Conserved Protein Domain Family
DNA_pol_phi

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pfam04931: DNA_pol_phi (This model is not part of the current CDD release)
DNA polymerase phi
This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localised exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.
Statistics
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PSSM-Id: 516517
Aligned: 91 rows
Threshold Bit Score: 344.993
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003672725          46 YVLNRLIKGLASDRNSARLGFSLCLTEAINLALgmgdnapqgVQSINEFLDLLSKTLPIDSnt--vAtenktalkkKKGR 123 
6_pfamImport           1 YTFKRLVDGLGHTRETARPGFSLALGQVLVAFE---------EIPLQSILDRVKQKHSLQA---------------VKKK 56  
XP_002025137         111 YVVKRLIRATGADNKETVAKVGSIIRLIIRNVP---------DVNELDLLDIVERELPVNG-----Q---------PKKK 167 
XP_002067473         145 YTLKRLVRATGSDDMQSVSQSAANIHCILTSVP---------NIDIYDLLETMKRDLPVSSgiggkQ---------KKGK 206 
XP_001966550         110 YVLKRLIRSTGADDIKSVAQAASYIHCILSSVP---------GIDALEVLATLKKDLAVGS-----Q---------QKGK 166 
Q9W5E4               115 YVLKRLIRSTGADDMKTVSLAASYIHCILNAVP---------AIDAFEVLETLKRDLAVGS-----Q---------QRGK 171  fruit fly
XP_002010684         147 YALKRLIRCTGADDMDTVATSAGYILNILSSVP---------GLNPIDLLALLKHELPCNG-----S---------PKGK 203 
WGS:AANI:GJ16694-PA  147 YALKRLVRCTGADDKEAVALNASYINSILRDVP---------GLDPIELISVLKRELHASS-----Q---------QKGK 203 
XP_001992496         136 YALKRLVRCTGADDMDAVALNASYINGIVSQVS---------GLKPIELLDVLKRELKVNS-----Q---------QKGK 192 
XP_032526445          55 YTLKRLVRSLGANIAELRMGYFAALVTILTRFP---------EITVTQLLELIKKELHASG---------------SSKS 110 
XP_003672725         124 DERGILFGKLFALQALLNEPLFSTIFlsedkkkiDSSLFIRYVDELFTLGSKKNWIRESCFFTLYQTIEKLLPYA-DIEF 202 
6_pfamImport          57 LAKNAMFGNLFGVLALHQSGRLFKEP----------QVVLACVQLLQSLSPHKQHLKDLPTKTIMDILTEIPEEVfEEVL 126 
XP_002025137         168 EETLAAVGQVITASSILELSQKLSNE----------RELAPIYAKLIGYMKGREYLMCLSNNVIVESFATVPEKRfATDV 237 
XP_002067473         207 TDSLASVGQVITVYTIMQTPYF-KNa--------EPKLLTALYTILIGQLKGREYLASMSANILADSFTQLNASVfESHV 277 
XP_001966550         167 EDTLAAVGQLVTAFCIVQTPQFMEEP--------NPKLVASVYEILVSQLKGREYLVSMCSDILAGSFKKLPAEIfEEQV 238 
Q9W5E4               172 EDSLAAVGQLVTAFCILQTPQFAKAE---------PKLVTAVFQILAAQLKGREYLVSLCGDILAVSFKQLPAAIfEEYV 242  fruit fly
XP_002010684         204 EESLAGIGQLITVLCLMQTEYFDQPS---------SDLIQVVYPILIPNLKGREYLTSMCADIMGSSFAAVDVSNfKTYV 274 
