Conserved Protein Domain Family
Uso1_p115_C

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pfam04871: Uso1_p115_C 
Uso1 / p115 like vesicle tethering protein, C terminal region
Also known as General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerization, and a short C-terminal acidic region. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the golgi stack. This family consists of the acidic C-terminus, which binds to the golgins giantin and GM130. p115 is thought to juxtapose two membranes by binding giantin with one acidic region, and GM130 with another.
Statistics
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PSSM-Id: 398507
Aligned: 18 rows
Threshold Bit Score: 47.0587
Threshold Setting Gi: 28917322
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9W3N6        695 EQSLKAQ--LLDQNTLLKAQLGASTGQVQSAQGAeatppnEEELNAARYQANMYFAENIRLTK-ELETLRQQLSAEKQSA 771  fruit fly
Q6C359       1781 LESKTTE--LKTINTELKDRTSELKTKTTELESK-------------STELKTVSDTQSATEK-ALAELQSKYDELLKTN 1844 Yarrowia lipo...
CDF91372     1773 YEKETSS--LIHEKNSLGVKADSLAKELRNLASSn-----EQCKIDSDARERQIKEENDYLSS-ELEKLRLQVAESESSK 1844 Zygosaccharom...
XP_003958487 1754 LEEKASL--LESELLDLKNSLEEKDSVIQKKEQLi-----SQSQQKNNSELMELRDLLKKLEE-ENKKLSEQVSD----- 1820 Kazachstania ...
CBY00474      903 SQSTVEK--FKSEIQELKTKLQDQTWKVKDTEEK----------------LRKAESSAKSSNNkAVKDLEAKLKKAQESE 964  Leptosphaeria...
EPS25288      950 TEESTNS--IEAANKASLSKLSALEARAVEAERK----------------AKEAESQAKKTEN-ALKKIQAQLEKVQEEA 1010 Penicillium o...
GAD96573      916 AEKRAQD--AEKQVKAANDKAQKAEERARKAEEQ---------KKSAGKGADDTEKRIAKVQE-QLKELQAALEKAKAEA 983  Byssochlamys ...
EPS35462      876 VERKAAEkrLSDLKREMESRLQETARIAEDSAKK----------------AATAEAEILKVKE-AAKKEKAEMEMEREGE 938  Dactylellina ...
EAA27030     1056 IETRLQK--------EKEDELAQMRKQLEKEREE------AVAKAVAEAVAKAVEEAKKEATN-QVKEVKEKLDEEIKNA 1120 Neurospora cr...
XP_007926739 1006 LEEAKSS--AEEELEKTKAELSAAKKSAEDQHQKtkt-elKSAKEAAESLQSELEASKKSLEQ-AQKQAQKAVAEAKENE 1081 Pseudocercosp...
Q9W3N6        772 daaq-dslAAM--QKDQEDLLELLADQEAKLTRYEEAGSTNTLPTsnvAPSVPAAGGGSPI---PSG 832  fruit fly
Q6C359       1845 kaks-aatKDMvpKSEYEELMLMITDLDEKVEKYKEKLEEHGVEI---SDDDDDDDDDDDD---DED 1904 Yarrowia lipolytica
CDF91372     1845 tkgdnkspKSSegNSEVDELMLLVTDLDEKNTKYKAKLKELGVEL---SSDEDDEEEDDEEgdeEEE 1908 Zygosaccharomyces bailii C...
XP_003958487 1821 -------------RTEIDDLMLLVTDLDEKNSRYREKLESLGVEVs--SDEEDDDEEDEEEgtg--- 1869 Kazachstania africana CBS ...
CBY00474      965 ke----------kQTELDDLFVLLGDLEEKRSRDKKRLKALGEEV---SDGEDDDDDEEDDeevDEE 1018 Leptosphaeria maculans JN3
EPS25288     1011 keke-earQAT--QTELDDLLIVFGDLEAKRAEDKKRLKDLGQEV---SEGEDEDDEDEED---DEE 1068 Penicillium oxalicum 114-2
GAD96573      984 eeke-karESA--QGELEDLLIVFGDLEAKRNQDKKRLKELGQEV---SEDEDDEEDQEEDgdeDDE 1044 Byssochlamys spectabilis N...
EPS35462      939 reka------aiaQAEADDLMLVMADLEENVKKYKARLKKLGEDV---TDDEGEGEEEEEE---EEE 993  Dactylellina haptotyla CBS...
EAA27030     1121 -------------QSERDDLLLLFDDLEEKRQKYKEQLKKLGGEV---SEDEEEEEDEDED---GAE 1168 Neurospora crassa OR74A
XP_007926739 1082 kq----------aKEELESMLLVMGDIEAKRDEYKAKIKVLGGEV---SEDENEDDSEEES---EGD 1132 Pseudocercospora fijiensis...
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