Conserved Protein Domain Family
Tcf25

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pfam04910: Tcf25 (This model is not part of the current CDD release)
Transcriptional repressor TCF25
Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions.
Statistics
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PSSM-Id: 516503
Aligned: 74 rows
Threshold Bit Score: 224.775
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8I434       304 FKIEKNKLYLDAENLFYLLLDTHDI-QAMNELVKKYPFHVDTLLVLAEYY-NETR------------------NYEVANK 363  Plasmodium fal...
Q38EB2       296 YLDVSAPESQRADADLAECEKLVDAvDGLMGCLGKTPYHIPTLIVVSNVFeTMG-------------------NVPRALE 356  Trypanosoma br...
XP_001613240 234 FKLEKHKLYLEAENLFYALLDTHDI-EAMHNLVKKFPFHVDTLLVLSEYY-NESS------------------NFEVANK 293 
Q7RGJ4       246 FKIEKEKLYLEAENLFYLLLDTHDI-QSMNDLIKKYPFHIDTILILAEYY-NETN------------------NYEVANQ 305  Plasmodium yoe...
ESK89923     265 WTVEYGKKYKSVTKAFLRTVFSGDP-QGFFDLLYRTPWHADTLLQLSEVY-RHRD------------------EHAQAID 324 
XP_007334276 256 WTVEYSKKYKSVTRAFMQIVQSGDP-QALFDVLRMLPWHADTLLQISEVY-RHRE------------------EYSQAAD 315 
XP_001887908 243 WAVEYSKKYKSMTKAFMQTVLSGDP-QGFWDLLGKSPWHADTLLQVSEVY-RHRD------------------EHAQAFD 302 
XP_007391560 151 WTVEYSRKYRGMTKTFIQMVMSGDP-EGLFHILRSFPYHADTLLQLSEVY-FHRE------------------EHSTAAD 210 
EPS95213     271 WTIEYSKKYRAFTLAFMQTVMSGDP-EGFNQILGQMPYHADTLLQMSEVY-FHRE------------------EHSTAAD 330 
EMD31786     256 WAVEYSKKYRGVTLAFMQTVMSGDP-EGFYQLQRVLPYHADTLLQLSEVY-HHREgtpsssykailvfrsyeiEHSTASD 333 
Q8I434       364 FIKMSILLLQNIFHI--NFHPnflNKNF-NIFINPYIYDNKCLFKSLYMHMLSLENEACTITSLEIAKLLCKIDLANDLC 440  Plasmodium fal...
Q38EB2       357 VIDLALYHLGVLLQ---SFPLrqtARQRc---VPFSIPSNKQLFQVLRCGIHHALRKAAVRTAWETCKLLYSLDPK-DPF 429  Trypanosoma br...
XP_001613240 294 FTKLALLILQHVFHI--DFSPnslNRSR-EIYVNPHLYDNKALFKALYMHMLSLENEACTITSLEVAKLLCKMDLQFDLC 370 
Q7RGJ4       306 YIKMALLLLQNIFHM--NFNIdyiNNNH-KIYVNPQLYDNKVLFKTLYMHMQSLEYEGCTITSLEIAKLLCKIDLCNDLC 382  Plasmodium yoe...
ESK89923     325 LIDRSIFAYERAFLGmgSF-----NFTSgVNRLDFDRVENRVFFMAVHRVVADLTRRGLTRTAFEFARLLWALDPWADPH 399 
XP_007334276 316 FIDRALFTYERCFIG--AF-----TFTNgHNRLDFDRVENRPFFLALHRQVIDLQRRGCMRTAFEFARLLLSLNPSTDPH 388 
XP_001887908 303 FVDRALFTYERSFIG--AF-----NFTTgLNRLDFDHVENRPFFLAVHRQIADLQRRGCVRTSFEFARLLFSLDPWTDPH 375 
XP_007391560 211 FIDRALFTYERAFVG--AF-----NFTSgQNRLDFDRVENRPFFLAIHRQVSDLQRRGCVRTAFEFARLLFGLDPAIDPH 283 
EPS95213     331 MIDRALFGYERAFLGt-SF-----NFTTgANRLDFDRVENRPFFLAVHRQIGDLQRRGCVRTAFEFARMLYSLDPWTDPH 404 
EMD31786     334 FVDRALFAYERAFVG--SF-----NFTGgNNRLDFDRVENRPFFLALHRQLVDLQRRGCVRTAFEFGRLLYALEPWTDPH 406 
Q8I434       441 SILLRIDNIILKCNLYDFLLYFSFNFIIQNiqsvippntynqivtslmnqqnsitpnhiesnllknnmdninninteiqe 520  Plasmodium fal...
Q38EB2       430 GSLFLLDYLALRSKGWAWLVHVYYLLIREScripnsrtlpptaecvns-------------------------------- 477  Trypanosoma br...