WGS:AANI:GJ16694-PA  204 EETLAAVGQLITVLAIMQSQYFQQPT---------AELIAVVYPILIAQLKGREYLVSLCADIMADSFKQVSLASfQSHV 274 
XP_001992496         193 EESLAGVGHLITSYAIIKSPYFEPPA---------PELVDAIYPILVAHLKGRDYLVAMSIDIMAESFKQVDADIfESHV 263 
XP_032526445         111 EVGDVALGHILACGAVFRSGLMLKc---------TEEEQKEVLQLFETASSKKSYLSTVATLVFIDFINNLDEEQfATIV 181 
XP_003672725         203 YQLVLTLLDKYELTLSKEGLAIYLLIIyrsankkQLEkTLSDIQlSnSHW-KSNNPLARGNLPALTNILRDSnvtefqdh 281 
6_pfamImport         127 LSALKSDLA--SAFNTPEQLQLLLVALq------RFP-QSLKPKkLkKLL-GSATIINADNVPRLIEVLKM--------- 187 
XP_002025137         238 WPVLKQDISKPVSQLNLHTCDVLLAVHd------SYNnILTQDQlMaILW-----P-KKIEYSELFKIYFAA-------- 297 
XP_002067473         278 WSQLKSVILLPIAKQKIYLFDLLLAAY--------FQ-KILSRNqL-------ESALSLKNFEDVFELYLNS-------- 333 
XP_001966550         239 WPLLQSHLNKSLSALKVNTCDVLLSIHl------AYPaILGRKQlLsSLWtKK------PQYEQLFELYIAG-------- 298 
Q9W5E4               243 WPLLQPELNKPLSGLKVNTCDVLLAVHl------TFSsVLGRENiLaSLW-----P-KKPVYTQLFDLYFSG-------- 302  fruit fly
XP_002010684         275 WKILQPEINKPLTAQKLHTLDLLITVHn------RYPtVLPLEQlQsILW-RN----QPPQYEELFNFYLK--------- 334 
WGS:AANI:GJ16694-PA  275 WPLLQPELNKPITAQKLHGCDLLLSVHl------NYPkLLPLRQlQtMLWrKQ------TQFEQLFDTYLNN-------- 334 
XP_001992496         264 WPLLQPKLSASIAKQTLHSCDLLLAVHl------NYSaVLTLKKlKsILW-----QTQQSQYAQLFELYLNS-------- 324 
XP_032526445         182 WPNIKQNYKKAINEHNLDSLYFLMIVNe------KFPkKVKLRKlI-----GVPELLHEDHISDICDKLMT--------- 241 
XP_003672725         282 ekpptknnkqpPANWAPRLHFVWDILLPILttttteedtnsddkhiskkrkkikknQDSNEFIRFPEFWQMAIDESF--- 358 
6_pfamImport         188 -----------AAHSVKKELILPAVALDLL--------------------------KLSLKEDSFQLFWNKAVTEGM--- 227 
XP_002025137         298 -----------PKMYDPRIYARFGKFLGTA-----------------------------DKNSKILESWQNYA------- 330 
XP_002067473         334 -----------SISQNANAYKRFAKFLIQK------------------------------EQAKLLKQWQKYVDDKI--- 369 
XP_001966550         299 -----------STIHSDGVYSRLARFIA-------------------------------SGGQELLSAWQQFVDAKQpik 336 
Q9W5E4               303 -----------STIHSDGVYARLASFLV-------------------------------NGGKDMLAAWQQYIDSKQplk 340  fruit fly
XP_002010684         335 -----------APTLLKYTTYILGKFLAKC-----------------------------SNEQALEA-WLKHVIEKL--- 370 
WGS:AANI:GJ16694-PA  335 -----------ATMQGDGLYARLGKFLATC------------------------------SSEQVLAAWQQHIAEHLp-- 371 
XP_001992496         325 -----------ASMQSDGVYERLGKFLASN----------------------------ANGGEQLLTAWQQHIVAQL--- 362 
