Conserved Protein Domain Family
Phospholip_B

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pfam04916: Phospholip_B (This model is not part of the current CDD release)
Phospholipase B
Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.
Statistics
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PSSM-Id: 516508
Aligned: 17 rows
Threshold Bit Score: 507.26
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011270802  60 AYGTFE-DGLMTTGWGVFEVKT---NSAFKDAEQLYAAGFLEGALTYNRIYDHYQNMFTYFFPN---ASDPSVQl-YRNW 131
3_pfamImport   1 VRACFR-DSILTNGWSQLELES---QSTYTDTVQAYAAGIMEGALTWHNIYMHWSNTIDAVCSKdeeSEEFCDW--LRGL 74 
XP_001748267  54 ARASYF-PGVNETGWADLTVEAl--TGVCNSSEAAYAMGLLEGALSQPLIYDAFLNFEASNGYL---DKGHLPSk-LQAF 126
Q9XWV2        53 ATAYFH-DEVNQTGWAFLEVDVi--SPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDG---AKHFCDE--LGEF 124 Caenorhabditis ...
EFX77541      57 AGAQFT-NAINQTGWANFEVWT---NGNFPDSVQSKAAGFLEGYLTHELIYFSYLNTLQDYCKG---RDGYCSK--LRTF 127
O62146        82 AVARWQ-NAVNTTGWTFLEVET---KENYCPQLQAYSAGYLEGLLSKTVLTYHLKNAQEDYCKN---FTGYCSR--LSDF 152 Caenorhabditis ...
Q9BL07        73 ALGKYS-NQVNTTGWGILEIET---FASHSYDVQAYGAGVAEGELTRLQIYYHYRNTIETMCNN---HTLFCKR--LYIY 143 Caenorhabditis ...
XP_020430624  63 AWCLYG-NEMMTTGWGYISIQT---NGAYNDTQQASAAGYLEGYVSAEMIYQNWYNMYVNEYKK---S---VNDk-AIAW 131
Q54ZI6        55 AWGYFK-DEMNKDGWGKLSIET---VSTVSDNIAFKAAGYLEGYLTWEYIYKFSGNYFNSFFNT---SNIKEIPteTLTF 127 Dictyostelium d...
XP_004989826  59 ALASHNlPAYNMTGFAKLHVQTkpsTSVQNDNLAAFSAGYVEGLVTADMIYNTYLNLEPE-----------HDPk-VMAF 126
XP_011270802 132 FNQQDAWTRRNVQL----NPqvsFWVQTGSILAQFDGLVAGYNAV-AASSRK--L--DVFAFQVLNGNGDILDLMNVLqp 202
3_pfamImport  75 ITTNVDTVKKMADMkgkhDY---YWYQIALFYDQLDGLEIGFRKGvKRSRMDyeI--PKQDFLLMNAAVDIRDLKIYYt- 148
XP_001748267 127 VDAQLKYISDQWSRnp-aDP---FWRQAGHLLAQARGVQDGYm---LTAPQQqqL--QPDQILILTLAGDLEDLASALvd 197
Q9XWV2       125 MVDNLKWMEQEIREnp-eDE---YWQQVNLTVNQLFGLIHGYENQlGAEIDFkqI--AVHPIFMIQIAGDLEDLAMKFkk 198 Caenorhabditis ...
EFX77541     128 LATNTKWVNKMYTKlrntSP---FWHQVGLFYEQMEGLAAGW--EkAAVNTGhsM--GTYGFMWFNIFGDMEEFEQMFap 200
O62146       153 LTENQKWIQSSLETvapdDL---YWGAVNRTYHQVSGLIDAY----EGREFKprItyELHPILYLNLNGDFYDLEKKL-- 223 Caenorhabditis ...
Q9BL07       144 LQQNLDWMRSQVQAnpptDP---FWRQVNLTFAQLTGIYDAY----SKRNLTpeIgfDLHPIYMMQLAGDMFDLNKLL-- 214 Caenorhabditis ...
XP_020430624 132 IDSNNRYMQQQVAEnl-dDP---YWQQVGLVMTQVASLFQGYND--ATTDPSqsL--EFYDILLMNMDGDMIDLAPALni 203
Q54ZI6       128 VSDNWEYMMERVNSssttDP---YWIQIRNAMSQQIGLYEGYNAA-AGEDYQ--K--TFIEIYMINLYGDMGDIVtlttt 199 Dictyostelium d...
