Conserved Protein Domain Family
PigN

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pfam04987: PigN (This model is not part of the current CDD release)
Phosphatidylinositolglycan class N (PIG-N)
Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum. PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localised proteins that serve many important cellular functions.
Statistics
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PSSM-Id: 516552
Aligned: 148 rows
Threshold Bit Score: 239.44
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE09923             453 AGLRYLQTYDWLFLRALITIGYLGWMAYALT-------TVV-DLHVLDDKTrplpsKTLGNDIF---FSS--VLLA---- 515 
XP_001954652         420 NALKYYSTYLHIPVQVTTALALLGWMYFLMI-------KVS-KDSMESKEK-----SRGFVTCAtvtILS--LGLL---- 480 
Q9VGM0               416 KSLKFYHNYYHIPLVVTTVLALLGWQFYQLVklsqnvmAPH-Y------------------MRRgylTWCtiFLASlgll 476  fruit fly
XP_002013062         416 QCLDYYQDYYHTPLLVAIGASFLGWLFCLVVwlmrefsDQEpQ------------------PKMglqTWAtaLMLLlgsv 477 
XP_001954526         418 QCLDYYHSYYHIPLLVSTTLSYVAWFFCLLMqltressHPR-S------------------PRKgylTYPtlIISLaglm 478 
Q9VCV7               412 ECMEYYHGYYHLPLLVATTASYLVWFYLLLVrlaresnHPK-S------------------ERKgylTWTtlMMCLgglv 472  fruit fly
XP_001955336         452 ECIGYYTDYYKFPLLVATTASFFIWSVCMLLqltrlsmEEK-E------------------HREgylKWPtlIAILlgim 512 
WGS:AANI:GJ10050-PA  434 ECIEYYRVYYRIPLVVACLATYLGWFYYLLA-------KQT-RSMSAP----------KHHWINatnIMLllLEIV---- 491 
XP_002000563         413 ECLEYYRLYYRIPLVVACMLTYLGWFYYLLAkqgraehEPT----------------------RgwfTIAnlILLMmell 470 
XP_002069936         410 ECLEFYKNYYRSGLIAAMIASYLGWLYYLLLklsnkekKPT----------------------GglnSSItrWLMLlgll 467 
EPE09923             516 MYASFFASGSSPSYYAYAFFPVFFWKCVFGRRA-----SLaaacnklvsslgkrgaagslasssssrGARVVSLIFKAA- 589 
XP_001954652         481 VGELVFLQCSCLMTILCLLLPFGVWCLALAEMP-----C----------------------------EGRSLLEPLTHMg 527 
Q9VGM0               477 LGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPqnggwI---------------------------------FEPLKHLr 523  fruit fly
XP_002013062         478 LECLLFLQRVPCLTSFYLLLPIGIWTMALAERPlhgisI---------------------------------PYPLIHLa 524 
XP_001954526         479 VVPVIVLQNVPYLTAFYLVLPLGLLVVALAERPlegqsI---------------------------------ALPVLHLi 525 
Q9VCV7               473 LLELMILQRVPHLTAFYLLLPFGILILALAERPcqdrdLM-------------------------------CQFPVLHLv 521  fruit fly
XP_001955336         513 ALTVVVLQNVPLITGFYLLLPVGLFIMALAERGdqgnlI---------------------------------NVPIAHLa 559 
WGS:AANI:GJ10050-PA  492 VLLACYLDRVPCCISFYLLVPLPVWMFALQERG-----I----------------------------NSGCVRAPIIQLa 538 
XP_002000563         471 VALTCFLHSVPCSTSFYLLVPVPMWALALREQGlqyscM---------------------------------RAPLIQLa 517 
XP_002069936         468 LVSLMLLQKIPGWTAFYLSLPIPMWILALRERPiegrvI---------------------------------VAPITHTi 514 
EPE09923             590 LYIAVMESLALGYIYREIFTMLFVLGAFWPVTYGISF--LRK-HFALFAFWFISCLSMSSFTLL-PANKSE--------- 656 
XP_001954652         528 WIFVPAGGILVALNCPCLFGIIFVCSV---LI-YNRHg-WSY-FSPKFLAWLALLCLLCGFLWSqPAMQILmtt------ 595 