XP_032526445         242 -----------GVDFNSLSHPIYQECGKQI-----------------------------ANSPHLSIFWNK-IDSHL--- 277 
XP_003672725         359 FNEKA-SSERKYLGFLIFQKTIQ---S--IGknNAKlISTCFTRNF-MRSLIN---QSSDNKR--------------LLH 414 
6_pfamImport         228 FKE-P-SGPTHYLSFRLLGSALP---L--LS--LSQ-LKEVLSGEV-MMHYGE---HVVSAQKpd----------rfKLA 283 
XP_002025137         331 YEHRSqNVASKGCIFKVTKHLII---S--QKnaNEQqLIDLFASPL-MDFILD---ELLAAKTtsaknq---kpltmQFR 398 
XP_002067473         370 VTAN--NSRFKMCALQIITYVLLycnE--SS--DQRiIVELFSPNV-LEMLFN---ELQSAKRkrsekt---kashlELK 436 
XP_001966550         337 FNSAK-ACVIQVLGHIILNFAEE---D------EQP-ILDLFAPTT-IKFLLQ---ELSSVKGdkseak---kpsqkELR 398 
Q9W5E4               341 LNAAK-ACAIQVLSHVLLNFKPR----------EEQlILDIFTPTC-VQFLLH---ECSSVKWdkgegk---kpslkKLK 402  fruit fly
XP_002010684         371 PSNNI-VEKSCFISTLTNIIVYM---DenKPesRVQ-LKSIFAAEPlVTMLVE---ELRAMKKydnkkk--ggdakdKMR 440 
WGS:AANI:GJ16694-PA  372 FKHVT---AKSYIIQTLSHVLMH---YddGSrtDMQ-LEQLFTLEPlVSMLLG---ELTAAKKlnskanakakaaqrQLR 441 
XP_001992496         363 PVKRI--GAKCYIVQTLTHILLHyddDdgGKrnDAQ-LEQLFGTEPlVSMLLQ---ELASAKQrpkkski-cksaelQLR 435 
XP_032526445         278 VKH---NRNRELVSLNILNTVLL---N--LKdnVEV-IPDLLSDNF-FKLFMDwfkGLQTASKirnkrd--neddskIMV 345 
XP_003672725         415 KMSQIAIDTIVKVCE---DDPSnKLIPCLDALlFNTnvgGSINFDKLTKSKT-VSKLIsiKHLSSSTLRQLIKLFISQIN 490 
6_pfamImport         284 PEMEKYVSDFLRDCQ----DSD-KQLAVVVAF-------SSLTNNGYPVVPS-VWKVV--QHLQPAALQSYVAWLRSMFL 348 
XP_002025137         399 EICQEFECAVILLFEnpaTGDE-TKARILSNL-LRK----RGNLNELATTRRfTETLL--NTLKYGGLKILFDLYASLLA 470 
XP_002067473         437 AIFPQLEAILLLFYKskvSQDD-VKVQILMRL-LD----NAVRLESVIHLPKyIEQLI--NELSPDGVYKVYSYFRDLLF 508 
XP_001966550         399 EIVYKFEGSLLLAFEkqlKKEE-TKLQLFQKF-LEE----RLQVDLVINLPR-FSQQVi-GFLGVESLKTLYEFYQTKLT 470 
Q9W5E4               403 EICFKFEGSLVLCYEkqfQNDD-NKLHLLLKL-LE----HTLQLDSVISLPRfCQKLI--NQLSVESLHKLYDYYNNKLY 474  fruit fly
XP_002010684         441 FICRQFEAAIILCFDqifKQDD-SKLQILRPL-LEQ----QLNLDMIAQTPK-LTQTLf-TKLSAEGLDQMYDFYFENFT 512 
WGS:AANI:GJ16694-PA  442 YICRKFETALLVSFQqqlKQDA-CKLGILRPM-LQL----QLQLDNIVQTPR-FTQQLl-AQLGEQGLEQMYEFYSEQFT 513 
XP_001992496         436 GICHKFEKALLISFKhklKQQS-NKLHILRAL-LQQ----QLQLDNVTQTPR-FTQQLl-GQLDEAGRTMMYEFYREQLI 507 
XP_032526445         346 KKQKEVLMSLAKALQlpsVDSK-IRVKTLDKLlFSP---GEINFTEITGSTV-VKSIT--AGLDVDGLKKMAKSLKKVFL 418 
XP_003672725         491 A--------Ms-------------TEKEITIVNQFALDTILHVVRSHKS--EFDYDSVVEpLLNPLVKLAFFSK------ 541 
