Conserved Protein Domain Family
Wzy_C
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pfam04932: Wzy_C (This model is not part of the current CDD release)
O-Antigen ligase
This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.
Links
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Statistics
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PSSM-Id: 516518
Aligned: 75 rows
Threshold Bit Score: 36.2213
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_008402601 231 FVLFLGG--MAVIAANSDVAYIGI--GVPMVVLLLAGIRNRVktyddrmvigqnstcdPFLGWLI-GYAGIVLGYTVMAf 305 Clostridium sp....
Q5FQI9       196 AATVLAV--GIMVLAGQRMPLALS--LLGIGVCALLYRPMRP-----------------AALAAA-AMLPVLVLVARVF- 252 Gluconobacter o...
Q609Q8       225 IAVVIMA--IGLVLTRSRMGNVGF--AVSLSVTGAVYLLLAR----------------SSRFSSG-LVLAILSSIVLVDl 283 Methylococcus c...
Q4JZ62       213 FTTWILI--ITIMTTTSTTGVY----IIGLIFLYVLFSKTSG----------------VKRYVSSlFILATICCFSILW- 269 Streptococcus p...
Q97ER0       210 LYKFLLI--VCIMLTLSRT-AIGI--LLLYIIIKIIRSKNAK----------------SVVRFGI-ISLMVVLIGITLW- 266 Clostridium ace...
Q4K127       198 HNILIAL--IILFLSLKRIVFLSV--LIIIPVFLVIYWYDKK----------------VSKLGKErKILSLLNIFSLIF- 256 Streptococcus p...
Q9AQJ1       174 GALLSTI--ILPIGSGSRAGIIVVllQVIILLLNTIVIKRQT------------------IRFFL-YLVPILILLLVIL- 231 Streptococcus a...
WP_011721620 222 LLNIYIL--LTIAYTYSRTGYIVI--AIEFIIFNVLYLKQHSksi----------ykkIYATHSI-ILISIFIIILVIY- 285 Clostridium novyi
Q04RV1       208 QGIILLSflYVVFLNNARSSMLGAifSSITAFLVLGIVRKELps------------akILLFASG-ILMLLLVLGIVLS- 273 Leptospira borg...
WP_015753321 191 IILIFLL--GILLLLSSRS-TIVF--TLILSVFLLWRARKIAs---------------TPEFLGI-IAIIVLAVVFVFS- 248 Robiginitalea b...

WP_008402601 306 lttgtgkgydkltglaklvdhrliltiesivlvIGSLLYGWGSRKKADcvvaqkkglrsvkdkkqastmgcwkvifwsvv 385 Clostridium sp....
Q5FQI9       253 ---------------------------------SPGSFFHLVTLARQ--------------------------------- 266 Gluconobacter o...
Q609Q8       284 --------------------------------vIVGSYFGIEEVARRLe------------------------------- 300 Methylococcus c...
Q4JZ62           --------------------------------------------------------------------------------     Streptococcus p...
Q97ER0       267 ---------------------------------IAISKYNVYFF------------------------------------ 277 Clostridium ace...
Q4K127       257 ---------------------------------ITGIFFYVYSVKSDFiyt----------------------------- 274 Streptococcus p...
Q9AQJ1       232 ---------------------------------RFDNLVSIYNRII---------------------------------- 244 Streptococcus a...
WP_011721620 286 ---------------------------------KLDLSNNLISLL----------------------------------- 297 Clostridium novyi
Q04RV1       274 ---------------------------------FTQVGQKITDPLF---------------------------------- 286 Leptospira borg...
WP_015753321 249 ---------------------------------NRALIEKFKDAVNFDgqy----------------------------- 266 Robiginitalea b...

WP_008402601 386 gililtafvtvvtgvgnqweifTFDDEWGN--YRGYVWNRLFRIYQ-DLPFvnkvFGTGnes----------iyTLMSAR 452 Clostridium sp....
Q5FQI9       267 ----------------------QLTHFGQS--PYGEIYTHAVVMAQ-AHPW----IGQGydayrhfcaapstfhGIAGLS 317 Gluconobacter o...
Q609Q8       301 ----------------------QTTVAEAS--NRVDLYDYAVPYVLdYLP-----FGAGa--------------GSFVAS 337 Methylococcus c...
Q4JZ62       270 ----------------------DNKSGTGSatIRFDDYKAGFLAWQ-KSPI----WGLG---------------ISDGLR 307 Streptococcus p...
Q97ER0       278 ----------------------SASYIKAD--NRWIKWQVAIEYIK-KY------WAIGa--------------PFNIKV 312 Clostridium ace...
Q4K127       275 --------------------fiQEHNINSM--ARTDLWKGVESTYN-FAPIf---MGRGig-----------fvTKWMDN 317 Streptococcus p...
Q9AQJ1       245 ----------------------NLRSGSSE--SRFSLYKDTVHSVItDSLF----LGKG--------------------- 275 Streptococcus a...
WP_011721620 298 ----------------------DKNNISNI--TRFTSQKISLDLGI-NNFV----FGVGlgqyaf----yfkdiIKNYPI 344 Clostridium novyi
Q04RV1       287 ----------------------GKEKHTDS--GRTFIWDSTFPLIR-DNFF----AGVGpgnydr---eieksrKEHSEK 334 Leptospira borg...
WP_015753321 267 --------------------evTEYWGGRG--FRELIWDCTAHVIE-ANPA----LGTGygdq--------qteLELCFR 311 Robiginitalea b...

WP_008402601 453 YSDEMIEVTGTVYDSAHNEYLQYLVTMGIVGLITYL 488 Clostridium sp. L2-50
Q5FQI9       318 DAIPEQGWLSLCVQHPHNHYLQALVNAGVPGLILFV 353 Gluconobacter oxydans
Q609Q8       338 FLPYGGAEVVIPYDHAHNDYLEFLGEWGVVGWLPTA 373 Methylococcus capsulatus
Q4JZ62       308 AIEQHMDRTVRYNLGYSNSFFVVLAQGGIMLASYYF 343 Streptococcus pneumoniae
Q97ER0       313 QMYAYVNSAITSVEFSDNLFLEIASRFGVPLIACIF 348 Clostridium acetobutylicum
Q4K127       318 NWMTLNINGLTGSMGIHNDILKYYIEIGFVGLFIYF 353 Streptococcus pneumoniae
Q9AQJ1       276 --VKELWLNSDLPLGSHSTYIGYFYKTGLFGLINVI 309 Streptococcus agalactiae
WP_011721620 345 NDELYTVLISNIWPATHNIYCRIFCELGIIGLVIWG 380 Clostridium novyi
Q04RV1       335 YRELYYFYETTQRGHAHNDYFHLFAVFGFPGIFLFL 370 Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
WP_015753321 312 RHRYQALLLKGNTFNAHNLFLQITLATGLVGLVLFL 347 Robiginitalea biformata
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