6G18


Conserved Protein Domain Family
RIBIOP_C

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pfam04950: RIBIOP_C 
40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
RIBIOP_C is a family of eukaryotic proteins from the C-terminus of pre-rRNA-processing protein or ribosome biogenesis proteins BMS1 and TSR1. These proteins act, in the nucleolus, as a molecular switch during maturation of the 40S ribosomal subunit. This domain, domain IV of translation elongation factor selb, adopts the same fold as translation proteins such as domain II of GTP-elongation factor Tu proteins.
Statistics
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PSSM-Id: 398554
Aligned: 196 rows
Threshold Bit Score: 163.058
Threshold Setting Gi: 402471170
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6G18_UU       488 VDTPRDVAARIRFQKYRGLKSFRTSPWDPKEN---LPQDYARIFQFQNFTNTRKSIFK-----EVEEk------------ 547 
EFC48321      781 NDDILDELQKKRMEKKKSFDAQFDEKK-SSDKkegSAGVEEEEEDPITTIEKLKKKLReddpqMILNktefqn-----lt 854  Naegleria gru...
XP_001470226  786 QGGSLTEEQERLLQKKMAKKRAFDQDYd-------TGNVDGGKNTTFSYYHRLNRQVEe---kKERInealddv---gdd 852  Leishmania in...
Q384C0        744 GGKPLTEEQERLLQKRMAKKKAFNELYd-------M----GGKNNTYSHYHEMTREVEa---kKERLdtalqev---ghd 806  Trypanosoma b...
Q4CLA7        210 SGKTLTEEQERRLQKKMAKKKAFDESYd-------M----GDRSNTYAHYHQLTRVVEe---kKQRLdaalqem---ged 272  Trypanosoma c...
XP_011616339  708 NQANDEDLQKKRLEKKRKLRELFDESYDDGDAk-yLDVLKEEVQKQAELNRVEFEHMDd----ETRVq------------ 770  torafugu
XP_023197045  707 KMDNEEVQKNKRLEKKRRLKERFNSEYDDGDAt-yFDDLKEELQKQAELNRATFGDMDd----ESRVq------------ 769  southern plat...
EEQ83069      342 iiSESSDDEQDFESIKQQVKERFRKEA----------------FSENDFVEKFNEKYVe-----KINtadniylqekhli 400  Nosema cerana...
Q7RG00        765 EDEQNDEMDEKNEKMDDEMNEKVDDEMN----------DKSEAKGVRPIEENLKLAKEk----KEKEkakfl------et 824  Plasmodium yo...
Q8I275        968 SDDNNSNSDDNNSNSDDNNINSDDNNINSGDDnnlKDKDKGNIGNEINIKENLKKLKEe----KLIEkekfr------et 1037 Plasmodium fa...
6G18_UU       548 ---EVeGAEV---------GWYVTLH--VSEVPVSVVEcfrqgtPLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKAKEE 613 
EFC48321      855 reqRE-EIEGis------pGSYVRLE--INSFPTEFIEnvnfknPIIVGGMHPEECRMGLIKMRMKRHRWYPRTLKNKDP 925  Naegleria gru...
XP_001470226  853 mdkKI-QLVGyf------sGLYLRIV--IDSVPVEFLKafdpavPLIAGGINAGEDEFRIVQARIKRHRWFPKILKAQDP 923  Leishmania in...
Q384C0        807 itnKI-KLVGhf------sGLYVRFV--LENVPVEFVQlfdpsvPIIAGGVNAGEDQFQVVHAKLKRHRWFPKILKAQDP 877  Trypanosoma b...
Q4CLA7        273 vakKI-QLVGyf------sGLYVRFV--LENVPVEFVRlfdptiPLIAGGVNAGEDQFQIVHARLKRHRWYPKILKAQDP 343  Trypanosoma c...
XP_011616339  771 ---YE-GFRP---------GMYIRVE--ITSVPCEFVTnfdphyPIILGGLGSSESSIGFLQMRLKKHRWHGRILKTRDP 835  torafugu
XP_023197045  770 ---YE-GFRP---------GMYIRME--IGSLPCEFVTnfdaryPIILGGLGSSEGNLGYLQMRLKKHRWYERILKTKDP 834  southern plat...
EEQ83069      401 eenKL-KTEQfkirdiaypGEYVKIY-----LDIDFDKntdfskIIILGINLISETKQEILQGKIKTNKWYNKLLKTNDP 474  Nosema cerana...
Q7RG00        825 eeiGI-ISNAygts--vniGEYVKIEiiIKRSKLEILKn----nIIICGGLQRYEEKNSIIHCRIKKHRWFPKVMRSNDP 897  Plasmodium yo...
Q8I275       1038 ekiGV-LNSGygss--vniGEYVRIElnIEKKKLAILKn----nLIICGGIQTYEEKDSLIHCRIKKHRWFPKLLRSNDP 1110 Plasmodium fa...
6G18_UU       614 LIFHCGFRRFRASPLFSQHTa-ADKHKLQRFLtADMA-LVATVYAPITFPPASVLLFK--QKsnGMHSLIATGHLMSVDP 689 
EFC48321      926 LVFSIGWRRFQSIPTYCMQDd-NGRHRQIKYT-PEYMhCIAAIYGPFVPQNTGVIAFQtlSEkvDTFRVSATGYVMEMDQ 1003 Naegleria gru...