6_pfamImport         349 QpqmtklldfstrkqkdkqqvqpeMETPVSRLRKWLVARLCSIIDNHQVkkEE--ALIMD-VARFVFFHAFFSTkkvsqd 425 
XP_002025137         471 Tpv----gmEe-------------PQDNGPRNQLECVSQMQAILQHPELdaNKKERWS---MLKTILTAGVCHVasgl-- 528 
XP_002067473         509 K------------------------ESVSKSCRIYCLGRLNAILARDGL----TDENRKTeMLQMLYMATFNVNyeqk-- 558 
XP_001966550         471 T-----------------------LGDEEKLNRSYCLNQMHFILQNAQLa-EKESKWRNK-QLRQLMLAGLFHLdgsl-- 523 
Q9W5E4               475 S-----------------------LEDEDRVSRVHCLNQMQLILNHSKLsqTA--KWRQK-QLNYLLLAGLFHLdask-- 526  fruit fly
XP_002010684         513 Sn----------------------NEKLTPSDREHCLKQMQNLMHSKRN----QQ-------LRFLLNASVFHLddql-- 557 
WGS:AANI:GJ16694-PA  514 Sn----------------------NELLTRTNREHCLKQMQQLQNSRRN--KQ---------LEFLLFASLFHLndqq-- 558 
XP_001992496         508 Sq----------------------AENLGKSHREYCLNQMHQLQLEFSKrsDQ---------LDFLLHAAVFHLdaeqk- 555 
XP_032526445         419 NsskkvikeGv-------------ERNWYNNERVKAAELISYMVSHEAVkdDA--EFKIK-YMQLLMCFGFFKIg----- 477 
XP_003672725         542 -----DNE--ALNE----LAKERLYSI-LSELTGAts-----------sPKSSNAAHSWHYYTLQLILELEKSGN-Qe-L 596 
6_pfamImport         426 iketqETLsvSLDDktrgALVNSFFGL-LTSLHRVplceggnaasqkrvLGVTADGAMWIDHLAQYAHVLLNHPKhVq-T 503 
XP_002025137         529 --qpcPPAasILSDstadRCKTIFIGL-LIRSCHG----------------DIKELSKDLRKTLEFLRKFLSKTEnAnaQ 589 
XP_002067473         559 --pcsQANacEFNElkgtHFRAMFYNNlLKEARSL-----------------EDLLPQLNFFTSRVIKEFANSENeTklR 619 
XP_001966550         524 -epcaASEasAFSRqcsaRCEEIFLGS-LLHKCPG-----------------LPALCQLLQKNLGFLNKQLSKADaEtkL 584 
Q9W5E4               527 -kpceAAQasAFSRqcaaRCEEIFLGS-LLHKCSG-----------------LPGLCQLLQKTLSYLNKELGQPDaEskL 587  fruit fly
XP_002010684         558 -kkctAGDaaIFSRqaasRCEESLFNC-LVHKLGVn------------kEQLEDLNQVLRTLLLPFSRKLFKSSNeSk-L 622 
WGS:AANI:GJ16694-PA  559 -kpctADEaaVFSRqaasRCEETLFSClVNKIGTN--------------TEQLAALNEQLRPLLGQLAKKLSKPGiEgkL 623 
XP_001992496         556 -pcdgGQLaaQFSRqtasRCEEVLFSCvMHKLGSG--------------SEQLATLNGLLRGLLRQLAKHMSKPDfEskL 620 
XP_032526445         478 -----GDEsvAVSSslagSIKACFYRC-FTSRFSN-----------------VEGLVTVLSSLSSFITSMMTKEKvRskL 534 
XP_003672725         597 VNKLDADLETIKNNGLKVLNE--ISMTNT-DEMTQQSKGLELLLSMCILQLFSGD---TESLSTIEELVEFYSNSKQE-- 668 
6_pfamImport         504 SQPFTPEQRQAWDGMMESVTN--LKKKAKkGATA-ESNAFQQLFLLLGMHLFKAP---EELQDTMKDLQTCVDKAQEKka 577 
XP_002025137         590 RHAPNADQQLAWN----VLEK--LQHSDD-NESNASAQIIEVLILFVGLAQYTSCc--QLQIDILNDLMVCRNMKMKEqk 660 
