5XJR


Conserved Protein Domain Family
SIP1

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pfam04938: SIP1 (This model is not part of the current CDD release)
Survival motor neuron (SMN) interacting protein 1 (SIP1)
Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.
Statistics
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PSSM-Id: 516522
Aligned: 147 rows
Threshold Bit Score: 68.6384
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5XJR_2          6 PPRTPQEYLRRVQIEAAQCPDVVVAq---------------iDPKKLKRK------QSVNISLSGCQPAPEGY------- 57  human
XP_001841837   25 QPETGEQYLQKVMYERKKCPSVVVVr---------------pSSKRRLQA------SGSGIVPASSVRNRAHRm------ 77 
XP_002047563   29 PPQTGEEYLMHMLYERKRCPAVVTKrs-------------kkITYNVTTN------GCEMLHSPPMPPHRCL-------- 81 
CRL03075       22 TKMTALDYLKKVRCERKKIAQVVTVh----------------PMRNGECE------RLDNAIENENKISTFDQr------ 73 
11_pfamImport   9 IPTTPEEYFRQMRAERKKQPAVVAVrvptttkktstssgkadDGCTSPEA------KKQKWFTENGVIQEKRLgretaps 82 
Q9N405         23 PAMSAAQYLRQMQAERRGTKNVVRIaqk------------spDSTSPEAKkqkqwlESVGYQEVKKIETPSPL------- 83  Caenorhabditis...
KRX90640       20 PPTSAVDYLLQVAAEREQLEKILSSv----------------SKDEKKKC------STAKFVEQRNVDDDVSQea----- 72 
13_pfamImport   6 NPQNGHEYLYMARKMEDKLPPVMTAtn-------------veLQEFINKF------ENNAPTYVIPPLELPCIknk---k 63 
12_pfamImport   7 TPRDPTHYLQQVSVSRARCPEVVTAtk--------------iPVFEVGSS------ALPKDLFFTTDPPSEQS------- 59 
KHN82307       24 PPRSAIHYLRQVAVSRKRCPQVVKA-----------------SLDPKFLS------NRQSSSNFEKEQPSCVN------- 73 
5XJR_2         58 -SP---TLQWQ--Q-QQVAQFSTVRQNVnKHRSHWKS-QQLDSNVTMPKSEDEEGWKKFCLGeklcadgavgpatnespg 129 human
XP_001841837   78 lIP---TKEWE--A-MQIQKFAELRDTItGYRNSAQYqENLQRTQIFLCFENRKQLHEYCANn----------------- 134
XP_002047563   82 -LP---TPEWR--D-AQVKSFSKARARVvALRLELNA-QHYDQSIEPPLTTDVDKWLEFCRTq----------------- 136
CRL03075       74 -NP---TREWS--E-IQKEKFLNVQQQIiELRKCPSL-DERLNSHLDVDTTDENECIKFCQTs----------------- 128
11_pfamImport  83 lIP---SPEWQ--R-GKAAQFKEHRLKIaPLTADNQT-SVERRKIADLKTQDEEKWREILFGk----------------- 138
Q9N405         84 -IP---SEEWR--Q-EKCRKFEETRAKMaLKIEKFSP-----MRIDRLNSPEEEEWHEILLEk----------------- 134 Caenorhabditis...