XP_001613240 371 SILLRIDSLILKCNLFDFFIYFSFNFVIQNvqcvvpaarlseilatclhgemrlpgshrpewdehawkrqdggeageaaa 450 
Q7RGJ4       383 GILLRIDGIMLKGNVFEFLVFFSFNFILQNihyvmplsrtneiisdfffnendikngenciteklnpneeishnnipttn 462  Plasmodium yoe...
ESK89923     400 GALFHLEFLAPK-GMGSWMEEVSQVFEQREadsqgr-------------------------------------------- 434 
XP_007334276 389 GAALHLEHIAIKANMAQWFIDMYDFCNSQPispfrna------------------------------------------- 425 
XP_001887908 376 GSLLHLDFLAIKSGMYQWLIDVFDVFADRRkersgeig------------------------------------------ 413 
XP_007391560 284 GSLLHLDFLTIKAGMHQWLLDLWDTQCQMGaewqgr-------------------------------------------- 319 
EPS95213     405 GALLHLDYLAHKAGMTQWILDVWDFFSKAGdddgfrn------------------------------------------- 441 
EMD31786     407 GALLHLDFLAIKAGMHDWLLKLWDLFATQPdgsyrnr------------------------------------------- 443 
Q8I434       521 hninktnvesnkhdhnissnnqmstnq----------------------------------------------------- 547  Plasmodium fal...
Q38EB2           --------------------------------------------------------------------------------      Trypanosoma br...
XP_001613240 451 aggavavagggaeegaeegeaaegespshnnqvgeaagggaaeggapptperrtdeldptddakreppndadcndgppyq 530 
Q7RGJ4       463 qstneisktqenilkmeck------------------------------------------------------------- 481  Plasmodium yoe...
ESK89923         --------------------------------------------------------------------------------     
XP_007334276     --------------------------------------------------------------------------------     
XP_001887908     --------------------------------------------------------------------------------     
XP_007391560     --------------------------------------------------------------------------------     
EPS95213         --------------------------------------------------------------------------------     
EMD31786         --------------------------------------------------------------------------------     
Q8I434       548 -------nqsstqknknsynsnkeqdthtsncnenhilknnltsssqhcdifineqnkqsiimnkqnnlyifnnyelrlh 620  Plasmodium fal...
Q38EB2       478 ------------------------------------------------------------------gcsnlsnhelalsl 491  Trypanosoma br...
XP_001613240 531 megeneselpvgherhsadeqgekgeqnegdpleggkgsgggkvsgggkvsggcncfeggragtalqskllfenfeirlh 610 
Q7RGJ4       482 --------------enisslkrqdgdifddekiiyeqfsqnndftkklpeqdrnndkldylqnthtkkkydfqnyeirlh 547  Plasmodium yoe...
ESK89923     435 -----------------------------------------------------------------------------mnp 437 
XP_007334276 426 ----------------------------------------------------------------------------rhnp 429 
XP_001887908 414 ---------------------------------------------------------------------------grmdp 418 
XP_007391560 320 -----------------------------------------------------------------------------ahv 322 
EPS95213     442 ----------------------------------------------------------------------------rlrp 445 
EMD31786     444 -----------------------------------------------------------------------------lqv 446 
Q8I434       621 filPNFAFAIPMSLYlkmnthlnlddiklikkddiihsfsyeeckyliphf-------------nirficyksnhqinyt 687  Plasmodium fal...
Q38EB2       492 stlPGFFFSAALAKLflereeathtqkggk-------------------------------------------------- 521  Trypanosoma br...
XP_001613240 611 fllPNFAFSLPLSLYlknnngvdlqeirlisvddlvsafsyeecrflsphfairfdchggrakngndrlgqsdhaedhpd 690 
Q7RGJ4       548 filPNFAFSIPLCLYlknntnvnyneineikkndilssfsyeec---------------------------kfliphfni 600  Plasmodium yoe...
ESK89923     438 tvlPGWTWSRAVVLRlsidds----------------------------------------------------------- 458 
XP_007334276 430 stlPGWAYSHALALHil--------------------------------------------------------------- 446 
XP_001887908 419 sllPGWSYARALALRsee-------------------------------------------------------------- 436 
XP_007391560 323 ralPGWAYARALALFile-------------------------------------------------------------- 340 
EPS95213     446 tvlPGWAYARALALYsee-------------------------------------------------------------- 463 
EMD31786     447 talPGWSYARALALYiee-------------------------------------------------------------- 464 
Q8I434       688 gnqtcqnnihdtkqnqdnnqNYSLSFCAHLFLIRALLQYPCFLKTFLNYNNFKATkiVKQTiydylfqdila-appfsnt 766  Plasmodium fal...
Q38EB2       522 ------lsrvirdispaelhAFHDTPPSGVMLADAIGRFPSAAVLLVEKVGSQAQ--PSVApaawkevv-------kghm 586  Trypanosoma br...