XP_002067473         620 CGPRSAEQKGTWKAIENIILE--AKKQKN---TDKLKQTLDGLILFVSLTQLSGD---PRLVTVLKDLIQCKVFATSKek 691 
XP_001966550         585 LNQRDEALQKLWPHVEKLLTK----PSEE---SDVVAQSFEALILFVALALCTKS---NLPVAVLDDLIICRKNAVDKkk 654 
Q9W5E4               588 RSPRDESLQKAWKQVEKLLER----PSKE---SDVVGQSFEALILFVSLALCTKI---PPSITVLEDLIICRKNALQKsk 657  fruit fly
XP_002010684         623 RIKLTPELRKTWEKVQTVVESdpIKETEI---KA-YGLIFDTLIMFIGIATLMPNs--NMELDIIDDLLICKENAIKSks 696 
WGS:AANI:GJ16694-PA  624 RITVTPEMRVMWEKVQKVLNA----PVKE---KQALAVIFDALILFLGLAMFTPSc--NVALDLIDDLFICKQNALKTkq 694 
XP_001992496         621 RSKLVPDFQQVWPAISVVVNA----KAAAkDMTT-LALVFDALVLSLALAMFMPSc--SITPELVTDILICKQNALDPkp 693 
XP_032526445         535 EKQFDKENMDCWEMLTKVCGK--IEKNQS---KSKVENVFLILLYQLGLFLFSEPthvKIASSSIIELKSCYEHYMKDrk 609 
XP_003672725         669 -------------ESTSLVGITEILLSLLAQKKAILRKLSLSVWEHFISDIGKNELNVLLAVLPVR-ENk-QGFAHLFeg 733 
6_pfamImport         578 kkrkkkqaaeqeeEPEWVEVMVDILLSLLSQPSRHIRLVCRTVFSSICPHLNLAALNAILDVLNPD-KNs-EENSAVVvt 655 
XP_002025137         661 me--------seeDPSWQEVVTDILLQLLLETAGHWREFTNIIVKSMLPYLEQVHLTQILQRLDMD-SNp-LGEDENess 730 
XP_002067473         692 sk--------ktlDVSWKEVLTDSLLVLNLQNEQFWRKFINLVLASVIEHLEEQHLEQILAVLDMR-KNp-LSKNEned- 760 
XP_001966550         655 kk-------aggeEPDWQDVLTDALLQLLLQTGHFWREFVNLVASALIPHLRTSNLEQILEVLNMN-KNp-LSKKNade- 724 
Q9W5E4               658 eq--------vneELKWQDVLTDALLQLLLQTGHFWREFVQLVATALIPHLEHGNLEQVLEVLNMN-KNp-LSKKSdg-- 725  fruit fly
XP_002010684         697 qane---ssasesEPSWQSVVTEALIQLLLQTGNYWRQLIKSVGATLIHHLSRDNLKQILGFLDIT-KNplVGNSDIYvn 772 
WGS:AANI:GJ16694-PA  695 akdkq-rksaaeaEPNWQEVLTDVLLQLLLQTGHFWRLFVNAIGGALMPHLNKRNLEQFLELLDMD-RNp-LDDKDWd-- 769 
XP_001992496         694 ckenk-nnslsesEPCWQEVLTDVLLQLLLQTGHFWRSFVNNIFGALMPHLGSDNLGQMLDNLDMT-QNp-LGIKDGEqd 770 
XP_032526445         610 aktsk-kensikdEPEWIEVVTEVLLSILSIESSVLRSVVQCVFRLLWEYLTPSSIAQIVSVLDPEsEAnpLGQESDLed 688 
XP_003672725         734 a----deyEEDDDQEEGE----------GNEDEEENDdinssnsesdsgsssdSDSDDNDNvieNGDIANIdkeatsala 799 
6_pfamImport         656 d----dgnQTKKRKLEDD----------EEEEEETEDees-----------dgSDDDSEEEesdDAEMLEDeqeeqmgee 710 
XP_002025137         731 -----sdeNENENEGEGE----------SNDDDNDSSadd-----------ddNSEDEDED---AATLEDNaleklr--- 778 
XP_002067473         761 ------edADDDEEEDDE----------EDESEASSDeds-----------seDEDDENEKddeETEKEENeveeddten 813 
XP_001966550         725 -----eesDEEGEEEEEE----------EKDSSDDSDeed-----------seDDGDEEEDddeDGGEDEEesqlaqi-- 776 