XP_004989826 127 VQQNYNWTMDKIKHnp-qDP---FWTQVALVYQQLNGLVAGYN---AAGQKK--L--TFTDMLLLNLLVDLPTIELALyp 195
XP_011270802 203 strpswnd--mtpqqaqleAS--------RRGHCSGFIKMLP---GFEDILISHSSWFTFTATNRIYKHYNFQ------- 262
3_pfamImport 149 ------------------nFLmensglkpEPAKGIMLLKLLQqpnGQSKVLLGHTSDGSYSSMLRMVKKYTLRyhlsaet 210
XP_001748267 198 -----------------yvAPlhnefpdyEHMHCSGLVKLTI---SRDDLFTGHTTFNAYWCMLRIYKHYIVP------- 250
Q9XWV2       199 pen------------pkkvFS--------GPGHCSALVKLLP---KNEDILFSHVTWSSYGTMLRINKKYSFK------- 248 Caenorhabditis ...
EFX77541     201 qk-------------agkdWRlnkvgrrhMFASCSALIKVLP---DASDIYTSHVTWNGYESMIRILKKYNFEvhr---- 260
O62146       224 -------------------NKtrdpafeqTGGKCSGLIKVAP---GNADLFISQVTMSGFQNMLRVIKLYKFG------- 274 Caenorhabditis ...
Q9BL07       215 -------------------NKtadpmeypEGGRCSGFVKLAP---GNKDMFMAHVSMSSLSWMQRVLKIYKFG------- 265 Caenorhabditis ...
XP_020430624 204 sfdaataaalppkqhlenfMR--------KTGHCSSLIKLTD---DLTELYAGHTTWSSFYEMVRMFKIYTFA------- 265
Q54ZI6       200 pnnefi---pmdrkeveqlMA--------TTGHCTSIIKLTN---NCSDLMSAHTSWADFSVMIRIYKRINIP------- 258 Dictyostelium d...
XP_004989826 196 gkrpnvta--mtqqelkdfMA--------DTTHCSAMVKVTD---DLSDLMFTHTTWCPYSQMLRIFKVYHLP------- 255
XP_011270802 263 ----------L-NDQATA-AKRTSFSSYPAYLSSLDDFY-IMDSG---LVMIQTTNNVFNMSLY--DLVRPE-SLLAWQR 323
3_pfamImport 211 artvvsaqaaEdEDRAVVpGTNIVFTGYPGVLASLDDFYvISGRRqhrLVAAGVKMENEHVDLW--RKIDLVrSVSLAPR 288
XP_001748267 251 ----------------GVpGNVVSFSSRPGDLHSKDDYF-QTSAN---LTVIETSLTVFNKSLY--NTLQPN-SVPCWMR 307
Q9XWV2       249 ---------------TGDpGQIYSFSSYPASITSTDDFV-LTSAK---LAILETTIGNYNEKSL--DLITPN-TVLTWIR 306 Caenorhabditis ...
EFX77541     261 --------taA-EDSAVIpGHSMSFSSYPGLLYSGDDFS-VISSG---LVSMETTIGNNNVELF--KYIKPTgQVLEGVR 325
O62146       275 ------------YDRQFYpGYASSFSSYPGLLYSSDDFA-LQTSG---LAVIETTISVFNTSLF--ENTKPVgQLPTWIR 336 Caenorhabditis ...
Q9BL07       266 ------------YDVNEVpGHIVTFSGYPGVLISTDDYT-ITSAG---LTSIETTIAIFNQTLYtdKFMKPEgQVHCWIR 329 Caenorhabditis ...
XP_020430624 266 ----------F-SSSSLSrSATTMFSSYPASLSSIDDFY-LLDTG---LVVVETTNGMMNNNLY--YLVTPS-SVLSWIR 327
Q54ZI6       259 ----------V-ASTPY--GSETLFSSYPGLLVSIDDFYqIRPSK---LHLTETLNTILNQTLY--QQINAQ-SFMYWVR 319 Dictyostelium d...
