1Q78,1Q79,2HHP,1F5A,4LT6


Conserved Protein Domain Family
PAP_central
?
pfam04928: PAP_central (This model is not part of the current CDD release)
Poly(A) polymerase central domain
In eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a template-independent RNA polymerase which specifically incorporates ATP at the 3' end of mRNA. This entry represents the central domain.
Links
?
Statistics
?
PSSM-Id: 516515
Aligned: 91 rows
Threshold Bit Score: 175.406
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1Q78_A       219 NFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEW----PNPVLLKQPEEC- 293 domestic cattle
Q7XN15       209 AFRTTLRCVKHWAKARGVYSNVAGFLGGVGWAILVACVCLLYPNASPSMLLPRFFRVFARWKW----PSPVMLRAIEHDd 284 rice
XP_018515180 218 SFRTTLRCIRFWAKKRGVYSNVSGFLGGINWALLVARICQLYPNASPNMLVSRFFRVYTQWRW----PNPILLCSIDEDe 293
XP_024403013 207 HFRTTLRYVKLWAKRRGVYSNVIGFLGGVNWALLVARICQLYPNAVPSVLLSRFFRVYKQWRW----PNPVMLCAIEEG- 281
XP_002984181 210 HFRTTLRCMKLWARKRGVYSNVTGFLGGVNWALLVARICQLYPNALPSMLVSRFFRVYTQWRW----PNPVMLCEIEEG- 284
XP_048234452 217 HFRTTLRCLKFWAKRRGVYSNVTGFLGGVNWALLVARICQLYPNAIPSMLVSRFFRVYTQWRW----PNPVMLCPIEED- 291
CBI27991     211 HFRTTLRCLKFWAKRRGVYSNVTGFLGGVNLALLVARVCQLYPNANPSMLVSRFFRVYTQWHW----PNPVMLCPIEDK- 285
XP_002140497 223 SFRTALRFVKHWSKSRGIYSNVLGYLGGISWAILTARICQLYPNSAPNQIINRFFYVYKAWQW----KNPVILCEIKEVp 298
Q4E647       188 VFTTVLKSVKLWAMRRKVYGNLYCYPSGVVLAIMVARICQVMPASHPNVLLRFFFLFYTQWLSrhdrISPVYITTSLESr 267 Trypanosoma cruzi
Q4N9S7       213 YFRTTLRFIKLWASRRKIYSTVVGYLGGVAWAILTARVCQLYPNCAPNQLIEKFFRVYSVWQW----ECPVTLCKIKEPp 288 Theileria parva

1Q78_A       294 -----NLNLPVWDPRVNPSDRY--HLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEIL-LSKA---E-WSKL 361 domestic cattle
Q7XN15       285 g--elGLSLPVWDPRRNPRDKI--HLMPIVTPAYPCMNSGYNVSHATLRVITEQLAVGDAVCQEIV-KAGSgggG-WDKL 358 rice
XP_018515180 294 g---sSLGLQVWDPRRNPKDLL--HKMPIITPAYPCMNSSYNVSASTLRIMTGEFQRGRDVCAAME-A--E---Q-WDTL 361
XP_024403013 282 -----PLGLPVWDPRRNPRDRS--HLMPIITPTYPCQNSSFNVSNSTLRVMTEEFKRGDSICDSLD-SKVA---D-WSKL 349
XP_002984181 285 -----SLGLSVWDPRKNPRDRT--HQMPIITPAYPCMNSSYNVSSSTLRVMVEEFSRANGICEVIE-MNKA---E-WSAL 352
XP_048234452 292 -----ELGFSIWDPRKNPRDRT--HHMPIITPAYPCMNSSYNVSTSTLRVMMEQFQYGNKICEEIE-LIKT---Q-WATL 359
CBI27991     286 -----ELGFPVWDPRRNPLDRN--HHMPIITPAYPNMNSSYSVSTSTLEAMMKQFHTANKICNDIE-LNKS---S-WGAL 353
XP_002140497 299 knspgLMGFRVWNPNTNPQDRA--HLMPIITPAFPSMNSTHNVTQTTLRVITEELQRGSELVKEIE-NERA---Q-WSDL 371
Q4E647       268 gr-ipGLP-DSWDP---RRDACrdDLLPVINPAYPYVNDARNVGRCSLEVFYAELTYAYRLLSNLE--------TpLEAI 334 Trypanosoma cruzi
Q4N9S7       289 ni-pgLMSFKVWDPRVNPQDRH--HLMPIITPAFPSMNSTHNVTATTKRVITEELMRALEIFKTSNlTNVE---L-WEKV 361 Theileria parva

1Q78_A       362 FE 363 domestic cattle
Q7XN15       359 FQ 360 rice
XP_018515180 362 FE 363
XP_024403013 350 FE 351
XP_002984181 353 FE 354
XP_048234452 360 FE 361
CBI27991     354 FE 355
XP_002140497 372 WS 373
Q4E647       335 WE 336 Trypanosoma cruzi
Q4N9S7       362 LE 363 Theileria parva
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap