Conserved Protein Domain Family
SHQ1

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pfam04925: SHQ1 (This model is not part of the current CDD release)
SHQ1 protein, Shq1 domain
This domain is found at the C-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ribosomal RNA and telomerase RNA processing and metabolism. This protein contains two domains: an N-terminal CS or HSP20-like domain (pfam21413) and a C-terminal region called the Shq1 domain (this entry). This domain adopts a mostly helical structure that consists of 17 alpha-helices and two short beta-strands.
Statistics
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PSSM-Id: 516512
Aligned: 57 rows
Threshold Bit Score: 188.501
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_022464704 255 EPDTQATMPIEFSDKEKEQMQkNLPHKSYSllsSE--TTKLSYITILNILFSYSFDLLENEGDQTSESIWTVGKLTPQIA 332
XP_003283120 346 INNKYSKKLITFTDEEKDIMK-NLPNKEYM---ISn--EKSLLLGLVDIIFAYAYNERVNMGYENIESAWNICKISGTLS 419
XP_004360853 391 EPSSSSNKVITFTDEERDIMK-NLPNKEYN---VKn--EKQLLLGLIDIVFSYCYNVRSTYGEDTIESAWNICKVSSTLS 464
XP_001027942 227 VASINQDTSSSYTPEEWNQLK-KLPNKEFI---INn--KNKCLMEIIDILFAFAYELRCMGGEFSCESAATINYLSSVLS 300
A0DFG4       208 VLVYEFQFQKQFTIDEINKIS-KLGKREYL---IEn--KEICLFGIIDILFAYLYENNLFQGDLNQESAITINQLSSQFQ 281 Paramecium tetr...
XP_004035954 234 QEQENHATLVSFSEEEKYQLR-KFVNKSYL---LDkrACRQVCYSLIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLC 309
XP_012399030 237 EQSNPEEFQVSFSKEENYQLL-KFTNKSYL---LDkrARYYVYFGLIDILLAYCYEIRVTEGESNVESPWNIRKLSGTLS 312
6_pfamImport   1 SSEQEGESAVPFTDDEKEQLR-KFTNRSYL---LDkaSRYQAWLSLVDILLAYTYEVRSTEGEYNVETPWTIRKLSGTLC 76 
XP_003217839 293 SNEINQPALVSFTEDEKEQLR-KFSNRTFL---LDkrACHQVYLSLVDILLAYCYEIYASEGEKNVESPWNIRKLSSTLC 368
XP_414429    232 sQNHGSHTLVIFSDEEREQLR-KFTNKSYL---LDktSRHLVYLGLIDILLAYCYEIRVNEGDKNVESSWNVRKLSATLC 307 chicken
XP_022464704 333 YLDqqlvpeepplqenvlikeathssnnpatkQESIIQSSIRAGFRRSLCYPLHRVFDLSERAWRHAYHILSGGKRLVIK 412
XP_003283120 420 CLD-----------------------------TFSNLTSVVECCLKRSLTYPLYRSWDLSARVFQDTQQIFQLGKRCLLK 470
XP_004360853 465 CME-----------------------------TFSTLKSVIVASFRRSITFPLFRSWKLASRVLEDTRTIFKLGKRCILK 515
XP_001027942 301 CFI-----------------------------CDNTLNEIIRQCYRRALTFPMLRNFKLIQQAQQDLVIILQSGRAGVLK 351
A0DFG4       282 AFY-----------------------------IDNNLENILINNYQRALTFPMIRSFEICVKTKNLLVEILE-NKINIIK 331 Paramecium tetr...
XP_004035954 310 WFE-----------------------------TWTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQLGKSAVLK 360
XP_012399030 313 WFE-----------------------------SWNNVHEILVSFGRRVLCYPLYRHFKLVTKAYIDTIKILQLGRSAVLK 363
6_pfamImport  77 WLE-----------------------------TYSSLQEVLVSFGRRVLCYPLYRHFSLVSLAIHDTAKILHSGKACVLK 127
XP_003217839 369 WLE-----------------------------TFTGMSDVLISFGRRVLCYPLYRHFSLVTRAINDTIVILQLGKSAVLK 419
XP_414429    308 WLE-----------------------------CFTSIHDVLVSFGRRVVCYPLYRHFGLVTRAFNDTVMILQLGRAAVLK 358 chicken
XP_022464704 413 VLLAVHELFRYHDVYYVYNKCLLDDLCSWFIDQGnETVIRSLALEVHKElsQVSKSTVDFLV 474
XP_003283120 471 CLLDIKKKLEGHEFKYYLNRLYIDDYCVWLQHAS-KKKLKSLKLKLSDY--KITKNIVDWPL 529
XP_004360853 516 CLLHIRKCLEGHDYKYYLNRLYIDDYCVWLQYAS-KKKLKSLTAKLNEV--VIEKMDVEWPL 574
XP_001027942 352 TLLQIKYLFEVNEPRYHLNNLYIEDFCIWVQTLK-DEDFQNLAGQIQQI--EINKKDLDLNL 410
A0DFG4       332 ILVAVEGLFSKAKPRNYLNLIYVQDYIVWAQNLK-EDELKNLSKQLKQL--QINKSQLQLNI 390 Paramecium tetraurelia
XP_004035954 361 CLLDIHKIFQENDPAYILNDLYISDYCVWIQKVK-SKKLAALAEALKEV--SLTKAQLGLEL 419
XP_012399030 364 CLLDIHKIFQENDPAYILNDLYISDYCIWIQKIK-SQKLASLAETLQRT--YITKSQLGLEI 422
6_pfamImport 128 CLLDIHKVFRENEPAYILNDLYITDYCIWIQRVK-SKKVADLAATLEKA--TLQKNDLELEI 186
XP_003217839 420 CLLDIHKIFRENDPAYILNDLYITDYCIWIQKAK-SKKLAALAECMQQT--ELTKAKLGLEL 478
XP_414429    359 CLLDIHRIFRESDPAYILNDLFITDYCIWIQKIK-SKKLAALSESLQKT--TLAKSHLGFEL 417 chicken
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