XP_001613240 691 gatpdesappkvstneqkkgQPSLSFSAHVTLLRALLCFPNFLQTFLNYNNFKTTkvVKKTiyessfkdila-sppfssp 769 
Q7RGJ4       601 nfncywgnnnvsnlcdkkniSYSLSYSSHLFLIRALLFYPDFVQIFVKYNNFNTSkiVKNTiydisfkhilshppfsdnt 680  Plasmodium yoe...
ESK89923     459 --------------gkgnfeREELEKKSTEALIEAIKSFPTVLPLLADKVDVTVP--DWVRslkecrve------vdgss 516 
XP_007334276 447 -------------------eKDDDHRASTAALSEAVQDFPSIVPLLADKLEVSLS--DTIRghpsckie------teegs 499 
XP_001887908 437 -----------------vakKSKDHQPSTDALKEAIKDFPSIVPLLADKIDGSLS--ASIRahpdsriqt-----dsnsl 492 
XP_007391560 341 -----------------eerKDNEHKRSTEALLEAVNAFPSVVPLLADKADIILP--GAIRahaafriht-----dastl 396 
EPS95213     464 ------------------esKKSDHAASTSALEEAILAFPSIVPVLADKADISLP--ASVRghsafrvyp-----dassl 518 
EMD31786     465 -----------------eskGDKVHEKSTNALKEAVLAFPSTVPLLADKADISLT--GAVRghkvfriht-----dastl 520 
Q8I434       767 qqlNREEYEIVQKivsCFLEKNNIYYKSEKVITWLHVCSsfiHEMYKD----------KKvsqeidevrkeycqkialLD 836  Plasmodium fal...
Q38EB2       587 nnnGGQRLRVAT----LWVARNAEMWNAAEPSGFLRRVIteeSGVYLKslsv---saaNPc----------------aDV 643  Trypanosoma br...
XP_001613240 770 slfRLGEFDVVQKiicCYLEKNNIYYKSERVITWFHVCSaflHELYRD----------PSaaraldkaraewhgkvhlLD 839 
Q7RGJ4       681 lfsNKEEYEIVQKiilAYLEKNNIYYKSEKMITWVHVCSafiHEMYKD----------ELvakeldearkqwhrriplLD 750  Plasmodium yoe...
ESK89923     517 lplEQAILHLLSH---LYVQRAWSLWKTPTISSWLSQTIksvFGSSPSgkqp---lppTPrrirflelysstspaantLR 590 
XP_007334276 500 lslVDAVLHMVSH---LYAQRSYQLWK--DHSSWFAETVsttFAFFPQvkl-----pnTMrhenfcn-----ltgnmgLR 564 
XP_001887908 493 sdpV-AILHLLSH---LYVQRSGAAWK--EHTAWFIETVsdsFSALPSsl------pvTErrkdfls-----lyqnenLR 555 
XP_007391560 397 sdySHAILHLLSH---LYALRSASLWKVKSRAAWFAKTVsilEGKLPSmtfgtsskstSPspslfhs-----lysrpaLT 468 
EPS95213     519 ptpSAGVLHLLSH---LYAQRSSALWKTTERASWFARTVtasLSSLPPsyd-----tmSPaylgfva-----lysrpeLA 585 
EMD31786     521 stqAEAIVHLLSH---IYAQRSFSLWKIPSRASWFAQTVestLSSLSSp--------iPArriladt-----lfanhvLA 584 
Q8I434       837 INKYKHVRVGEFK----SHNYLLPDFLMekNRSYTPNVTNRA 874  Plasmodium falciparum 3D7
Q38EB2       644 PTPWEHEMLREEDlm-gTVMAAIPAHL------------LDP 672  Trypanosoma brucei
XP_001613240 840 VSKYKDVRVGEFK----STNYLLPDFMMekNRTYSPHTPAAP 877 
Q7RGJ4       751 INKYKGIRVSEFK----SRNYLLPDFMMekTVSHPA--PVPN 786  Plasmodium yoelii yoelii
ESK89923     591 HSVWRHVIGLETTy--rSLFKFMPRSIT--ETRSLSCDPLPP 628 
XP_007334276 565 FSFFRHVQVLSSDtnyrRLLAFFPGYTFn-EASFLTCDPIPP 605 
XP_001887908 556 FSVYRHIVVLEPTn--rRLFAFIPRQVQ--EVKSLSCDPLPP 593 
XP_007391560 469 YSVYRHVIVLESVtragRLFGFLPPNIL--TSKQLACDPVPP 508 
EPS95213     586 HGAYRHAIVNEASc--rRLFGFIPREVT--NTKHLACDPLPP 623 
EMD31786     585 LSIYRHTIVNEASc--rRLFSFIPRDVT--NAKHLACDPLPP 622 
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