XP_004989826 256 ----------Y-STTAGTkTSTVMFSGYPALLESLDDYY-ITSER---MAIMETTNGIFNNTLY--DMVNPS-TLPYWVR 317
XP_011270802 324 V-------------RLANTMAHDG-REWSHIVAQfNSGTYNNQYMVVTLDQIKL-GQ----------------------- 365
3_pfamImport 289 V-------------MAANRLGHSG-RSWARYFAR-NPSTGVKQWLVIDMSRFVG-SNetevellatspasvavdqsvedn 352
XP_001748267 308 SqlsltsstfgglpQIANRLATSS-DTWMEFFAReNSGTHNNQWIVSNYNLFTP-GT----------------------- 362
Q9XWV2       307 A-------------EIAHRTASSG-LQWAEAFGRhNSGTYNNEWVVVDYKQFHRgKE----------------------- 349 Caenorhabditis ...
EFX77541     326 S-------------MVANRLASSGiKKWTEVFSRhNSGTYNNQWMIVDYKLFKP-FK----------------------- 368
O62146       337 A-------------IVSNQLARDA-REWCKLYSLyNSGTYNNQWAVLDYKKFKP-NQ----------------------- 378 Caenorhabditis ...
Q9BL07       330 S-------------MISNLLSRTG-KQWVDMFGRyNSGTYNNQWTVLDWKQFTP-EK----------------------- 371 Caenorhabditis ...
XP_020430624 328 V-------------IIANRMASNG-ANWCTTFGReNSGTYNNQWIIVDYNKFES-GV----------------------- 369
Q54ZI6       320 N-------------LVANRLANNG-FQWVSIFVEnNSGTNNIQFVVLDYKLFTPyST----------------------- 362 Dictyostelium d...
XP_004989826 318 V-------------IVATRMTNTG-REWHERFYQyQSGTYNNQWMTIDYKLFVP-GQ----------------------- 359
XP_011270802 366 -------------------------------------------------------------------AVLD-GALWVVEQ 377
3_pfamImport 353 diaaeggqdvvadgehqrivtkrmedyvdddfkehlsairqvrmvtipkapepvageelvvepsvghTFGS-GMFWVVDQ 431
XP_001748267 363 -------------------------------------------------------------------DLPA-HAVSMLEQ 374
Q9XWV2       350 -------------------------------------------------------------------VQPEtGIIHVVEQ 362 Caenorhabditis ...
EFX77541     369 -------------------------------------------------------------------PLRD-GLFWVLEQ 380
O62146       379 -------------------------------------------------------------------PLPKnGLFYVLEQ 391 Caenorhabditis ...
Q9BL07       372 -------------------------------------------------------------------ELPDkDVLWISEQ 384 Caenorhabditis ...
XP_020430624 370 -------------------------------------------------------------------DAHD-GMVYVLEQ 381
Q54ZI6       363 -------------------------------------------------------------------ELQS-DLLWIVEQ 374 Dictyostelium d...
XP_004989826 360 -------------------------------------------------------------------PLPH-GIFWVSEQ 371
XP_011270802 378 IPGYVESADVTPIL-RAGYFSSFNVPFFERVFDMSGYPAMVAkygvsfthDLAPRAEIFRRDSNTVVDFSSLKQLMRSNS 456
3_pfamImport 432 LPGRLHAEDITDKIvSDGYWLTNGVPYFKEALDIGQATANAT--------NTTAPSSTMEKILQNITDLETLARFFRQSA 503
XP_001748267 375 MVAVIETSDLSAVInQEGYIASYNIPRSPVIFEISGYAAQgy------syENDTRARIFRRDQHTVTSLNSMSALLNAND 448
Q9XWV2       363 MPGHIVHSDKTAHLfRETYWPGYNQPYYKQIIRFSDTDKMVEkfgdwysyDKTPRALIFKRDHNTVTDMSSMIALMRSNN 442 Caenorhabditis ...
EFX77541     381 LPTLIESRDATDVLrSQSFWPSYNSPYFPTIFNLSGVPALVEeygdwftyDKTPRALIFNRDQSKITDMDSMIRMMRYND 460
O62146       392 MPGKIVYSDLTWFVeKYSYFPSYNIPFFKEITEISGFIGQAAkmgdwfkwGASPRAKIFERDHGNVHDLDSLTALMRYND 471 Caenorhabditis ...