XP_001470226  924 LLLSMGWRRFQTQPIFSTEDp-NGRCRYLKYT-PLHMhCMAAFYAPVAPPNTGFLAIPvrDPrvSSFRIPCTGYTIGNDV 1001 Leishmania in...
Q384C0        878 LLLSMGWRRFQTQPILATEDp-NGRMRYLKYT-PMHMhCAAAFYAPVAPANTGFVAIPvrEQrsPNFRISCTGYTVGNDL 955  Trypanosoma b...
Q4CLA7        344 LLLSMGWRRFQTQPIFATEDp-NGRVRYLKYT-PQHMhCIAAFYAPVVPTNTGFIAIPvkEQrsPNFRVSCTGYTLGNDH 421  Trypanosoma c...
XP_011616339  836 IILSLGWRRFQTMPLYHVEDh-NGRHRLLKYT-PQNMhCGATIWGPLTSPGTGFVAVQtvTRnnVNFRIAATGVVLNLDS 913  torafugu
XP_023197045  835 LIFSLGWRRFQTIPLFHMEDh-NGRHRLLKYT-PQHMhCGASIWGPITPQGSGFLAVQsvTGtkASFRIAATGVILDLDK 912  southern plat...
EEQ83069      475 LLFSVGWRRFQSIPVYSSKT--SGENRMLKYS-FKHGfCLINFYGTIVPPGTSFSVFSe--S--AKFRVLGYGNIMDVTG 547  Nosema cerana...
Q7RG00        898 LIFSVGWRRYQSIPIYSINErnNVRIRFLKYT-TEHMhCNCTFYGPLAGVNSGILAIYnyKKi-PFYRICINGIILETNN 975  Plasmodium yo...
Q8I275       1111 LIFSVGWRRYQSIPIYSISErnNVRLRYLKYT-TEHMhCNCTFYGPLASVNSGILALYnyKKv-PFYRICINGLIIETNN 1188 Plasmodium fa...
6G18_UU       690 DRMVIKRVVLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPL----GT-HGHMKCSFDGKLKSQDT 764 
EFC48321     1004 DFSIVKKLKLLGYPKIVHKNTCIVTKMFTSDLEVAKYEGASLRTVSGLRGSVKKPFrgdkASp-GDFRATFEDKLIRGDI 1082 Naegleria gru...
XP_001470226 1002 STPIVKKLKLTGTPAKVEKTTAFIKGMFSSDVEAAKFIGAKLRTVSGIRGIIKSVM----KGkQGLVRATFEDKLFPSDI 1077 Leishmania in...
Q384C0        956 ASNIVKKLKLIGTPQKIMKTTAFIKGMFNSDLEAAKYVGAKLKTVAGIRGIVKTVL----KGkNGLIRATFEDKIFPSDI 1031 Trypanosoma b...
Q4CLA7        422 ATNIVKKLKLTGTPHKIMKTTVFVRGMFNSDMEATKFVGAKLKSVSGIRGIVKAAL----KGkDGLIRATFEDKLLPSDI 497  Trypanosoma c...
XP_011616339  914 SVTIVKKLKLIGYPYKIFKNTSFVKGMFNTVLEVAKFEGASVRTVSGIRGQIKKAL----SSpPGAYRATFEDRLLMSDI 989  torafugu
XP_023197045  913 SVTIVKKLKLIGYPFKIFKNTCFVKGMFNTVLEVAKFEGASVRTVSGIRGQIKKAL----SSpAGAFRATFEDRLLMSDI 988  southern plat...
EEQ83069      548 EHNLVKKLKLVGYPSKIMGNTAFIKDMFTSHLEVLKFKNAKVKSVSGLKGIVKNPV----GKf-GEFRGAFEGEMLMSDI 622  Nosema cerana...
Q7RG00        976 NINIMKKLKLIGEPYKIFKNTAFVKNMFNTDLEVCKFINCPVITPSGIKGLIKNKI----ND-KGDFRCTFSDQIKKSDI 1050 Plasmodium yo...
Q8I275       1189 NLNIMKKLKLIGEPYKIFKNTAFVKNMFNSDLEVCKFLNCPVVTPSGIKGLIKNKI----NN-NGDFRCTFADKIRMSDI 1263 Plasmodium fa...
6G18_UU       765 VLMNLYKRVFP 775 
EFC48321     1083 IFLRCWYALEL 1093 Naegleria gruberi
XP_001470226 1078 VFISAWKSVEP 1088 Leishmania infantum JPCM5
Q384C0       1032 VFCRAWKMVEP 1042 Trypanosoma brucei
Q4CLA7        498 VFCRAWKTVHP 508  Trypanosoma cruzi
XP_011616339  990 VFLRSWYPVTV 1000 torafugu
XP_023197045  989 VFLRSWYPVSV 999  southern platyfish
EEQ83069      623 VILKCFVPFPV 633  Nosema ceranae BRL01
Q7RG00       1051 VILKLYVNVSI 1061 Plasmodium yoelii yoelii
Q8I275       1264 VILKLYVNVKI 1274 Plasmodium falciparum 3D7
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