Q9VGM0               524 WIVGPAAVMIASIYCNCPLSLAYILCV-----GFYNRrgWLH-PSPKFLAWLALVLLLGGFLWSqKGMQILmtt------ 591  fruit fly
XP_002013062         525 WTVIPAGLVVATSFMNRHVGLMYAGVA-----VAYNRhgFRR-PTLKFFIWLGTVLLPSGFMIVkQNYSFElm------- 591 
XP_001954526         526 GIVVPAGLLILMAFENTHIGILYGLLT-----IFGNTkaFCH-QSWKTVSWFLLVILLTVILMAkQNSWLDwlihpihdl 599 
Q9VCV7               522 GIVMPGVLLILMAFHNSHIGLLYLPIV-----CLNNRraFFR-PSLKLIFWLALVFLLSGILLVkQSASLHfitdtigvy 595  fruit fly
XP_001955336         560 FIMIPAGLLVLMVFTYQHLAVLYTALV-----CLHNRraFRK-PSIKFFVWLSMVVLMGGGLYLqQNPKKKfdvl----s 629 
WGS:AANI:GJ10050-PA  539 WIGGTVVLLIGTYFFKQLISLGFLIVVCANNG--RAF--TRA-PRLRFWLWLALVALLTGFTIKrPDFGRN--------- 604 
XP_002000563         518 WIGAAVVLFIATYFFKPLIALGYLIVV-----CANNGhaFTRaPRLRFWLWVAVVALLTGFTVKrPDFGCN--------- 583 
XP_002069936         515 WIGSISSLLVAAFFDRRLLWMGFVLFR-----CACNRqgFAQ-PSVKFVTWFFLVVLLGLFTMVpPSLGRR--------- 579 
EPE09923             657 --NIGLIMLGGAVMVVIGIIYlvfeetiisdfaaasksaskavvtnatavakdpiSRALLgAQVGLIIL-SMLVTRSSAL 733 
XP_001954652         596 eyRVPLQAASMFMVVLRPFVL----------------------------------KHQFP-GHVWLLNV-VALVAGGVGI 639 
Q9VGM0               592 nyRVVLQAISMLVVIVRPCVLnenh------------------------------------kwkVWVINgGILFVAAIGI 635  fruit fly
XP_002013062         592 -pSEYVLGFSMCLAVLLPWILghkh------------------------------------qmrVWLINsFILLIGIYGI 634 
XP_001954526         600 vrNSHVLFVSMVLSLLRPVVMshql------------------------------------sirVWTVNlAALLFAGYGV 643 
Q9VCV7               596 igNSHVVYFSMILSIIRPLILghqh------------------------------------strVWIVNmAALLVTAYGI 639  fruit fly
XP_001955336         630 iqNNYLLHMGMLLALVRPVFLghhh------------------------------------eppVWIFNtITLMLGAYGA 673 
WGS:AANI:GJ10050-PA  605 --SPYLLCLSMLVTMLRPLLLs---------------------------------ERHAC--RVWLING-AALLLGAYLV 646 
XP_002000563         584 --SIVLLFLSMLVTILRPLLMnerh------------------------------------vcrVWLSNgSALLLATYLA 625 
XP_002069936         580 --DTKLLSFSMLFALLRPLVLrehh------------------------------------kmrIWIINgCTLVMGAYLT 621 
EPE09923             734 AIR-NKTGLPRGNQIVGLITLFSSFTvMPLAHRSRPsgnyLNRLMVVFLTFAPTFVILTISYEGLFYVAFSAVLIAWVRI 812 
XP_001954652         640 YFHeIGKTVPIYILAGSWIHLIYAILsSAYCVNSGP----RNRWEIICFNLLTVHALLSDSYSSLFVQALVTEYQMGGEV 715 
Q9VGM0               636 FLKeMGKPVPLYLFAANWAYLIYAFAsVPCSSRTTP----QSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQMGLEV 711  fruit fly
XP_002013062         635 YLSeNNLEVPLYLQVAFWAFLGYAFLsVPYSNADTP----ESRLHLISFNLIAVHALLSLSTGSLFNQMMITEFLLSHEI 710 
XP_001954526         644 YQWdAEKDVCFYVYAVCWTYLAYSFLsIPYSGVKHP----KRRVELIIFNMLTLHIMLTTSIESIVAQIMITEFSLNMDL 719 
Q9VCV7               640 YQWdADQPVCTYVYAACWSYLLFAFLsIPYSGTKDL----RRRLELIIFNMLTVHIMLTTSIGSLFVQIMVTEFVLGLEL 715  fruit fly
XP_001955336         674 YQFeANTPVWNYVKATCWSFLVYAFLsIRYFSDKLPt--aKGRLQLITLNMITLICLLSTSWGALLIQILVTEFVFGLEL 751 
WGS:AANI:GJ10050-PA  647 HQRlCKKELSPVLQGTAWGYVCYALIsIPYSDTKTP----RHRVQLILFNLSTIYTLMSLSYESMFMQLLCTEFLLGVQV 722 
XP_002000563         626 YERlSKNEINCVLQGAAWFYVLYAFIsIPYSNTKTP----RRRVQLILFNLSTVYTLLSVSYESIFMQLLCTEFLLGMQV 701 