Q9BL07       385 TPGYYETRDMTWYLkKYTYFASYNIPFLPKVSEISGFDNKARqfaw-fdwGGSPRARIFDRDHSKVTDIDSLTKLMRYND 463 Caenorhabditis ...
XP_020430624 382 IPGYVEYDDVTNIV-RTGYWPSYNVPYFEYIYNVSGFNNT-QsygnffsySGNPRAMIFRRDANNVYTFEQYQAELRYNN 459
Q54ZI6       375 YPGGYQAADVTLTLwEQGYWPSYNRPYFEEVFDILGYPYYVEkfgdlftyEYNPRANIFRRDHSKLETLQDMMNIIDYNQ 454 Dictyostelium d...
XP_004989826 372 IPGAYVLEDKTMDL-QRSYWPSYNVPYYPWIYNVSNYPAAARahgddytyQLAPRAKIFRRDAGAVESVDDLKTFIRMNH 450
XP_011270802 457 Yktdpysgg-------spanavcsRYDLI----Angg---------spDGCYDTKATNYARARLLQADALNGPTTA---- 512
3_pfamImport 504 Y-----------------------RGDLDqdepAa-------------FGNIDLKMYTETADGTVHFRAYSGPLYDpars 547
XP_001748267 449 Yendplarg-------dpcnqisaRCDLPkagnAsgn--------pyaFGGIDCKVTGRAQVLQQEARVAGAPSHA---- 509
Q9XWV2       443 Ytkdplskcdcn-ppysaenaiacRSDLN----PlngtypfkslgfrdHGAIDVKVTNSKLINSLQFTAVSGPPGGv--- 514 Caenorhabditis ...
EFX77541     461 YrndplsrcekcepkysgenaisaRNDLN----PangtypfhalshrsHGATDCKVTSHQLMTSLDFIAVGGPTFD---- 532
O62146       472 Ykndefskckcn-ppysaeagisaRGDLN----PangtyefpgqghvnHGALDYKGTNVELMKKLQFVAQGGPTWG---- 542 Caenorhabditis ...
Q9BL07       464 YtheefarckctpnpytgeggisaRGDLN----TpggtyevesmgfrdHAGLDFKGTNYEMFKKMRFRAWGGPPYD---- 535 Caenorhabditis ...
XP_020430624 460 Wehdplsag-------nsgnaissRFDLV----Tksdpnnp-ylnkdaFGGIDSKAVNHAMVRNMQVAAQSGPTYD---- 523
Q54ZI6       455 Yktdpfsmg-------ypgnsinaRFDIKggslPsgnpiys-wfyhgtHGGIDGKAINYDMVNSFTAVARNGPTVT---- 522 Dictyostelium d...
XP_004989826 451 Feqhdplap-------tadsaiaaRRDLD----Ptap---------raDGAIDAKIVNAAMVLDMSVTAIAGPTHD---- 506
XP_011270802 513 -----------------------------------NStlPAY----SWSA---FANlPHVGLPETYNFDFITV 543
3_pfamImport 548 tpgqaakrsivkseqlhqstatdqksapashgdsaTVasHPF----DWSRilpFEV-RHQGHPDVWDFEHITP 615
XP_001748267 510 -----------------------------------IQ--PVFaftpEWSSv------AHAGMPTQLNFTFRQV 539
Q9XWV2       515 -----------------------------------TKdvPIF----DWKTsplREKvPHFGQPDRWNFAPVTY 548 Caenorhabditis elegans
EFX77541     533 -----------------------------------SL--PAF----RWSEsdfVNL-SHIGHPDLWKFEPVQT 563
O62146       543 -----------------------------------KV--PSF----KWSEfdfKDKvNHVGHPDEWKFNTLVH 574 Caenorhabditis elegans
Q9BL07       536 -----------------------------------PL--PVF----DWNHtnlTNV-RHFGQPDVWNFTYVDL 566 Caenorhabditis elegans
XP_020430624 524 -----------------------------------QQ--PPF----NWKQgd--wTyTHVGMPEIWQFPWMIM 553
Q54ZI6       523 -----------------------------------SDc-PPF----NWND---WSLiSHQYMPQIYNFTWISI 552 Dictyostelium discoideum
XP_004989826 507 -----------------------------------TQ--PVFswtgMWAN---ETRgKHYGHAQRFGFDWHVI 539
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