDDYERLIRlCKEG--RLgd--kYEFDYpnkdadaktvfLKIYR 119  Parabacteroides
CBK67710       24 CKEHNLRYYIMAGTMLGAVRHKGFIPWDDDLDIGMPRADYDLLMA-NAKEw-LPk---pYEAVCaendkeyplpfAKVQD 98   Bacteroides x...
WP_120381757   24 CKEHGLRYYIMAGTMLGAVRHKGFIPWDDDLDIGMPRADYDLLMS-HSKEw-LPq---pYEAVCaendpnyplpfAKIQD 98   Bacteroides s...
Q832P6         27 CEEHNLTCYFCGGGCIGAIRSQGFIPWDDDLDFFMPRPDYEKLKV-LWPK--YAdt-ecYPLLVasktyndhnsfMTIRD 102  Enterococcus ...
P36044        556 VSDSLTVRINGNGKnnidarfidvDTGLYIDITGLastsAPSRDYLnsyieerlqeehldINNIPesngETATLPDKvdd 635  Saccharomyces...
WP_119963389  100 TRTRLDKYYTKDKY----------DIYLWMDIFPMd--gLPDDDAEie-----------kIYKKA----LWYRRVIQy-- 150  Clostridium s...
CDC06053       98 KRYQLVREIFSDNK----------AYDVWIDVFPLd--gLPKGRLSlta--------hkcWITFH----ILTLKLSRln- 152  Clostridium l...
EDO62957      100 NDLKIIQHVTENSQ----------PHDVNIDIMQLd--gMPKG---------------------KlknkLHQYHLLGlka 146  [Clostridium]...
wustl:BV2880   99 TRYKLEVGKGMKKA----------TMSVWVDILIId--gVPNPGTFky----------kiFSAAYltarLLYKFSNFsn- 155  Bacteroides v...
Q87Q28         99 NDSVISNGRIK-------------GVGINIDIFPId--sLGKEKGA--------------AKLRFslmkAINFFARI--- 146  Vibrio paraha...
WP_011966606  120 KNSFNIELFNENSPf---------PKGLYIDVFALd--sVPQSKF-----------------MQAmkgfVANVIQF---- 167  Parabacteroides
CBK67710       99 ADTTLIERMHLKY-----------LGGVYIDIFPLd--gVPESRMAqr-----------mHFAKY----EFYKRIL---- 146  Bacteroides x...
WP_120381757   99 ADTTLIERMHLKY-----------LGGIYLDVFPLd--gVPQSNL-----------------KQR----IHFARYEFyk- 143  Bacteroides s...
Q832P6        103 AQTTFIKTYQDGLAi---------PHGIPIDIFPLd--gAP-KGN-----------------FQRkkqkIWALIYA---- 149  Enterococcus ...
P36044        636 g------lvnMATLNITELRDYITSDENKNHKRVPTD-TDLKDLLKKELEELPksktieNKLNPKQRYFLNEKLKLyn-- 706  Saccharomyces...
WP_119963389  151 ---------lKMKTGRGGNLVKKIVKPILKPFAHLIW-GKKRTVKKLIRLCTQ------YDFESCKYVGGIACGYG---- 210  Clostridium s...
CDC06053      153 --------yhGTDYSKRTWWQCAVLKANKVIHFSRLL-SMTKEIRKFNDFLSR------YPFEQSEWCINCFGEYI---- 213  Clostridium l...
EDO62957      147 lakmtqpetiGTHLQNRPAIDRVLIFLAKHCNPFRKM-NTKKMYLRLDRCLKK------YDVRTSGQVFIFISDYR---- 215  [Clostridium]...
wustl:BV2880  156 ---------eVDLEKDRSAIETFFISFARITHIEKVI-NQHWAGCFIDWISRR------YDLDKCEYGATLGGPQK---- 215  Bacteroides v...
Q87Q28        147 -----------QRSRHDRANPIVNIAFRLFQKCLKLL-PKKWFLSAIKGLCST------CSVNDDGYAVSIGSSYL---- 204  Vibrio paraha...
WP_011966606  168 ------------ISIMVLYAQYPSKSLSEFVSLDSSL-KRRYQIKKIMGSFFGiiphakWVYWFDRFVASSKNGNPlgip 234  Parabacteroides
CBK67710      147 -----------YLIHRDPYKHGKGPSSWIPLLCRKLF-TLTGAQESIRKVMKK------YDFDQSALVCDYDDG------ 202  Bacteroides x...
WP_120381757  144 --------rvLYFIYRDPYKHGKGLGSWLPLLCRRLF-TTAGVQRSIRNVMTT------YDFDKSSLVCDYDDG------ 202  Bacteroides s...
Q832P6        150 ------------LFCSQVVPEKHGGILATGSRVLLNIfPSKKVRYHIWRFAEKrm--tkYSFGSTPYVTELCVGPRy--- 212  Enterococcus ...
P36044        707 ----crNNHFNSFEELSPLINTVFHGVPALIPHRHTYCLHNEYH 746  Saccharomyces cerevisiae S288C
WP_119963389  211 ------PQEKMPREEYVKPMKVTFGGRELIAPGCTDYYLTSLYG 248  Clostridium sp. AF15-41
CDC06053      214 ------YRESFPISWLGDGRKISFEGESFSAPQEAEKYLTKVYG 251  Clostridium leptum CAG:27
EDO62957      216 ------FREMFSRDCYFPFRELPFEDMVIRCPAQSEKVLEGLYG 253  [Clostridium] leptum DSM 753
wustl:BV2880  216 ------MGETQPKYWFGKGKELLFEDIIVNGMEETENFLTKFYG 253  Bacteroides vulgatus ATCC 8482
Q87Q28        205 ------AKEFTESSLYHDYTSCPFEDRQYKCIARYDDYLSMIYG 242  Vibrio parahaemolyticus
WP_011966606  235 tgrkyyNGEIFDASVYFPPKEALFEGEIVYIPADYDRYLTNLYH 278  Parabacteroides
CBK67710      203 ------MKGIMSKDILGTPTPVLFENEEVWGVQKYDVYLSQKYG 240  Bacteroides xylanisolvens XB1A
WP_120381757  203 ------MRGIMPKAELGAPTPVSFEGETVWGVQDYDAYLTRKYG 240  Bacteroides sp. AF39-16AC
Q832P6        213 ------MGNIYHLEDFKSAIFVPFEDTKMPIPVGYKRYLTEVFG 250  Enterococcus faecalis
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