KRX90640       73 -----aQQELAlfYcKLVEHFEKFRHRIpDLRKLAYR-LGLMGDVSLPRPVDEKEWKQFFMDi----------------- 129
13_pfamImport  64 lLP---TKA-E--ImSYIEQYESARTKIqDTRKCITH-----PGNLLPISNSPTAWFTFLFGr----------------- 115
12_pfamImport  60 -IAmvnPSK----------RFSMQRAFVrNQRSKWKE---EAITFKWPSLRNPDAWRIFCLEerk--------------- 110
KHN82307       74 -AP---SREWA--Y-AKCDDFSWNRTLLqAKRAKYKK----PDNIVYPGWGDYERWRLFCLG------------------ 124
5XJR_2        130 idyvqigF-------------------------PPL--LSIVSRMNQATVTSVLEYL--SN----------WF-GE-RD- 167 human
XP_001841837  135 ---------------------------------qPF--VRILLSIPQRNLEILLEYL--FE----------WL-QGdGEs 166
XP_002047563  137 ---------------------------------qPL--LSTLLRLSQSDLELLLELL--CK----------WL-QEpNQp 168
CRL03075      129 ---------------------------------qPL--LSTILLLNQKQLEELIECL--SS----------YL-ADeILk 160
11_pfamImport 139 ------cLpefenqlv---------nfpnhtgtPPC--LPMVLSIPKKFLTQLIEYL--AT----------WA-AEeG-- 186
Q9N405        135 ------cLpefqdiag---------nflnhtgtPPA--LRMVFSIPKRHLSQLIEYL--VD----------WS-IEeG-- 182 Caenorhabditis...
KRX90640      130 ------vDsknc------------------ahsLPL--LSIVLPMDDKQIKQAIIMN--LF----------VL-YShG-- 168
13_pfamImport 116 ------qInas-------------------tpvNPVhnIDKIVYFFQSHCAAVICNF--VQ----------WI-MKkII- 156
12_pfamImport 111 -----npFp-----------------------iKPKdiPRFAHHRGNPPTLRLLFNL--SQsq-------tFL-EEg--- 149
KHN82307      125 -------EkeeitgkaneigeernsgrafrsghLPT--PAIVMNLSENQVNSLIQHLvqKFgcilcvacniWMfLEdG-- 193
5XJR_2        168 ------------------FTPEl--gRWLYALLACLEkPLLPEAHSLIRQLARRCSEVRLL-------VDSKDDERVPAL 220 human
XP_001841837  167 qqeesg------gtavaaSSEWi--tQWIYAILACIItPLEPYVHSVLRDIAKTCIAARNE-------LTAEDELKVLPL 231
XP_002047563  169 pvetaepstsaaakpidlLRDAwl-aRWLYANLVCLHlPLEPHVFSTLRYIARSCVLLRNE-------LQPQELERAAPY 240
CRL03075      161 tete----------lykkLNDMiwitKWLYAGLACLRlPLDPEVHSCLRVIAKSC--IQVTdyl--ktFPDTSNDSFLPW 226
11_pfamImport 187 ------------------FNRPi--rEWLFAILVIIDePLVQEAVSAIREIAKQCRNLRSQ-------LSEDRKLEAYEY 239
Q9N405        183 ------------------LNRPi--rEWIYSLLAVIDlPLVQDVVSALRRLVKECRSLRSE-------LSIDRKSEANEF 235 Caenorhabditis...
KRX90640      169 ------------------YHHNl--lQWLYALFALTFfPFSDQFRMRMKVLSSYCSVNREK--------LLKSNPKAARS 220
13_pfamImport 157 ------------------STSDv--tSWTFSVYASMDsDPSETLLSDMRILTQYFINARAE-------IEDHLDVSALRY 209
12_pfamImport 150 ------------------YTRPl--fEWIYALMLVLQkPLWHDVCSSIRQLAKHSRILRNTld----eKMPNSSKMHEEF 205
KHN82307      194 ------------------YSKQl--fQWLYSVLLVVEkPLLHDVCASLRAFAKQCRLLRATpaddssgLAVGDVPTPNEF 253
5XJR_2        221 NLLICLVSRYFDQR 234 human
XP_001841837  232 NLLICIISKNFHQL 245
XP_002047563  241 NLIITLIALYFAQT 254
CRL03075      227 NLITVVITLNFKQF 240
11_pfamImport 240 SLFITIVGVYFVQK 253
Q9N405        236 SLFITIITIFFGQK 249 Caenorhabditis elegans
KRX90640      221 FLVIRDITEYLLQH 234
13_pfamImport 210 SCLINLVSEKFKQH 223
12_pfamImport 206 SLFIAIVGVYFEQL 219
KHN82307      254 SLFIALISIYFEQK 267
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