Q9W5E4               726 ------eeESDDELDKEE----------SLKDSSDDSede-----------deDEEEDEGEddaESHLAqire------- 771  fruit fly
XP_002010684         773 s----dgdGDTSEDDEDD----------DDNDGADDDddd-----------ddDDDDADDDkeaAMDIDEAtnlevv--- 824 
WGS:AANI:GJ16694-PA  770 -------dDDDKSDEEDE----------EDEDDDDDEddd-----------ddEDDEDEDEdedDEATNLArire----- 816 
XP_001992496         771 dvedededEEMETDEDEDnepasaekqdKDEKDEDEEedd-----------deDNDDEENEdadDADDDEYddatnldq- 838 
XP_032526445         689 de---gefDDSDEEGNEN----------CQENEENGEhnd----------seeSESEMDDDdddEKDLNTPdqlrm---- 741 
XP_003672725         800 k-alnlpenivnEKGEVDlaklenmsdndldnsINDDDDDESDee------sMDDEKMMELDDQLSEIFKR-RKEAlsni 871 
6_pfamImport         711 vvdqnfrlelmkVLQQQNa--------------LATEEDASSDe-------dLDDEAMMKLDQSLSALFLE-QKKRiqa- 767 
XP_002025137         779 -------ddvrqALQNGD---------------DGASEASSVDwn------dVAEESGKRLDESLAAIFKM-RSQAsq-- 827 
XP_002067473         814 arleelresvrlALTKDM----------------ANNDDDDNDgassvdwndVDEAEGERLNAALERSFQAfKPKTaks- 876 
XP_001966550         777 ------resvrqALVAEG---------------EAEDDASSVDwn------dVDEEQGQRLNAALERSFQLfKPKSgks- 828 
Q9W5E4               772 --------svrqALVNDGd--------------ADDDGASSVDwn------dVDEEQGERLNAALERSFQMfRPKSrka- 822  fruit fly
XP_002010684         825 ------renvrkALLDDA---------------NNDDDASSIDwn------dVDEEQGERLNKALEAAFQVnKKGKgnsq 877 
WGS:AANI:GJ16694-PA  817 --------gvrqALLSNE---------------NDDFDSSSIDwn------dVGEEEGERLNQALERAFHIrKPKGakg- 866 
XP_001992496         839 -----irenvrlALLNDDn--------------DEDNDASSVDwn------dVSEEQGDRLNRALETAFHAfKPKGqsk- 892 
XP_032526445         742 --------aiqkALGNTT----------------VDTDVESIDad------mITEEEGKKLDEALAEAFKQfHQGKn--- 788 
XP_003672725         872 stgnqRKIEVKESR---ENVIAFKHRVIDMLMIYM 903 
6_pfamImport         768 --kkdEKAKLQKEK---SLVLDFKIKVLDLLEVFV 797 
XP_002025137         828 ----rKKRPTKSDRihsTTLLHFRVRVLDLVEVFA 858 
XP_002067473         877 ---eaKRRPTKSERinsTTLMHFRIRALDMLEVFV 908 
XP_001966550         829 ---laKQRPTKSERidnTSLLHFRIRALDLLDLFS 860 
Q9W5E4               823 ---qeKERPTKSERidsTNLLHFRIRALDLLELFI 854  fruit fly
XP_002010684         878 qgkdsKKRPPKSVRiteTTLLHLRVRILDLVELFF 912 
WGS:AANI:GJ16694-PA  867 ---knAKRQTKSERitdTALLHLRIRVLDLVELFI 898 
XP_001992496         893 ---skSKRQTKSERinsTTLLHFRIRVLDLVEQFV 924 
XP_032526445         789 ----kKTKKERKNK---KSLSDFRIKVLDLIDIYL 816 
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