Conserved Protein Domain Family
SAM_NCD1
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pfam04904: SAM_NCD1 
NAB conserved region 1 (NCD1) SAM domain
Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerisation. This domain is related to the SAM domain.
Links
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Statistics
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PSSM-Id: 487414
Aligned: 8 rows
Threshold Bit Score: 146.852
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDS42126      48 PSNEAELQLYRVLQRASLLSYFDTLLAMGGDDLEQFTSSSQ-EFMEIVDLVGMQSKPLHVRRLQKALQEWIANPSAFQ 124
KAF8361528   149 PSTVSEWQLLAILHRANLLQYYDVFIDKGGDDVNQIMCSEEsEFLEIMSIVGMLSKPLHVRRLQRALAQYSNDPTAFN 226
Q22002        84 PTTLSEWQLLAVLSKANLVQYYDVFIAQGGDDINQIMACEErEFLEIMNLVGMLPKPLHVRRMQRALAEYSQDQTAFN 161 Caenorhabditis el...
XP_003371789  13 PNSPSEWQLYLVLQRANLLQYYDTFISQGGDDVQQLLEAGEeEFLEIMALVGMASKPLHVRRLQKSLQEYGSNPSTFQ 90 
XP_009022947  11 giSKSEWILFKVLEKANLLQYYDNFISQGGDDVTQLCEASEdEFLEIMALVGMSSRPLHVRRLQKVLKEWISNPDMFg 88 
XP_011665953  10 PQTLSELQLYRVLDRANLLPYYTNFILQGGDDVQQLCEAGEdEFLEIMSLVGMGSKPLHVRRLQKALQEWVASPAAFQ 87 
NP_001071775   6 PTTLGELQLYKVLQRANLLGYYDIFISHGGDDVQQLCEAGEeEFLEIMALIGMASKPLHVRRFQKTLQDWVTSPHLFQ 83  vase tunicate
XP_064408539  35 PRTLGELQLYRVLQRANLLSYYDTFIQQGGDDVQQLCEAGEeEFLEIMALVGMATKPLHVRRLQKALREWATNPAVFN 112 coelacanth
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