XP_002069936         622 YRKnDNVVVLMVFRQLAIANLAYGFIcIPFSSSTTA----QCRLNLIWFNLSTIYTLLSTSFESFFMQLLLMECLMSRKL 697 
EPE09923             813 EHAVFVhtqgqipeeaeqpqiqaqpapptpkpskkkqdkaakanggsngkptngATPTSKPKATIPAAPADTASPRSLTL 892 
XP_001954652         716 HEESKQ------------------------------------------------LNEVEQADEEMQPGKETPMTSSMHLH 747 
Q9VGM0               712 HEkfk----------------------------------------------eadEDVK-----ILTSSKHLQ-------- 732  fruit fly
XP_002013062         711 HSeinqaknnailet--------------------------depesdsnnenasETTQKNEENPSTPLEHLK-------- 756 
XP_001954526         720 LQerklqkeikvredeve---------------------eiehigdnqevseelELDRVIP--SKSPLKHLK-------- 768 
Q9VCV7               716 YEesfsyanlkda------------------------------ianqqqnnqglEESRNES--PNNPLEHVR-------- 755  fruit fly
XP_001955336         752 YEeskqvkddgkv------------------------------vadkeeeeeeqEEIAVEEELSYNPEGYLK-------- 793 
WGS:AANI:GJ10050-PA  723 HEDYKQ-------------------------------------------------SAVEDSEDDDEQTPDKSLTPEGHIN 753 
XP_002000563         702 DTgkknltd---------------------------------------sedsegVEDEAKPDKSLSSEDHIN-------- 734 
XP_002069936         698 NG-------------------------------------------------------------------EINLYKGCPLK 710 
EPE09923             893 ADARIALFFFVLLQSAFFSASNVASVSSFSLDSVQRLIPVFDPFSQGALLIVKLLVPFALISANLGMLNVRLGVAPSALF 972 
XP_001954652         748 MSYRFAVSILLYFYVSLLGSGHWIGGFTYLGNTARLYLPEPYSVPMALLVLIHLLIPVFVFLSSLRAKSSFARLGTRSII 827 
Q9VGM0               733 MCYRFAVSILLYFYASLFGTGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASVVALSSFGRQQIRTIF 812  fruit fly
XP_002013062         757 LSYHYAAFILFYFYLSFFGSGHWLFSFAFKPTTSRLLISNYSPFIMTALIILKILIPSIIVISGVYTFSAYARKKSRAVF 836 
XP_001954526         769 ESYRYAIIFLVYFYVSFFGTGHWFFNFTFKATVSRLFLSSFSLHLSVALILLKIFIPSIIIMSSVYALVSFGRKNARSIM 848 
Q9VCV7               756 QSYRYAALILLYLYISFFGTGHWFFNFTFKPMTSRLFFPQFHLHMLVAFILLKIFIPSIIVMSSIYALVSFGRKNVRSIF 835  fruit fly
XP_001955336         794 QSYRYAFAILMYFYVAFVAAGHWVYGFQFVPTTARLFYSHISMALSGSFIILKIGLPAVIVIATLYALVPFARHNSRSII 873 
WGS:AANI:GJ10050-PA  754 RSYRYAVLILIYAYFSMIGSGILPNINSLDASVARIFVSECSIILIGFIYVLKLMIPIIIIMSSMYAFCAHARQNLCGIF 833 
XP_002000563         735 KIYRYAVLILVYAYFSMIGTGNLLNISAFDTSFAHIFVSDCSTVLIFLLYMLKVMIPLIIIMSSLCAFRAYVRHNLCGIF 814 
XP_002069936         711 NSYRYASFILLYAYLSFFGIGNLSSISSFDPNTGRLFMAGDTIIFTGFLVLLKLSIPSIVIIASMYLTCSFVRHNVREIF 790 
EPE09923             973 MVVMAMSDVLTLYFFWVVKDEGS 995 
XP_001954652         828 TCLVLICNAVVLFYVVFIDHRSD 850 
Q9VGM0               813 SSLMLICNAVVLFFVVFVPHNAY 835  fruit fly
XP_002013062         837 ICMFLISDVMCFYFCFYVQNQGS 859 
XP_001954526         849 ICVFLVNDAMSLYFCFYVENRGS 871 
Q9VCV7               836 ICLFLMNDAMSLYFCYFVINRGS 858  fruit fly
XP_001955336         874 TCMLLISNVMSMYFCYFVGNEGS 896 
WGS:AANI:GJ10050-PA  834 ICIFLICDVLCLYFFFFVRNSGS 856 
XP_002000563         815 ICLFLICDVLCLYFFFFVRNSGS 837 
XP_002069936         791 ISLFLMADTMSLYFLLQMRSEGS 813 
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